TABLE OF CONTENTS
| April 2012 Volume 18, Issue 4 |  | | |  |  Editorial
News
Book Review
Correspondence
News and Views
Community Corner
Between Bedside and Bench
Research Highlights
Articles
Letters
Technical Reports
Erratum
Corrigendum
| | | | | |
Advertisement |  | Next-generation molecular and evolutionary epidemiology of infectious disease 14-15 May 2012 at the Royal Society, London. This meeting will bring together researchers integrating unconnected data and models of infectious disease to address issues in human and animal health. Free to attend, pre-registration online essential royalsociety.org/events/2012/infectious-disease | 
| | | | | | Advertisement | | Nature Medicine and the Volkswagen Foundation present:
Herrenhausen Symposium on Viral Pathogenesis
June 4-7, 2012 • Seeon, Germany
A subset of leaders in the field will attend the Herrenhausen Symposium and participate in an interdisciplinary discussion that will point in the direction of solutions to the greatest challenges that the field of viral pathogenesis faces.
Application deadline: April 13, 2012
For more information and to apply, visit:
www.nature.com/natureconferences/hhs2012vp  | | | | | Nature Medicine Podcast |  Top | |  | | Achy breaky
Why individuals vary in their sensitivity to pain and how gut bacteria could hold the secret to controlling allergic reactions.
Listen Now | | Editorial | Top | | | | A marriage of convenience pp469 - 470
doi:10.1038/nm.2732
Translational research that takes place in academic settings is increasingly being funded by private-public partnerships. As these partnerships become more prevalent, scientists need to strike a balance between the benefits from this welcome funding source and the protection of their academic freedom.
Full Text | PDF | | News | Top | | | | Four-strain flu vaccines coming to a pharmacy near you p471
Elie Dolgin
doi:10.1038/nm0412-471
Full Text | PDF | | | | Panel backs pain drug studies with new safety checks p472
Elie Dolgin
doi:10.1038/nm0412-472
Full Text | PDF | | | | HIV researchers show virus the door p473
Charlotte Schubert
doi:10.1038/nm0412-473
Full Text | PDF | | | | Companies hope for rare win with cancer stem cell therapies p474
Anna Azvolinsky
doi:10.1038/nm0412-474a
Full Text | PDF | | | | Battle looms over regulatory classification of complex drugs pp474 - 475
Rebecca Hersher
doi:10.1038/nm0412-474b
Full Text | PDF | | | | Microfluidic chips promise better diagnosis for sickle cell disease p475
Rebecca Hersher
doi:10.1038/nm0412-475
Full Text | PDF | | | | With a slip under the tongue, allergy tablets subdue the sniffles p476
Megan Scudellari
doi:10.1038/nm0412-476a
Full Text | PDF | | | | Corrections p476
doi:10.1038/nm0412-476b
Full Text | PDF | | | | Europe plans molecular screening center for translational research p477
Lucas Laursen
doi:10.1038/nm0412-477a
Full Text | PDF | | | | Analysis of drug failures underscores value of robust phase 2 testing p477
Roxanne Palmer
doi:10.1038/nm0412-477b
Full Text | PDF | | | | Vaccines shoot for more precise population targets p478
Alla Katsnelson
doi:10.1038/nm0412-478
Full Text | PDF | | | | | Q&A | | | | Straight talk with...David Kaslow p479
Roxanne Khamsi
doi:10.1038/nm0412-479
Since inception of the Malaria Vaccine Initiative (MVI) in 1999, the Washington, DC–based initiative has played an instrumental part in advancing a number of leading vaccine candidates, including RTS,S, the first to show clinical efficacy in a major phase 3 trial. Steering the ship in the next phase of the journey is David Kaslow, who spoke with Roxanne Khamsi about how his experience in the public and private sectors will help inform his decisions in the nonprofit world.
