Nature Immunology Contents: May 2012 Volume 13 pp 421 - 518

TABLE OF CONTENTS June 2012 Volume 13, Issue 6 Editorial Commentary News and Views Research Highlights Review Articles Errata Corrigendum Advertisement Fast Quantitative Western Blotting The new V3 Western Workflow™ from Bio-Rad streamlines your western blot protocol and delivers reliable results faster. Visualize and verify results at each step of your experiment, and quantify your proteins with confidence. See more V3 Western Workflow here. Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Nature Outlook: Malaria The past attempts to eradicate malaria have failed. What will it take to finally subdue this deadly disease? Access the Outlook free online for six months. Produced with support from: Medicines for Malaria Venture (MMV), Sigma-Tau, Vestergaard Frandsen New York   Editorial Top On supplementary information p519 doi:10.1038/ni.2325 Nature Immunology is implementing new editorial guidelines for the supplementary material of research articles. Full Text | PDF Commentary Top Immune to addiction: the ethical dimensions of vaccines against substance abuse pp521 - 524 Michael J Young, Dominic A Sisti, Hila Rimon-Greenspan, Jason L Schwartz and Arthur L Caplan doi:10.1038/ni.2321 Abstract | Full Text | PDF News and Views Top DOCKing innate to adaptive signaling for persistent antibody production pp525 - 526 Markus Werner and Hassan Jumaa doi:10.1038/ni.2317 Protection against recurrent infections requires the generation of memory B cells and persistent antibody production. An adaptor complex of DOCK8-MyD88-Pyk2 now links signaling via TLR9 to activation of the transcription factor STAT3 and the establishment of serological memory. Full Text | PDF See also: Article by Jabara et al. Don't mess with ERAAP! pp526 - 528 Jonathan W Yewdell and Xiuju Lu doi:10.1038/ni.2306 Immunosurveillance monitors subversion of the endoplasmic reticulum aminopeptidase ERAAP. ERAAP-deficient cells are killed by T cells that recognize nonclassical major histocompatibility complex class I Qa-1 molecules presenting peptides generated in the absence of ERAAP. Full Text | PDF See also: Article by Nagarajan et al. Death diverted, but to what? pp528 - 530 Gretta L Stritesky and Kristin A Hogquist doi:10.1038/ni.2311 The role of the coreceptor CD28 in thymic clonal deletion has been controversial. New evidence suggests that CD28 deficiency impairs the clonal deletion of self-reactive T cells but also results in their developmental diversion to an anergic lineage that ends up in the gut. Full Text | PDF See also: Article by Pobezinsky et al. Tespa1: another gatekeeper for positive selection pp530 - 532 Nicholas R J Gascoigne and Guo Fu doi:10.1038/ni.2315 A previously unknown protein, Tespa1, that regulates the thymocyte positive-selection checkpoint has now been identified. The phenotype of Tespa1-deficient mice and the role of Tespa1 in thymocyte signaling are very similar to those of Themis-deficient mice and Themis itself, another recently described but unrelated protein. Full Text | PDF See also: Article by Wang et al. Immunology JOBS of the week Post doctoral scientist (Immunology), New York Columbia University Associate PHC Leader Immunology Genentech Professor of Immunology Massachusetts General Hospital, Harvard Medical School HIV Immunology Postdoctoral Fellow New York University School of Medicine Senior Scientist, Biotherapeutics (Multi-specific Biologics) Immunology / Inflammation- Boehringer Ingelheim Pharmaceuticals, Inc. More Science jobs from Immunology EVENT