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TABLE OF CONTENTS
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April 2012 Volume 30, Issue 4 |
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Editorial
News
Bioentrepreneur
Correspondence
Features
News and Views
Research Highlights
Computational Biology
 Research
Errata
Corrigendum
Careers and Recruitment
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In This Issue |  Top |
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In this issue ppvii - viii
doi:10.1038/nbt.2192
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Editorial | Top |
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Reforming accelerated approval p293
doi:10.1038/nbt.2194
Proposed US legislation aiming to expand and expedite patient access to novel drugs represents a good start, but is unlikely to strongly boost approval numbers.
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News | Top |
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Oxford Nanopore announcement sets sequencing sector abuzz pp295 - 296
Michael Eisenstein
doi:10.1038/nbt0412-295
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Pharma incubates without strings p297
Brian Orelli
doi:10.1038/nbt0412-297b
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Biotech innovators jump on biosimilars bandwagon pp297 - 299
Nuala Moran
doi:10.1038/nbt0412-297a
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Anti-nerve growth factor drugs exonerated p298
Karen Carey
doi:10.1038/nbt0412-298a
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Biosimilar fees plug FDA deficit p298
Jeffrey L Fox
doi:10.1038/nbt0412-298b
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Corn rot. 1090 p299
doi:10.1038/nbt0412-299
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First HEV vaccine approved p300
Allison Proffitt
doi:10.1038/nbt0412-300a
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India's GM clamor mounts p300
Killugudi Jayaraman
doi:10.1038/nbt0412-300b
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Amgen swallows Micromet to BiTE into ALL market pp300 - 301
Cormac Sheridan
doi:10.1038/nbt0412-300c
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Biologics inch toward cholesterol-lowering market pp302 - 304
Ken Garber
doi:10.1038/nbt0412-302
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Around the world in a month p303
doi:10.1038/nbt0412-303
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Hemacord approval may foreshadow regulatory creep for HSC therapies p304
Malorye Allison
doi:10.1038/nbt0412-304
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| Newsmaker |
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Tensha Therapeutics p305
Jennifer Rohn
doi:10.1038/nbt0412-305
Tensha is staking a claim on drugging bromodomains as an innovative epigenetic approach to novel anti-cancer agents.
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| News Features |
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Positive signals from Washington pp306 - 308
Jeffrey L Fox
doi:10.1038/nbt.2175
US biotech seems reenergized, but unsettled policy questions take a back seat to pending national elections, particularly with the presidency at stake. Jeffrey L Fox reports.
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National prescription for drug development pp309 - 312
Meredith Wadman
doi:10.1038/nbt.2176
Vowing to reengineer drug discovery, NIH bets big with a new translational research center. Meredith Wadman reports.
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Bioentrepreneur | Top |
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The art of the alliance pp313 - 315
Garry E Menzel and Kleanthis G Xanthopoulos
doi:10.1038/nbt.2150
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Correspondence | Top |
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Addgene provides an open forum for plasmid sharing pp316 - 317
Melanie Herscovitch, Eric Perkins, Andy Baltus and Melina Fan
doi:10.1038/nbt.2177
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Use of genome-wide association studies for drug repositioning pp317 - 320
Philippe Sanseau, Pankaj Agarwal, Michael R Barnes, Tomi Pastinen, J Brent Richards, Lon R Cardon and Vincent Mooser
doi:10.1038/nbt.2151
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Bias in high-tier medical journals concerning physician-academic relationships with industry pp320 - 322
Roman Lesko, Samuel Scott and Thomas P Stossel
doi:10.1038/nbt.2179
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Features | Top |
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| Patents |
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Gene patents in Australia: where do we stand? pp323 - 324
David P Simmons and Mark E Wickham
doi:10.1038/nbt.2173
The provision of a patent system that protects innovators and researchers while ensuring reasonable access to emerging technologies and medical treatments are the key objectives of the Australian government's response to three important reports concerning Australia's patent system and gene patents.
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Recent patent applications related to drug discovery automation p325
doi:10.1038/nbt.2186
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15th European Congress on Biotechnology
23 - 26 September 2012 - ISTANBUL, TURKEY
www.ecb15.org
Abstract Submission Deadline:
30th April 2012 |  | |
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News and Views | Top |
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Research Highlights | Top |
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Turning intestines into insulin factories | How sulfa drugs work | Reverse plant breeding success | Starving HIV of genome building blocks | Nanodevices measure bioelectricity
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Computational Biology | Top |
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| News Feature |
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Finding correlations in big data pp334 - 335
doi:10.1038/nbt.2182
A new statistical method called MIC can find diverse types of correlations in large data sets. Nature Biotechnology asked eight experts to weigh in on its utility.
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Research | Top |
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Using virally expressed melanoma cDNA libraries to identify tumor-associated antigens that cure melanoma pp337 - 343
Jose Pulido, Timothy Kottke, Jill Thompson, Feorillo Galivo, Phonphimon Wongthida, Rosa Maria Diaz, Diana Rommelfanger, Elizabeth Ilett, Larry Pease, Hardev Pandha, Kevin Harrington, Peter Selby, Alan Melcher and Richard Vile
doi:10.1038/nbt.2157
Vaccination with a virus-expressed cDNA library derived from normal prostate cells can cure established prostate cancer in mouse models. Pulido et al. extend this approach and identify specific tumor-associated antigens from tumor-derived virus-expressed cDNA libraries that can be used in combination to cure established melanoma in mice.
