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| | | 01 May 2012 | | | Featured image: | |  | | | Goodkin et al. use radiocarbon measurements from coral to reveal stable ocean circulation over the past 200 years in the subtropical North Atlantic. |
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POSTER - MITOCHONDRIAL FUNCTION AND CANCER
Author: Douglas C. Wallace
This Poster highlights some recent discoveries that have led to a renewed interest in the function of mitochondria in cancer cells. Mitochondria carry out a number of crucial functions in cells and these can be altered through mutations in either the nuclear DNA or the mitochondrial DNA.
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| | | | | | Latest Articles | View all Articles | | | | | Quantum phases with differing computational power | | | Jian Cui, Mile Gu, Leong Chuan Kwek, Marcelo França Santos, Heng Fan and Vlatko Vedral | | | Quantum phase transitions are generally associated with many-body quantum systems undergoing changes between different phases. This study examines the connection between such phase transitions and quantum information processing, and finds that different quantum phases can have different computational power. | | | 01 May | Nat Commun 3:812 doi:10.1038/ncomms1809 (2012) | | | Physical sciences Theoretical physics | | | Abstract | Full Text | PDF (511 kB) |
| Reliable detection of subclonal single-nucleotide variants in tumour cell populations | | | Moritz Gerstung, Christian Beisel, Markus Rechsteiner, Peter Wild, Peter Schraml, Holger Moch and Niko Beerenwinkel | | | The detection of subclonal variants in heterogeneous cancer specimens is a challenge due to errors that occur during sequencing. In this study, a statistical algorithm and a sequencing strategy are reported that circumvent this issue and can accurately detect variants at a frequency as low as 1/10,000. | | | 01 May | Nat Commun 3:811 doi:10.1038/ncomms1814 (2012) | | | Biological sciences Bioinformatics | | | Cancer Genetics | | | | Abstract | Full Text | PDF (6,889 kB) |
Supplementary Information |
| Topological repulsion between domain walls in magnetic nanowires leading to the formation of bound states | | | Luc Thomas, Masamitsu Hayashi, Rai Moriya, Charles Rettner and Stuart Parkin | | | The manipulation of domain walls in magnetic nanodevices is a topic of increasing technological relevance. This study examines the interactions that occur between vortex domain walls in permalloy nanowires, and finds that bound states occur between domain walls with opposite magnetic charge. | | | 01 May | Nat Commun 3:810 doi:10.1038/ncomms1808 (2012) | | | Physical sciences Materials science Nanotechnology | | Abstract | Full Text | PDF (947 kB) |
Supplementary Information |
| Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm | | | Hiromitsu Negoro, Akihiro Kanematsu, Masao Doi, Sylvia O. Suadicani, Masahiro Matsuo, Masaaki Imamura, Takeshi Okinami, Nobuyuki Nishikawa, Tomonori Oura, Shigeyuki Matsui, Kazuyuki Seo, Motomi Tainaka, Shoichi Urabe, Emi Kiyokage, Takeshi Todo, Hitoshi Okamura, Yasuhiko Tabata and Osamu Ogawa | | | Humans and rodents normally store more urine in the bladder when fast asleep than when awake. In this study, the production of the gap junction protein connexin43, a regulator of bladder capacity, is shown to oscillate in mouse urinary bladder muscle in synchrony with the circadian clock. | | | 01 May | Nat Commun 3:809 doi:10.1038/ncomms1812 (2012) | | | Biological sciences Cell biology | | | | Abstract | Full Text | PDF (1,188 kB) |
Supplementary Information |
| TEMPRANILLO genes link photoperiod and gibberellin pathways to control flowering in Arabidopsis | | | Michela Osnato, Cristina Castillejo, Luis Matías-Hernández and Soraya Pelaz | | | In Arabidopsis the photoperiod pathway promotes flowering in response to longer days, but during short days flowering depends on gibberellin accumulation. This study shows that TEMPRANILLO downregulation is required to induce flowering, as TEMPRANILLO genes repress floral induction in the photoperiod and gibberellin pathways. | | | 01 May | Nat Commun 3:808 doi:10.1038/ncomms1810 (2012) | | | Biological sciences Biochemistry | | | Developmental biology | | | Genetics Plant sciences | | Abstract | Full Text | PDF (695 kB) |