Abstract | Full Text | PDF | | | | | News in Brief | | | | Biomedical briefing pp480 - 481
doi:10.1038/nm0412-480
Full Text | PDF | | | | | News Feature | | | | Remembered for Forgetting pp482 - 484
Cassandra Willyard
doi:10.1038/nm0412-482
Abstract | Full Text | PDF | | | | | Opinion | | | | Cockamamie state laws threaten genetic rights p485
Jennifer Wagner
doi:10.1038/nm0412-485
In the US, states anxious to establish genetic rights are acting in the absence of clear, informed leadership. The result is specious legislative language and conflicting proposals that create confusion and disrupt genetic research and healthcare activities. It's time to look beyond our state and national borders for guidance.
Full Text | PDF | | Book Review | Top | | | | Improving African lab medicine p487
Deborah Birx reviews Divining Without Seeds: The Case for Strengthening Laboratory Medicine in Africa by Iruka N. Okeke
doi:10.1038/nm.2730
Full Text | PDF | | Correspondence | Top | | | | Basophils from humans with systemic lupus erythematosus do not express MHC-II pp488 - 489
Dorothea Dijkstra, Christian Hennig, Torsten Witte and Gesine Hansen
doi:10.1038/nm.2663
Full Text | PDF | | | | Reply to: Basophils from humans with systemic lupus erythematosus do not express MHC-II pp489 - 490
Nicolas Charles, Barbara Dema and Juan Rivera
doi:10.1038/nm.2664
Full Text | PDF | | News and Views | Top | | | | Vitamin E: good for the heart, bad for the bones? pp491 - 492
G David Roodman
doi:10.1038/nm.2718
Vitamin E is commonly taken as a dietary supplement because it has been shown to have cardioprotective effects. However, its effects on bone metabolism are unknown. A new study in mice shows that a-tocopherol, the main isoform of vitamin E, stimulates bone osteoclast fusion independently of its antioxidant activity, resulting in increased bone resorption (pages 589- 594).
Full Text | PDF
See also: Letter by Fujita et al. | | | | Breathe easy: microbes protect from allergies pp492 - 494
Arya Khosravi and Sarkis K Mazmanian
doi:10.1038/nm.2723
Changes in gut microbial composition have been linked to inflammatory bowel disease, obesity and allergies in humans. A new study shows that pattern recognition of commensal bacteria by B cells reduces allergic inflammation in mice, adding to the mounting evidence for the 'hygiene hypothesis' (pages 538-546).
Full Text | PDF
See also: Article by Hill et al. | | | | In cancer drug resistance, germline matters too pp494 - 496
Emily H Cheng and Charles L Sawyers
doi:10.1038/nm.2725
Cancer genome sequencing projects focus exclusively on the discovery of somatic changes. A new study shows that germline alterations in the proapoptotic protein BIM can have a crucial role in how a tumor responds to treatment (pages 521-528).
Full Text | PDF
See also: Article by Ng et al. | | | | Hypothalamic BDNF and obesity: found in translation pp496 - 497
Elizabeth Schwartz and Charles V Mobbs
doi:10.1038/nm.2716
A recent study provides new insights into the central control of energy balance and obesity, showing that feeding behavior in mice can be modulated by local dendritic translation of a key protein in neuronal plasticity brain-derived neurotrophic factor (pages 564-571).
Full Text | PDF
See also: Article by Liao et al. | | | | Neighborhood watch orchestrates liver regeneration pp497 - 499
Anna Mae Diehl
doi:10.1038/nm.2719
Liver injury promotes the outgrowth of cell types that are relatively rare in healthy livers, including progenitors and stromal cells. A new study shows that the type of injury influences the cellular composition of the liver progenitor niche, which then seems to direct the fate of progenitors during regeneration (pages 572-579).
