TABLE OF CONTENTS
| | 07 March 2012 | Volume 31, Issue 5 |  | | |  |  Have you seen?
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$89 trial size primary antibodies for cancer, cell biology, cell signaling and neuroscience research. All guaranteed to give predictable, repeatable results. Spend $900 and receive a free Kindle! Protect your experiments with Rockland antibodies. Compromise elsewhere. Click here to choose your $89 trial size antibodies or browse our content-rich website at www.rockland-inc.com | | | | Have you seen? | Top | |  | | Enlightening the impact of immunogenic cell death in photodynamic cancer therapy This feature highlights novel molecular pathways underlying the cell surface presentation of calreticulin and ATP secretion, critical damage-associated molecular patterns (DAMPs) that trigger immunogenic cell death. Lorenzo Galluzzi, Oliver Kepp and Guido Kroemer The EMBO Journal (2012), 31, 1055 - 1057; 10.1038/emboj.2012.2 Abstract | Full text | PDF Published online: 17 January 2012 | | | | B-type lamins and their elusive roles in metazoan cell proliferation and senescence Recent papers question the traditional role of B-type lamins in DNA replication and transcription, but highlight an entirely novel yet fundamental role for lamin B1 in cell proliferation and cellular senescence. Christopher J Hutchison The EMBO Journal (2012), 31, 1058 - 1059; 10.1038/emboj.2012.39 Abstract | Full text | PDF Published online: 17 February 2012 | | | | To be or not to be a stem cell: dissection of cellular and molecular components of haematopoietic stem cell niches Genetic ablation of stem cell factor (SCF) facilitates the identification of cellular population(s) that constitute the haematopoietic stem cell (HSC) niche. John M Perry and Linheng Li The EMBO Journal (2012), 31, 1060 - 1061; 10.1038/emboj.2012.29 Abstract | Full text | PDF Published online: 10 February 2012 | | Articles | Top | | | | A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death Unravelling molecular mechanisms that trigger immunogenic apoptosis of cancer cells could improve therapeutic intervention. Here, photo-oxidative ER stress increases presentation of ‘eat me’ (surface-exposed calreticulin) and ‘find me’ (ATP secretion) signals via a novel, PERK-dependent pathway. Abhishek D Garg, Patrizia Agostinis and colleagues The EMBO Journal (2012), 31, 1062 - 1079; 10.1038/emboj.2011.497 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 17 January 2012 Subject Categories: Signal Transduction | Molecular Biology of Disease | | | | Oxidative stress induces an ATM-independent senescence pathway through p38 MAPK-mediated lamin B1 accumulation Altered lamin B1 levels are found to induce cellular senescence as well as abnormal nuclear morphology, a marker of both physiological and premature ageing in animals. Lamin B1 accumulation is induced by oxidative stress and p38 kinase, providing links with two other key factors in ageing and senescence. Aurelia Barascu, Pascale Bertrand and colleagues The EMBO Journal (2012), 31, 1080 - 1094; 10.1038/emboj.2011.492 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 13 January 2012 Subject Categories: Genome Stability and Dynamics | Molecular Biology of Disease | | | | A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB Under basal conditions TFEB, a master regulator of lysosomal biogenesis, is sequestered in the cytosol due to mTORC1-dependent phosphorylation at the lysosomal membrane. Nutrient starvation or lysosomal dysfunction inhibit mTORC1 activity and induce nuclear translocation of TFEB inducing target gene expression. Carmine Settembre, Andrea Ballabio and colleagues The EMBO Journal (2012), 31, 1095 - 1108; 10.1038/emboj.2012.32 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 17 February 2012 Subject Categories: Membranes and Transport | Signal Transduction | | | | A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling The Hippo pathway effector YAZ is found to bind β-catenin and prevents its nuclear translocation. The resulting downregulation of Wnt signal transduction provides a new example for intersection of Hippo and Wnt signalling, two key regulatory pathways in animal development Masamichi Imajo, Koichi Miyatake, Akira Iimura, Atsumu Miyamoto and Eisuke Nishida The EMBO Journal (2012), 31, 1109 - 1122; 10.1038/emboj.2011.487 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 10 January 2012 Subject Categories: Signal Transduction | Development | | | | STIM1 is required for attenuation of PMCA-mediated Ca2+ clearance during T-cell activation The ER Ca2+ sensor STIM1 and the plasma membrane Ca2+ pump, ATPase, PMCA, are recruited to the immunological synapse upon T-cell stimulation where STIM1 binds to and inhibits PMCA function to regulate cytosolic Ca2+ concentration. Michael F Ritchie, Elsie Samakai and Jonathan Soboloff The EMBO Journal (2012), 31, 1123 - 1133; 10.1038/emboj.2011.495 