Nature Reviews Genetics Contents May 2012 Volume 13 Number 5 pp 297-376

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TABLE OF CONTENTS
May 2012 Volume 13 Number 5
Impact Factor 32.745 *	In this issue Research Highlights Reviews Perspectives Also this month Article Series: Study designs Non-coding RNA Translational genetics  Featured article: Histone methylation: a dynamic mark in health, disease and inheritance Eric L. Greer & Yang Shi
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RESEARCH HIGHLIGHTS Top Functional genomics: Complexities of occupancy and sequence p297 | doi:10.1038/nrg3219 PDF Adaptation: Malarial bet hedging p298 | doi:10.1038/nrg3224 PDF Developmental biology: Re-evaluating gut insulin instinct p298 | doi:10.1038/nrg3225 PDF Technology: Breeding vigour backwards p300 | doi:10.1038/nrg3220 PDF Cancer genomics: Constructing a 'cancerpaedia' p300 | doi:10.1038/nrg3221 PDF Genome evolution: Mapping recombination in chimpanzees p301 | doi:10.1038/nrg3222 PDF Complex traits: Old meets new in obesity genetics p301 | doi:10.1038/nrg3223 PDF IN BRIEF Bioinformatics: Personalized omics profiling | Genome biology: New family of DNA molecule found in mammals | Gene expression: Anti-Shine-Dalgarno regulation of translation | Transcriptomics: Long non-coding RNA stability | Epigenetics: Mapping histone modifications and DNA methylation together | Evo-devo: Stickleback genomes illuminate adaptive evolution | Small RNAs: Small RNAs in DNA repair | Complex traits: Imprinting meets maternal effects for birth weight control PDF Genetics JOBS of the week Editorial Assistant, Nature Genetics Nature Publishing Group Full Professorship in Statistical Genetics University of Copenhagen Post-Doctoral (CM) Statistical genetics / genetic epidemiology, mapping genes for complex disease - Arthritis and Clinical Immunology Oklahoma Medical Research Foundation (OMRF) postdoctoral fellow in bioinformatics, statistical genetics and pharmacogenomics University of Illinois at Chicago (UIC) Post-doctoral Position in Bioinformatics and Statistical Genetics Virginia Institute for Psychiatric and Behavioral Genetics More Science jobs from Genetics EVENT Genomic Epidemiology of Malaria 10.-13.06.12 Cambridge, UK More science events from
REVIEWS		Top
Article series: Study designs Molecular phylogenetics: principles and practice Ziheng Yang & Bruce Rannala p303 | doi:10.1038/nrg3186 Phylogenetic analysis is pervading every field of biological study. The authors review and assess the main methods of phylogenetic analysis — including parsimony, distance, likelihood and Bayesian methods — and provide guidance for selecting the most appropriate approach and software package. Abstract | Full Text | PDF
Article series: Study designs Harnessing genomics and genome biology to understand malaria biology Sarah K. Volkman, Daniel E. Neafsey, Stephen F. Schaffner, Daniel J. Park & Dyann F. Wirth p315 | doi:10.1038/nrg3187 This Review describes how genome-wide analyses have provided various insights into the most lethal malarial parasite, Plasmodium falciparum, including determinants of antimalarial drug resistance. The authors also propose how genetic tools can be refined to monitor future therapeutic interventions. Abstract | Full Text | PDF
Article series: Study designs A beginner's guide to eukaryotic genome annotation Mark Yandell & Daniel Ence p329 | doi:10.1038/nrg3174 Although genome sequencing is becoming routine, genome annotation is becoming increasingly challenging. The authors provide an overview of the steps and software tools that are available for annotating eukaryotic genomes, and describe the best practices for sharing, quality checking and updating the annotation. Abstract | Full Text | PDF
Histone methylation: a dynamic mark in health, disease and inheritance Eric L. Greer & Yang Shi p343 | doi:10.1038/nrg3173 This Review provides a broad overview of the regulation of and by histone methylation. A balance between dynamism and stability is highlighted by links to disease and ageing, and current studies are exploring these histone marks in the context of inheritance. Abstract | Full Text | PDF | Supplementary information
Article series: Non-coding RNA MicroRNA profiling: approaches and considerations Colin C. Pritchard, Heather H. Cheng & Muneesh Tewari p358 | doi:10.1038/nrg3198 Owing to the important role of microRNAs in gene regulation, profiling repertoires of expressed microRNAs can be informative in basic research and clinical settings. This Review describes the methods that are available for microRNA profiling and considerations for choosing among analytical options. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
SCIENCE AND SOCIETY From patients to partners: participant-centric initiatives in biomedical research Jane Kaye, Liam Curren, Nick Anderson, Kelly Edwards, Stephanie M. Fullerton, Nadja Kanellopoulou, David Lund, Daniel G. MacArthur, Deborah Mascalzoni, James Shepherd, Patrick L. Taylor, Sharon F. Terry & Stefan F. Winter p371 | doi:10.1038/nrg3218 Participant-centred initiatives use social media technologies to allow long-term interactive partnerships to be established between study participants and researchers. These varied initiatives improve research governance and quality and give participants greater knowledge of and control over how their data are used. Abstract | Full Text | PDF
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*2010 Journal Citation Report (Thomson Reuters, 2011)

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