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| | | | | | | Academy of Military Medical Sciences - Celebrating 60 years of research at one of China's leading organizations for medical science The Academy of Military Medical Sciences (AMMS) in Beijing has developed beyond its military heritage to become a world leader in medical science with a string of achievements in both military and civilian applications that have resonated around the globe. Find out more about the AMMS in Part 3 of the five-part series of this special sponsor feature on nature.com. | | | | | | | | |
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| | | | | Allergic host defences | Have we got it wrong about allergy? Allergic reactions tend to be seen as the result of a misfire from an immune system that evolved to repel invasive parasites. In a Perspective article this week Palm et al. suggest a rather different model, in which allergic reactions are excessive or exaggerated responses of a system that serves a necessary function, protecting the body from environmental toxins such as noxious substances, venoms and xenobiotics. | | | | | | | | | Multiple dynamic representations in the motor cortex during sensorimotor learning | Although it is known that many neurons in a circuit experience plasticity changes during long-term learning, the limitations of electrophysiological methodology mean that these changes are usually examined in only a few neurons at a time. This study uses genetically encoded neural activity markers to simultaneously follow large populations of motor cortex neurons during learning in mice. | | | | | | | | | Systematic variation of the stellar initial mass function in early-type galaxies | A survey of 260 early galaxies reveals considerable variation in the stellar initial mass function or IMF, which describes the mass distribution of stars at the time of their formation. The IMF had been thought to be independent of galaxy type, but this evidence suggests that stars somehow sense what kind of galaxy they are in the process of creating. | | | | | | | | | | | | | | THE TARA OCEANS EXPEDITION A Special Podcast
In a 2.5 year journey across the globe's oceans, the TARA OCEANS expedition has collected unique information on the biodiversity and biogeography of the marine ecosystem. Project co-director Eric Karsenti shares his excitement about this exceptional human and scientific adventure and explains how researchers will analyze the data to better understand life on our planet. Listen to our FREE podcast now! | | | | | | | | | | | | | | | In this week's podcast: organic versus inorganic farming, a long-running study of development comes of age and experiments on the edge of acceptability. | | | | | | | Specials - Outlook: Malaria | | | | The war against the malaria parasite has raged for millennia, and still claims hundreds of thousands of lives each year. Resistance is a growing issue — for both the parasite to current therapy, and the mosquito to pesticides. Past attempts to eradicate malaria have failed. What will it take to finally subdue this deadly disease? ▼ more | | | | | | |
| | | | | | | | | | | | | | | | | For better or worse ▶ | | | Frank debate is needed about the balance between beneficial and detrimental uses of research. Scientists must be the first to open discussions. | | | | | | | | Chase the dragon ▶ | | | A planned commercial trip to the space station shows a future direction for NASA. | | | | | | | | | | | | | | | | | | | | Seven days: 20-26 April 2012 ▶ | | | The week in science: Roche drops pursuit of Illumina; UN ecosystems panel launches; and a venture to mine asteroids launches. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Oceanography: Ultra marine ▶ | | | Stephen R. Palumbi finds both stark warnings and buoyant optimism in an encyclopaedic take on the state of the oceans. | | | | | | | | | | | | | | | | | | | | | | | Ecology: Trashed world ▶ | | | Sonja Vermeulen ponders two takes on the twinned global issues of consumption and waste. | | | | | | | | | | | | | | | | | | | | | | | |
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| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Multiple dynamic representations in the motor cortex during sensorimotor learning ▶ | | | D. Huber, D. A. Gutnisky, S. Peron, D. H. O’Connor, J. S. Wiegert et al. | | | Genetically encoded neural activity markers were used in mice to simultaneously follow large populations of motor cortex neurons during sensorimotor learning, revealing that spatially intermingled neurons represent either sensory or motor behaviour, with population-level representations of subsets of motor programs strengthening as training progressed. | | | | | | | | | | | Sexual selection enables long-term coexistence despite ecological equivalence ▶ | | | Leithen K. M’Gonigle, Rupert Mazzucco, Sarah P. Otto & Ulf Dieckmann | | | A theoretical model shows how sexual selection, on its own, can maintain biodiversity, provided that two realistic assumptions are met: that carrying capacity varies spatially, and that females searching for mates incur costs in doing so. | | | | | | | | | | | Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β ▶ | | | Christina E. Zielinski, Federico Mele, Dominik Aschenbrenner, David Jarrossay, Francesca Ronchi et al. | | | Infection with Candida albicans and Staphylococcus aureus gives rise to TH17 cells with different properties; microbe-induced T-cell differentiation is shown here to depend on the balance between polarizing cytokines rather than absolute amounts. | | | | | | | | IFITM3 restricts the morbidity and mortality associated with influenza ▶ | | | Aaron R. Everitt, Simon Clare, Thomas Pertel, Sinu P. John, Rachael S. Wash et al. | | | Interferon-inducible transmembrane (IFITM) protein 3 is shown to be an innate defence mechanism against viral infection in vivo; furthermore, a subset of the patients hospitalized during the H1N1 2009 pandemic carried a variant form of the IFITM3 gene. | | | | | | | | | | | Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’ ▶ | | | Aron M. Levin, Darren