Clinical Pharmacology and Therapeutics - Table of Contents alert Volume 91 Issue 5

TABLE OF CONTENTS Volume 91, Issue 5 (May 2012) In this issue In This Issue Editorial News & Views Perspectives Clinical Trial State of the Art Reviews Research Discovery & Development Regulation & Use Also new AOP Advertisement Let’s partner for Early Phase success! For 30 years, PAREXEL has been a premier partner to clients relying on our industry-leading Early Phase expertise. With a full scope of services from First-in-Human through Proof of Concept, PAREXEL is right where you need us. Discover more at www.parexel.com/early-phase Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement Sign me up for the CPT:PSP alert A new online open access journal from Clinical Pharmacology & Therapeutics in the pharmacometrics and systems pharmacology space. Stay updated on newly published research from the beginning. Coming Summer 2012   In This Issue Top In This Issue Clin Pharmacol Ther 2012 91: 753; 10.1038/clpt.2012.48 Full Text Editorial Top The Many Sides of Off-Label Prescribing R S Epstein and S-M Huang Clin Pharmacol Ther 2012 91: 755-758; 10.1038/clpt.2012.37 Full Text News & Views Top HIGHLIGHTS Clin Pharmacol Ther 2012 91: 760-761; 10.1038/clpt.2012.47 Full Text ASCPT NEWS Clin Pharmacol Ther 2012 91: 762-766; 10.1038/clpt.2012.38 Full Text BOOKS Drug Metabolism and Pharmacokinetics Quick Guide Reviewed by  M E Morris Clin Pharmacol Ther 2012 91: 767-768; 10.1038/clpt.2012.35 Full Text Perspectives Top COMMENTARIES Using Models to Predict the Future: What to Do When the Data Run Out? S G Pauker and F R Goss Clin Pharmacol Ther 2012 91: 769-771; 10.1038/clpt.2012.25 Abstract | Full Text The Need for Translational Research on Drug–Drug Interactions S Hennessy and D A Flockhart Clin Pharmacol Ther 2012 91: 771-773; 10.1038/clpt.2012.39 Abstract | Full Text Clopidogrel: A Case for Indication-Specific Pharmacogenetics J A Johnson, D M Roden, L J Lesko, E Ashley, T E Klein and A R Shuldiner Clin Pharmacol Ther 2012 91: 774-776; 10.1038/clpt.2012.21 Abstract | Full Text Clinical Trial Top Pharmacokinetic and Pharmacodynamic Variability of Fluindione in Octogenarians E Comets, B Diquet, S Legrain, M-G Huisse, A Godon, C Bruhat, M-P Chauveheid, S Delpierre, X Duval, G Berrut, C Verstuyft, M-C Aumont and F Mentré Clin Pharmacol Ther 2012 91: 777-786; advance online publication, April 4, 2012; 10.1038/clpt.2011.309 Abstract | Full Text State of the Art Top Monitoring the Safety of Medicines Used Off-Label G J Dal Pan Clin Pharmacol Ther 2012 91: 787-795; advance online publication, April 4, 2012; 10.1038/clpt.2012.24 Abstract | Full Text Reviews Top REVIEW Off-Label Drug Use in Pediatric Patients E Kimland and V Odlind Clin Pharmacol Ther 2012 91: 796-801; advance online publication, April 4, 2012; 10.1038/clpt.2012.26 Full Text Interpatient Pharmacokinetic and Pharmacodynamic Variability of Carrier-Mediated Anticancer Agents W P Caron, G Song, P Kumar, S Rawal and W C Zamboni Clin Pharmacol Ther 2012 91: 802-812; advance online publication, April 4, 2012; 10.1038/clpt.2012.12 Abstract | Full Text Research Top ARTICLES Sildenafil Increases Digital Skin Blood Flow During All Phases of Local Cooling in Primary Raynaud's Phenomenon M Roustit, M Hellmann, C Cracowski, S Blaise and J L Cracowski Clin Pharmacol Ther 2012 91: 813-819; advance online publication, March 28, 2012; 10.1038/clpt.2011.302 Abstract | Full Text Likert Pain Score Modeling: A Markov Integer Model and an Autoregressive Continuous Model E L Plan, J-P Elshoff, A Stockis, M L Sargentini-Maier and M O Karlsson Clin Pharmacol Ther 2012 91: 820-828; advance online publication, March 21, 2012; 10.1038/clpt.2011.301 Abstract | Full Text A Risk–Benefit Assessment of Prasugrel, Clopidogrel, and Genotype-Guided Therapy in Patients Undergoing Percutaneous Coronary Intervention G F Guzauskas, D A Hughes, S M Bradley and D L Veenstra Clin Pharmacol Ther 2012 91: 829-837; advance online publication, March 28, 2012; 10.1038/clpt.2011.303 Abstract | Full Text Impact of Safety-Related Regulatory Action on Drug Use in Ambulatory Care in the Netherlands S Piening, K C Reber, J E Wieringa, S M J M Straus, P A de Graeff, F M Haaijer-Ruskamp and P G M Mol Clin Pharmacol Ther 2012 91: 838-845; advance online publication, April 4, 2012; 10.1038/clpt.2011.308 Abstract | Full Text Gemfibrozil Is a Strong Inactivator of CYP2C8 in Very Small Multiple Doses J Honkalammi, M Niemi, P J Neuvonen and J T Backman Clin Pharmacol Ther 2012 91: 846-855; advance online publication, April 4, 2012; 10.1038/clpt.2011.313 Abstract | Full Text Intranasal Midazolam: Pharmacokinetics and Pharmacodynamics Assessed by Quantitative EEG in Healthy Volunteers M Hardmeier, R Zimmermann, S Rüegg, M Pflüger, S Deuster, K Suter, M Donzelli, J Drewe, S Krähenbühl, P Fuhr and M Haschke Clin Pharmacol Ther 2012 91: 856-862; advance online publication, March 28, 2012; 10.1038/clpt.2011.316 Abstract | Full Text Joint Modeling of Efficacy, Dropout, and Tolerability in Flexible-Dose Trials: A Case Study in Depression A Russu, E Marostica, G De Nicolao, A C Hooker, I Poggesi, R Gomeni and S Zamuner Clin Pharmacol Ther 2012 91: 863-871; advance online publication, April 4, 2012; 10.1038/clpt.2011.322 Abstract | Full Text Safety Learning From Drugs of the Same Class: Room for Improvement G Stefansdottir, M J Knol, A H Arnardottir, M E van der Elst, D E Grobbee, H G M Leufkens and M L De Bruin Clin Pharmacol Ther 2012 91: 872-880; advance online publication, March 28, 2012; 10.1038/clpt.2011.319 Abstract | Full Text Safety and Pharmacokinetics of Escalating Daily Doses of the Antituberculosis Drug Rifapentine in Healthy Volunteers K E Dooley, E E Bliven-Sizemore, M Weiner, Y Lu, E L Nuermberger, W C Hubbard, E J Fuchs, M T Melia, W J Burman and S E Dorman Clin Pharmacol Ther 2012 91: 881-888; advance online publication, April 4, 2012; 10.1038/clpt.2011.323 Abstract | Full Text Effects of Ritonavir-Boosted Lopinavir on the Pharmacokinetics of Quinine M M Nyunt, Y Lu, Q Yu, M El-Gasim, T L Parsons, B G Petty and C W Hendrix Clin Pharmacol Ther 2012 91: 889-895; advance online publication, April 4, 2012; 10.1038/clpt.2011.326 Abstract | Full Text A Screening Study of Drug–Drug Interactions in Cerivastatin Users: An Adverse Effect of Clopidogrel J S Floyd, R Kaspera, K D Marciante, N S Weiss, S R Heckbert, T Lumley, K L Wiggins, B Tamraz, P-Y Kwok, R A Totah and B M Psaty Clin Pharmacol Ther 2012 91: 896-904; advance online publication, March 14, 2012; 10.1038/clpt.2011.295 Abstract | Full Text Human Pregnane X Receptor Genotype of the Donor but Not of the Recipient Is a Risk Factor for Delayed Graft Function After Renal Transplantation I A Hauser, S Kruck, S Gauer, A T Nies, S Winter, J Bedke, H Geiger, H Hoefeld, J Kleemann, A Asbe-Vollkopf, J Engel, O Burk, M Schwab and E Schaeffeler Clin Pharmacol Ther 2012 91: 905-916; advance online publication, March 28, 2012; 10.1038/clpt.2011.346 Abstract | Full Text Discovery & Development Top TRANSLATION Electronic Health Records: The New Vehicle for Drug Labeling, Safety, and Efficacy E J Fotsch Clin Pharmacol Ther 2012 91: 917-919; advance online publication, April 4, 2012; 10.1038/clpt.2012.31 Abstract | Full Text DEVELOPMENT Off-Label Use of Drugs and Medical Devices: A Review of Policy Implications R S Stafford Clin Pharmacol Ther 2012 91: 920-925; advance online publication, April 4, 2012; 10.1038/clpt.2012.22 Abstract | Full Text Regulatory Experience With Physiologically Based Pharmacokinetic Modeling for Pediatric Drug Trials R Leong, M L T Vieira, P Zhao, Y Mulugeta, CS Lee, S-M Huang and G J Burckart Clin Pharmacol Ther 2012 91: 926-931; advance online publication, April 4, 2012; 10.1038/clpt.2012.19 Full Text Clinical Pharmacology and Orphan Drugs: An Informational Inventory 2006–2010 E D Bashaw and L Fang Clin Pharmacol Ther 2012 91: 932-936; advance online publication, March 28, 2012; 10.1038/clpt.2012.23 Full Text The Use of Observational Health-Care Data to Identify and Report on Off-Label Use of Biopharmaceutical Products J Morris Clin Pharmacol Ther 2012 91: 937-942; advance online publication, April 4, 2012; 10.1038/clpt.2012.30 Abstract | Full Text Regulation & Use Top PRACTICE Influence of Pharmacy Benefit Practices on Off-Label Dispensing of Drugs in the United States J R Teagarden, W B Dreitlein, H Kourlas and L Nichols Clin Pharmacol Ther 2012 91: 943-945; advance online publication, March 28, 2012; 10.1038/clpt.2011.367 Full Text Advertisement Ensure your access If you are unable to access the articles in thisalert, your library may not subscribe to this journal. 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