Full Text | PDF
See also: Article by Boulter et al. | | | | | | | Community Corner | Top | | | | Revelations into resveratrol's mechanism pp500 - 501
doi:10.1038/nm.2727
Full Text | PDF | | Between Bedside and Bench | Top | | | | Getting to the core of addiction: Hatching the addiction egg pp502 - 503
Peter W Kalivas and Kathleen Brady
doi:10.1038/nm.2726
Addiction to drugs of abuse, such as cocaine, remains a clinical and social problem, in part owing to the lack of effective treatment. The challenges of coping with addiction extend to the bench, pulling researchers to continue exploring the origins of addiction and the molecular and structural changes in the brain driving lack of self-control and impulsivity in people suffering from addiction or relapses. But what triggers these brain alterations has not been fully elucidated, and addiction animal models showing disparate outcomes have puzzled researchers. An assumed paradigm poses that brain changes during addiction result from chronic drug use. In 'Bedside to Bench,' Peter W. Kalivas and Kathleen Brady examine a clinical study that counters this model, suggesting that pathological brain alterations involved in cocaine addiction may also be inherited, contributing to addiction vulnerability. The implications for future preclinical studies and clinical care are numerous. But the controversy surrounding addiction also reaches the molecular level. In 'Bench to Bedside,' Marisela Morales and Antonello Bonci peruse a study in mice showing that activation of brain cannabinoid receptor 2[mdash]thought to have no effect on addiction owing to its scarcity in the brain[mdash]attenuates effects of cocaine use, including rewarding and locomotor stimulation. This may open the door to the development of selective drugs to treat cocaine addiction.
Full Text | PDF | | | | Getting to the core of addiction: Hooking CB2 receptor into drug abuse? pp504 - 505
Marisela Morales and Antonello Bonci
doi:10.1038/nm.2722
Full Text | PDF | | Research Highlights | Top | | | | Immunity: Anti-infective alarmin | Drug delivery: Drug delivery goes remote | Genetics: Multitude effects of MCM4 mutation | Neurodegeneration: The spread of tau | Cancer: Complex cancer roles for telomerase | New from NPG | Articles | Top | | | | A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer pp521 - 528
King Pan Ng, Axel M Hillmer, Charles T H Chuah, Wen Chun Juan, Tun Kiat Ko, Audrey S M Teo, Pramila N Ariyaratne, Naoto Takahashi, Kenichi Sawada, Yao Fei, Sheila Soh, Wah Heng Lee, John W J Huang, John C Allen Jr, Xing Yi Woo, Niranjan Nagarajan, Vikrant Kumar, Anbupalam Thalamuthu, Wan Ting Poh, Ai Leen Ang, Hae Tha Mya, Gee Fung How, Li Yi Yang, Liang Piu Koh, Balram Chowbay, Chia-Tien Chang, Veera S Nadarajan, Wee Joo Chng, Hein Than, Lay Cheng Lim, Yeow Tee Goh, Shenli Zhang, Dianne Poh, Patrick Tan, Ju-Ee Seet, Mei-Kim Ang, Noan-Minh Chau, Quan-Sing Ng, Daniel S W Tan, Manabu Soda, Kazutoshi Isobe, Markus M Nothen, Tien Y Wong, Atif Shahab, Xiaoan Ruan, Valere Cacheux-Rataboul, Wing-Kin Sung, Eng Huat Tan, Yasushi Yatabe, Hiroyuki Mano, Ross A Soo, Tan Min Chin, Wan-Teck Lim, Yijun Ruan and S Tiong Ong
doi:10.1038/nm.2713
Intrinsic resistance to tyrosine kinase inhibitor (TKI) drugs is limiting the progress of targeted cancer therapies. The efficacy of TKIs relies on their inhibition of oncogenic signaling but also on the induction of apoptosis in cancer cells, driven by activation of pro-apoptotic BIM proteins. The authors identify a germline BIM polymorphism common in East Asian individuals that switches BIM splicing, eliminating the BH3 domain responsible for apoptosis induction. The polymorphism provides resistance to TKIs, such as BCR-ABL inhibitors in chronic myeloid leukemia and EGFR inhibitors in non-small-cell lung cancer samples, and drug sensitivity can be reinstated by addition of BH3-mimetic drugs. The polymorphism predicts treatment responses and outcome in East Asian patients with leukemia and lung cancer and could provide useful guidance for therapeutic implementation.
