Monday, April 2, 2012

Scientific Reports Biology Table of Contents e-alert: April 2012

 02 April 2012  
 
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Biological Sciences
 
 
 
 
 
 
 

Functionally Distinct Subpopulations of CpG-Activated Memory B Cells

 
 

Alicia D. Henn, Michael Laski, Hongmei Yang et al.

 
 

During the human B cell (Bc) recall response, rapid cell division results in multiple Bc subpopulations. The TLR-9 agonist CpG oligodeoxynucleotide, combined with cytokines, …

 
 
 
 
 
 

Having a pair: the key to immune evasion for the diploid pathogen Schistosoma japonicum

 
 

Xindong Xu, Jun Sun, Jingjing Zhang et al.

 
 

Schistosomes, unlike malaria parasites, are in their diploid stage when targeted by the human immune system. Diploids can be either homozygous or heterozygous. The difference has …

 
 
 
 
 
 

Sustainable institutionalized punishment requires elimination of second-order free-riders

 
 

Matjaž Perc

 
 

Although empirical and theoretical studies affirm that punishment can elevate collaborative efforts, its emergence and stability remain elusive. By peer-punishment the sanctioning …

 
 
 
 
 
 

Detecting early-warning signals for sudden deterioration of complex diseases by dynamical network biomarkers

 
 

Luonan Chen, Rui Liu, Zhi-Ping Liu et al.

 
 

Considerable evidence suggests that during the progression of complex diseases, the deteriorations are not necessarily smooth but are abrupt, and may cause a critical transition …

 
 
 
 
 
 

A Broadly Cross-Reactive Monoclonal Antibody Against an Epitope on the N-terminus of Meningococcal fHbp

 
 

David M. Vu, Rolando Pajon, Donald C. Reason et al.

 
 

Meningococcal factor H binding protein (fHbp) is an important vaccine antigen for prevention of disease caused by capsular group B strains. The protein has been sub-classified …

 
 
 
 
 
 

Metabolic engineering of the iodine content in Arabidopsis

 
 

Martina Landini, Silvia Gonzali, Claudia Kiferle et al.

 
 

Plants are a poor source of iodine, an essential micronutrient for human health. Several attempts of iodine biofortification of crops have been carried out, but the scarce …

 
 
 
 
 
 

Lipids induce expression of serum-responsive transmembrane kinase EhTMKB1-9 in an early branching eukaryote Entamoeba histolytica

 
 

Shiteshu Shrimal, Arpita Saha, Sudha Bhattacharya et al.

 
 

Mechanisms underlying the initiation of proliferative response are known only for a few organisms, and are not understood for the medically important organisms including Entamoeba …

 
 
 
 
 
 

Infection of specific strains of Streptococcus mutans, oral bacteria, confers a risk of ulcerative colitis

 
 

Ayuchi Kojima, Kazuhiko Nakano, Koichiro Wada et al.

 
 

Although oral bacteria-associated systemic diseases have been reported, association between Streptococcus mutans, pathogen of dental caries, and ulcerative colitis (UC) has not …

 
 
 
 
 
 

Roles of residues in the interface of transient protein-protein complexes before complexation

 
 

Lakshmipuram S. Swapna, Ramachandra M. Bhaskara, Jyoti Sharma et al.

 
 

Transient protein-protein interactions play crucial roles in all facets of cellular physiology. Here, using an analysis on known 3-D structures of transient protein-protein …

 
 
 
 
 
 

Different inhibitory potency of febuxostat towards mammalian and bacterial xanthine oxidoreductases: insight from molecular dynamics

 
 

Hiroto Kikuchi, Hiroshi Fujisaki, Tadaomi Furuta et al.

 
 

Febuxostat, a drug recently approved in the US, European Union and Japan for treatment of gout, inhibits xanthine oxidoreductase (XOR)-mediated generation of uric acid during purine …

 
 
 
 
 
 

A fast and flexible panoramic virtual reality system for behavioural and electrophysiological experiments

 
 

Jouni Takalo, Arto Piironen, Anna Honkanen et al.

 
 

Ideally, neuronal functions would be studied by performing experiments with unconstrained animals whilst they behave in their natural environment. Although this is not feasible …

 
 
 
 
 
 

Parasite-insecticide interactions: a case study of Nosema ceranae and fipronil synergy on honeybee

 
 

Julie Aufauvre, David G. Biron, Cyril Vidau et al.

 
 

In ecosystems, a variety of biological, chemical and physical stressors may act in combination to induce illness in populations of living organisms. While recent surveys reported …

 
 
 
 
 
 

Scale-invariant structure of size fluctuations in plants

 
 

S. Picoli, R. S. Mendes, E. K. Lenzi et al.

 
 

A wide range of physical and biological systems exhibit complex behaviours characterised by a scale-invariant structure of the fluctuations in their output signals. In the context …

 
 
 
 
 
 

Human behavior in Prisoner's Dilemma experiments suppresses network reciprocity

 
 

Carlos Gracia-Lázaro, José A. Cuesta, Angel Sánchez et al.

