Molecular Therapy - Table of Contents alert Volume 20 Issue 3

TABLE OF CONTENTS Volume 20, Issue 3 (March 2012) In this issue Editorial In This Issue Research Highlights Meeting Report Commentary Reviews Original Articles Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement Be part of the research that is changing the course of medicine! Molecular Therapy is the leading international journal for basic, translational and clinical research aimed at the development of novel cell and gene therapy approaches to treat disease. To submit your research or view the complete Guide to Authors visit www.nature.com/mt/author_instructions.html   Editorial Top The Need for Increased Clarity and Transparency in the Regulatory Pathway for Gene Medicines in the European Union Seppo Ylä-Herttuala Mol Ther 2012 20: 471-472; 10.1038/mt.2012.14 Full Text In This Issue Top In This Issue Mol Ther 2012 20: 474; 10.1038/mt.2012.16 Full Text Research Highlights Top Research Highlights Mol Ther 2012 20: 475; 10.1038/mt.2012.17 Full Text Meeting Report Top Escaping the Valley of Death Robert M Frederickson Mol Ther 2012 20: 476-478; 10.1038/mt.2012.21 Full Text Commentary Top Clinical Development of Advanced Therapy Medicinal Products in Europe: Evidence That Regulators Must Be Proactive Romaldas Maciulaitis, Lucia D’Apote, Andrew Buchanan, Laura Pioppo and Christian K Schneider Mol Ther 2012 20: 479-482; 10.1038/mt.2012.13 Full Text Reviews Top Progress Toward In Vivo Use of siRNAs-II Garrett R Rettig and Mark A Behlke Mol Ther 2012 20: 483-512; advance online publication, December 20, 2011; 10.1038/mt.2011.263 Abstract | Full Text Action and Reaction: The Biological Response to siRNA and Its Delivery Vehicles Rosemary L Kanasty, Kathryn A Whitehead, Arturo J Vegas and Daniel G Anderson Mol Ther 2012 20: 513-524; advance online publication, January 17, 2012; 10.1038/mt.2011.294 Abstract | Full Text Cell-penetrating Peptides as Versatile Vehicles for Oligonucleotide Delivery Helerin Margus, Kärt Padari and Margus Pooga Mol Ther 2012 20: 525-533; advance online publication, January 10, 2012; 10.1038/mt.2011.284 Abstract | Full Text Original Articles Top Efficient Gene Therapy for Parkinson's Disease Using Astrocytes as Hosts for Localized Neurotrophic Factor Delivery Anja Drinkut, Yuliya Tereshchenko, Jörg B Schulz, Mathias Bähr and Sebastian Kügler Mol Ther 2012 20: 534-543; advance online publication, November 15, 2011; 10.1038/mt.2011.249 Abstract | Full Text Striatal Pleiotrophin Overexpression Provides Functional and Morphological Neuroprotection in the 6-Hydroxydopamine Model Sara E Gombash, Jack W Lipton, Timothy J Collier, Lalitha Madhavan, Kathy Steece-Collier, Allyson Cole-Strauss, Brian T Terpstra, Anne L Spieles-Engemann, Brian F Daley, Susan L Wohlgenant, Valerie B Thompson, Fredric P Manfredsson, Ronald J Mandel and Caryl E Sortwell Mol Ther 2012 20: 544-554; advance online publication, October 18, 2011; 10.1038/mt.2011.216 Abstract | Full Text An Artificial PAP Gene Breaks Self-tolerance and Promotes Tumor Regression in the TRAMP Model for Prostate Carcinoma Elmar Spies, Wilfried Reichardt, Gerardo Alvarez, Marcus Groettrup and Peter öhlschläger Mol Ther 2012 20: 555-564; advance online publication, November 15, 2011; 10.1038/mt.2011.241 Abstract | Full Text Concomitant Intravenous Nitroglycerin With Intracoronary Delivery of AAV1.SERCA2a Enhances Gene Transfer in Porcine Hearts Ioannis Karakikes, Lahouaria Hadri, Kleopatra Rapti, Dennis Ladage, Kiyotake Ishikawa, Lisa Tilemann, Geng-Hua Yi, Charlotte Morel, Judith K Gwathmey, Krisztina Zsebo, Thomas Weber, Yoshiaki Kawase and Roger J Hajjar Mol Ther 2012 20: 565-571; advance online publication, January 3, 2012; 10.1038/mt.2011.268 Abstract | Full Text Self-complementary AAVs Induce More Potent Transgene Product-specific Immune Responses Compared to a Single-stranded Genome TeLang Wu, Katrin Töpfer, Shih-Wen Lin, Hua Li, Ang Bian, Xiang Y Zhou, Katherine A High and Hildegund CJ Ertl Mol Ther 2012 20: 572-579; advance online publication, December 20, 2011; 10.1038/mt.2011.280 Abstract | Full Text Long-term Restoration of Cardiac Dystrophin Expression in Golden Retriever Muscular Dystrophy Following rAAV6-mediated Exon Skipping Lawrence T Bish, Meg M Sleeper, Sean C Forbes, Bingjing Wang, Caryn Reynolds, Gretchen E Singletary, Dennis Trafny, Kevin J Morine, Julio Sanmiguel, Sylvain Cecchini, Tamas Virag, Adeline Vulin, Cyriaque Beley, Janet Bogan, James M Wilson, Krista Vandenborne, Joe N Kornegay, Glenn A Walter, Robert M