The EMBO Journal - Table of Contents alert Volume 31 Issue 8

TABLE OF CONTENTS 18 April 2012 | Volume 31, Issue 8 Have you seen? Focus Review Articles Also new AOP Advertisement BEYOND BASIC – Circulation Research for the iPad®. Basic cardiovascular research that's critical to your profession is now brought to you on the iPad. Sample issue is available – click here to download the app for free today! Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement The EMBO Meeting 2012 22 - 25 September in Nice, France Keynotes: Paul Nurse & Linda Partridge 20 concurrent sessions covering the life sciences Speakers include: Kari Alitalo, Karl Deisseroth, Steven Henikoff, Ruth Lehmann, Dirk Schübeler & Rob Singer Abstract submission & early registration: 12 June 2012 www.the-embo-meeting.org   Have you seen? Top The demise of a TUDOR under stress opens a chromatin link to 53BP1 Recent studies provide long-sought molecular links between RNF8-dependent ubiquitin signalling at DNA damage sites and chromatin-mediated recruitment of the damage response protein 53BP1. Grant S Stewart The EMBO Journal (2012), 31, 1847 - 1849; 10.1038/emboj.2012.78 Abstract | Full text | PDF Published online: 27 March 2012 CyclinD2 at the edge: splitting up cell fate The team of Noriko Osumi reports that the mRNA of cyclinD2, a positive regulator of G1 progression, is asymmetrically inherited during neural stem cell division. The daughter cell inheriting cyclinD2 maintains its self-renewal capability, while lengthening of G1 and differentiation occurs in the sibling cell. Federico Calegari The EMBO Journal (2012), 31, 1850 - 1852; 10.1038/emboj.2012.74 Abstract | Full text | PDF Published online: 27 March 2012 Focus Review Top Shaping the role of mitochondria in the pathogenesis of Huntington's disease Mitochondrial dysfunctions affecting the transcriptional regulation of their biogenesis, bioenergetics, calcium buffering, fission/fusion dynamics and motility are emerging as key determinants in the pathogenesis of Huntington's disease (HD). Veronica Costa and Luca Scorrano The EMBO Journal (2012), 31, 1853 - 1864; 10.1038/emboj.2012.65 Abstract | Full text | PDF Published online: 23 March 2012 Subject Categories: Neuroscience | Molecular Biology of Disease Articles Top RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites How histone marks and ubiquitination cooperate to recruit the 53BP1 repair protein to DNA double-strand breaks is incompletely understood. Ubiquitin-mediated degradation is found to remove the histone demethylase JMJD2A from methylated histones, unmasking 53BP1 binding sites. Frédérick A Mallette, Stéphane Richard and collegaues The EMBO Journal (2012), 31, 1865 - 1878; 10.1038/emboj.2012.47 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 28 February 2012 Subject Categories: Proteins | Genome Stability and Dynamics Cyclin D2 in the basal process of neural progenitors is linked to non-equivalent cell fates Localized translation of the cell-cycle regulator Cyclin D2 in the basal process of radial glial progenitor cells leads to its selective inheritance by the daughter cell undergoing self-renewal, thus representing a new mechanism for asymmetric cell fate determination. Yuji Tsunekawa, Joanne M Britto, Masanori Takahashi, Franck Polleux, Seong-Seng Tan and Noriko Osumi The EMBO Journal (2012), 31, 1879 - 1892; 10.1038/emboj.2012.43 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 06 March 2012 Subject Categories: Cell and Tissue Architecture | Neuroscience N-cadherin specifies first asymmetry in developing neurons Neuronal polarization is determined by localized N-cadherin expression at one pole of the newborn neuron towards which the Golgi and centrosome move in a PI3K and the actin/microtubule cytoskeleton-dependent manner. Annette Gärtner, Carlos G Dotti and collegaues The EMBO Journal (2012), 31, 1893 - 1903; 10.1038/emboj.2012.41 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 21 February 2012 Subject Categories: Cell and Tissue Architecture | Neuroscience NLK positively regulates Wnt/β-catenin signalling by phosphorylating LEF1 in neural progenitor cells Nemo-like kinase (NLK) regulates the Wnt/β-catenin pathway in zebrafish midbrain and mammalian neural progenitor cells. NLK2 is activated downstream of Dishevelled and phosphorylates the transcription factor Lef1, promoting its dissociation from the histone deacetylase HDAC1 to activate gene expression. Satoshi Ota, Shizuka Ishitani, Nobuyuki Shimizu, Kunihiro Matsumoto, Motoyuki Itoh and Tohru Ishitani The EMBO Journal (2012), 31, 1904 - 1915; 10.1038/emboj.2012.46 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 28 February 2012 Subject Categories: Signal Transduction | Neuroscience Nutrient/TOR-dependent regulation of RNA polymerase III controls tissue and organismal growth in Drosophila The mechanisms underlying organismal growth regulation by the TOR pathway remain unclear. TOR stimulates RNA polymerase III in the Drosophila fat body via the transcription factors Maf1 and c-Myc, regulating systemic insulin signalling and growth. Lynne Marshall, Elizabeth J Rideout and Savraj S Grewal The EMBO Journal (2012), 31, 1916 - 1930; 10.1038/emboj.2012.33 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 24 February 2012 Subject Categories: Signal Transduction | Development Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC A genome-wide siRNA screen identifies autophagy regulators. The Golgi protein SCOC regulates the interaction between ULK1 kinase and the Beclin 1 complexes in a nutrient-dependent manner; WAC enhances starvation-induced autophagy, while