Cell Symposia: Human Immunity 19th August - 21st August 2012 Lisbon, Portugal More science events from Research Highlights Top Inflammasome jigsaw puzzles | Pathogen-tailored TH17 cells | Building blocks of hematopoiesis | TSLP underlies the atopic march | TCR tuning | Good microbes Review Top Genetic variation in Toll-like receptors and disease susceptibility pp535 - 542 Mihai G Netea, Cisca Wijmenga and Luke A J O'Neill doi:10.1038/ni.2284 Abstract | Full Text | PDF Articles Top Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E pp543 - 550 Barbara Herdy, Maritza Jaramillo, Yuri V Svitkin, Amy B Rosenfeld, Mariko Kobayashi, Derek Walsh, Tommy Alain, Polen Sean, Nathaniel Robichaud, Ivan Topisirovic, Luc Furic, Ryan J O Dowling, Annie Sylvestre, Liwei Rong, Rodney Colina, Mauro Costa-Mattioli, Jörg H Fritz, Martin Olivier, Earl Brown, Ian Mohr and Nahum Sonenberg doi:10.1038/ni.2291 The eukaryotic translation-initiation factor eIF4E is a rate-limiting factor in protein translation. Sonenberg and colleagues show that phosphorylation of eIF4E modulates the antiviral response by selectively stimulating translation of the NF-κB inhibitor IκBα Abstract | Full Text | PDF Constitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps-SHP-2 pathway pp551 - 559 Sheng Xu, Xingguang Liu, Yan Bao, Xuhui Zhu, Chaofeng Han, Peng Zhang, Xuemin Zhang, Weihua Li and Xuetao Cao doi:10.1038/ni.2283 Major histocompatibility complex (MHC) molecules are known to mediate reverse signaling. Cao and colleagues show that reverse signaling via MHC class I attenuates Toll-like receptor-triggered innate inflammatory responses through an Fps-SHP-2 pathway. Abstract | Full Text | PDF Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling pp560 - 568 Di Wang, Mingzhu Zheng, Lei Lei, Jian Ji, Yunliang Yao, Yuanjun Qiu, Lie Ma, Jun Lou, Chuan Ouyang, Xue Zhang, Yuewei He, Jun Chi, Lie Wang, Ying Kuang, Jianli Wang, Xuetao Cao and Linrong Lu doi:10.1038/ni.2301 Positive selection of thymocytes is controlled by TCR expression and signaling. Lu and colleagues describe a previously uncharacterized protein, Tespa1, which associates with TCR signaling components and has a critical role in positive selection. Abstract | Full Text | PDF See also: News and Views by Gascoigne & Fu Clonal deletion and the fate of autoreactive thymocytes that survive negative selection pp569 - 578 Leonid A Pobezinsky, Georgi S Angelov, Xuguang Tai, Susanna Jeurling, François Van Laethem, Lionel Feigenbaum, Jung-Hyun Park and Alfred Singer doi:10.1038/ni.2292 The role of costimulation in negative selection is controversial. Singer and colleagues demonstrate that it is critical for clonal deletion and its absence results in the diversion of thymocytes to an intraepithelial lymphocyte population. Abstract | Full Text | PDF See also: News and Views by Stritesky & Hogquist Nonclassical MHC class Ib-restricted cytotoxic T cells monitor antigen processing in the endoplasmic reticulum pp579 - 586 Niranjana A Nagarajan, Federico Gonzalez and Nilabh Shastri doi:10.1038/ni.2282 The aminopeptidase ERAAP trims peptides loaded onto MHC class I molecules and can be targeted during evasion of the immune response by pathogens. Shastri and colleagues show that inhibition of ERAAP identifies a protective nonclassical MHC presentation pathway involving Qa-1. Abstract | Full Text | PDF See also: News and Views by Yewdell & Lu TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells pp587 - 595 Hayato Takahashi, Tomohiko Kanno, Shingo Nakayamada, Kiyoshi Hirahara, Giuseppe Sciumé, Stefan