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TABLE OF CONTENTS
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May 2012 Volume 30, Issue 5 |
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 |  In This Issue
Editorials
News
Bioentrepreneur
Correspondence
Features
News and Views
Research Highlights
Computational Biology
 Research
Errata
Careers and Recruitment
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Trade Secrets
A Nature Network blog by Bioentrepreneur
Brought to you by Nature Biotechnology
Access the insights, advice and commentary from scientists and entrepreneurs building biotech sectors around the world.
Click here to join the global dialogue on life science entrepreneurship and don’t forget to follow us on Twitter! | |
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In This Issue |  Top |
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In this issue ppvii - viii
doi:10.1038/nbt.2233
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Editorials | Top |
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Shining a light on trial data p371
doi:10.1038/nbt.2237
The European Medicines Agency's request to make all clinical trial data available is key to countering bias in publication, drug prescription practice and health policy.
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Biomarkers unbound p372
doi:10.1038/nbt.2221
Controversies surrounding government walk-in rights or patent eligibility that grabbed headlines in recent weeks presage broader changes in biomarker patenting.
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News | Top |
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Industry reels as Prometheus falls and Myriad faces further reviews pp373 - 374
Jeffrey L. Fox
doi:10.1038/nbt0512-373
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JAK pot for Galapagos p374
Gunjan Sinha
doi:10.1038/nbt0512-374
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Stromedix acquisition signals growing interest in fibrosis pp375 - 376
Malorye Allison
doi:10.1038/nbt0512-375
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1000 genomes on Amazon's cloud p376
Emily Waltz
doi:10.1038/nbt0512-376
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Affymax poised to challenge Amgen pp377 - 379
Nuala Moran
doi:10.1038/nbt0512-377
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UK biotech's shot in the arm p378
Susan Aldridge
doi:10.1038/nbt0512-378
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Texas legitimizes path around FDA oversight p379
Laura DeFrancesco
doi:10.1038/nbt0512-379
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Blood test for Down syndrome p380
Jennifer Rohn
doi:10.1038/nbt0512-380a
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Industry trial bias refuted p380
Josh P Roberts
doi:10.1038/nbt0512-380b
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Fifth time's the charm for infant respiratory distress drug p380
Alla Katsnelson
doi:10.1038/nbt0512-380c
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Hypoxia-activated prodrugs forge ahead in cancer p381
Jim Kling
doi:10.1038/nbt0512-381
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Around the world in a month p382
doi:10.1038/nbt0512-382
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| Data Page |
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Drug pipeline: 1Q12 p383
Craig Mak
doi:10.1038/nbt.2210
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Biotech equities heat up in 1Q12 p384
Walter Yang
doi:10.1038/nbt.2211
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| News Feature |
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Recasting natural product research pp385 - 387
Cormac Sheridan
doi:10.1038/nbt.2208
Can the commercial sector capitalize on the merger of high-throughput technology and natural products? Cormac Sheridan investigates.
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Bioentrepreneur | Top |
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| Building a business |
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| A work in progress pp388 - 389
Bill Polvino
doi:10.1038/nbt.2178
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Correspondence | Top |
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High-efficiency TALEN-based gene editing produces disease-resistant rice pp390 - 392
Ting Li, Bo Liu, Martin H Spalding, Donald P Weeks and Bing Yang
doi:10.1038/nbt.2199
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How Europe's ethical divide looms over biotech law and patents pp392 - 394
George Gaskell, Sally Stares and Alain Pottage
doi:10.1038/nbt.2201
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The many faces of Bruton's tyrosine kinase p394
C Patrick McAtee
doi:10.1038/nbt.2200
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Features | Top |
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Biotech's wellspring: a survey of the health of the private sector pp395 - 400
Brady Huggett
doi:10.1038/nbt.2209
An examination of the private biotech industry reveals shrinking financial resources and higher hurdles to obtain funding, but new models are evolving to meet the challenge.
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Biotech innovation in a first-to-file world pp401 - 403
Jennifer A Camacho
doi:10.1038/nbt.2204
You may win the race, but can you take home the prize?
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Recent patent applications in genomic mapping p404
doi:10.1038/nbt.2217
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News and Views | Top |
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Research Highlights | Top |
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Docetaxel-loaded nanoparticles shrink human tumors | Engineering a thymus | Zinc-finger nucleases hone tumor cell therapy | Drug lead for osteoarthritis | Pharmacogenomic profiling of cancer drugs
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Computational Biology | Top |
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| Analysis |
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Absolute quantification of somatic DNA alterations in human cancer pp413 - 421
Scott L Carter, Kristian Cibulskis, Elena Helman, Aaron McKenna, Hui Shen, Travis Zack, Peter W Laird, Robert C Onofrio, Wendy Winckler, Barbara A Weir, Rameen Beroukhim, David Pellman, Douglas A Levine, Eric S Lander, Matthew Meyerson and Gad Getz
doi:10.1038/nbt.2203
Tumors vary in their ratio of normal to cancerous cells and in their genomic copy number. Carter et al. describe an analytic method for inferring the purity and ploidy of a tumor sample, enabling longitudinal studies of subclonal mutations and tumor evolution.
