EMBO Reports - Table of Contents alert Volume 13 Issue 5, pp 393-468

TABLE OF CONTENTS May 2012 | Volume 13, Issue 5 Upfront Science & Society Reviews Scientific Reports Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement EMBO publications survey How do you search the scientific literature? How should we ‘embed’ data and supplementary information in papers? Please, take a few minutes to complete our anonymous ONLINE SURVEY: www.surveymonkey.com/s/embo-data-search EMBO is striving to improve the quality and depth of the scientific information included in published papers and your input will guide important developments at our journals.   Upfront Top Editorial Don't ask, don't tell, don't publish Howy's editorial to accompany the launch of EMBO reports focus series on Sex and Molecular Biology asks whatever happened to the ‘gay gene’. Howy Jacobs EMBO reports (2012), 13, 393; 10.1038/embor.2012.48 Abstract | Full text | PDF Published online: 01 May 2012 Subject Categories: Societal Issues & Politics The science of sex The ‘sex and science’ focus series in EMBO reports will highlight the biological and social importance of sex, and the contribution of science to understanding its influence. Holger Breithaupt EMBO reports (2012), 13, 394; 10.1038/embor.2012.45 Abstract | Full text | PDF Published online: 01 May 2012 Subject Categories: Evolution, Environment & Agriculture | Societal Issues & Politics Opinion The cost of research in developing countries Scientists in developing countries face lower absolute levels of funding and often have to pay scandalously higher prices for consumables and equipment. Paul van Helden EMBO reports (2012), 13, 395; 10.1038/embor.2012.43 Abstract | Full text | PDF Published online: 03 April 2012 Subject Categories: Science Policy & Funding Stemness as a cell default state Could it be that stemness is not a specific fate resulting from a distinct stem-cell programme, but simply a result of a stem cell escaping ulterior differentiation? Stemness could be entirely intrinsic to non-differentiated cells. Jordi Casanova EMBO reports (2012), 13, 396 - 397; 10.1038/embor.2012.47 Abstract | Full text | PDF Published online: 10 April 2012 Subject Categories: Development | Differentiation & Death Science & Society Top Sperm counts and fertility in men: a rocky road ahead Declining sperm counts and the increasing average age of first-time parents spell trouble for human fertility, especially when set against the backdrop of ageing populations. Richard M Sharpe EMBO reports (2012), 13, 398 - 403; 10.1038/embor.2012.50 Abstract | Full text | PDF Published online: 10 April 2012 Subject Categories: Health & Disease | Societal Issues & Politics | Technology, Development & Applications The new geography of scientific collaborations The science ethics melting pot is just heating up; what role will emerging nations play in setting new standards of practice that ensure successful international collaborations? Sonia M R Vasconcelos, Nicholas H Steneck, Melissa Anderson, Hatisaburo Masuda, Marisa Palacios, José C S Pinto and Martha M Sorenson EMBO reports (2012), 13, 404 - 407; 10.1038/embor.2012.51 Abstract | Full text | PDF Published online: 10 April 2012 Subject Categories: Scientific Training & Careers Back down to Earth Despite not yet living up to the early hype, systems biology has become an integral component of biological research and should soon yield its first tangible results. Philip Hunter EMBO reports (2012), 13, 408 - 411; 10.1038/embor.2012.49 Abstract | Full text | PDF Published online: 10 April 2012 Subject Categories: Technology, Development & Applications Reviews Top The pro-metastatic role of bone marrow-derived cells: a focus on MSCs and regulatory T cells Bone marrow-derived cells promote tumorigenesis, mesenchymal stem cells and regulatory T cells have been recently shown to also contribute to cancer metastasis. A better understanding of how these cells enable metastasis could pave the way for novel therapeutics. Bong Ihn Koh and Yibin Kang EMBO reports (2012), 13, 412 - 422; 10.1038/embor.2012.41 Abstract | Full text | PDF Published online: 03 April 2012 Subject Categories: Molecular Biology of Disease | Signal Transduction Enhancers: emerging roles in cell fate specification Enhancers, which dictate the patterns of