A Muljo, Stefan Kuchen, Rafael Casellas, Lai Wei, Yuka Kanno and John J O'Shea doi:10.1038/ni.2286 Polarized CD4+ T cells can demonstrate considerable plasticity depending on the cytokine milieu they encounter. O'Shea and colleagues show that retinoic acid induces the microRNA miR-10a, which suppresses the transcription factor Bcl-6 to prevent conversion into follicular helper T cells. Abstract | Full Text | PDF TRIM28 prevents autoinflammatory T cell development in vivo  pp596 - 603 Shunsuke Chikuma, Naomasa Suita, Il-Mi Okazaki, Shiro Shibayama and Tasuku Honjo doi:10.1038/ni.2293 TRIM28 is a nuclear protein associated with repressive heterochromatin. Honjo and colleagues show that loss of TRIM28 in T cells alters peripheral T cell homeostasis and regulatory T cell function, which leads to autoimmunity. Abstract | Full Text | PDF Divergent transcriptional programming of class-specific B cell memory by T-bet and RORα pp604 - 611 Nathaniel S Wang, Louise J McHeyzer-Williams, Shinji L Okitsu, Thomas P Burris, Steven L Reiner and Michael G McHeyzer-Williams doi:10.1038/ni.2294 Activated B cells can tailor their ensuing antibody responses by isotype switching. McHeyzer-Williams and colleagues demonstrate B cell-intrinsic requirements for the transcription factors T-bet and RORα in maintaining IgG2a+ and IgA+ memory cells, respectively. Abstract | Full Text | PDF DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation pp612 - 620 Haifa H Jabara, Douglas R McDonald, Erin Janssen, Michel J Massaad, Narayanaswamy Ramesh, Arturo Borzutzky, Ingrid Rauter, Halli Benson, Lynda Schneider, Sachin Baxi, Mike Recher, Luigi D Notarangelo, Rima Wakim, Ghassan Dbaibo, Majed Dasouki, Waleed Al-Herz, Isil Barlan, Safa Baris, Necil Kutukculer, Hans D Ochs, Alessandro Plebani, Maria Kanariou, Gerard Lefranc, Ismail Reisli, Katherine A Fitzgerald, Douglas Golenbock, John Manis, Sevgi Keles, Reuben Ceja, Talal A Chatila and Raif S Geha doi:10.1038/ni.2305 Dock8 deficiency leads to defects in humoral immunity. Geha and colleagues show that Dock88 interacts with MyD88 to bridge TLR9 signaling to the Src-Syk-STAT3 pathway to promote B cell proliferation and differentiation. Abstract | Full Text | PDF See also: News and Views by Werner & Jumaa Errata Top Solving vaccine mysteries: a systems biology perspective p621 Lydie Trautmann and Rafick-Pierre Sekaly doi:10.1038/ni0612-621a Full Text | PDF Writing a first grant proposal p621 Julian Gomez-Cambronero, Lee-Ann H Allen, Martha K Cathcart, Louis B Justement, Elizabeth J Kovacs, Kenneth R McLeish and William M Nauseef doi:10.1038/ni0612-621b Full Text | PDF SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates p621 Hichem Lahouassa, Waaqo Daddacha, Henning Hofmann, Diana Ayinde, Eric C Logue, Loïc Dragin, Nicolin Bloch, Claire Maudet, Matthieu Bertrand, Thomas Gramberg, Gianfranco Pancino, Stéphane Priet, Bruno Canard, Nadine Laguette, Monsef Benkirane, Catherine Transy, Nathaniel R Landau, Baek Kim and Florence Margottin-Goguet doi:10.1038/ni0612-621c Full Text | PDF Body-barrier surveillance by the epidermal γδ TCRs p621 Grzegorz Chodaczek, Veena Papanna, M Anna Zal and Tomasz Zal doi:10.1038/ni0612-621d Full Text | PDF Corrigendum Top The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation p621 Anke Di, Xiao-Pei Gao, Feng Qian, Takeshi Kawamura, Jin Han, Claudie Hecquet, Richard D Ye, Stephen M Vogel and Asrar B. Malik doi:10.1038/ni0612-621e Full Text | PDF Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. 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