Nature Reviews Cancer contents May 2012 Volume 12 Number 5 pp 315-373

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TABLE OF CONTENTS
May 2012 Volume 12 Number 5		Advertisement
Impact Factor 37.178 *	In this issue Research Highlights Reviews Perspectives Correspondence Also this month  Featured article: Intra-tumour heterogeneity: a looking glass for cancer? Andriy Marusyk, Vanessa Almendro & Kornelia Polyak	Free Sample: New Brilliant Violet™ 421 Reagents Add a brilliant new dimension to your multicolor panels with Brilliant Violet™ 421 from BD Biosciences. Request a free sample of this new violet-excitable dye with significantly improved brightness over other dyes offered for the violet laser and get the high-sensitivity fluorescence needed to better resolve dim populations. bdbiosciences.com/go/brilliant
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RESEARCH HIGHLIGHTS Top Genomics: Constructing a 'cancerpaedia' p315 | doi:10.1038/nrc3275 Two recent papers published in Nature report on genomic changes in cancer cell lines that indicate sensitivity to targeted drugs. PDF Cancer genetics: HIF enhances its reputation p316 | doi:10.1038/nrc3266 A new study links HIF signalling to cyclin D1 expression through a novel enhancer function of a cancer susceptibility locus. PDF Metastasis: SIX1 of the best p316 | doi:10.1038/nrc3272 The transcription factor SIX1 can promote lymphangiogenesis and metastasis through regulating the expression of vascular endothelial growth factor C. PDF Tumour heterogeneity: Darwin's finches p317 | doi:10.1038/nrc3269 The extent of tumour heterogeneity has been explored in a paper recently published in the New England Journal of Medicine. PDF IN THE NEWS Running a MUC1 p317 | doi:10.1038/nrc3274 PDF Stem cells: Marking stem cells p318 | doi:10.1038/nrc3268 A paper in Cell identifies a subpopulation of intestinal stem cells that are characterized by the expression of LRIG1, which the authors show is a tumour suppressor. PDF Mouse models: Of mice and men p318 | doi:10.1038/nrc3270 A clinical trial in mice with lung cancer indicates the likely efficacy of the MEK inhibitor selumetinib in a current ongoing human clinical trial. PDF Trial watch: Hodgkin's lymphoma progress p319 | doi:10.1038/nrc3276 The results of two trials suggest ways in which the treatment of advanced, relapsed or refractory Hodgkin's lymphoma might be improved. PDF Tumorigenesis: Cut here for differentiation p320 | doi:10.1038/nrc3259 Some of the pathways through which the transcription factor and potential tumour suppressor Cut regulates both differentiation and apoptosis in Drosophila melanogaster have been identified. PDF Hypoxia: New connections p320 | doi:10.1038/nrc3267 Michael Ohh and colleagues delineate a pathway in which HIF increases the expression of caveolin 1, leading to increased ligand-independent mitogenic signalling by EGFR in cancer cells. PDF Metabolism: Unravelling metabolic dependencies p321 | doi:10.1038/nrc3273 A new study identifies a metabolic dependency in prostate cancer cells. PDF Cancer JOBS of the week Early detection of Cancer Biomarkers by means of optical biosensors based on the propagation of Bloch surface waves on one dimensional photonic crystals Università Sapienza Dipartimento di Scienze di Scienze di Base e applicate per l'Ingegneria Post-Doctoral Associate in molecular biology and cancer research Washington University in St Louis (School of Medicine) Postdoc positions for molecular cancer biology Baylor College of Medicine Post-Doctoral (WW) - Target Identification and Drug Discovery - Immunobiology and Cancer Research Program (W Wang) Oklahoma Medical Research Foundation (OMRF) Postdoc in Cancer Genomics University of Toronto - University Health Network More Science jobs from Cancer EVENT Nobel Conference on Breast Cancer 14.-17.06.12 Stockholm, Sweden More science events from
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REVIEWS		Top
Intra-tumour heterogeneity: a looking glass for cancer? Andriy Marusyk, Vanessa Almendro & Kornelia Polyak p323 | doi:10.1038/nrc3261 Populations of tumour cells display remarkable phenotypic diversity as a result of both genetic and non-genetic influences. This Review discusses underlying causes of this intra-tumour phenotypic heterogeneity, and why this phenomenon may affect our ability to diagnose and effectively treat tumours. Abstract | Full Text | PDF
The genetic architecture of multiple myeloma Gareth J. Morgan, Brian A. Walker & Faith E. Davies p335 | doi:10.1038/nrc3257 This review discusses some of the new insights on the development of multiple myeloma that can be gained from considering the evolution of this disease from a Darwinian perspective. Abstract | Full Text | PDF
From genes to drugs: targeted strategies for melanoma Keith T. Flaherty, F. Stephen Hodi & David E. Fisher p349 | doi:10.1038/nrc3218 There are multiple subclasses of melanoma that are partly categorized on the basis of their oncogenic molecular drivers. As discussed in this Review, the understanding of the molecular features of melanoma has led to several exciting advances in the treatment of patients with melanoma. Abstract | Full Text | PDF
PERSPECTIVES		Top
INNOVATION Cancer imaging by optical coherence tomography: preclinical progress and clinical potential Benjamin J. Vakoc, Dai Fukumura, Rakesh K. Jain & Brett E. Bouma p363 | doi:10.1038/nrc3235 Technological advances in optical coherence tomography (OCT) have enabled this imaging tool to be used to characterize various aspects of tumour biology in vivo. This Innovation article discusses the distinguishing features of OCT, its successful preclinical applications and its potential for clinical adoption. Abstract | Full Text | PDF | Supplementary information
ESSAY Screening for cancer with molecular markers: progress comes with potential problems John A. Baron p368 | doi:10.1038/nrc3260 Recent research has raised hopes for impressively accurate screening for cancer with molecular biomarkers. In this Essay, John A. Baron argues that more sensitive screening tests might be clinically valuable — but that they will present unique issues in implementation and interpretation. Abstract | Full Text | PDF
CORRESPONDENCE		Top
Correspondence: Initiation, evolution, phenotype and outcome of BRCA1 and BRCA2 mutation-associated breast cancer Ke-Da Yu & Zhi-Ming Shao p372 | doi:10.1038/nrc3181-c1 Full Text | PDF
Correspondence: BRCA1 and BRCA2: a common pathway of genome protection but different breast cancer subtypes Simon A. Joosse p372 | doi:10.1038/nrc3181-c2 Full Text | PDF
Correspondence: BRCA1 and BRCA2: important differences with common interests Rohini Roy, Jarin Chun & Simon N. Powell p372 | doi:10.1038/nrc3181-c3 Full Text | PDF
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Nature Reviews Cancer POSTER - MITOCHONDRIAL FUNCTION AND CANCER Author: Douglas C. Wallace This Poster highlights some recent discoveries that have led to a renewed interest in the function of mitochondria in cancer cells. Mitochondria carry out a number of crucial functions in cells and these can be altered through mutations in either the nuclear DNA or the mitochondrial DNA. Access the Poster FREE online! www.nature.com/nrc/posters/mitochondria This Poster is freely available thanks to sponsorship from Abcam
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*2010 Journal Citation Report (Thomson Reuters, 2011)

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