 
 

During the last few years, much research has been devoted to strategic interactions on complex networks. In this context, the Prisoner's Dilemma has become a paradigmatic model, …

 
 
 
 
 
 

How well do the substrates KISS the enzyme? Molecular docking program selection for feruloyl esterases

 
 

D. B. R. K. Gupta Udatha, Nobuyoshi Sugaya, Lisbeth Olsson et al.

 
 

Molecular docking is the most commonly used technique in the modern drug discovery process where computational approaches involving docking algorithms are used to dock small …

 
 
 
 
 
 

Inactivating alternative NADH dehydrogenases: enhancing fungal bioprocesses by improving growth and biomass yield?

 
 

Ioannis Voulgaris, Andrew O'Donnell, Linda M. Harvey et al.

 
 

Debate still surrounds the physiological roles of the alternative respiratory enzymes found in many fungi and plants. It has been proposed that alternative NADH:ubiquinone …

 
 
 
 
 
 

BALB/c-Fcgr2b−/−Pdcd1−/− mouse expressing anti-urothelial antibody is a novel model of autoimmune cystitis

 
 

Osamu Ogawa, Yoshio Sugino, Nobuyuki Nishikawa et al.

 
 

We report the impact of anti-urothelial autoantibody (AUAb) on urinary bladder phenotype in BALB/c mice deficient of the FcγRIIb and PD-1. AUAb was present in serum samples from …

 
 
 
 
 
 

Modelling bluetongue virus transmission between farms using animal and vector movements

 
 

Joanne Turner, Roger G. Bowers, Matthew Baylis

 
 

Bluetongue is a notifiable disease of ruminants which, in 2007, occurred for the first time in England. We present the first model for bluetongue that explicitly incorporates farm …

 
 
 
 
 
 

Factors limiting the transmission of HIV mutations conferring drug resistance: fitness costs and genetic bottlenecks

 
 

Sally Blower, Bradley G. Wagner, J. Gerardo Garcia-Lerma

 
 

Transmission of HIV strains with drug-resistance mutations (DRMs) causes public health problems in resource-rich countries. We use a stochastic model, with data from viral …

 
 
 
 
 
 

Towards the understanding of microRNA and environmental factor interactions and their relationships to human diseases

 
 

Qinghua Cui, Chengxiang Qiu, Geng Chen

 
 

Increasing studies have shown that the interactions between microRNAs (miRNAs) and environmental factors (EFs) play critical roles in determining phenotypes and diseases. In this …

 
 
 
 
 
 

Evaluating the Viscoelastic Properties of Tissue from Laser Speckle Fluctuations

 
 

Seemantini K. Nadkarni, Zeinab Hajjarian

 
 

Most pathological conditions such as atherosclerosis, cancer, neurodegenerative, and orthopedic disorders are accompanied with alterations in tissue viscoelasticity. Laser Speckle …

 
 
 
 
 
 

Fetal Radiofrequency Radiation Exposure From 800-1900 Mhz-Rated Cellular Telephones Affects Neurodevelopment and Behavior in Mice

 
 

Hugh S. Taylor, Tamir S. Aldad, Geliang Gan et al.

 
 

Neurobehavioral disorders are increasingly prevalent in children, however their etiology is not well understood. An association between prenatal cellular telephone use and …

 
 
 
 
 
 

Stilbene derivatives promote Ago2-dependent tumour-suppressive microRNA activity

 
 

Takahiro Ochiya, Keitaro Hagiwara, Nobuyoshi Kosaka et al.

 
 

It is well known that natural products are a rich source of compounds for applications in medicine, pharmacy, and biology. However, the exact molecular mechanisms of natural …

 
 
 
 
 
 

Statistical Laws Governing Fluctuations in Word Use from Word Birth to Word Death

 
 

Alexander M. Petersen, Joel Tenenbaum, Shlomo Havlin et al.

 
 

We analyze the dynamic properties of 107 words recorded in English, Spanish and Hebrew over the period 1800–2008 in order to gain insight into the coevolution of language and …

 
 
 
 
 
 

A Bio-Catalytic Approach to Aliphatic Ketones

 
 

Yao Fu, Kechun Zhang, Mingyong Xiong et al.

 
 

Depleting oil reserves and growing environmental concerns have necessitated the development of sustainable processes to fuels and chemicals. Here we have developed a general …

 
 
 
 
 
 

Expression of GluK1c underlies the developmental switch in presynaptic kainate receptor function

 
 

Sari E. Lauri, Aino Vesikansa, Prasanna Sakha et al.