Abstract | Full Text | PDF
See also: News and Views by Avogadri & Wolchok
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| Letters |
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Automated forward and reverse ratcheting of DNA in a nanopore at 5-A precision pp344 - 348
Gerald M Cherf, Kate R Lieberman, Hytham Rashid, Christopher E Lam, Kevin Karplus and Mark Akeson
doi:10.1038/nbt.2147
A key obstacle to sequencing DNA as it passes through a nanopore is that the translocation rate is too fast to resolve individual bases. Cherf et al. solve this problem with an improved method for ratcheting DNA forward and backward through the nanopore using a DNA polymerase.
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See also: News and Views by Schneider & Dekker
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Reading DNA at single-nucleotide resolution with a mutant MspA nanopore and phi29 DNA polymerase pp349 - 353
Elizabeth A Manrao, Ian M Derrington, Andrew H Laszlo, Kyle W Langford, Matthew K Hopper, Nathaniel Gillgren, Mikhail Pavlenok, Michael Niederweis and Jens H Gundlach
doi:10.1038/nbt.2171
Protein nanopores are being developed as sensors that could perform rapid, electronic sequencing of long single molecules of DNA. Manrao et al. report the first demonstration of single nucleotide-resolution current traces from a nanopore, and show that these data can be mapped to known DNA sequences.
First paragraph | Full Text | PDF
See also: News and Views by Schneider & Dekker
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Design of a dynamic sensor-regulator system for production of chemicals and fuels derived from fatty acids pp354 - 359
Fuzhong Zhang, James M Carothers and Jay D Keasling
doi:10.1038/nbt.2149
Expressing heterologous pathways in cells can create detrimental metabolic imbalances. Zhang et al. increase the yield of a biofuel by engineering regulators in Escherichia coli that sense and adjust pathway expression based on the presence of key intermediate metabolites.
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Wheat grain yield on saline soils is improved by an ancestral Na+ transporter gene pp360 - 364
Rana Munns, Richard A James, Bo Xu, Asmini Athman, Simon J Conn, Charlotte Jordans, Caitlin S Byrt, Ray A Hare, Stephen D Tyerman, Mark Tester, Darren Plett and Matthew Gilliham
doi:10.1038/nbt.2120
Salinization of cultivated land and the need to increase agricultural productivity make the development of salt-resistant crops imperative. Field trials show that a durum wheat containing a sodium transporter derived from an ancestral wheat relative produces substantially more grain than a commercial durum wheat lacking this transporter on saline soil.
First paragraph | Full Text | PDF
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Errata | Top |
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Erratum: Fresh from the pipeline 2011 p365
Jim Kling
doi:10.1038/nbt0412-365a
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Erratum: Profiling PARP inhibitors p365
Philip Jones
doi:10.1038/nbt0412-365b
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Corrigendum | Top |
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Corrigendum: The BioPAX community standard for pathway data sharing p365
Emek Demir, Michael P Cary, Suzanne Paley, Ken Fukuda, Christian Lemer, Imre Vastrik, Guanming Wu, Peter D'Eustachio, Carl Schaefer, Joanne Luciano, Frank Schacherer, Irma Martinez-Flores, Zhenjun Hu, Veronica Jimenez-Jacinto, Geeta Joshi-Tope, Kumaran Kandasamy, Alejandra C Lopez-Fuentes, Huaiyu Mi, Elgar Pichler, Igor Rodchenkov, Andrea Splendiani, Sasha Tkachev, Jeremy Zucker, Gopal Gopinath, Harsha Rajasimha, Ranjani Ramakrishnan, Imran Shah, Mustafa Syed, Nadia Anwar, Ozgun Babur, Michael Blinov, Erik Brauner, Dan Corwin, Sylva Donaldson, Frank Gibbons, Robert Goldberg, Peter Hornbeck, Augustin Luna, Peter Murray-Rust, Eric Neumann, Oliver Reubenacker, Matthias Samwald, Martijn van Iersel, Sarala Wimalaratne, Keith Allen, Burk Braun, Michelle Whirl-Carrillo, Kei-Hoi Cheung, Kam Dahlquist, Andrew Finney, Marc Gillespie, Elizabeth Glass, Li Gong, Robin Haw, Michael Honig, Olivier Hubaut, David Kane, Shiva Krupa, Martina Kutmon, Julie Leonard, Debbie Marks, David Merberg, Victoria Petri, Alex Pico, Dean Ravenscroft, Liya Ren, Nigam Shah, Margot Sunshine, Rebecca Tang, Ryan Whaley, Stan Letovksy, Kenneth H Buetow, Andrey Rzhetsky, Vincent Schachter, Bruno S Sobral, Ugur Dogrusoz, Shannon McWeeney, Mirit Aladjem, Ewan Birney, Julio Collado-Vides, Susumu Goto, Michael Hucka, Nicolas Le Novere, Natalia Maltsev, Akhilesh Pandey, Paul Thomas, Edgar Wingender, Peter D Karp, Chris Sander and Gary D Bader
doi:10.1038/nbt0412-365c
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Careers and Recruitment | Top |
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The rise of the professional master's degree: the answer to the postdoc/PhD bubble pp367 - 368
Maria Theodosiou, Jean-Philippe Rennard and Arsia Amir-Aslani
doi:10.1038/nbt.2180
Professional master's degrees have a proven record of benefitting science-oriented individuals, reorienting their career towards nontraditional fields.
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| People |
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People p370
doi:10.1038/nbt.2185
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