inhibiting the ubiquitin-proteasome system. Nicole C McKnight, Sharon A Tooze and collegaues The EMBO Journal (2012), 31, 1931 - 1946; 10.1038/emboj.2012.36 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 21 February 2012 Subject Categories: Membranes and Transport | Differentiation and Death Ebola virus entry requires the host-programmed recognition of an intracellular receptor Niemann-Pick C1 (NPC1), a lysosomal cholesterol transporter, is known to be required for Ebola virus entry. Here, NPC1 is shown to be sufficient for Ebola infection by directly binding the viral glycoprotein, GP, after its NPC1-binding site is unmasked by endosomal protease cleavage. Emily Happy Miller, Kartik Chandran and collegaues The EMBO Journal (2012), 31, 1947 - 1960; 10.1038/emboj.2012.53 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 06 March 2012 Subject Categories: Membranes and Transport | Microbiology and Pathogens Multiple factors dictate target selection by Hfq-binding small RNAs Target recognition by bacterial small RNAs is not well understood. The accessibility of the targeted sequences, stability of the duplex, and the binding and positioning of the RNA chaperone Hfq on the mRNA are critical. Chase L Beisel, Taylor B Updegrove, Ben J Janson and Gisela Storz The EMBO Journal (2012), 31, 1961 - 1974; 10.1038/emboj.2012.52 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 02 March 2012 Subject Categories: RNA Dehydration stress activates Arabidopsis MPK6 to signal DCP1 phosphorylation The pathways regulating mRNA stability in response to environment stress in plants are not well understood. The stress responsive MAPK, MPK6, phosphorylates the mRNA decapping enzyme DCP1 to enhance its activity and regulate mRNA stability. Jun Xu and Nam-Hai Chua The EMBO Journal (2012), 31, 1975 - 1984; 10.1038/emboj.2012.56 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 09 March 2012 Subject Categories: RNA | Plant Biology A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells Molecular analyses in this study identify inflammation-induced miRNA regulation of central glycolytic enzymes. Focussing on hexokinase-2 as major target therapeutically exploitable consequences for cell proliferation, migration, and metastasis are functionally established. Shuai Jiang, Mo-Fang Liu and collegaues The EMBO Journal (2012), 31, 1985 - 1998; 10.1038/emboj.2012.45 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 21 February 2012 Subject Categories: Signal Transduction | Molecular Biology of Disease Claudin-14 regulates renal Ca++ transport in response to CaSR signalling via a novel microRNA pathway Cldn14 is normally repressed in the kidney by miR-9 and miR-374. Hypercalcaemia inhibits these miRNAs to allow for Cldn14 enrichment, which in turn inhibits the CLDN16–CLDN19 paracellular channel and thus blocks renal calcium reabsorption. Yongfeng Gong, Jianghui Hou and collegaues The EMBO Journal (2012), 31, 1999 - 2012; 10.1038/emboj.2012.49 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 28 February 2012 Subject Categories: Membranes and Transport | Molecular Biology of Disease Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply The histone chaperone Asf1 important for chromatin replication is regulated by Codanin-1, via interactions that are disrupted by congenital anaemia-associated Codanin-1 mutations. Katrine Ask, Zuzana Jasencakova, Patrice Menard, Yunpeng Feng, Geneviève Almouzni and Anja Groth The EMBO Journal (2012), 31, 2013 - 2023; 10.1038/emboj.2012.55 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 09 March 2012 Subject Categories: Chromatin and Transcription | Genome Stability and Dynamics | Molecular Biology of Disease Organismal propagation in the absence of a functional telomerase pathway in Caenorhabditis elegans Mutant worm strains that proliferate indefinitely without telomerase provide the first multicellular model for studying recombination-mediated telomere maintenance (ALT), a mechanism active in telomerase-deficient human tumours. Daniel H Lackner, Marcela Raices, Hugo Maruyama, Candy Haggblom and Jan Karlseder The EMBO Journal (2012), 31, 2024 - 2033; 10.1038/emboj.2012.61 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 16 March 2012 Subject Categories: Genome Stability and Dynamics RPA facilitates telomerase activity at chromosome ends in budding and fission yeasts The single-stranded DNA-binding protein RPA is an essential cofactor in repair, recombination and chromosomal DNA replication. Its presence on replicating telomeres is now linked to direct interaction with the telomerase enzyme and regulation of its telomere elongation activity. Pierre Luciano, Vincent Géli and collegaues The EMBO Journal (2012), 31, 2034 - 2046; 10.1038/emboj.2012.40 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 21 February 2012 Subject Categories: Genome Stability and Dynamics Lysophospholipid presentation by CD1d and recognition by a human Natural Killer T-cell receptor Invariant Natural Killer T-cell receptors, iNKT TCRs, recognize lipid-based antigens presented by CD1d molecules. Here, structural analysis reveals a novel mode of recognition by iNKT TCR of the endogenous lipid LPC presented by human CD1d. Jacinto López-Sagaseta, Leah V Sibener, Jennifer E Kung, Jenny Gumperz and Erin J Adams The EMBO Journal (2012), 31, 2047 - 2059; 10.1038/emboj.2012.54 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 06 March 2012 Subject Categories: Immunology Advertisement Follow EMBO on Twitter for as-it-happens access to news, comments and articles. 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