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 13 January 2012 Subject Categories: Membranes and Transport | Immunology | | | | Akt-dependent Skp2 mRNA translation is required for exiting contact inhibition, oncogenesis, and adipogenesis Nogueira et al identify a novel, translational component of AKT to regulate Skp2 level. General significance comes from two distinct biological systems, escape from contact inhibition/oncogenic transformation and adipocyte differentiation. Veronique Nogueira, Nissim Hay and colleagues The EMBO Journal (2012), 31, 1134 - 1146; 10.1038/emboj.2011.478 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 03 February 2012 Subject Categories: Signal Transduction | Proteins | Cell Cycle | | | | Ablation of Rassf2 induces bone defects and subsequent haematopoietic anomalies in mice The Ras-binding protein RASSF2 has poorly defined functions in cell-cycle control and apoptosis, and has been linked to Hippo signalling. Loss of Rassf2 in vivo disrupts osteoblast differentiation via NF-κB pathway deregulation, with consequent effects on bone formation and haematopoietic development. Hoogeun Song, Dae-Sik Lim and colleagues The EMBO Journal (2012), 31, 1147 - 1159; 10.1038/emboj.2011.480 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 06 January 2012 Subject Categories: Signal Transduction | Development | | | | APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer Proteomic profiling identifies APRIN/PDS5B, a human homologue of the yeast cohesin factor Pds5, as a BRCA2-associated protein required for efficient homologous recombination mediated by this tumour suppressor. BRCA2 cancer mutations disrupt this interaction, and APRIN expression correlates with clinical parameters in breast cancer. Rachel Brough, Alan Ashworth and colleagues The EMBO Journal (2012), 31, 1160 - 1176; 10.1038/emboj.2011.490 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 31 January 2012 Subject Categories: Genome Stability and Dynamics | Molecular Biology of Disease | | | | ATR maintains select progenitors during nervous system development ATR kinase acts as a safeguard against replication stress, and hypomorphic mutations result in the neurodevelopmental disorder Seckel syndrome. Conditional ATR deletion in developing neurons reveals a selective role in maintenance of only a subset of neuronal progenitors, which may be distinct from ATR's canonical DNA damage-response roles. Youngsoo Lee, Peter J McKinnon and colleagues The EMBO Journal (2012), 31, 1177 - 1189; 10.1038/emboj.2011.493 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 20 January 2012 Subject Categories: Genome Stability and Dynamics | Molecular Biology of Disease | | | | RP58 controls neuron and astrocyte differentiation by downregulating the expression of Id1–4 genes in the developing cortex Neuronal stem cell differentiation during cortical development requires to exit cell cycle and p57 kinase regulation. Here, the transcription factor RP58 is shown to control neuronal differentiation and migration during embryogenesis by repressing all four Id genes, which in turn downregulates p57, thereby restricting astrogenesis. Shinobu Hirai, Haruo Okado and colleagues The EMBO Journal (2012), 31, 1190 - 1202; 10.1038/emboj.2011.486 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 10 January 2012 Subject Categories: Development | Neuroscience | | | | CaMKII binding to GluN2B is critical during memory consolidation Mice expressing a mutant form of the NMDA-type glutamate receptor subunit GluN2B that is deficient in CaMKII binding exhibit impaired hippocampus-dependent memory consolidation, revealing an important functional role for the activity-driven interaction of CaMKII with GluN2B. Amy R Halt, Johannes W Hell and colleagues The EMBO Journal (2012), 31, 1203 - 1216; 10.1038/emboj.2011.482 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 10 January 2012 Subject Categories: Signal Transduction | Neuroscience | | | | Raising cytosolic Cl− in cerebellar granule cells affects their excitability and vestibulo-ocular learning The cerebellar circuitry underlying motor control and learning consists of granule cells (GCs) and Purkinje cells (PCs). Deletion of the Kcc2 K-Cl cotransporter ablates Cl− extrusion in both cell types. Unexpectedly, a critical role for GC excitability in the consolidation of motor learning is uncovered. Patricia Seja, Thomas J Jentsch and colleagues The EMBO Journal (2012), 31, 1217 - 1230; 10.1038/emboj.2011.488 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 17 January 2012 Subject Categories: Signal Transduction | Neuroscience | | | | Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism Microvesicles (MVs) shed from microglia stimulate neuronal exocytosis and enhance neurotransmission by inducing sphingolipid metabolism in neurons. Flavia Antonucci, Claudia Verderio and colleagues The EMBO Journal (2012), 