gene expression during development, might be regulated by a combination of DNA methylation, transcription factor binding and histone modifications. Understanding this regulation could lead to cell reprogramming strategies for use in regenerative medicine. Chin-Tong Ong and Victor G Corces EMBO reports (2012), 13, 423 - 430; 10.1038/embor.2012.52 Abstract | Full text | PDF Published online: 10 April 2012 Subject Categories: Chromatin & Transcription Scientific Reports Top Tie1 deficiency induces endothelial–mesenchymal transition The mechanisms controlling endothelial–mesenchymal transition (EndMT) are largely unknown. Inactivation of the Tie1 RTK induces EndMT via Erk1/2, Erk5 and Akt. Interestingly, EndMT is also observed in human pancreatic tumours where it might contribute to stromal formation. Julie Garcia, Maria José Sandi, Pierre Cordelier, Bernard Binétruy, Jacques Pouysségur, Juan Lucio Iovanna and Roselyne Tournaire EMBO reports (2012), 13, 431 - 439; 10.1038/embor.2012.29 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 16 March 2012 Subject Categories: Cell & Tissue Architecture | Molecular Biology of Disease Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma Allergic asthma rates are increasing in developed countries, arguing for an environmental aetiology. Profound changes in gut microbiota are reported in response to treatment in early life with the widely used antibiotic vancomycin, influencing asthma susceptibility. Shannon L Russell, Matthew J Gold, Martin Hartmann, Benjamin P Willing, Lisa Thorson, Marta Wlodarska, Navkiran Gill, Marie-Renée Blanchet, William W Mohn, Kelly M McNagny and Brett B Finlay EMBO reports (2012), 13, 440 - 447; 10.1038/embor.2012.32 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 16 March 2012 Mitotic spindle orientation can direct cell fate and bias Notch activity in chick neural tube Live imaging in the chick neural tube reveals that induction of apico-basal divisions in neural progenitor cells results in neuronal differentiation of the apical daughter, while the basal daughter remains a progenitor with high Notch activity. Raman M. Das and Kate G. Storey EMBO reports (2012), 13, 448 - 454; 10.1038/embor.2012.42 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 10 April 2012 JNK regulates the photic response of the mammalian circadian clock Deletion of neuron-specific JNK in mice alters behavioural rhythms and phase shifts to light. JNK deletion also inhibits BMAL1 phosphorylation and lengthens circadian period, indicating that this kinase regulates a core aspect of the mammalian clock. Hikari Yoshitane, Sato Honma, Kiyomichi Imamura, Hiroto Nakajima, Shin-ya Nishide, Daisuke Ono, Hiroshi Kiyota, Naoya Shinozaki, Hirokazu Matsuki, Naoya Wada, Hirofumi Doi, Toshiyuki Hamada, Ken-ichi Honma and Yoshitaka Fukada EMBO reports (2012), 13, 455 - 461; 10.1038/embor.2012.37 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 23 March 2012 Subject Categories: Signal Transduction | Proteins A non-canonical UBA–UBL interaction forms the linear-ubiquitin-chain assembly complex Cystallography and mutational analyses reveal an unexpected structural basis for the assembly of a linear ubiquitin chain E3-ligase crucial for NF-κB activation. This highlights the versatility and specificity of interactions involving ubiquitin-binding domains. Hirokazu Yagi, Kazuhiro Ishimoto, Takeshi Hiromoto, Hiroaki Fujita, Tsunehiro Mizushima, Yoshinori Uekusa, Maho Yagi-Utsumi, Eiji Kurimoto, Masanori Noda, Susumu Uchiyama, Fuminori Tokunaga, Kazuhiro Iwai and Koichi Kato EMBO reports (2012), 13, 462 - 468; 10.1038/embor.2012.24 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 20 March 2012 Subject Categories: Proteins | Structural Biology Corrections Top Corrigendum What doesn't kill you makes you dumber Philip Hunter EMBO reports (2012), 13, 469; 10.1038/embor.2012.46 Abstract | Full text | PDF Published online: 10 April 2012 Advertisement Follow EMBO on Facebook for access to news, comments and articles make it a place to share information with others interested in the life sciences. https://www.facebook.com/EMBO.excellence.in.life.sciences   Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to EMBO reports. In order to do so, please purchase a subscription. 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