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| | | 10 April 2012 | | | Featured image: | |  | | | Kössl et al. find an innate mechanism for sonar ranging that enhances the survival of juvenile moustached bats. |
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Advertisement | | Nature Climate Change – First anniversary highlights
To mark the first anniversary of Nature Climate Change the editors have put together their favourite articles from the first 12 issues.
The selection is currently free to view online. |
| | | | | | Latest Articles | View all Articles | | | | | Discreteness-induced concentration inversion in mesoscopic chemical systems | | | Rajesh Ramaswamy, Nélido González-Segredo, Ivo F. Sbalzarini and Ramon Grima | | | The kinetics of chemical reactions occurring within small volumes, such as inside biological cells, are generally modelled using the linear noise approximation. This study demonstrates how this approximation can break down, leading to the inversion of the concentrations of two chemical species below a critical volume. | | | 10 Apr | Nat Commun 3:779 doi:10.1038/ncomms1775 (2012) | | | Chemical sciences | | Abstract | Full Text | PDF (559 kB) |
Supplementary Information |
| Nanodomain Ca2+ of Ca2+ channels detected by a tethered genetically encoded Ca2+ sensor | | | Lai Hock Tay, Ivy E. Dick, Wanjun Yang, Marco Mank, Oliver Griesbeck and David T. Yue | | | Calcium nanodomains arise from the cytoplasmic mouth of calcium channels but have not been directly visualized. In this study, the nanodomain of the CaV2.2 calcium channel is imaged using total internal reflection fluorescence microscopy and a genetically encoded calcium sensor attached to the carboxy terminus. | | | 10 Apr | Nat Commun 3:778 doi:10.1038/ncomms1777 (2012) | | | Biological sciences Biophysics | | | | Abstract | Full Text | PDF (1,322 kB) |
Supplementary Information |
| Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation | | | Demian Obregon, Huayan Hou, Juan Deng, Brian Giunta, Jun Tian, Donna Darlington, Md Shahaduzzaman, Yuyuan Zhu, Takashi Mori, Mark P. Mattson and Jun Tan | | | The loss of neurotrophic factors is responsible for key neurodegenerative processes in Alzheimer's disease. In this study, Obregon and colleagues treat amyloidogenic cells with the neurotrophin soluble amyloid precursor protein-α and find that it halts amyloidogenesis by interacting with the β-secretase BACE1. | | | 10 Apr | Nat Commun 3:777 doi:10.1038/ncomms1781 (2012) | | | Biological sciences Neuroscience | | Abstract | Full Text | PDF (807 kB) |
Supplementary Information |
| Dissecting a central flip-flop circuit that integrates contradictory sensory cues in C. elegans feeding regulation | | | Zhaoyu Li, Yidong Li, Yalan Yi, Wenming Huang, Song Yang, Weipin Niu, Li Zhang, Zijing Xu, Anlian Qu, Zhengxing Wu and Tao Xu | | | Animals sense multiple environmental cues simultaneously and use this sensory information to regulate feeding behaviour, which is fundamental to survival. Li and co-workers describe a central circuit in Caenorhabditis elegans that can be activated by attractive odours or repellents to facilitate or suppress feeding behaviour. | | | 10 Apr | Nat Commun 3:776 doi:10.1038/ncomms1780 (2012) | | | Biological sciences Neuroscience | | | | Abstract | Full Text | PDF (578 kB) |
Supplementary Information |
| Atomic-scale evolution of modulated phases at the ferroelectric–antiferroelectric morphotropic phase boundary controlled by flexoelectric interaction | | | A.Y. Borisevich, E.A. Eliseev, A.N. Morozovska, C.-J. Cheng, J.-Y. Lin, Y.H. Chu, D. Kan, I. Takeuchi, V. Nagarajan and S.V. Kalinin | | | Morphotropic phase boundaries—regions of abrupt structural change and enhanced material response—are of practical importance and are a challenge for the fundamental theory of phase transitions. Here, the ferroelectric–antiferroelectric boundary is studied using atomically resolved mapping in BiFeO3. | | | 10 Apr | Nat Commun 3:775 doi:10.1038/ncomms1778 (2012) | | | Physical sciences Condensed matter | | | Materials science | | | | Abstract | Full Text | PDF (1,078 kB) |
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| Staged decline of neuronal function in vivo in an animal model of Alzheimer's disease OPEN | | | Christine Grienberger, Nathalie L. Rochefort, Helmuth Adelsberger, Horst A. Henning, Daniel N. Hill, Julia Reichwald, Matthias Staufenbiel and Arthur Konnerth | | | The amyloid-β-peptide is pivotal to the pathology of Alzheimer's disease, but its mechanism of action remains uncertain. This study utilizes in vivo two-photon calcium imaging to investigate the effects of this peptide on single cortical neurons of the visual cortex in a mouse model of Alzheimer's disease. | | | 10 Apr | Nat Commun 3:774 doi:10.1038/ncomms1783 (2012) | | | Biological sciences Neuroscience | | Abstract | Full Text | PDF (1,907 kB) |
Supplementary Information |
| Auditory cortex of newborn bats is prewired for echolocation | | | Manfred Kössl, Cornelia Voss, Emanuel C. Mora, Silvio Macias, Elisabeth Foeller and Marianne Vater | | | Bats use a process known as echolocation to measure the distance of an object by echo delay. Here, studies in newborn bats reveal that echo delay tuning of neurons in the auditory cortex is present at birth rather than acquired as a result of echolocation experience. | | | 10 Apr | Nat Commun 3:773 doi:10.1038/ncomms1782 (2012) | | | Biological sciences Developmental biology | | | Neuroscience Zoology | | Abstract | Full Text | PDF (654 kB) |
Supplementary Information |
| Earliest known coelacanth skull extends the range of anatomically modern coelacanths to the Early Devonian | | | Min Zhu, Xiaobo Yu, Jing Lu, Tuo Qiao, Wenjin Zhao and Liantao Jia | | | The coelacanth body plan can be traced to the late Middle Devonian, but the group's early history is unclear due to a limited fossil record. This study presents the earliest known coelacanth skull (Euporosteus yunnanensis sp. nov.), extending the chronological range of anatomically modern coelacanths by 17 million years. | | | 10 Apr | Nat Commun 3:772 doi:10.1038/ncomms1764 (2012) | | | Biological sciences Evolution | | | Palaeontology Zoology | | Abstract | Full Text | PDF (1,607 kB) |
Supplementary Information |
| CYLD negatively regulates transforming growth factor-β-signalling via deubiquitinating Akt OPEN | | | Jae Hyang Lim, Hirofumi Jono, Kensei Komatsu, Chang-Hoon Woo, Jiyun Lee, Masanori Miyata, Takashi Matsuno, Xiangbin Xu, Yuxian Huang, Wenhong Zhang, Soo Hyun Park, Yu-Il Kim, Yoo-Duk Choi, Huahao Shen, Kyung-Sun Heo, Haodong Xu, Patricia Bourne, Tomoaki Koga, Haidong Xu, Chen Yan, Binghe Wang, Lin-Feng Chen, Xin-Hua Feng and Jian-Dong Li | | | Lung injury initiates a series of wound-healing responses, which if unregulated, can lead to fibrosis. Li et al. show that the deubquitinase CYLD has a key role in the prevention of fibrosis by inhibiting transforming growth factor β-signalling through the direct deubiquitination of the protein kinase Akt. | | | 10 Apr | Nat Commun 3:771 doi:10.1038/ncomms1776 (2012) | | | Biological sciences Cell biology | | | | Abstract | Full Text | PDF (1,726 kB) |
Supplementary Information |
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