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Nature Reviews Cancer POSTER - MITOCHONDRIAL FUNCTION AND CANCER Author: Douglas C. Wallace
This Poster highlights some recent discoveries that have led to a renewed interest in the function of mitochondria in cancer cells. Mitochondria carry out a number of crucial functions in cells and these can be altered through mutations in either the nuclear DNA or the mitochondrial DNA.
Anti-NGF painkillers back on track? doi:10.1038/nrd3732 Following an FDA advisory committee vote to restart clinical development of nerve growth factor antagonists, could this novel class of analgesics still fulfil its once-anticipated potential? Full Text
Oncology trials gear up for high-throughput sequencing doi:10.1038/nrd3733 Researchers are starting to use high-throughput genomic technologies to guide patients into trials of experimental cancer therapies, but is our understanding of the cancer genome ready yet? Full Text
FDA says study overestimated non-compliance with data-reporting laws doi:10.1038/nature.2012.10549 US drug regulator finds no evident harm caused by sponsors failing to post drug-trial data. Full Text
An audience with Stephen Frye doi:10.1038/nrd3726 Stephen Frye, from the University of North Carolina in Chapel Hill, USA, discusses emerging capabilities of academic drug discoverers. Full Text
Cancer cell line encyclopedias doi:10.1038/scibx.2012.431 Two research teams have independently developed large-scale screening platforms to profile hundreds of human cancer cell lines and identify drug sensitivity biomarkers. Novartis, a member of one of the groups, is now using the platform to guide patient selection in Phase I cancer trials. Full Text
Fresh from the Pipeline: Ivacaftor doi:10.1038/nrd3723 First disease-modifying drug approved in the United States for the treatment of cystic fibrosis in patients with a specific mutation in the gene encoding the cystic fibrosis transmembrane conductance regulator. Full Text
From the analyst's couch: Drug development risk and the cost of capital doi:10.1038/nrd3722 This article analyses the relationship between risk and the cost of capital for projects in different stages of drug development and describes a framework that could improve portfolio optimization strategies. Full Text
Neurodegenerative disease: The stress of misfolding doi:10.1038/nrd3731 Two studies provide evidence that α-synuclein-induced endoplasmic reticulum (ER) stress has a crucial role in promoting neurodegeneration in α-synucleinopathies, and that targeting chronic ER stress may represent a plausible target for future therapies. Full Text
Cancer genomics: Constructing a 'cancerpaedia' doi:10.1038/nrd3730 Two recent papers published in Nature report on genomic changes in cancer cell lines that indicate sensitivity to targeted drugs. Full Text
Mouse models: Of mice and men doi:10.1038/nrc3270 A clinical trial in mice with lung cancer indicates the likely efficacy of the MEK inhibitor selumetinib in a current ongoing human clinical trial. Full Text
Epigenetic protein families: a new frontier for drug discovery doi:10.1038/nrd3674 In this article, the authors review the protein families that mediate epigenetic signalling through histone acetylation and methylation, and highlight progress in the pharmacological modulation of each class of proteins. Full Text
Intra-tumour heterogeneity: a looking glass for cancer? doi:10.1038/nrc3261 This Review outlines both genetic and non-genetic causes of phenotypic heterogeneity of tumour cells and the implications of intra-tumour heterogeneity in diagnostics and the development of therapeutic resistance. Full Text
The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma doi:10.1038/nature11114 A transposon-mediated insertional mutagenesis screen reveals inactivation of the X-linked deubiquitinase gene Usp9x in over 50% of pancreatic ductal adenocarcinomas, suggesting Usp9x has prognostic and therapeutic relevance for this disease. Full Text
A selective inhibitor reveals PI3Kγ dependence of TH17 cell differentiation doi:10.1038/nchembio.957 A chemoproteomic approach adapted for high-throughput screening leads to the identification of a selective PI3Kγ inhibitor. Application of this inhibitor in human and mouse cellular models reinforces selective inhibition of PI3Kγ as a potential treatment for inflammatory and autoimmune diseases. Full Text
Career snapshots archive Career snapshots feature people associated with drug discovery and drug development, with the aim of providing expert insights and advice on a wide range of positions and career paths in this field. Full Text
SciBX: Science-Business eXchange is a weekly publication that identifies and analyzes the most important translational research articles from over 40 journals. Find out which papers have real scientific and commercial potential, and why.
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