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|  | | 06 March 2012 | | | Featured image: | |  | | | Pan et al. report that acetylcholine binds to the pentameric ligand gated ion channel ELIC and is a competitive antagonist. |
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| | | | | | Latest Review | View all Reviews | | | | | The biology and chemistry of high-valent iron–oxo and iron–nitrido complexes | | | Johannes Hohenberger, Kallol Ray and Karsten Meyer | | | High-valent iron–oxo and –nitrido complexes are intermediates in the catalytic cycles of various metalloenzymes that activate dioxygen and dinitrogen. Hohenberger et al. review the advances in the chemistry of model high-valent iron–oxo and –nitrido systems and relate them to our understanding of related enzymes. | | | 06 Mar | Nat Commun 3:720 doi:10.1038/ncomms1718 (2012) | | | Chemical sciences Catalysis Inorganic chemistry | | | | | Abstract | Full Text | PDF (692 kB) |
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| | | Latest Articles | View all Articles | | | | | Ptychographic electron microscopy using high-angle dark-field scattering for sub-nanometre resolution imaging OPEN | | | M.J. Humphry, B. Kraus, A.C. Hurst, A.M. Maiden and J.M. Rodenburg | | | Diffractive imaging can deliver wavelength-scale resolution with X-rays, although its use with electrons is hampered by experimental constraints. By applying ptychographic methods to transmission electron microscopy, Humphry et al. demonstrate sub-nanometre resolution using low-energy electrons. | | | 06 Mar | Nat Commun 3:730 doi:10.1038/ncomms1733 (2012) | | | Physical sciences Applied physics | | | Optical physics | | | Abstract | Full Text | PDF (662 kB) |
| Charge state manipulation of qubits in diamond OPEN | | | Bernhard Grotz, Moritz V. Hauf, Markus Dankerl, Boris Naydenov, Sébastien Pezzagna, Jan Meijer, Fedor Jelezko, Jörg Wrachtrup, Martin Stutzmann, Friedemann Reinhard and Jose A. Garrido | | | Point defects in diamond in the form of nitrogen vacancy centres are believed to be promising candidates for qubits in quantum computers. Grotz et al. present a method for manipulating the charge state of nitrogen vacancies using an electrolytic gate electrode. | | | 06 Mar | Nat Commun 3:729 doi:10.1038/ncomms1729 (2012) | | | Physical sciences Applied physics | | | Condensed matter Materials science | | | | | Abstract | Full Text | PDF (557 kB) |
| Microwave cavity-enhanced transduction for plug and play nanomechanics at room temperature OPEN | | | T. Faust, P. Krenn, S. Manus, J.P. Kotthaus and E.M. Weig | | | Advances in nanoelectromechanical systems have brought improvements in the quality factor of nanomechanical resonators, yet few low-loss transduction schemes exist at high temperature. Using non-dissipative dielectric coupling to a microwave cavity, Faust et al. present an integrated nanomechanical transducer. | | | 06 Mar | Nat Commun 3:728 doi:10.1038/ncomms1723 (2012) | | | Physical sciences Nanotechnology | | | | Abstract | Full Text | PDF (1,025 kB) |
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| Room temperature ferromagnetism in Teflon due to carbon dangling bonds | | | Y.W. Ma, Y.H. Lu, J.B. Yi, Y.P. Feng, T.S. Herng, X. Liu, D.Q. Gao, D.S. Xue, J.M. Xue, J.Y. Ouyang and J. Ding | | | Teflon is a carbon based polymer that cannot be intrinsically ferromagnetic. This study shows that room temperature ferromagnetism can be induced in Teflon tape by applying mechanical stress such as stretching or cutting, which gives rise to dangling carbon bonds. | | | 06 Mar | Nat Commun 3:727 doi:10.1038/ncomms1689 (2012) | | | Physical sciences Applied physics | | | Atomic and molecular physics Materials science | | | Organic chemistry | | Abstract | Full Text | PDF (724 kB) |
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| Power laws reveal phase transitions in landscape controls of fire regimes | | | Donald McKenzie and Maureen C. Kennedy | | | Understanding the environmental controls of past wildfires is difficult due to the lack of records of weather or vegetation. This study shows, using cross-scale analysis, how power laws associated with fire-event time series can identify critical thresholds in landscape dynamics in a rapidly changing climate. | | | 06 Mar | Nat Commun 3:726 doi:10.1038/ncomms1731 (2012) | | | Earth sciences Ecology | | | | Abstract | Full Text | PDF (1,597 kB) |
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| Self-assembly of amorphous calcium carbonate microlens arrays OPEN | | | Kyubock Lee, Wolfgang Wagermaier, Admir Masic, Krishna P. Kommareddy, Mathieu Bennet, Inderchand Manjubala, Seung-Woo Lee, Seung B. Park, Helmut Cölfen and Peter Fratzl | | | Biological materials efficiently exploit self-assembly of simple constituents to produce complex functional structures such as optical devices. By controlling organic molecules, Lee et al. show fast two-step self-assembly of CaCO3 microlens arrays, reminiscent of their biological counterparts. | | | 06 Mar | Nat Commun 3:725 doi:10.1038/ncomms1720 (2012) | | | Physical sciences Materials science | | | | Abstract | Full Text | PDF (1,482 kB) |
