Wednesday, May 2, 2012

Molecular Therapy - Table of Contents alert Volume 20 Issue 5


TABLE OF CONTENTS

Volume 20, Issue 5 (May 2012)

In this issue
Editorial
In This Issue
Research Highlights
Commentaries
Original Articles
Corrigendum

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Molecular Therapy-Nucleic Acids is a peer-reviewed, fully open access, online journal. sibling journal to the well-established high impact journal, Molecular Therapy. The journal publishes high quality basic, translational, and clinical research and cutting edge reviews and commentaries targeted to the advances in oligonucleotide- and gene-based therapies.

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Editorial

Top

The State of Gene Therapies: The FDA Perspective

Daniel Takefman and Wilson Bryan

Mol Ther 2012 20: 877-878; 10.1038/mt.2012.51

Full Text

In This Issue

Top

In This Issue

Mol Ther 2012 20: 880; 10.1038/mt.2012.74

Full Text

Research Highlights

Top

Research Highlights

Mol Ther 2012 20: 881; 10.1038/mt.2012.75

Full Text

Commentaries

Top

Human Tumor Xenografts: The Good, the Bad, and the Ugly

Richard A Morgan

Mol Ther 2012 20: 882-884; 10.1038/mt.2012.73

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Is the Induction of Tumor Cell Senescence the Key to a Good Irradiated Tumor Vaccine?

Michael P Brown

Mol Ther 2012 20: 884-886; 10.1038/mt.2012.72

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Original Articles

Top

Regulation of Stem Cell Plasticity: Mechanisms and Relevance to Tissue Biology and Cancer

Robert Strauss, Petra Hamerlik, André Lieber and Jiri Bartek

Mol Ther 2012 20: 887-897; advance online publication, February 7, 2012; 10.1038/mt.2012.2

Abstract | Full Text

Neonatal Gene Therapy With a Gamma Retroviral Vector in Mucopolysaccharidosis VI Cats

Katherine P Ponder, Thomas M O'Malley, Ping Wang, Patricia A O'Donnell, Anne M Traas, Van W Knox, Gustavo A Aguirre, N Matthew Ellinwood, Jason A Metcalf, Bin Wang, Emma J Parkinson-Lawrence, Meg M Sleeper, Doug A Brooks, John J Hopwood and Mark E Haskins

Mol Ther 2012 20: 898-907; advance online publication, March 6, 2012; 10.1038/mt.2012.9

Abstract | Full Text

Lens Epithelium-derived Growth Factor/p75 Qualifies as a Target for HIV Gene Therapy in the NSG Mouse Model

Sofie Vets, Janine Kimpel, Andreas Volk, Jan De Rijck, Rik Schrijvers, Bert Verbinnen, Wim Maes, Dorothee Von Laer, Zeger Debyser and Rik Gijsbers

Mol Ther 2012 20: 908-917; advance online publication, February 14, 2012; 10.1038/mt.2012.6

Abstract | Full Text

Reversal of Diabetes Through Gene Therapy of Diabetic Rats by Hepatic Insulin Expression via Lentiviral Transduction

Matthias Elsner, Taivankhuu Terbish, Anne Jörns, Ortwin Naujok, Dirk Wedekind, Hans-Jürgen Hedrich and Sigurd Lenzen

Mol Ther 2012 20: 918-926; advance online publication, February 21, 2012; 10.1038/mt.2012.8

Abstract | Full Text

Cancer Immunotherapy Using a Membrane-bound Interleukin-12 With B7-1 Transmembrane and Cytoplasmic Domains

Wen-Yu Pan, Chia-Hui Lo, Chun-Chi Chen, Ping-Yi Wu, Steve R Roffler, Song-Kun Shyue and Mi-Hua Tao

Mol Ther 2012 20: 927-937; advance online publication, February 14, 2012; 10.1038/mt.2012.10

Abstract | Full Text

Soluble Vascular Endothelial Growth Factor Decoy Receptor FP3 Exerts Potent Antiangiogenic Effects

De-Chao Yu, Jung-Sun Lee, Ji Young Yoo, Hyewon Shin, Hongxin Deng, Yuquan Wei and Chae-Ok Yun

Mol Ther 2012 20: 938-947; advance online publication, January 24, 2012; 10.1038/mt.2011.285

Abstract | Full Text

Increased Erythropoiesis in Mice Injected With Submicrogram Quantities of Pseudouridine-containing mRNA Encoding Erythropoietin

Katalin Karikó, Hiromi Muramatsu, Jason M Keller and Drew Weissman

Mol Ther 2012 20: 948-953; advance online publication, February 14, 2012; 10.1038/mt.2012.7

Abstract | Full Text

UU/UA Dinucleotide Frequency Reduction in Coding Regions Results in Increased mRNA Stability and Protein Expression

Maher Al-Saif and Khalid SA Khabar

Mol Ther 2012 20: 954-959; advance online publication, March 20, 2012; 10.1038/mt.2012.29

Abstract | Full Text

Microvesicle-associated AAV Vector as a Novel Gene Delivery System

Casey A Maguire, Leonora Balaj, Sarada Sivaraman, Matheus HW Crommentuijn, Maria Ericsson, Lucia Mincheva-Nilsson, Vladimir Baranov, Davide Gianni, Bakhos A Tannous, Miguel Sena-Esteves, Xandra O Breakefield and Johan Skog

Mol Ther 2012 20: 960-971; advance online publication, February 7, 2012; 10.1038/mt.2011.303

Abstract | Full Text

Directing Integrin-linked Endocytosis of Recombinant AAV Enhances Productive FAK-dependent Transduction

Paul M Kaminsky, Nicholas W Keiser, Ziying Yan, Diana CM Lei-Butters and John F Engelhardt

