TABLE OF CONTENTS
|  |  |  | Volume 106, Issue 8 (1361-1466) Published online 10 April 2012
|  | In this issue Clinical Studies Translational Therapeutics Molecular Diagnostics Genetics and Genomics Letters to the Editor
Also new today Advance online publication
| |  |  |  | | Advertisement |  | |  | | | Clinical Studies | Top |  | Major ethnic group differences in breast cancer screening uptake in Scotland are not extinguished by adjustment for indices of geographical residence, area deprivation, long-term illness and educationN Bansal, R S Bhopal, M F C Steiner and D H Brewster on behalf of the Scottish Health and Ethnicity Linkage Study Br J Cancer 2012 106: 1361-1366; advance online publication, March 13, 2012; 10.1038/bjc.2012.83 Abstract | Full Text |  |  |  | Increased signalling of EGFR and IGF1R, and deregulation of PTEN/PI3K/Akt pathway are related with trastuzumab resistance in HER2 breast carcinomasA Gallardo, E Lerma, D Escuin, A Tibau, J Muñoz, B Ojeda, A Barnadas, E Adrover, L Sánchez-Tejada, D Giner, F Ortiz-Martínez and G Peiró Br J Cancer 2012 106: 1367-1373; advance online publication, March 27, 2012; 10.1038/bjc.2012.85 Abstract | Full Text |  |  |  | Survival advantage observed with the use of metformin in patients with type II diabetes and colorectal cancerC R Garrett, H M Hassabo, N A Bhadkamkar, S Wen, V Baladandayuthapani, B K Kee, C Eng and M M Hassan Br J Cancer 2012 106: 1374-1378; advance online publication, March 15, 2012; 10.1038/bjc.2012.71 Abstract | Full Text |  |  |  | First-in-man phase I trial of two schedules of the novel synthetic tetrahydroisoquinoline alkaloid PM00104 (Zalypsis) in patients with advanced solid tumoursT A Yap, H Cortes-Funes, H Shaw, R Rodriguez, D Olmos, R Lal, P C Fong, D S Tan, D Harris, J Capdevila, C Coronado, V Alfaro, A Soto-Matos, C Fernández-Teruel, M Siguero, J M Tabernero, L Paz-Ares, J S de Bono and J A López-Martin Br J Cancer 2012 106: 1379-1385; 10.1038/bjc.2012.99 Abstract | Full Text |  | Translational Therapeutics | Top |  | The synergistic interaction of MEK and PI3K inhibitors is modulated by mTOR inhibitionE J Haagensen, S Kyle, G S Beale, R J Maxwell and D R Newell Br J Cancer 2012 106: 1386-1394; advance online publication, March 13, 2012; 10.1038/bjc.2012.70 Abstract | Full Text |  |  |  | Impact of mutant β-catenin on ABCB1 expression and therapy response in colon cancer cellsU Stein, C Fleuter, F Siegel, J Smith, A Kopacek, D A Scudiero, K M Hite, P M Schlag, R H Shoemaker and W Walther Br J Cancer 2012 106: 1395-1405; advance online publication, March 29, 2012; 10.1038/bjc.2012.81 Abstract | Full Text |  | Molecular Diagnostics | Top |  | Cross-suppression of EGFR ligands amphiregulin and epiregulin and de-repression of FGFR3 signalling contribute to cetuximab resistance in wild-type KRAS tumour cellsC Oliveras-Ferraros, S Cufí, B Queralt, A Vazquez-Martin, B Martin-Castillo, R de Llorens, J Bosch-Barrera, J Brunet and J A Menendez Br J Cancer 2012 106: 1406-1414; 10.1038/bjc.2012.103 Abstract | Full Text |  |  |  | High expression of Lin28 is associated with tumour aggressiveness and poor prognosis of patients in oesophagus cancerR Hamano, H Miyata, M Yamasaki, K Sugimura, K Tanaka, Y Kurokawa, K Nakajima, S Takiguchi, Y Fujiwara, M Mori and Y Doki Br J Cancer 2012 106: 1415-1423; advance online publication, March 20, 2012; 10.1038/bjc.2012.90 Abstract | Full Text |  |  |  | Comparison and