Nature Reviews Cancer contents June 2012 Volume 12 Number pp pp 373-444

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TABLE OF CONTENTS
June 2012 Volume 12 Number 6		Advertisement
Impact Factor 37.178 *	In this issue Research Highlights Progress Reviews Perspectives Also this month  Featured article: Spatial regulation of receptor tyrosine kinases in development and cancer Jessica B. Casaletto & Andrea I. McClatchey	Get the most from your NGS data with Sequenom’s MassARRAY® system • Validate from tens to thousands of samples across tens to hundreds of SNPs • Design you own assays against any SNP of interest • Run a variety of applications including genotyping, DNA methylation and somatic mutation analysis
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RESEARCH HIGHLIGHTS Top Lung cancer: Radial targets p373 | doi:10.1038/nrc3280 A paper published in Cell identifies pathways regulated by GATA2 as potential targets in RAS pathway-mutant non-small-cell lung cancer. PDF Therapeutics: Iterations of BRAF p374 | doi:10.1038/nrc3284 Röring and colleagues investigate the involvement of the dimer interface in the ability of RAF to mediate downstream signalling, with implications for targeting BRAF. PDF Breast cancer: Divide and conquer? p375 | doi:10.1038/nrc3279 Two papers have been published in Nature that analyse genomic and transcriptomic changes in breast tumours to further understand the biology of breast cancer. PDF Therapeutics: siRNAs jump the hurdle p376 | doi:10.1038/nrc3281 Specific delivery of small interfering RNAs directed against Polo-like kinase 1 to tumour cells using a single-chain fragmented antibody against ERBB2 can reduce xenograft tumour growth and experimental metastases, with minimal toxicities, in mice. PDF Multiple myeloma: Evolution by alternating dominance p376 | doi:10.1038/nrc3285 A new study characterizes the evolutionary dynamics of multiple myeloma progression. PDF IN THE NEWS Curcumin curries favour? p376 | doi:10.1038/nrc3288 A clinical trial will aim to uncover whether curcumin can improve response to chemotherapy in patients with advanced bowel cancer. PDF Metastasis: Dynamic interactions p378 | doi:10.1038/nrc3282 Timothy Thomson and colleagues have used prostate and bladder cancer models, derived from human cell lines, to show that epithelial-to-mesenchymal transition can suppress tumour-initiating potential and colonization of distant organs. PDF Cell cycle: A WEE pointer p378 | doi:10.1038/nrc3286 Cancer cells with mutant p53 and high expression levels of EZH2 and mitotic cyclins are likely to be sensitive to a combination of an inhibitor of the WEE1 kinase and chemotherapeutic agents that induce S phase arrest. PDF Inflammation: The gut takes a toll on liver cancer p379 | doi:10.1038/nrc3283 Schwabe and colleagues show that PAMPs and intestinal bacteria promote TLR4 signalling in the liver, which promotes liver tumour progression. PDF IN BRIEF Sequencing: CpG islands and 5-hydroxymethylcytosine | Metabolism: In need of a NADPH rush? | Therapeutics: Anticancer effect only in diabetics? | Pancreatic cancer: Cooperation | Genetics: Mutation identified for an inherited cancer | Migration: Transporting ions and moving cells | Genomic instability: Potential predictive value of somatic mosaicism | Therapy: Enhancing efficacy by reducing side effects PDF Cancer JOBS of the week miRNAs for the treatment of human cancers Unieversità Magna Graecia di Catanzaro - AIRC Research Assistant Professor of Cancer Bioinformatics Vanderbilt University Medical Center Postdoctoral Fellow - Breast Cancer Research Beckman Research Institute City of Hope Postdoctoral Fellow in Mouse Genetics / Cancer Genomics Fred Hutchinson Cancer Research Center Postdoctoral Fellowships in Cancer Research German Cancer Research Center More Science jobs from Cancer EVENT IDIBELL Cancer Conference (ICC) on Epigenetics in Lymphocyte Biology and Disease 13.-17.09.12 Barcelona, Spain More science events from
PROGRESS		Top
Pioneer factors in hormone-dependent cancers Kamila M. Jozwik & Jason S. Carroll p381 | doi:10.1038/nrc3263 Pioneer factors are a special class of transcription factor that can associate with compacted chromatin to facilitate the binding of additional transcription factors. This Progress article discusses the importance of pioneer factors in breast cancer and prostate cancer. Abstract | Full Text | PDF
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REVIEWS		Top
Spatial regulation of receptor tyrosine kinases in development and cancer Jessica B. Casaletto & Andrea I. McClatchey p387 | doi:10.1038/nrc3277 This Review discusses the importance of spatial control of receptor tyrosine kinase (RTK) activity during development and tissue homeostasis, and how spatial deregulation of RTKs may contribute to tumorigenesis and affect the sensitivity and resistance of cancers to pharmacological RTK inhibitors. Abstract | Full Text | PDF
Deconvoluting the context-dependent role for autophagy in cancer Eileen White p401 | doi:10.1038/nrc3262 Autophagy can have two functions in cancer: it can be tumour suppressive or tumour promoting. Therefore, defining the context-specific role for autophagy in cancer and the mechanisms involved is important for the use of autophagy-based therapeutics. Abstract | Full Text | PDF
Killing a cancer: what are the alternatives? Peter Kreuzaler & Christine J. Watson p411 | doi:10.1038/nrc3264 Research over the past decade has greatly increased our understanding of non-apoptotic programmed cell death events, such as lysosomal-mediated cell death, necroptosis and cell death with autophagy. This Review discusses converging and diverging features of these pathways with a view to developing new therapeutics for cancer. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION To differentiate or not — routes towards metastasis Thomas Brabletz p425 | doi:10.1038/nrc3265 Why are many metastases differentiated? This Opinion article proposes that this is due to phenotypic plasticity involving transient epithelial–mesenchymal transition (EMT). In undifferentiated metastasis, it might be that cells are genetically locked into an undifferentiated state. The therapeutic consequences of this hypothesis are also discussed. Abstract | Full Text | PDF
OPINION Towards the use of cannabinoids as antitumour agents Guillermo Velasco, Cristina Sánchez & Manuel Guzmán p436 | doi:10.1038/nrc3247 Cannabinoids have well-established roles in palliating cancer-associated symptoms, but numerous recent studies also support their antitumorigenic activity. This Opinion article focuses on preclinical studies of the antitumour effects of cannabinoids, including the associated cellular signalling pathways and resistance mechanisms. Abstract | Full Text | PDF | Supplementary information
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