Abstract | Full Text | PDF | | | | Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop pp529 - 537
Nicola Aceto, Nina Sausgruber, Heike Brinkhaus, Dimos Gaidatzis, Georg Martiny-Baron, Giovanni Mazzarol, Stefano Confalonieri, Micaela Quarto, Guang Hu, Piotr J Balwierz, Mikhail Pachkov, Stephen J Elledge, Erik van Nimwegen, Michael B Stadler and Mohamed Bentires-Alj
doi:10.1038/nm.2645
The authors uncover a role for the tyrosine phosphatase SHP2 in the propagation and maintenance of breast cancer tumor initiating cells. This role of SHP2 contributes to the growth and metastasis of tumors in vivo and is mediated by a newly uncovered downstream pathway that, through regulation of ERK, modulates the activity of transcription factors such as ZEB1 and Myc, also affecting microRNAs such as let-7. A genetic signature of SHP2 activation is indicative of increased aggressiveness in human breast cancers.
Abstract | Full Text | PDF | | | | Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation pp538 - 546
David A Hill, Mark C Siracusa, Michael C Abt, Brian S Kim, Dmytro Kobuley, Masato Kubo, Taku Kambayashi, David F LaRosa, Ellen D Renner, Jordan S Orange, Frederic D Bushman and David Artis
doi:10.1038/nm.2657
Alterations in commensal bacteria are associated with an increased risk of allergic disease. David Artis and his colleagues now report that commensal-derived signals influence basophil development and TH2 cytokine-dependent allergic airway inflammation by suppressing serum IgE levels. Individuals with hyper IgE syndrome also have elevated circulating basophil numbers, suggesting a mechanistic link between commensal bacteria, B cell-mediated production of IgE and basophil hematopoiesis.
Abstract | Full Text | PDF | | | | IL-17A produced by [alpha][beta] T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction pp547 - 554
Makoto Kudo, Andrew C Melton, Chun Chen, Mary B Engler, Katherine E Huang, Xin Ren, Yanli Wang, Xin Bernstein, John T Li, Kamran Atabai, Xiaozhu Huang and Dean Sheppard
doi:10.1038/nm.2684
IL-17 is associated with asthma, and THH17 cells are found in the airways of individuals with asthma. Dean Sheppard and his colleagues now report that IL-17A (but not IL-17F) directly enhances contractile responses in airway smooth muscle cells. Mice lacking TH17 cells in the lungs exhibit reduced airway hyper-responsiveness in response to allergen challenge.
Abstract | Full Text | PDF | | | | NOD2 triggers an interleukin-32-dependent human dendritic cell program in leprosy pp555 - 563
Mirjam Schenk, Stephan R Krutzik, Peter A Sieling, Delphine J Lee, Rosane M B Teles, Maria Teresa Ochoa, Evangelia Komisopoulou, Euzenir N Sarno, Thomas H Rea, Thomas G Graeber, Soohyun Kim, Genhong Cheng and Robert L Modlin
doi:10.1038/nm.2650
In human leprosy, a dendritic cell differentiation pathway that depends on interleukin-32 and is induced by NOD2 represents a novel mechanism of host defense against infection.
Abstract | Full Text | PDF | | | | Dendritically targeted Bdnf mRNA is essential for energy balance and response to leptin pp564 - 571
Guey-Ying Liao, Juan Ji An, Kusumika Gharami, Emily G Waterhouse, Filip Vanevski, Kevin R Jones and Baoji Xu
doi:10.1038/nm.2687
Leptin and BDNF are two protein cytokines known to inhibit food intake. Baoji Xu and colleagues have now shown that leptin-mediated inhibition of food intake is dependent on leptin binding to one set of hypothalamic neurons, which results in neuronal activation of other hypothalamic neurons to increase the dendritic expression of BDNF in those targeted neurons. These results show a new functional link between these two anorexigenic cytokines and how leptin signaling is propagated to regulate food intake.
Abstract | Full Text | PDF | | | | Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease pp572 - 579
Luke Boulter, Olivier Govaere, Tom G Bird, Sorina Radulescu, Prakash Ramachandran, Antonella Pellicoro, Rachel A Ridgway, Sang Soo Seo, Bart Spee, Nico Van Rooijen, Owen J Sansom, John P Iredale, Sally Lowell, Tania Roskams and Stuart J Forbes
doi:10.1038/nm.2667
Hepatic precursor cells (HPCs) are known to be bipotent and to give rise to both new hepatocytes and cholangiocytes upon acute liver injury. Stuart J. Forbes and his colleagues now show that interactions of HPCs with local macrophages and myofibroblasts potentiate Wnt and Notch signaling, respectively, to determine fate specification of the HPCs. Together, these mechanisms help determine proper organ regeneration after liver injury.