Supplementary Information |
| Multi-octave supercontinuum generation from mid-infrared filamentation in a bulk crystal | | | F. Silva, D.R. Austin, A. Thai, M. Baudisch, M. Hemmer, D. Faccio, A. Couairon and J. Biegert | | | Broadband coherent light sources are crucial for numerous applications, such as imaging and spectroscopy. Using filamentation of mid-infrared laser pulses in bulk crystals, Silva et al. generate supercontinuum spectra over three octaves, from 4.5 μm to 450 nm, with carrier-envelope phase stability. | | | 01 May | Nat Commun 3:807 doi:10.1038/ncomms1816 (2012) | | | Physical sciences Optical physics | | Abstract | Full Text | PDF (526 kB) |
Supplementary Information |
| Frequency stabilization in nonlinear micromechanical oscillators OPEN | | | Dario Antonio, Damián H. Zanette and Daniel López | | | Micromechanical oscillators present a route to miniaturisation of devices and may be used as frequency references or sensitive sensors, but their small size means that they often behave nonlinearly. Antonio et al. demonstrate frequency stabilisation of nonlinear resonators by coupling two vibrational modes. | | | 01 May | Nat Commun 3:806 doi:10.1038/ncomms1813 (2012) | | | Physical sciences Applied physics | | | Nanotechnology | | | | Abstract | Full Text | PDF (736 kB) |
Supplementary Information |
| Non-polydimethylsiloxane devices for oxygen-free flow lithography | | | Ki Wan Bong, Jingjing Xu, Jong-Ho Kim, Stephen C. Chapin, Michael S. Strano, Karen K. Gleason and Patrick S. Doyle | | | Flow lithography is used to synthesize microparticles but relies on polydimethylsiloxane microchannels for oxygen to permeate and inhibit polymerization near channel interfaces. Now, non-polydimethylsiloxane devices have been developed, which allow oxygen-free lithography, increasing the capabilities of flow lithography. | | | 01 May | Nat Commun 3:805 doi:10.1038/ncomms1800 (2012) | | | Chemical sciences Fluids and plasma physics | | | Materials science | | Abstract | Full Text | PDF (1,406 kB) |
Supplementary Information |
| Dinosaur morphological diversity and the end-Cretaceous extinction | | | Stephen L. Brusatte, Richard J. Butler, Albert Prieto-Márquez and Mark A. Norell | | | Dinosaurs became extinct 65 million years ago due to volcanism and a bolide impact, but whether their numbers were already declining is still not clear. This study calculates the morphological disparity of seven dinosaur subgroups, showing that at least some groups were in a long-term decline before the extinction. | | | 01 May | Nat Commun 3:804 doi:10.1038/ncomms1815 (2012) | | | Biological sciences Evolution | | | Palaeontology | | Abstract | Full Text | PDF (583 kB) |
Supplementary Information |
| Two centuries of limited variability in subtropical North Atlantic thermocline ventilation OPEN | | | Nathalie F. Goodkin, Ellen R. M. Druffel, Konrad A. Hughen and Scott C. Doney | | | Ocean circulation moves heat and gases between the ocean and atmosphere, impacting the carbon cycle at decadal timescales. Here, a radiocarbon coral record of ocean mixing from Bermuda suggests that the formation of mode water, and thus carbon uptake, have been more stable over the past 200 years than previously thought. | | | 01 May | Nat Commun 3:803 doi:10.1038/ncomms1811 (2012) | | | Earth sciences Oceanography | | | Abstract | Full Text | PDF (589 kB) |
| Adaptive mutations in NEP compensate for defective H5N1 RNA replication in cultured human cells | | | Benjamin Mänz, Linda Brunotte, Peter Reuther and Martin Schwemmle | | | Adaptive mutations in the avian influenza virus permit replication in mammals but how these mutations enable this effect is unclear. In this study, mutations found in the nuclear export protein of human isolates of H5N1 are shown to enhance the replication of viral RNA in human cells in culture. | | | 01 May | Nat Commun 3:802 doi:10.1038/ncomms1804 (2012) | | | Biological sciences Medical research Microbiology | | | Molecular biology Virology | | Abstract | Full Text | PDF (799 kB) |
Supplementary Information |
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