TABLE OF CONTENTS
|  |  |  | Volume 20, Issue 5 (May 2012) |  | In this issue Editorial In This Issue Research Highlights Commentaries Original Articles Corrigendum
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| |  |  |  | Advertisement |  | Molecular Therapy-Nucleic Acids Online. Open Access. High-Quality Research. Molecular Therapy-Nucleic Acids is a peer-reviewed, fully open access, online journal. sibling journal to the well-established high impact journal, Molecular Therapy. The journal publishes high quality basic, translational, and clinical research and cutting edge reviews and commentaries targeted to the advances in oligonucleotide- and gene-based therapies. Submit your research TODAY!! | |  | | Editorial | Top |  | The State of Gene Therapies: The FDA PerspectiveDaniel Takefman and Wilson Bryan Mol Ther 2012 20: 877-878; 10.1038/mt.2012.51 Full Text |  | In This Issue | Top |  | In This IssueMol Ther 2012 20: 880; 10.1038/mt.2012.74 Full Text |  | Research Highlights | Top |  | Research HighlightsMol Ther 2012 20: 881; 10.1038/mt.2012.75 Full Text |  | Commentaries | Top |  | Human Tumor Xenografts: The Good, the Bad, and the UglyRichard A Morgan Mol Ther 2012 20: 882-884; 10.1038/mt.2012.73 Full Text |  |  |  | Is the Induction of Tumor Cell Senescence the Key to a Good Irradiated Tumor Vaccine?Michael P Brown Mol Ther 2012 20: 884-886; 10.1038/mt.2012.72 Full Text |  | Original Articles | Top |  | Regulation of Stem Cell Plasticity: Mechanisms and Relevance to Tissue Biology and CancerRobert Strauss, Petra Hamerlik, André Lieber and Jiri Bartek Mol Ther 2012 20: 887-897; advance online publication, February 7, 2012; 10.1038/mt.2012.2 Abstract | Full Text |  |  |  | Neonatal Gene Therapy With a Gamma Retroviral Vector in Mucopolysaccharidosis VI CatsKatherine P Ponder, Thomas M O'Malley, Ping Wang, Patricia A O'Donnell, Anne M Traas, Van W Knox, Gustavo A Aguirre, N Matthew Ellinwood, Jason A Metcalf, Bin Wang, Emma J Parkinson-Lawrence, Meg M Sleeper, Doug A Brooks, John J Hopwood and Mark E Haskins Mol Ther 2012 20: 898-907; advance online publication, March 6, 2012; 10.1038/mt.2012.9 Abstract | Full Text |  |  |  | Lens Epithelium-derived Growth Factor/p75 Qualifies as a Target for HIV Gene Therapy in the NSG Mouse ModelSofie Vets, Janine Kimpel, Andreas Volk, Jan De Rijck, Rik Schrijvers, Bert Verbinnen, Wim Maes, Dorothee Von Laer, Zeger Debyser and Rik Gijsbers Mol Ther 2012 20: 908-917; advance online publication, February 14, 2012; 10.1038/mt.2012.6 Abstract | Full Text |  |  |  | Reversal of Diabetes Through Gene Therapy of Diabetic Rats by Hepatic Insulin Expression via Lentiviral TransductionMatthias Elsner, Taivankhuu Terbish, Anne Jörns, Ortwin Naujok, Dirk Wedekind, Hans-Jürgen Hedrich and Sigurd Lenzen Mol Ther 2012 20: 918-926; advance online publication, February 21, 2012; 10.1038/mt.2012.8 Abstract | Full Text |  |  |  | Cancer Immunotherapy Using a Membrane-bound Interleukin-12 With B7-1 Transmembrane and Cytoplasmic DomainsWen-Yu Pan, Chia-Hui Lo, Chun-Chi Chen, Ping-Yi Wu, Steve R Roffler, Song-Kun Shyue and Mi-Hua Tao Mol Ther 2012 20: 927-937; advance online publication, February 14, 2012; 10.1038/mt.2012.10 Abstract | Full Text |  |  |  | Soluble Vascular Endothelial Growth Factor Decoy Receptor FP3 Exerts Potent Antiangiogenic EffectsDe-Chao Yu, Jung-Sun Lee, Ji Young Yoo, Hyewon Shin, Hongxin Deng, Yuquan Wei and Chae-Ok Yun Mol Ther 2012 20: 938-947; advance online publication, January 24, 2012; 10.1038/mt.2011.285 Abstract | Full Text |  |  |  | Increased Erythropoiesis in Mice Injected With Submicrogram Quantities of Pseudouridine-containing mRNA Encoding ErythropoietinKatalin Karikó, Hiromi Muramatsu, Jason M Keller and Drew Weissman Mol Ther 2012 20: 948-953; advance online publication, February 14, 2012; 10.1038/mt.2012.7 Abstract | Full Text |  |  |  | UU/UA Dinucleotide Frequency Reduction in Coding Regions Results in Increased mRNA Stability and Protein ExpressionMaher Al-Saif and Khalid SA Khabar Mol Ther 2012 20: 954-959; advance online publication, March 20, 2012; 10.1038/mt.2012.29 Abstract | Full Text |  |  |  | Microvesicle-associated AAV Vector as a Novel Gene Delivery SystemCasey A Maguire, Leonora Balaj, Sarada Sivaraman, Matheus HW Crommentuijn, Maria Ericsson, Lucia Mincheva-Nilsson, Vladimir Baranov, Davide Gianni, Bakhos A Tannous, Miguel Sena-Esteves, Xandra O Breakefield and Johan Skog Mol Ther 2012 20: 960-971; advance online publication, February 7, 2012; 10.1038/mt.2011.303 Abstract | Full Text |  |  |  | Directing Integrin-linked Endocytosis of Recombinant AAV Enhances Productive FAK-dependent TransductionPaul M Kaminsky, Nicholas W Keiser, Ziying Yan, Diana CM Lei-Butters and John F Engelhardt Mol Ther 2012 20: 972-983; advance online publication, January 10, 2012; 10.1038/mt.2011.295 Abstract | Full Text |  |  |  | Transient Focal Membrane Deformation Induced by Arginine-rich Peptides Leads to Their Direct Penetration into CellsHisaaki Hirose, Toshihide Takeuchi, Hiroko Osakada, Sílvia Pujals, Sayaka Katayama, Ikuhiko Nakase, Shouhei Kobayashi, Tokuko Haraguchi and Shiroh Futaki Mol Ther 2012 20: 984-993; advance online publication, February 14, 2012; 10.1038/mt.2011.313 Abstract | Full Text |  |  |  | Replication-competent Herpes Simplex Virus Retargeted to HER2 as Therapy for High-grade GliomaEleonora Gambini, Elisa Reisoli, Irene Appolloni, Valentina Gatta, Gabriella Campadelli-Fiume, Laura Menotti and Paolo Malatesta Mol Ther 2012 20: 994-1001; advance online publication, February 21, 2012; 10.1038/mt.2012.22 Abstract | Full Text |  |  |  | Cell Fate Control Gene Therapy Based on Engineered Variants of Human Deoxycytidine KinaseAnton Neschadim, James CM Wang, Takeya Sato, Daniel H Fowler, Arnon Lavie and Jeffrey A Medin Mol Ther 2012 20: 1002-1013; advance online publication, January 24, 2012; 10.1038/mt.2011.298 Abstract | Full Text |  |  |  | Extensive Methylation of Promoter Sequences Silences Lentiviral Transgene Expression During Stem Cell Differentiation In VivoFriederike Herbst, Claudia R Ball, Francesca Tuorto, Ali Nowrouzi, Wei Wang, Oksana Zavidij, Sebastian M Dieter, Sylvia Fessler, Franciscus van der Hoeven, Ulrich Kloz, Frank Lyko, Manfred Schmidt, Christof von Kalle and Hanno Glimm Mol Ther 2012 20: 1014-1021; advance online publication, March 20, 2012; 10.1038/mt.2012.46 Abstract | Full Text |  |  |  | Alpharetroviral Self-inactivating Vectors: Long-term Transgene Expression in Murine Hematopoietic Cells and Low GenotoxicityJulia D Suerth, Tobias Maetzig, Martijn H Brugman, Niels Heinz, Jens-Uwe Appelt, Kerstin B Kaufmann, Manfred Schmidt, Manuel Grez, Ute Modlich, Christopher Baum and Axel Schambach Mol Ther 2012 20: 1022-1032; advance online publication, February 14, 2012; 10.1038/mt.2011.309 Abstract | Full Text |  |  |  | Nonmyeloablative Conditioning Regimen to Increase Engraftment of Gene-modified Hematopoietic Stem Cells in Young Rhesus MonkeysAlice F Tarantal, Francesca Giannoni, C Chang I Lee, Jennifer Wherley, Teiko Sumiyoshi, Michele Martinez, Christoph A Kahl, David Elashoff, Stan G Louie and Donald B Kohn Mol Ther 2012 20: 1033-1045; advance online publication, January 31, 2012; 10.1038/mt.2011.312 Abstract | Full Text |  |  |  | Radiation-inducible Immunotherapy for Cancer: Senescent Tumor Cells as a Cancer VaccineYuru Meng, Elena V Efimova, Khaled W Hamzeh, Thomas E Darga, Helena J. Mauceri, Yang-Xin Fu, Stephen J Kron and Ralph R Weichselbaum Mol Ther 2012 20: 1046-1055; advance online publication, February 14, 2012; 10.1038/mt.2012.19 Abstract | Full Text |  |  |  | Targeting CD20 in Melanoma Patients at High Risk of Disease RecurrenceAlice Pinc, Rajasekharan Somasundaram, Christine Wagner, Marcus Hörmann, Georgios Karanikas, Ahmad Jalili, Wolfgang Bauer, Patrick Brunner, Katharina Grabmeier-Pfistershammer, Melanie Gschaider, Chiou-Yan Lai, Mei-Yu Hsu, Meenhard Herlyn, Georg Stingl and Stephan N Wagner Mol Ther 2012 20: 1056-1062; advance online publication, February 21, 2012; 10.1038/mt.2012.27 Abstract | Full Text |  |  |  | Dendritic Cells Loaded With mRNA Encoding Full-length Tumor Antigens Prime CD4+ and CD8+ T Cells in Melanoma PatientsAn MT Van Nuffel, Daphné Benteyn, Sofie Wilgenhof, Lauranne Pierret, Jurgen Corthals, Carlo Heirman, Pierre van der Bruggen, Pierre G Coulie, Bart Neyns, Kris Thielemans and Aude Bonehill Mol Ther 2012 20: 1063-1074; advance online publication, February 28, 2012; 10.1038/mt.2012.11 Abstract | Full Text |  | Corrigendum | Top |  | Corrigendum to “Hepatitis C Virus NS3/NS4A DNA Vaccine Induces Multiepitope T Cell Responses in Rhesus Macaques Mimicking Human Immune Responses”Mol Ther 2012 20: 1075; 10.1038/mt.2011.238 Full Text |  |  |  | Corrigendum: Discovery of a Linear Peptide for Improving Tumor Targeting of Gene Products and Treatment of Distal Tumors by IL-12 Gene TherapyMol Ther 2012 20: 1076; 10.1038/mt.2011.300 Full Text |  |  |  |  |  | Pediatric Research Reviews Highlights Cell-based therapies in 2012 Published in April 2012 as a special supplemental issue of Pediatric Research, the annual review issue highlights cell-based therapies in pediatrics. The articles in this issue examine developments in cell-based therapies used for treating neonatal/pediatric neuronal damage, hematologic diseases, chronic inflammatory diseases and cancers. Visit www.nature.com/pr and gain access to these articles before they are published in print. | |  | | Please note that you need to be a subscriber or site-license holder to enjoy full-text access to Molecular Therapy. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. 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