Abstract | Full Text | PDF | | | | A systems approach identifies HIPK2 as a key regulator of kidney fibrosis pp580 - 588
Yuanmeng Jin, Krishna Ratnam, Peter Y Chuang, Ying Fan, Yifei Zhong, Yan Dai, Amin R Mazloom, Edward Y Chen, Vivette D'Agati, Huabao Xiong, Michael J Ross, Nan Chen, Avi Ma'ayan and John Cijiang He
doi:10.1038/nm.2685
HIV infection is often associated with severe nephropathy, including renal fibrosis. John He and his colleagues have used a systems biology approach in a mouse model of HIV infection to identify the key factors involved in this process, thus identifying the kinase HIPK2 as one such factor. They also show that HIPK2 genetic deletion prevented renal fibrosis in two other mouse models, suggesting this kinase has a general role in the fibrotic process.
Abstract | Full Text | PDF | | Letters | Top | | | | Vitamin E decreases bone mass by stimulating osteoclast fusion pp589 - 594
Koji Fujita, Makiko Iwasaki, Hiroki Ochi, Toru Fukuda, Chengshan Ma, Takeshi Miyamoto, Kimitaka Takitani, Takako Negishi-Koga, Satoko Sunamura, Tatsuhiko Kodama, Hiroshi Takayanagi, Hiroshi Tamai, Shigeaki Kato, Hiroyuki Arai, Kenichi Shinomiya, Hiroshi Itoh, Atsushi Okawa and Shu Takeda
doi:10.1038/nm.2659
Vitamin E has long been proposed to favor bone growth owing to its antioxidant properties. This study shows instead that, by promoting osteoclast fusion, vitamin E decreases bone mass.
First paragraph | Full Text | PDF | | | | Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity pp595 - 599
Robert E Sorge, Tuan Trang, Ruslan Dorfman, Shad B Smith, Simon Beggs, Jennifer Ritchie, Jean-Sebastien Austin, Dmitri V Zaykin, Heather Vander Meulen, Michael Costigan, Teri A Herbert, Merav Yarkoni-Abitbul, David Tichauer, Jessica Livneh, Edith Gershon, Ming Zheng, Keith Tan, Sally L John, Gary D Slade, Joanne Jordan, Clifford J Woolf, Gary Peltz, William Maixner, Luda Diatchenko, Ze'ev Seltzer, Michael W Salter and Jeffrey S Mogil
doi:10.1038/nm.2710
Individual variation in pain sensation makes pain clinical trials quite challenging to interpret. Now, Michael Salter and colleagues report that genetic variation in the P2RX7 gene affects pore formation of the protein and pain sensation in humans.
First paragraph | Full Text | PDF | | | | Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis pp600 - 604
Brian D Gulbransen, Mohammad Bashashati, Simon A Hirota, Xianyong Gui, Jane A Roberts, Justin A MacDonald, Daniel A Muruve, Derek M McKay, Paul L Beck, Gary M Mawe, Roger J Thompson and Keith A Sharkey
doi:10.1038/nm.2679
Enteric neuron death is linked to the pathogenesis of inflammatory bowel disease. Now, Brian Gulbransen and his colleagues demonstrate that P2X7 receptor-pannexin-1 signaling is responsible for enteric neuron death in mouse models of colitis.
First paragraph | Full Text | PDF | | | | Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia pp605 - 611
Tino Schenk, Weihsu Claire Chen, Stefanie Gollner, Louise Howell, Liqing Jin, Katja Hebestreit, Hans-Ulrich Klein, Andreea C Popescu, Alan Burnett, Ken Mills, Robert A Casero Jr, Laurence Marton, Patrick Woster, Mark D Minden, Martin Dugas, Jean C Y Wang, John E Dick, Carsten Muller-Tidow, Kevin Petrie and Arthur Zelent
doi:10.1038/nm.2661
Drugs that induce redifferentiation of cancer cells are efficient only in some subtypes of AML. The authors show that sensitivity to pro-differentiation drugs such as ATRA can be induced by co-treatment with epigenetic drugs. An inhibitor of histone demethylase, LSD1, safely used as an antidepressant in humans, reprograms AML cells and makes them sensitive to the effects of ATRA in vitro and in vivo, suggesting that epigenetic interventions can increase response to cancer treatments.