Kotin, Luis Garcia and H Lee Sweeney Mol Ther 2012 20: 580-589; advance online publication, December 6, 2011; 10.1038/mt.2011.264 Abstract | Full Text Sustained miRNA-mediated Knockdown of Mutant AAT With Simultaneous Augmentation of Wild-type AAT Has Minimal Effect on Global Liver miRNA Profiles Christian Mueller, Qiushi Tang, Alisha Gruntman, Keith Blomenkamp, Jeffery Teckman, Lina Song, Phillip D Zamore and Terence R Flotte Mol Ther 2012 20: 590-600; advance online publication, January 17, 2012; 10.1038/mt.2011.292 Abstract | Full Text In Vivo Delivery of Nucleic Acids via Glycopolymer Vehicles Affords Therapeutic Infarct Size Reduction In Vivo Michael Tranter, Yemin Liu, Suiwen He, James Gulick, Xiaoping Ren, Jeffrey Robbins, W. Keith Jones and Theresa M. Reineke Mol Ther 2012 20: 601-608; advance online publication, December 20, 2011; 10.1038/mt.2011.267 Abstract | Full Text Systemic Delivery of siRNA via LCP Nanoparticle Efficiently Inhibits Lung Metastasis Yang Yang, Jun Li, Feng Liu and Leaf Huang Mol Ther 2012 20: 609-615; advance online publication, December 20, 2011; 10.1038/mt.2011.270 Abstract | Full Text A General RNA Motif for Cellular Transfection Maria LB Magalhães, Michelle Byrom, Amy Yan, Linsley Kelly, Na Li, Raquel Furtado, Deborah Palliser, Andrew D Ellington and Matthew Levy Mol Ther 2012 20: 616-624; advance online publication, January 10, 2012; 10.1038/mt.2011.277 Abstract | Full Text Correction of Murine Bernard–Soulier Syndrome by Lentivirus-mediated Gene Therapy Sachiko Kanaji, Erin L Kuether, Scot A Fahs, Jocelyn A Schroeder, Jerry Ware, Robert R Montgomery and Qizhen Shi Mol Ther 2012 20: 625-632; advance online publication, November 1, 2011; 10.1038/mt.2011.231 Abstract | Full Text Redirected Antitumor Activity of Primary Human Lymphocytes Transduced With a Fully Human Anti-mesothelin Chimeric Receptor Evripidis Lanitis, Mathilde Poussin, Ian S Hagemann, George Coukos, Raphael Sandaltzopoulos, Nathalie Scholler and Daniel J Powell, Jr Mol Ther 2012 20: 633-643; advance online publication, November 29, 2011; 10.1038/mt.2011.256 Abstract | Full Text Combined Tbet and IL12 Gene Therapy Elicits and Recruits Superior Antitumor Immunity In Vivo Yanyan Qu, Lu Chen, Devin B Lowe, Walter J Storkus and Jennifer L Taylor Mol Ther 2012 20: 644-651; advance online publication, January 3, 2012; 10.1038/mt.2011.283 Abstract | Full Text Long-term Persistence of CD4+ but Rapid Disappearance of CD8+ T Cells Expressing an MHC Class I-restricted TCR of Nanomolar Affinity Boris Engels, Adam S Chervin, Andrea J Sant, David M Kranz and Hans Schreiber Mol Ther 2012 20: 652-660; advance online publication, January 10, 2012; 10.1038/mt.2011.286 Abstract | Full Text NF-κB Negatively Impacts the Myogenic Potential of Muscle-derived Stem Cells Aiping Lu, Jonathan D Proto, Lulin Guo, Ying Tang, Mitra Lavasani, Jeremy S Tilstra, Laura J Niedernhofer, Bing Wang, Denis C Guttridge, Paul D Robbins and Johnny Huard Mol Ther 2012 20: 661-668; advance online publication, December 13, 2011; 10.1038/mt.2011.261 Abstract | Full Text Hepatitis C Virus NS3/NS4A DNA Vaccine Induces Multiepitope T Cell Responses in Rhesus Macaques Mimicking Human Immune Responses Krystle A Lang Kuhs, Arielle A Ginsberg, Jian Yan, Roger W Wiseman, Amir S Khan, Niranjan Y Sardesai, David H O'Connor and David B Weiner Mol Ther 2012 20: 669-678; advance online publication, September 27, 2011; 10.1038/mt.2011.188 Abstract | Full Text Phase I Trial of “bi-shRNAifurin/GMCSF DNA/Autologous Tumor Cell” Vaccine (FANG) in Advanced Cancer Neil Senzer, Minal Barve, Joseph Kuhn, Anton Melnyk, Peter Beitsch, Martin Lazar, Samuel Lifshitz, Mitchell Magee, Jonathan Oh, Susan W Mill, Cynthia Bedell, Candice Higgs, Padmasini Kumar, Yang Yu, Fabienne Norvell, Connor Phalon, Nicolas Taquet, Donald D Rao, Zhaohui Wang, Chris M Jay, Beena O Pappen, Gladice Wallraven, F Charles Brunicardi, David M Shanahan, Phillip B Maples and John Nemunaitis Mol Ther 2012 20: 679-686; advance online publication, December 20, 2011; 10.1038/mt.2011.269 Abstract | Full Text American Society for Gene and Cell Therapy - Call for Abstracts TheAmerican Society for Gene and Cell Therapy will be accepting late abstract submissions for their upcoming 15th Annual Meeting to be held from May 16 - 19, 2012 in Philadelphia, PA; beginning March 1, 2012, with a deadline of April 2, 2012.   Please note that you need to be a subscriber or site-license holder to enjoy full-text access to Molecular Therapy. 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