31, 1231 - 1240; 10.1038/emboj.2011.489 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 13 January 2012 Subject Categories: Membranes and Transport | Neuroscience | | | | Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking TDP-43 is a major constituent of inclusions characteristic of a number of neurodegenerative diseases. Oxidative stress induces reversible intra- and inter-molecular disulphide bond formation at the second RNA-recognition motif impairing the solubility and the RNA processing function of TDP-43. Todd J Cohen, Andrew W Hwang, Travis Unger, John Q Trojanowski and Virginia M Y Lee The EMBO Journal (2012), 31, 1241 - 1252; 10.1038/emboj.2011.471 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 23 December 2011 Subject Categories: Proteins | Neuroscience | Molecular Biology of Disease | | | | Genetic evidence of a redox-dependent systemic wound response via Hayan Protease-Phenoloxidase system in Drosophila Melanin production is a rapid response to wounding in Drosophila. The enzymatic reactions generate reactive oxygen species. ROS-dependent activation of JNK signalling in the nervous system contributes to the systemic wound response and promotes survival upon physical trauma. Hyuck-Jin Nam, In-Hwan Jang, Hyejin You, Kyung-Ah Lee and Won-Jae Lee The EMBO Journal (2012), 31, 1253 - 1265; 10.1038/emboj.2011.476 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 06 January 2012 Subject Categories: Immunology | | | | A DR4:tBID axis drives the p53 apoptotic response by promoting oligomerization of poised BAX Depending on the context, cells either arrest or undergo apoptosis in response to p53 activation. Key mediators of both pathways are activated irrespective of the fate choice, but apoptotic cells selectively induce the DR4 death receptor pathway, caspase 8-mediated BID cleavage and activation of BAX. Ryan E Henry, Joaquín M Espinosa and colleagues The EMBO Journal (2012), 31, 1266 - 1278; 10.1038/emboj.2011.498 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 13 January 2012 Subject Categories: Cell Cycle | Differentiation and Death | | | | Rsk-mediated phosphorylation and 14-3-3ε binding of Apaf-1 suppresses cytochrome c-induced apoptosis In response to various stimuli, the MAP kinase cascade and its effector kinase Rsk promote cell viability. Rsk phosphorylates Apaf-1 and prevents its interaction with cytochrome c in a 14-3-3ε-dependent manner, which results in the inhibition of apoptosome formation. Jiyeon Kim, Sally Kornbluth and colleagues The EMBO Journal (2012), 31, 1279 - 1292; 10.1038/emboj.2011.491 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 13 January 2012 Subject Categories: Signal Transduction | Differentiation and Death | | | | Nonsense mutations in the COX1 subunit impair the stability of respiratory chain complexes rather than their assembly Respiratory chain complexes are organized into supercomplexes. Patient cell lines expressing a truncated COX1 subunit point to an m-AAA protease-dependent quality control pathway that clears unstable respiratory complexes that are still capable to assemble into supercomplexes. Hue-Tran Hornig-Do, Rudolf J Wiesner and colleagues The EMBO Journal (2012), 31, 1293 - 1307; 10.1038/emboj.2011.477 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 17 January 2012 Subject Categories: Membranes and Transport | Molecular Biology of Disease | | | | Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin In this article, the authors characterize the phosphotyrosine-binding domain of the E3 ubiquitin ligase Hakai. They find that Hakai homodimerizes to form a phosphotyrosine-binding pocket that recognizes Src targets. This represents a novel phosphotyrosine recognition structure, fundamentally different from the previously known SH2 and PTB domains. Manjeet Mukherjee, J Sivaraman and colleagues The EMBO Journal (2012), 31, 1308 - 1319; 10.1038/emboj.2011.496 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 17 January 2012 Subject Categories: Cell and Tissue Architecture | Signal Transduction | | | | Mechanism of RNA synthesis initiation by the vesicular stomatitis virus polymerase The genome of most negative-strand RNA viruses is encased by the nucleoprotein N forming the N-RNA RNP and replicated by the L/P polymerase complex. The authors show for the first time that in vesicular stomatitis virus L protein can initiate de-novo synthesis of naked RNA independently of N or P, although P stimulates L initiation and processivity. Benjamin Morin, Amal A Rahmeh and Sean PJ Whelan The EMBO Journal (2012), 31, 1320 - 1329; 10.1038/emboj.2011.483 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 13 January 2012 Subject Categories: RNA | Microbiology and Pathogens | | | Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to The EMBO Journal. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. 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