L. Bates, Aaron M. Ring, Carsten Krieg, Jack T. Lin et al. | | | Although IL-2 has been studied for its immune-stimulating activity against metastatic cancer, its side effects have limited its clinical use; here, an engineered IL-2 ‘superkine’ is shown to have increased activity, particularly in inducing antitumour T cells, but fewer side effects. | | | | | | | | An inverse relationship to germline transcription defines centromeric chromatin in C. elegans ▶ | | | Reto Gassmann, Andreas Rechtsteiner, Karen W. Yuen, Andrew Muroyama, Thea Egelhofer et al. | | | Centromere identity is thought to be epigenetically propagated by stable inheritance of nucleosomes containing the histone variant CENP-A; the authors propose a different model here in which germline transcription defines the genomic regions that exclude CENP-A incorporation during embryogenesis in the holocentric worm Caenorhabditis elegans. | | | | | | | | | | | | | | | | | | | | Allergic host defences ▶ | | | Noah W. Palm, Rachel K. Rosenstein & Ruslan Medzhitov | | | A review of allergic host defences argues that allergic immunity has an important role in host defence against noxious environmental substances. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
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| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’ ▶ | | | Aron M. Levin, Darren L. Bates, Aaron M. Ring, Carsten Krieg, Jack T. Lin et al. | | | Although IL-2 has been studied for its immune-stimulating activity against metastatic cancer, its side effects have limited its clinical use; here, an engineered IL-2 ‘superkine’ is shown to have increased activity, particularly in inducing antitumour T cells, but fewer side effects. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Systematic variation of the stellar initial mass function in early-type galaxies ▶ | | | Michele Cappellari, Richard M. McDermid, Katherine Alatalo, Leo Blitz, Maxime Bois et al. | | | A study of the stellar kinematics of a large sample of early-type galaxies provides evidence that the stellar initial mass function depends on the galaxy’s stellar mass-to-light ratio and thus is strongly dependent on the galaxy’s formation history. | | | | | | | | | | | Thermal and electrical transport across a magnetic quantum critical point ▶ | | | Heike Pfau, Stefanie Hartmann, Ulrike Stockert, Peijie Sun, Stefan Lausberg et al. | | | The heavy-fermion compound YbRh2Si2 possesses a quantum critical point, at which the standard theory of electron behaviour in metals is expected to break down; such anomalous behaviour has now been observed. | | | | | | | | Antarctic ice-sheet loss driven by basal melting of ice shelves ▶ | | | H. D. Pritchard, S. R. M. Ligtenberg, H. A. Fricker, D. G. Vaughan, M. R. van den Broeke et al. | | | Using satellite laser altimetry, basal melting of ice shelves is determined to be the main driver of Antarctic ice-sheet loss, with changing climate the likely cause. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Comparing the yields of organic and conventional agriculture ▶ | | | Verena Seufert, Navin Ramankutty & Jonathan A. Foley | | | A meta-analysis assessing the relative yields of organic and conventional agriculture shows that organic yields are on average lower, but that the magnitude of the difference is dependent on context. | | | | | | | | | | | Deposition of 1.88-billion-year-old iron formations as a consequence of rapid crustal growth ▶ | | | Birger Rasmussen, Ian R. Fletcher, Andrey Bekker, Janet R. Muhling, Courtney J. Gregory et al. | | | The reappearance of major iron formations at 1.88 billion years ago (after the rise in atmospheric oxygen) is puzzling because their deposition requires anoxic and iron-rich sea water, but is here explained as a consequence of major mantle activity and rapid crustal growth at that time. | | | | | | | | Antarctic ice-sheet loss driven by basal melting of ice shelves ▶ | | | H. D. Pritchard, S. R. M. Ligtenberg, H. A. Fricker, D. G. Vaughan, M. R. van den Broeke et al. | | | Using satellite laser altimetry, basal melting of ice shelves is determined to be the main driver of Antarctic ice-sheet loss, with changing climate the likely cause. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | The numbers game ▶ | | | Nature Outlook maps the challenges in tackling the malaria epidemic. | | | | | | | | | | | | | | | | | | | | | | | | | | |
| | | | | | | Frontiers in Materials: Spintronics May 13, 2012 • Strasbourg, France This workshop will provide an overview of the most interesting developments in the field of spintronics, a technology that aims at controlling the electron spin beside the electron charge and that could provide efficient electronic devices with potentially new functionalities. The early booking cutoff is April 5, 2012. Online registration will close on May 4, 2012. Register today! | | | | | | | | |
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| | | | | | | | | A lab app for that ▶ | | | Having a mobile device can save researchers a huge amount of time. It can also mean that they never switch off. | | | | | | | | | | | | | | | | | Careers related news & comment | | | | | | | | | | | | |
| | |  naturejobs.com Science jobs of the week | | | | | | | | | | Assistant Specialist | | | University of California, San Francisco (UCSF)gineering and Therapeutic Sciences | | | | | | | | | No matter what your career stage, student, postdoc or senior scientist, you will find articles on naturejobs.com to help guide you in your science career. Keep up-to-date with the latest sector trends, vote in our reader poll and sign-up to receive the monthly Naturejobs newsletter. | | | | | | | • Nature events featured events | | | | | |  natureevents featured events | | | | | | | Nature events is the premier resource for scientists looking for the latest scientific conferences, courses, meetings and symposia. Featured across Nature Publishing Group journals and centrally at natureevents.com it is an essential reference guide to scientific events worldwide. | | | | |
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