combination of blood-based inflammatory markers with faecal occult blood tests for non-invasive colorectal cancer screeningS Tao, U Haug, K Kuhn and H Brenner Br J Cancer 2012 106: 1424-1430; advance online publication, March 27, 2012; 10.1038/bjc.2012.104 Abstract | Full Text |  |  |  | Serum matrix metalloproteinase 9 and colorectal neoplasia: a community-based evaluation of a potential diagnostic testS Wilson, S Damery, D D Stocken, G Dowswell, R Holder, S T Ward, V Redman, M J Wakelam, J James, F D R Hobbs and T Ismail Br J Cancer 2012 106: 1431-1438; advance online publication, March 20, 2012; 10.1038/bjc.2012.93 Abstract | Full Text |  |  |  | A novel, externally validated inflammation-based prognostic algorithm in hepatocellular carcinoma: the prognostic nutritional index (PNI)D J Pinato, B V North and R Sharma Br J Cancer 2012 106: 1439-1445; advance online publication, March 20, 2012; 10.1038/bjc.2012.92 Abstract | Full Text |  |  |  | NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificityH Wang, S Lee, C Lo Nigro, L Lattanzio, M Merlano, M Monteverde, R Matin, K Purdie, N Mladkova, D Bergamaschi, C Harwood, N Syed, P Szlosarek, E Briasoulis, A McHugh, A Thompson, A Evans, I Leigh, C Fleming, G J Inman, E Hatzimichael, C Proby and T Crook Br J Cancer 2012 106: 1446-1452; advance online publication, March 27, 2012; 10.1038/bjc.2012.95 Abstract | Full Text |  |  |  | Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor-negative breast cancerJ Ohotski, J S Long, C Orange, B Elsberger, E Mallon, J Doughty, S Pyne, N J Pyne and J Edwards Br J Cancer 2012 106: 1453-1459; advance online publication, March 29, 2012; 10.1038/bjc.2012.98 Abstract | Full Text |  | Genetics and Genomics | Top |  | Mutation analysis of RAD51D in non-BRCA1/2 ovarian and breast cancer familiesD J Osher, K De Leeneer, G Michils, N Hamel, E Tomiak, B Poppe, K Leunen, E Legius, A Shuen, E Smith, J Arseneau, P Tonin, G Matthijs, K Claes, M D Tischkowitz and W D Foulkes Br J Cancer 2012 106: 1460-1463; advance online publication, March 13, 2012; 10.1038/bjc.2012.87 Abstract | Full Text |  | Letters to the Editor | Top |  | Metronomic chemotherapy with cyclophosphamide and dexamethasone in patients with metastatic carcinoma of the prostateP D Dickinson, D N Y Peel and S Sundar Br J Cancer 2012 106: 1464-1465; advance online publication, March 13, 2012; 10.1038/bjc.2012.78 Full Text |  |  |  | Reply: Metronomic chemotherapy with cyclophosphamide and dexamethasone in patients with metastatic carcinoma of the prostateO A Khan, A D Blann, M J Payne, M R Middleton, A S Protheroe, D C Talbot, M Taylor, C Han, M Patil and A L Harris Br J Cancer 2012 106: 1466; advance online publication, March 13, 2012; 10.1038/bjc.2012.79 Full Text |  |  |  |  |  | | Advertisement |  | British Journal of Cancer presents: Web Focus on MicroRNA MicroRNAs have emerged as major new mechanisms of regulation of gene function, potential therapeutic targets, with roles in diagnosis, prognosis and biomarkers.
This collection puts MicroRNA in context of other molecular classifications and then investigative articles and reviews cover the main tumour types where microRNAs are emerging as having important roles in biological processes including lung cancer, AML, melanoma, colorectal cancer, nasopharyngeal carcinoma, bladder cancer, rhabdomyosarcoma and heptacellular carcinoma.
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