Nature Reviews Microbiology contents May 2012 Volume 10 Number 5 pp 307-372

TABLE OF CONTENTS
May 2012 Volume 10 Number 5
Impact Factor 20.686 *	In this issue Editorial Research Highlights News and Analysis Progress Reviews Perspectives Also this month  Featured article: How glycan metabolism shapes the human gut microbiota Nicole M. Koropatkin, Elizabeth A. Cameron & Eric C. Martens
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EDITORIAL		Top
The drugs can work p307 | doi:10.1038/nrmicro2794 There are signs that the therapeutic successes that have contributed to the downward trajectory for HIV-1 mortality may soon be repeated for HCV. Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS Top Bacterial pathogenesis: A competitive edge for Salmonella p309 | doi:10.1038/nrmicro2784 S. Typhimurium is resistant to the effects of calprotectin owing to its Zn transporter and thus has a competitive growth advantage in the inflamed host gut. PDF Cellular microbiology: Ironing out Hfq regulation p310 | doi:10.1038/nrmicro2780 The stringent response regulator RelA promotes multimerization of Hfq and increases its affinity for target small RNAs. PDF Bacterial physiology: From indolence to persistence p310 | doi:10.1038/nrmicro2792 Persistence in Escherichia coli is induced in part by the stationary phase signalling molecule indole. PDF Host response: Attack is the best form of defence p311 | doi:10.1038/nrmicro2782 Lumenal vesicles provide a mechanism for the host innate defences to extend into the gut lumen to attack pathogenic bacteria and their inflammatory products at a distance. PDF Immune evasion: Influenza's sting in the tail p312 | doi:10.1038/nrmicro2785 The H3N2 influenza A virus protein NS1 suppresses the host's antiviral response by acting as a histone H3 mimic. PDF Cellular microbiology: Replication comes in all sizes p312 | doi:10.1038/nrmicro2793 Confirmation that initiation of DNA replication in bacteria is controlled by divergent methods in two model organisms. PDF Bacterial transcription: Rho gets to grips with the riboswitch p313 | doi:10.1038/nrmicro2791 Two different bacterial riboswitches regulate transcription of their associated mRNAs by controlling the activity of the transcription termination factor Rho. PDF IN BRIEF Bacterial Genomics: Unexpected introns in the 16S | Techniques & applications: Mastering staphylococcal transformation | Host response: Pro-angiogenic bacteria in the gut PDF Microbiology JOBS of the week Marie Curie Experienced Researcher in NEXT AIR BIOTREAT (Zwolle, Netherlands): Developing the next generation air treatment based on replacing non-renewable resources by microbiology PAS Solutions BV (Pure air solutions) Part Time Microbiology Technician Kelly Scientific Resources Medical Technologist (Microbiology) Kelly Scientific Resources Quality Control Microbiology Lab Supervisor 1975 EMD Millipore US Co-op - QC Microbiology / Environmental / Molecular Genentech More Science jobs from Microbiology EVENT Molecular Basis of Microbial One-Carbon Metabolism 05.-10.08.12 ME, US More science events from
NEWS AND ANALYSIS		Top
GENOME WATCH The first green revolution Isheng J. Tsai p314 | doi:10.1038/nrmicro2781 This month's Genome Watch describes how analysis of a basal member of the Plantae can inform us about the evolution of photosynthetic eukaryotes. PDF
DISEASE WATCH In the news p315 | doi:10.1038/nrmicro2789 Our monthly round up of infectious diseases news, which this month includes the discovery of a gene that confers susceptibility to influenza A virus, the finding that disturbing the gut microbiota can lead to the development of asthma, and studies on a drug that forces HIV out of latency. PDF
PROGRESS		Top
A new player in the puzzle of filovirus entry Judith M. White & Kathryn L. Schornberg p317 | doi:10.1038/nrmicro2764 The search for therapeutics to treat infections by ebolaviruses and Marburg virus has focused on identifying compounds that interfere with viral entry into host cells. Here, White and Schornberg discuss recent studies that have identified Niemann–Pick C1 (NPC1), a protein that resides deep in the endocytic pathway, as an important host factor in this process. Abstract | Full Text | PDF
REVIEWS		Top
How glycan metabolism shapes the human gut microbiota Nicole M. Koropatkin, Elizabeth A. Cameron & Eric C. Martens p323 | doi:10.1038/nrmicro2746 In this Review, Martens and colleagues describe how dietary and endogenous glycans shape the composition of the gut microbiota and how individual microorganisms degrade these glycans. They also highlight the potential to influence this ecosystem for better health and nutrition. Abstract | Full Text | PDF
The type II secretion system: biogenesis, molecular architecture and mechanism Konstantin V. Korotkov, Maria Sandkvist & Wim G. J. Hol p336 | doi:10.1038/nrmicro2762 Many Gram-negative bacteria use type II secretion systems (T2SSs) to translocate a range of proteins across the outer membrane from the periplasm. In this Review, Hol and colleagues describe how recent structural and biochemical studies have provided insights into the biogenesis and architecture of T2SSs and the mechanism by which they function. Abstract | Full Text | PDF | Supplementary information
New insights into bacterial adaptation through in vivo and in silico experimental evolution Thomas Hindré, Carole Knibbe, Guillaume Beslon & Dominique Schneider p352 | doi:10.1038/nrmicro2750 Over the past 30 years researchers have developed a global picture of bacterial evolution by using both laboratory-based in vivo evolution experiments and in silico evolution of digital organisms. Schneider and colleagues review the advantages and disadvantages of both approaches and synthesize the contributions of both methods to our understanding of bacterial adaptation. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION A road map for the development of community systems (CoSy) biology Karsten Zengler & Bernhard O. Palsson p366 | doi:10.1038/nrmicro2763 Understanding how microorganisms interact with other species in a community is a major goal for microbial ecologists. In this Opinion article, Zengler and Palsson describe how successes from systems biology efforts can be used as a road map for the emerging field of community systems (CoSy) biology. Abstract | Full Text | PDF
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*2010 Journal Citation Report (Thomson Reuters, 2011)

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