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| Melanoma whole-exome sequencing identifies V600E B-RAF amplification-mediated acquired B-RAF inhibitor resistance | | | Hubing Shi, Gatien Moriceau, Xiangju Kong, Mi-Kyung Lee, Hane Lee, Richard C. Koya, Charles Ng, Thinle Chodon, Richard A. Scolyer, Kimberly B. Dahlman, Jeffrey A. Sosman, Richard F. Kefford, Georgina V. Long, Stanley F. Nelson, Antoni Ribas and Roger S. Lo | | | B-RAF is mutated in a large proportion of melanomas, and the first small molecule inhibitor has recently been approved for melanoma treatment. Here, by exome sequencing melanoma samples, Shi and colleagues show that B-RAF is amplified in tumours that have acquired resistance to the B-RAF inhibitor vemurafenib. | | | 06 Mar | Nat Commun 3:724 doi:10.1038/ncomms1727 (2012) | | | Biological sciences Cancer | | | Medical research | | | | Abstract | Full Text | PDF (1,312 kB) |
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| Organic transistors with high thermal stability for medical applications | | | Kazunori Kuribara, He Wang, Naoya Uchiyama, Kenjiro Fukuda, Tomoyuki Yokota, Ute Zschieschang, Cherno Jaye, Daniel Fischer, Hagen Klauk, Tatsuya Yamamoto, Kazuo Takimiya, Masaaki Ikeda, Hirokazu Kuwabara, Tsuyoshi Sekitani, Yueh-Lin Loo and Takao Someya | | | Organic electronic devices are promising for many applications, particularly in biomedical research, but are hindered by thermal instability and low melting points. Now, organic thin-film transistors are shown with excellent thermal properties that can withstand medical sterilization processes. | | | 06 Mar | Nat Commun 3:723 doi:10.1038/ncomms1721 (2012) | | | Physical sciences Materials science | | Abstract | Full Text | PDF (1,285 kB) |
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| LIS1-dependent retrograde translocation of excitatory synapses in developing interneuron dendrites OPEN | | | Izumi Kawabata, Yutaro Kashiwagi, Kazuki Obashi, Masamichi Ohkura, Junichi Nakai, Anthony Wynshaw-Boris, Yuchio Yanagawa and Shigeo Okabe | | | Maturation of synaptic junctions is important for proper neuronal connections. Using live cell imaging, Okabe et al. show that interneuron dendrites extend filopodia-like projections and use microtubule-dependent retrograde transport to guide proper synaptic distribution on dendrites. | | | 06 Mar | Nat Commun 3:722 doi:10.1038/ncomms1736 (2012) | | | Biological sciences Cell biology | | | Neuroscience | | Abstract | Full Text | PDF (2,290 kB) |
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| Ultrafast changes in lattice symmetry probed by coherent phonons | | | S. Wall, D. Wegkamp, L. Foglia, K. Appavoo, J. Nag, R.F. Haglund , Jr, J. Stähler and M. Wolf | | | Ultrafast excitation offers new routes to controlling material properties on short timescales, but probes are needed to better understand the changes. By studying the phonon spectrum of VO2 in the time domain, Wall et al. find a prompt change in lattice potential after a photoinduced structural transition. | | | 06 Mar | Nat Commun 3:721 doi:10.1038/ncomms1719 (2012) | | | Physical sciences Condensed matter | | | Materials science Optical physics | | | Abstract | Full Text | PDF (699 kB) |
| Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners | | | Stephanie I. Fraley, Yunfeng Feng, Anjil Giri, Gregory D. Longmore and Denis Wirtz | | | Molecular and oscillations are common in biology, but periodic cell migrations have not been observed. Fraley et al. report regular, periodic migrations of cells along tracks generated inside 3D matrices, and show that these 1D oscillations are controlled by zyxin and its binding partners α-actinin and p130Cas. | | | 06 Mar | Nat Commun 3:719 doi:10.1038/ncomms1711 (2012) | | | Biological sciences Bioengineering | | | Biophysics Cell biology | | Abstract | Full Text | PDF (1,585 kB) |
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| γ-Glutamylcysteine detoxifies reactive oxygen species by acting as glutathione peroxidase-1 cofactor OPEN | | | Ruben Quintana-Cabrera, Seila Fernandez-Fernandez, Veronica Bobo-Jimenez, Javier Escobar, Juan Sastre, Angeles Almeida and Juan P. Bolaños | | | Glutathione's key role as a modulator of reactive oxygen species levels has recently been challenged. Quintana-Cabrera et al. now provide in vivo evidence supporting an antioxidant and neuroprotective function for γ-glutamylcysteine, which replaces glutathione by acting as glutathione peroxidase-1 cofactor. | | | 06 Mar | Nat Commun 3:718 doi:10.1038/ncomms1722 (2012) | | | Biological sciences Cell biology | | | Neuroscience | | Abstract | Full Text | PDF (697 kB) |