Mol Ther 2012 20: 972-983; advance online publication, January 10, 2012; 10.1038/mt.2011.295

Abstract | Full Text

Transient Focal Membrane Deformation Induced by Arginine-rich Peptides Leads to Their Direct Penetration into Cells

Hisaaki Hirose, Toshihide Takeuchi, Hiroko Osakada, Sílvia Pujals, Sayaka Katayama, Ikuhiko Nakase, Shouhei Kobayashi, Tokuko Haraguchi and Shiroh Futaki

Mol Ther 2012 20: 984-993; advance online publication, February 14, 2012; 10.1038/mt.2011.313

Abstract | Full Text

Replication-competent Herpes Simplex Virus Retargeted to HER2 as Therapy for High-grade Glioma

Eleonora Gambini, Elisa Reisoli, Irene Appolloni, Valentina Gatta, Gabriella Campadelli-Fiume, Laura Menotti and Paolo Malatesta

Mol Ther 2012 20: 994-1001; advance online publication, February 21, 2012; 10.1038/mt.2012.22

Abstract | Full Text

Cell Fate Control Gene Therapy Based on Engineered Variants of Human Deoxycytidine Kinase

Anton Neschadim, James CM Wang, Takeya Sato, Daniel H Fowler, Arnon Lavie and Jeffrey A Medin

Mol Ther 2012 20: 1002-1013; advance online publication, January 24, 2012; 10.1038/mt.2011.298

Abstract | Full Text

Extensive Methylation of Promoter Sequences Silences Lentiviral Transgene Expression During Stem Cell Differentiation In Vivo

Friederike Herbst, Claudia R Ball, Francesca Tuorto, Ali Nowrouzi, Wei Wang, Oksana Zavidij, Sebastian M Dieter, Sylvia Fessler, Franciscus van der Hoeven, Ulrich Kloz, Frank Lyko, Manfred Schmidt, Christof von Kalle and Hanno Glimm

Mol Ther 2012 20: 1014-1021; advance online publication, March 20, 2012; 10.1038/mt.2012.46

Abstract | Full Text

Alpharetroviral Self-inactivating Vectors: Long-term Transgene Expression in Murine Hematopoietic Cells and Low Genotoxicity

Julia D Suerth, Tobias Maetzig, Martijn H Brugman, Niels Heinz, Jens-Uwe Appelt, Kerstin B Kaufmann, Manfred Schmidt, Manuel Grez, Ute Modlich, Christopher Baum and Axel Schambach

Mol Ther 2012 20: 1022-1032; advance online publication, February 14, 2012; 10.1038/mt.2011.309

Abstract | Full Text

Nonmyeloablative Conditioning Regimen to Increase Engraftment of Gene-modified Hematopoietic Stem Cells in Young Rhesus Monkeys

Alice F Tarantal, Francesca Giannoni, C Chang I Lee, Jennifer Wherley, Teiko Sumiyoshi, Michele Martinez, Christoph A Kahl, David Elashoff, Stan G Louie and Donald B Kohn

Mol Ther 2012 20: 1033-1045; advance online publication, January 31, 2012; 10.1038/mt.2011.312

Abstract | Full Text

Radiation-inducible Immunotherapy for Cancer: Senescent Tumor Cells as a Cancer Vaccine

Yuru Meng, Elena V Efimova, Khaled W Hamzeh, Thomas E Darga, Helena J. Mauceri, Yang-Xin Fu, Stephen J Kron and Ralph R Weichselbaum

Mol Ther 2012 20: 1046-1055; advance online publication, February 14, 2012; 10.1038/mt.2012.19

Abstract | Full Text

Targeting CD20 in Melanoma Patients at High Risk of Disease Recurrence

Alice Pinc, Rajasekharan Somasundaram, Christine Wagner, Marcus Hörmann, Georgios Karanikas, Ahmad Jalili, Wolfgang Bauer, Patrick Brunner, Katharina Grabmeier-Pfistershammer, Melanie Gschaider, Chiou-Yan Lai, Mei-Yu Hsu, Meenhard Herlyn, Georg Stingl and Stephan N Wagner

Mol Ther 2012 20: 1056-1062; advance online publication, February 21, 2012; 10.1038/mt.2012.27

Abstract | Full Text

Dendritic Cells Loaded With mRNA Encoding Full-length Tumor Antigens Prime CD4+ and CD8+ T Cells in Melanoma Patients

An MT Van Nuffel, Daphné Benteyn, Sofie Wilgenhof, Lauranne Pierret, Jurgen Corthals, Carlo Heirman, Pierre van der Bruggen, Pierre G Coulie, Bart Neyns, Kris Thielemans and Aude Bonehill

Mol Ther 2012 20: 1063-1074; advance online publication, February 28, 2012; 10.1038/mt.2012.11

Abstract | Full Text

Corrigendum

Top

Corrigendum to “Hepatitis C Virus NS3/NS4A DNA Vaccine Induces Multiepitope T Cell Responses in Rhesus Macaques Mimicking Human Immune Responses”

Mol Ther 2012 20: 1075; 10.1038/mt.2011.238

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Corrigendum: Discovery of a Linear Peptide for Improving Tumor Targeting of Gene Products and Treatment of Distal Tumors by IL-12 Gene Therapy

Mol Ther 2012 20: 1076; 10.1038/mt.2011.300

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Pediatric Research Reviews
Highlights Cell-based therapies in 2012

Published in April 2012 as a special supplemental issue of Pediatric Research, the annual review issue highlights cell-based therapies in pediatrics. The articles in this issue examine developments in cell-based therapies used for treating neonatal/pediatric neuronal damage, hematologic diseases, chronic inflammatory diseases and cancers.

Visit www.nature.com/pr and gain access to these articles before they are published in print.
 

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