 
 

Kainate-type glutamate receptors (KARs) regulate synaptic transmission and neuronal excitability via multiple mechanisms, depending on their subunit composition. Presynaptic KARs …

 
 
 
 
 
 

Specificity quantification of biomolecular recognition and its implication for drug discovery

 
 

Jin Wang, Zhiqiang Yan

 
 

Highly efficient and specific biomolecular recognition requires both affinity and specificity. Previous quantitative descriptions of biomolecular recognition were mostly driven by …

 
 
 
 
 
 

On Quantum Effects in a Theory of Biological Evolution

 
 

M. A. Martin-Delgado

 
 

We construct a descriptive toy model that considers quantum effects on biological evolution starting from Chaitin's classical framework. There are smart evolution scenarios in …

 
 
 
 
 
 

Premenstrual enhancement of snake detection in visual search in healthy women

 
 

N. Masataka, M. Shibasaki

 
 

It is well known that adult humans detect images of snakes as targets more quickly than images of flowers as targets whether the images are in color or gray-scale. When such …

 
 
 
 
 
 

Effects of arterial cannulation stress on regional cerebral blood flow in major depressive disorder

 
 

Jonathan Savitz, Allison C. Nugent, Dara M. Cannon et al.

 
 

Individuals with major depressive disorder (MDD) display abnormal neurophysiological responses to psychological stress but little is known about their neurophysiological responses …

 
 
 
 
 
 

Photo-induced proton gradients for the in vitro investigation of bacterial efflux pumps

 
 

Isabelle Broutin, Martin Picard, Alice Verchère

 
 

We describe an original activity assay for membrane transport that uses the proton motive force-dependent efflux pump MexAB from Pseudomonas aeruginosa. This pump is …

 
 
 
 
 
 

Self-circularizing 5′-ETS RNAs accumulate along with unprocessed pre ribosomal RNAs in growth-stressed Entamoeba histolytica

 
 

Sudha Bhattacharya, Abhishek Kumar Gupta, Sunil Kumar Panigrahi et al.

 
 

The primary transcript of rRNA genes is a large pre rRNA which is precisely processed to release the mature rRNAs. The 5′-external transcribed spacer (ETS) of rRNA genes contains …

 
 
 
 
 
 

Fast by Nature - How Stress Patterns Define Human Experience and Performance in Dexterous Tasks

 
 

I. Pavlidis, P. Tsiamyrtzis, D. Shastri et al.

 
 

In the present study we quantify stress by measuring transient perspiratory responses on the perinasal area through thermal imaging. These responses prove to be sympathetically …

 
 
 
 
 
 

The role of GRK6 in animal models of Parkinson's Disease and L-DOPA treatment

 
 

Francesca Managò, Stefano Espinoza, Ali Salahpour et al.

 
 

G protein-coupled Receptor Kinase 6 (GRK6) belongs to a family of kinases that phosphorylate GPCRs. GRK6 levels were found to be altered in Parkinson's Disease (PD) and D2

 
 
 
 
 
 

A novel cytofluorometric assay for the detection and quantification of glucose-6-phosphate dehydrogenase deficiency

 
 

Shivang S. Shah, Seidina A. S. Diakite, Karim Traore et al.

 
 

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked enzymopathy that affects hundreds of millions of people worldwide, conferring increased risk of neonatal …

 
 
 
 
 
 

Reduced sampling efficiency causes degraded Vernier hyperacuity with normal aging: Vernier acuity in position noise

 
 

Roger W. Li, Brian Brown, Marion H. Edwards et al.

 
 

Vernier acuity, a form of visual hyperacuity, is amongst the most precise forms of spatial vision. Under optimal conditions Vernier thresholds are much finer than the …

 
 
 
 
 
 

Assessment of Extracts from Red Yeast Rice for Herb-Drug Interaction by in-vitro and in-vivo assays

 
 

Wai To Fung, G. Subramaniam, Joel Lee et al.

 
 

Red yeast rice (RYR) is made by fermenting the yeast Monascus purpureus over rice. It is a source of natural red food colorants, a food garnish and a traditional medication. …

 
 
 
 
 
 

TNF-α and TGF-β Counter-Regulate PD-L1 Expression on Monocytes in Systemic Lupus Erythematosus

 
 

Jing-Ni Ou, Alice E. Wiedeman, Anne M. Stevens

 
 

Monocytes in patients with systemic lupus erythematosus (SLE) are hyperstimulatory for T lymphocytes. We previously found that the normal program for expression of a negative …

 
 
 
 
 
 

Identification of Hot and Cold spots in genome of Mycobacterium tuberculosis using Shewhart Control Charts

 
 

Sarbashis Das, Priyanka Duggal, Rahul Roy et al.

 
 

The organization of genomic sequences is dynamic and undergoes change during the process of evolution. Many of the variations arise spontaneously and the observed genomic changes …

 
 
 
 
 
 

Win-stay, lose-switch and public information strategies for patch fidelity of songbirds with rare extra-pair paternity

 
 

Andrew J. Campomizzi, Michael L. Morrison, J. Andrew DeWoody et al.

 
 

Determining where organisms breed and understanding why they breed in particular locations are fundamental biological questions with conservation implications. Breeding-site …

 
 
 
 
 
 

Communication during sex among female bonobos: effects of dominance, solicitation and audience

 
 

Zanna Clay, Klaus Zuberbühler

 
 

Bonobo females frequently form close bonds, which give them social power over other group members. One potential mechanism to facilitate female bonding is the performance of …

 
 
 
 
 
 
 
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