Drug Discovery@nature.com 16 March 2012

Advertisement THE ESSENCE OF BIOLUMINESCENCE: Real time, non-invasive, in vivo imaging from Taconic can illuminate your cancer studies and provide new insights into tumor development. • More data. • Better data. • Less cost. • Fewer animals. Choose from a repository of over 50 bioluminescent cell lines! Click here for more information. TABLE OF CONTENTS 16 March 2012 News Analysis Research Highlights Research & Reviews Careers Nature Reviews Drug Discovery is on Twitter Advertisement The nature.com open innovation pavilion now has several research and development Challenges in genetics, molecular cell biology, chemistry, physics, immunology and more! Submit your solution to any of our Challenges for a chance to win cash awards ranging from $5,000 to $1M. Visit the pavilion or become a Solver today!   News Top Drug data reveal sneaky side effects doi:10.1038/nature.2012.10220 Mining of surveillance data highlights thousands of previously unknown consequences when drugs are taken together. Full Text Cystic fibrosis drug Vertex's latest triumph doi:10.1038/nbt0312-201a Vertex Pharmaceutics has won approval to start selling Kalydeco (ivacaftor) for a rare form of cystic fibrosis. Full Text HIV neutralizing antibodies reignite interest in vaccine doi:10.1038/nbt0312-204c Interest is growing in exploiting the epitopes that elicit HIV-neutralizing antibodies as the basis for new vaccine opportunities. Full Text Companies in rapid pursuit of Btk immunokinase doi:10.1038/nbt0312-199 Recent deals highlight a growing interest in Bruton's tyrosine kinase inhibitors, a promising drug class already in development for B-cell malignancies and with additional potential in B cell–driven autoimmune disease. Full Text Analysis Top Working on the brain gang(lioside) doi:10.1038/scibx.2012.243 Canadian researchers have found that ganglioside GM1, a naturally occurring lipid, improves motor function and slows disease progression in mice with Huntington's disease. The team is in talks to license the findings to an undisclosed company. Full Text Fresh from the Pipeline: Tafamidis doi:10.1038/nrd3675 In November 2011, the first-in-class drug tafamidis (Vyndaqel; Pfizer), which inhibits protein misfolding, was approved in Europe for the treatment of familial amyloid polyneuropathy. Full Text From the analyst's couch: Maximizing the value of diagnostics in Alzheimer's disease drug development doi:10.1038/nrd3535 This article examines strategic issues faced by pharmaceutical companies relating to the development of biomarkers and diagnostics for Alzheimer's disease. Full Text Research Highlights Top Neurodegenerative disease: Harnessing virus-mediated mitochondrial protection to combat neurodegeneration doi:10.1038/nrd3688 A novel therapeutic strategy could have important implications for the treatment of Parkinson's disease and other neurodegenerative diseases involving impaired mitochondrial function. Full Text Anticancer drugs: Targeting menin doi:10.1038/nrd3689 Inhibitors that target the interaction between menin and MLL could be useful for the treatment of acute lymphocytic leukaemia. Full Text Angiogenesis: Scheduled delivery doi:10.1038/nrc3232 Angiogenesis inhibitors may not provide clinical benefit by normalizing blood vessels and thereby increasing the delivery of chemotherapy, as has been hypothesized. Full Text Research & Reviews Top Diagnosing the decline in pharmaceutical R&D efficiency doi:10.1038/nrd3681 The authors of this Perspectives article discuss four factors that they consider to contribute significantly to the decline in pharmaceutical R&D efficiency. Full Text The insulin and insulin-like growth factor receptor family in neoplasia: an update doi:10.1038/nrc3215 Possible reasons for the disappointing outcomes of Phase III clinical trials for therapies targeting the insulin and insulin-like growth factor I receptor family, potential next steps and relevance to other areas of drug development in oncology are the subject of this Review. Full Text Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors doi:10.1038/nbt.2121 PARP inhibitors have recently entered Phase III clinical trials as cancer therapeutics, but the specificity of many of these compounds is unknown. Wahlberg et al. used biochemical approaches to show that most PARP inhibitors target multiple PARP family members. Full Text Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis doi:10.1038/nm.2629 Raghu Kalluri and colleagues have identified an orally available, small-peptide agonist of activin-like kinase 3, the key co-receptor for BMP7 in the kidney, that reduces established fibrosis in animal models of kidney injury. Full Text Drug Discovery JOBS of the week Scientist Novozymes Senior Researcher and Head of Section for Immunology and Vaccinology Technical University of Denmark, Section of Immunology and Vaccinology at The National Veterinary Institute Postdoctoral Scientist Breast Cancer Group, Cancer Research Program Garvan Institute of Medical Research Postdoctoral Training Fellow: Surface Plasmon Resonance for the discovery of novel anticancer agents The Institute of Cancer Research Head of Cancer Immunotherapy (m / f) CureVac GmbH More Science jobs from Drug Discovery EVENT 6th Annual Conference in Japan for Asian New Drug Development 26.-27.03.12 Tokyo, Japan More science events from Careers Top Career snapshots archive Career snapshots feature people associated with drug discovery and drug development, with the aim of providing expert insights and advice on a wide range of positions and career paths in this field. Full Text Top Advertisement SciBX: Science-Business eXchange is a weekly publication that identifies and analyzes the most important translational research articles from over 40 journals. Find out which papers have real scientific and commercial potential, and why. Recommend SciBX to your library today.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant) For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our customer feedback department Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.