Supplementary Information |
| RUNX1-induced silencing of non-muscle myosin heavy chain IIB contributes to megakaryocyte polyploidization | | | Larissa Lordier, Dominique Bluteau, Abdelali Jalil, Céline Legrand, Jiajia Pan, Philippe Rameau, Dima Jouni, Olivier Bluteau, Thomas Mercher, Catherine Leon, Christian Gachet, Najet Debili, William Vainchenker, Hana Raslova and Yunhua Chang | | | Megakaryocytes undergo polyploidization prior to forming platelets but this process is poorly characterised. In this study, non-muscle myosin IIB heavy chain, that localizes to the contractile ring during mitosis, is shown to be silenced prior to polyploidization in a RUNX1-dependent manner. | | | 06 Mar | Nat Commun 3:717 doi:10.1038/ncomms1704 (2012) | | | Biological sciences Cell biology Molecular biology | | Abstract | Full Text | PDF (1,404 kB) |
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| Host factors dictate control of viral replication in two HIV-1 controller/chronic progressor transmission pairs | | | Robert W. Buckheit , III, Tracy G. Allen, Angela Alme, Maria Salgado, Karen A. O'Connell, Sarah Huculak, Oluwaseun Falade-Nwulia, Thomas M. Williams, Joel E. Gallant, Robert F. Siliciano and Joel N. Blankson | | | Human immunodeficiency virus patients who maintain low levels of virus or have undetectable levels of virus exist. In this study, the HIV found in two of these patients is shown to replicate in vitro, suggesting that host factors have a role in suppressing virus levels. | | | 06 Mar | Nat Commun 3:716 doi:10.1038/ncomms1697 (2012) | | | Biological sciences Immunology Medical research | | | Virology | | | Abstract | Full Text | PDF (729 kB) |
| Perpendicular exchange bias in ferrimagnetic spin valves | | | F. Radu, R. Abrudan, I. Radu, D. Schmitz and H. Zabel | | | Exchange bias is a technologically relevant effect that occurs when thin ferromagnetic films are placed in direct proximity to antiferromagnets. Radu et al. show that an exchange bias occurs at room temperature in ferrimagnetic trilayers, in which the magnetization is aligned perpendicular to the structures. | | | 06 Mar | Nat Commun 3:715 doi:10.1038/ncomms1728 (2012) | | | Physical sciences Applied physics | | | Condensed matter Materials science | | | | Abstract | Full Text | PDF (931 kB) |
Supplementary Information |
| Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine OPEN | | | Jianjun Pan, Qiang Chen, Dan Willenbring, Ken Yoshida, Tommy Tillman, Ossama B. Kashlan, Aina Cohen, Xiang-Peng Kong, Yan Xu and Pei Tang | | | The pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) is similar in structure to the nicotinic acetylcholine receptor, a member of the Cys-loop receptor family. This study reports the crystal structure of ELIC bound to acetylcholine and shows that acetylcholine is a competitive antagonist of ELIC. | | | 06 Mar | Nat Commun 3:714 doi:10.1038/ncomms1703 (2012) | | | Biological sciences Biophysics | | | Neuroscience | | | | Abstract | Full Text | PDF (1,568 kB) |
Supplementary Information |
| Acquisition of aluminium tolerance by modification of a single gene in barley OPEN | | | Miho Fujii, Kengo Yokosho, Naoki Yamaji, Daisuke Saisho, Miki Yamane, Hirokazu Takahashi, Kazuhiro Sato, Mikio Nakazono and Jian Feng Ma | | | Barley is an important food crop that has been adapted to grow on acidic soils that often contain toxic soluble aluminium. In this study, an insertion in the upstream region of a citrate transporter is shown to confer resistance of barley to aluminium toxicity and is found in aluminium-tolerant barley accessions. | | | 06 Mar | Nat Commun 3:713 doi:10.1038/ncomms1726 (2012) | | | Biological sciences Evolution | | | Genetics Plant sciences | | Abstract | Full Text | PDF (693 kB) |
Supplementary Information |
| The tRNA methyltransferase NSun2 stabilizes p16INK4 mRNA by methylating the 3′-untranslated region of p16 | | | Xiaotian Zhang, Zhenyun Liu, Jie Yi, Hao Tang, Junyue Xing, Minqwei Yu, Tanjun Tong, Yongfeng Shang, Myriam Gorospe and Wengong Wang | | | The expression of the tumour suppressor p16 is frequently lost in cancer. Zhang et al. show in cultured cells that p16 mRNA levels are stabilised by methylation of the 3′-untranslated region by the tRNA methyltransferase NSun2, revealing a new mechanism for regulating p16. | | | 06 Mar | Nat Commun 3:712 doi:10.1038/ncomms1692 (2012) | | | Biological sciences Biochemistry | | | Cell biology Molecular biology | | | | Abstract | Full Text | PDF (1,026 kB) |
Supplementary Information |
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