Pathway Studio® is a complete research informatics solution that integrates proprietary knowledge with findings from published literature in an analytical framework to reveal molecular connections that summarize the state of current knowledge and power novel discovery. To learn more visit: www.pathwaystudio.com
A new online open access journal from Clinical Pharmacology & Therapeutics.
CPT: Pharmacometrics & Systems Pharmacology publishes advances in quantitative methods as applied in pharmacology, physiology, and therapeutics in humans with a common focus on the application of these two areas on drug development.
Roche chases stake in medical sequencing doi:10.1038/484152a Biotech firm Illumina continues to resist takeover — but analysts suggest that a merger is inevitable. Full Text
Deal watch: Biogen acquires Stromedix to pursue novel fibrosis therapy doi:10.1038/nrd3708 Biogen Idec has agreed to buy Stromedix, whose lead compound, STX-100, a humanized monoclonal antibody against αVβ6 integrin, is currently in a Phase II trial to treat idiopathic pulmonary fibrosis. Full Text
Patent Watch: India issues compulsory licence for sorafenib doi:10.1038/nrd3719 A round-up of patent-related news, including the decision by the Indian Controller of Patents to issue a compulsory licence for Bayer's anticancer drug sorafenib (Nexavar), which might pave the way for compulsory licences for other medicines in India. Full Text
Biologics inch toward cholesterol-lowering market doi:10.1038/nbt0412-302 Inhibition of proprotein convertase subtilisin/kexin type 9 is rapidly gaining traction in the clinic as it is backed by studies showing dramatic reductions in circulating cholesterol. Full Text
MRSA sensitivity training doi:10.1038/scibx.2012.351 Researchers at Merck & Co. Inc. have identified targets in methicillin-resistant Staphylococcus aureus that synergize with β-lactam antibiotic targets to restore antibiotic sensitivity. The findings suggest it may now be possible to use combinations of antibiotics to treat infections previously considered intractable. Full Text
Fresh from the Pipeline: Aflibercept doi:10.1038/nrd3700 Fusion protein that inhibits vascular endothelial growth factor signalling approved in the United States for the treatment of neovascular age-related macular degeneration. Full Text
From the analyst's couch: Rare diseases and orphan drugs doi:10.1038/nrd3654 This article discusses market trends in the development of drugs for rare diseases, which have increasingly been recognized as providing attractive opportunities for the biopharmaceutical industry. Full Text
Neuromuscular disorders: Troponin activator improves muscle function doi:10.1038/nrd3703 A small-molecule activator of the troponin complex increased skeletal muscle strength in a rodent model of neuromuscular disease. Full Text
Neurological disorders: A class of its own doi:10.1038/nrd3704 A potential new class of drugs offers enhanced selectivity and efficacy over the drugs that are currently used in the clinic to treat absence seizures. Full Text
Immunotherapy: Combinations that work doi:10.1038/nrc3250 Preclinical data support the strategy of combining tumour-targeted therapies with immune-stimulating agents. Full Text
Novel molecular targets for atrial fibrillation therapy doi:10.1038/nrd3682 This Review focuses on the mechanistic rationale for the development of new anti-atrial fibrillation drugs, on the molecular and structural motifs that they target and on the results obtained so far in experimental and clinical studies. Full Text
Combining immunotherapy and targeted therapies in cancer treatment doi:10.1038/nrc3237 This article outlines how combining targeted approaches, which inhibit molecular pathways that promote tumour growth and maintenance, with immunotherapy, which stimulates a host immune response that effectuates long-lived tumour destruction, could provide therapeutic synergy. Full Text
A proteomics approach for the identification and cloning of monoclonal antibodies from serum doi:10.1038/nbt.2167 Cheung et al. couple proteomics with next-generation sequencing of RNA from B cells to clone antibodies directly from the sera of immunized rabbits and mice, potentially advancing immunology and vaccinology research and the development of therapeutics. Full Text
Using virally expressed melanoma cDNA libraries to identify tumor-associated antigens that cure melanoma doi:10.1038/nbt.2157 Pulido et al. identify specific tumor-associated antigens from tumor-derived virus-expressed cDNA libraries that can be used in combination to cure established melanoma in mice. Full Text
Career snapshots archive Career snapshots feature people associated with drug discovery and drug development, with the aim of providing expert insights and advice on a wide range of positions and career paths in this field. Full Text
SciBX: Science-Business eXchange is a weekly publication that identifies and analyzes the most important translational research articles from over 40 journals. Find out which papers have real scientific and commercial potential, and why.
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