Abstract | Full Text | PDF
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Research | Top |
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| Perspective |
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B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study pp423 - 433
Barton F Haynes, Garnett Kelsoe, Stephen C Harrison and Thomas B Kepler
doi:10.1038/nbt.2197
Abstract | Full Text | PDF
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| Analysis |
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Performance comparison of benchtop high-throughput sequencing platforms pp434 - 439
Nicholas J Loman, Raju V Misra, Timothy J Dallman, Chrystala Constantinidou, Saheer E Gharbia, John Wain and Mark J Pallen
doi:10.1038/nbt.2198
Small sequencing machines no bigger than a laser printer have many potential applications in diagnostics and public health. Loman et al. compare the quality, throughput and cost of instruments from Illumina, Roche and Life Technologies.
Abstract | Full Text | PDF
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Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting pp440 - 446
Jun Fu, Xiaoying Bian, Shengbaio Hu, Hailong Wang, Fan Huang, Philipp M Seibert, Alberto Plaza, Liqiu Xia, Rolf Muller, A Francis Stewart and Youming Zhang
doi:10.1038/nbt.2183
Functional genomics requires facile methods to recover sequences of interest. Fu et al. show that the phage proteins RecE and RecT mediate recombination between linear DNA fragments and can facilitate natural product discovery.
Abstract | Full Text | PDF
See also: News and Views by Cobb & Zhao
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A proteomics approach for the identification and cloning of monoclonal antibodies from serum pp447 - 452
Wan Cheung Cheung, Sean A Beausoleil, Xiaowu Zhang, Shuji Sato, Sandra M Schieferl, James S Wieler, Jason G Beaudet, Ravi K Ramenani, Lana Popova, Michael J Comb, John Rush and Roberto D Polakiewicz
doi:10.1038/nbt.2167
The ability to identify antibodies circulating in the bloodstream would advance immunology and vaccinology research and the development of therapeutics. Cheung et al. couple proteomics with next-generation sequencing of RNA from B cells to clone antibodies directly from the sera of immunized rabbits and mice.
Abstract | Full Text | PDF
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Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation pp453 - 459
Farzaneh Modarresi, Mohammad Ali Faghihi, Miguel A Lopez-Toledano, Roya Pedram Fatemi, Marco Magistri, Shaun P Brothers, Marcel P van der Brug and Claes Wahlestedt
doi:10.1038/nbt.2158
Methods for specific gene silencing have advanced as far as clinical trials, but a similar set of tools does not exist for increasing gene expression. Modarresi et al. demonstrate gene-specific upregulation in vivo by treating mice with oligonucleotides that inhibit the function of natural antisense transcripts.
Abstract | Full Text | PDF
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FLASH assembly of TALENs for high-throughput genome editing pp460 - 465
Deepak Reyon, Shengdar Q Tsai, Cyd Khayter, Jennifer A Foden, Jeffry D Sander and J Keith Joung
doi:10.1038/nbt.2170
Transcription activator-like effector nucleases (TALENs) enable genetic modification at specific sites in a genome. Reyon et al. present a method for high-throughput generation of TALENs, facilitating large-scale genome engineering.
Abstract | Full Text | PDF
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Errata | Top |
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Personal medicine—the new banking crisis p466
Christopher Thomas Scott, Timothy Caulfield, Emily Borgelt and Judy Illes
doi:10.1038/nbt0512-466a
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Existing agbiotech traits continue global march p466
Andrew Marshall
doi:10.1038/nbt0512-466b
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Around the world in a month p466
doi:10.1038/nbt0512-466c
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Fate of novel painkiller mAbs hangs in balance p466
Ken Garber
doi:10.1038/nbt0512-466d
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Careers and Recruitment | Top |
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First-quarter biotech job picture p467
Michael Francisco
doi:10.1038/nbt.2212
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| People |
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People p468
doi:10.1038/nbt.2219
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Nature Reviews Neuroscience
ARTICLE SERIES ON NEURAL CIRCUITS
This article series explores different approaches for the analysis of the structure and function of neural circuits and describes the methodological advances that are driving research in this area.
Follow the Article Series online at:
www.nature.com/nrn/series/neuralcircuits | |
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