Drug Discovery@nature.com 30 March 2012

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Full Text Novartis challenges India's patent law doi:10.1038/nature.2012.10262 Drug company up for rematch against clause prohibiting indefinite extension of patents. Full Text Trial designs for vaccines adapt to the times doi:10.1038/nm0312-327 Researchers studying neglected diseases are being urged to implement adaptive trial designs. Full Text Opioid receptors revealed doi:10.1038/483383a Two more structures join the parade of once-intractable proteins. Full Text Analysis Top Bioartificial pancreas beta test doi:10.1038/scibx.2012.298 Beta-O2 Technologies and an international team of academic collaborators have shown that the company's bioartificial pancreas normalizes blood glucose levels in rat models of diabetes for up to three months. The team hopes to start a trial of the implant in a single patient this year. Full Text Fresh from the Pipeline: Tafamidis doi:10.1038/nrd3675 In November 2011, the first-in-class drug tafamidis (Vyndaqel; Pfizer), which inhibits protein misfolding, was approved in Europe for the treatment of familial amyloid polyneuropathy. Full Text From the analyst's couch: maximizing the value of diagnostics in Alzheimer's disease drug development doi:10.1038/nrd3535 This article examines strategic issues faced by pharmaceutical companies relating to the development of biomarkers and diagnostics for Alzheimer's disease. Full Text Research Highlights Top Neurodegenerative disease: Harnessing virus-mediated mitochondrial protection to combat neurodegeneration doi:10.1038/nrd3688 A novel therapeutic strategy could have important implications for the treatment of Parkinson's disease and other neurodegenerative diseases involving impaired mitochondrial function. Full Text Anticancer drugs: Targeting menin doi:10.1038/nrd3689 Inhibitors that target the interaction between menin and MLL could be useful for the treatment of acute lymphocytic leukaemia. Full Text Angiogenesis: Scheduled delivery doi:10.1038/nrc3232 Angiogenesis inhibitors may not provide clinical benefit by normalizing blood vessels and thereby increasing the delivery of chemotherapy, as has been hypothesized. Full Text Research & Reviews Top Diagnosing the decline in pharmaceutical R&D efficiency doi:10.1038/nrd3681 The authors of this Perspectives article discuss four factors that they consider to contribute significantly to the decline in pharmaceutical R&D efficiency. Full Text The insulin and insulin-like growth factor receptor family in neoplasia: an update doi:10.1038/nrc3215 Possible reasons for the disappointing outcomes of Phase III clinical trials for therapies targeting the insulin and insulin-like growth factor I receptor family, potential next steps and relevance to other areas of drug development in oncology are the subject of this Review. Full Text Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors doi:10.1038/nbt.2121 PARP inhibitors have recently entered Phase III clinical trials as cancer therapeutics, but the specificity of many of these compounds is unknown. Wahlberg et al. used biochemical approaches to show that most PARP inhibitors target multiple PARP family members. Full Text Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis doi:10.1038/nm.2629 Raghu Kalluri and colleagues have identified an orally available, small-peptide agonist of activin-like kinase 3, the key co-receptor for BMP7 in the kidney, that reduces established fibrosis in animal models of kidney injury. Full Text Drug Discovery JOBS of the week Associate Director - Tumor Immunology Ludwig Institute for cancer research spin-off Drug Safety Physician Job Yoh Role of ABCC1 and ABCC3 drug transporters in cell motility and homeostasis in neuroblastoma ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA - - CENTRO INTERDIP. CIRI SCIENZE DELLA VITA E TECNOLOGIE DELLA SALUTE PhD student for Biomedical Imaging Group Rotterdam (BIGR) - on the project Imaging biomarkers for oncology drug development Erasmus MC PhD position Statistical modelling of behavioural response to drugs in mouse models for neurological and psychiatric disorders Wageningen UR (University & Research centre) More Science jobs from Drug Discovery EVENT 7th Protein Kinases in Drug Discovery 30.-31.05.12 MA, US More science events from Careers Top Career snapshots archive Career snapshots feature people associated with drug discovery and drug development, with the aim of providing expert insights and advice on a wide range of positions and career paths in this field. Full Text Top Advertisement SciBX: Science-Business eXchange is a weekly publication that identifies and analyzes the most important translational research articles from over 40 journals. Find out which papers have real scientific and commercial potential, and why. 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