First paragraph | Full Text | PDF | | | | CITED2 links hormonal signaling to PGC-1[alpha] acetylation in the regulation of gluconeogenesis pp612 - 617
Mashito Sakai, Michihiro Matsumoto, Tomoko Tujimura, Cao Yongheng, Tetsuya Noguchi, Kenjiro Inagaki, Hiroshi Inoue, Tetsuya Hosooka, Kazuo Takazawa, Yoshiaki Kido, Kazuki Yasuda, Ryuji Hiramatsu, Yasushi Matsuki and Masato Kasuga
doi:10.1038/nm.2691
Dysregulated hepatic glucose production (HGP) is a key feature of type 2 diabetes (T2D). Masato Kasuga and his colleagues now show that under physiological conditions, the expression and activity of the protein CITED2 in the liver is altered in response to hormonal cues that regulate HGP. They also show in a mouse model of T2D that hepatic CITED2 expression is elevated and that its genetic knockdown reduces serum glucose concentrations, suggesting this protein as a possible therapeutic target in the clinic.
First paragraph | Full Text | PDF | | Technical Reports | Top | | | | Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell pp618 - 623
Shiro Yui, Tetsuya Nakamura, Toshiro Sato, Yasuhiro Nemoto, Tomohiro Mizutani, Xiu Zheng, Shizuko Ichinose, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Hans Clevers and Mamoru Watanabe
doi:10.1038/nm.2695
Building on their recent work establishing long-term cultures from Lgr5+ cells of the small intestine and stomach, Shiro Yui and colleagues describe a new colonic stem cell culture and expansion method generating organoids from single Lgr5+ stem cells. The study provides proof of principle that the cultured Lgr5+ cells can be used for stem cell therapy to repair superficially damaged epithelium in a dextran sulfate sodium (DSS)-induced acute colitis mouse model.
Abstract | Full Text | PDF | | | | 2-hydroxyglutarate detection by magnetic resonance spectroscopy in subjects with IDH-mutated gliomas pp624 - 630
Changho Choi, Sandeep K Ganji, Ralph J DeBerardinis, Kimmo J Hatanpaa, Dinesh Rakheja, Zoltan Kovacs, Xiao-Li Yang, Tomoyuki Mashimo, Jack M Raisanen, Isaac Marin-Valencia, Juan M Pascual, Christopher J Madden, Bruce E Mickey, Craig M Malloy, Robert M Bachoo and Elizabeth A Maher
doi:10.1038/nm.2682
Mutations in isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) in the majority of people with grade 2 and 3 gliomas is associated with elevated levels of 2-hydroxyglutarate (2HG) within the tumor. As harboring IDH1 or IDH2 mutations confers a considerable survival benefit in these individuals, there has been considerable interest in studying this metabolite as a potential biomarker. Here, Changho Choi et al. report the successful noninvasive detection of 2HG in 30 subjects with gliomas using a proton magnetic resonance spectroscopy approach.
Abstract | Full Text | PDF | | Erratum | Top | | | | Re-establishing immunological self-tolerance in autoimmune disease p630
Shimon Sakaguchi, Fiona Powrie and Richard M Ransohoff
doi:10.1038/nm0412-630a
Full Text | PDF | | Corrigendum | Top | | | | Epigenetic modulation of the renal [beta]-adrenergic-WNK4 pathway in salt-sensitive hypertension p630
ShengYu Mu, Tatsuo Shimosawa, Sayoko Ogura, Hong Wang, Yuzaburo Uetake, Fumiko Kawakami-Mori, Takeshi Marumo, Yutaka Yatomi, David S Geller, Hirotoshi Tanaka and Toshiro Fujita
doi:10.1038/nm0412-630b
Full Text | PDF | | | Top | |  | | Advertisement | | | | | | | | | | | | Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here.
Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com | | | | | | | | | |
No comments:
Post a Comment