Clinical Pharmacology and Therapeutics - Table of Contents alert Volume 91 Issue 4

TABLE OF CONTENTS Volume 91, Issue 4 (April 2012) In this issue In This Issue Editorial News & Views Perspectives Clinical Trial State of the Art Research Discovery & Development Regulation & Use Corrigendum Also new AOP Advertisement Myriad RBM's Comprehensive Protein Biomarker Solutions, helping turn biomarker studies into Biomarker Breakthroughs. From concept through clinical trial, Myriad RBM has the biomarkers, the platform and the expertise to guide your biomarker strategy. Click Here to learn more. Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement Launching Summer 2012 CPT: Pharmacometrics & Systems Pharmacology A new online open access journal from Clinical Pharmacology & Therapeutics. CPT: Pharmacometrics & Systems Pharmacology publishes advances in quantitative methods as applied in pharmacology, physiology, and therapeutics in humans with a common focus on the application of these two areas on drug development.   In This Issue Top In This Issue Clin Pharmacol Ther 2012 91: 559; 10.1038/clpt.2012.29 Full Text Editorial Top EDITORIAL Optimizing Therapeutics: The Next Front in the War on Rheumatoid Arthritis J D Edison and W R Gilliland Clin Pharmacol Ther 2012 91: 561-566; 10.1038/clpt.2012.8 Full Text News & Views Top Highlights Clin Pharmacol Ther 2012 91: 568-569; 10.1038/clpt.2012.28 Full Text ASCPT NEWS ASCPT News Clin Pharmacol Ther 2012 91: 570-573; 10.1038/clpt.2012.9 Full Text MACROSCOPY Therapeutic Blockade of Interleukin-6 in Chronic Inflammatory Disease K Yamamoto and S Rose-John Clin Pharmacol Ther 2012 91: 574-576; 10.1038/clpt.2012.11 Full Text Perspectives Top OPINION Autoimmunity and Graves’ Disease R S Bahn Clin Pharmacol Ther 2012 91: 577-579; 10.1038/clpt.2012.10 Abstract | Full Text LETTERS TO THE EDITOR Vardenafil-Associated QTc Changes: Not Merely a Normal Autonomic Process J T Barbey Clin Pharmacol Ther 2012 91: 580; advance online publication, February 29, 2012; 10.1038/clpt.2011.294 Full Text Response to “Vardenafil-Associated QTc Changes: Not Merely a Normal Autonomic Process” A A Fossa and M Zhou Clin Pharmacol Ther 2012 91: 580-581; advance online publication, February 29, 2012; 10.1038/clpt.2011.331 Full Text Clinical Trial Top CLINICAL TRIAL Low-Dose Lisinopril in Normotensive Men With Idiopathic Oligospermia and Infertility: A 5-Year Randomized, Controlled, Crossover Pilot Study A U Mbah, G O Ndukwu, S I Ghasi, E N Shu, F N Ozoemena, J O Mbah, O D Onodugo, E C Ejim, M I Eze, P O Nkwo and P O Okonkwo Clin Pharmacol Ther 2012 91: 582-589; advance online publication, February 29, 2012; 10.1038/clpt.2011.265 Abstract | Full Text High-Dose Ibuprofen for Patent Ductus Arteriosus in Extremely Preterm Infants: A Randomized Controlled Study C Dani, V Vangi, G Bertini, S Pratesi, I Lori, F Favelli, R Ciuti, A Bandinelli, C Martano, P Murru, H Messner, F Schena and F Mosca Clin Pharmacol Ther 2012 91: 590-596; advance online publication, November 16, 2011; 10.1038/clpt.2011.284 Abstract | Full Text State of the Art Top STATE OF THE ART Optimization of Pediatric Rheumatology Therapeutics M L Becker Clin Pharmacol Ther 2012 91: 597-606; advance online publication, March 7, 2012; 10.1038/clpt.2011.293 Abstract | Full Text Current Understanding of Rheumatoid Arthritis Therapy Inés Colmegna, Brent R. Ohata and Henri A. Menard Clin Pharmacol Ther 2012 91: 607-620; advance online publication, February 22, 2012; 10.1038/clpt.2011.325 Abstract | Full Text Advances in Imaging to Support the Development of Novel Therapies for Multiple Sclerosis D H Miller, D R Altmann and D T Chard Clin Pharmacol Ther 2012 91: 621-634; advance online publication, March 7, 2012; 10.1038/clpt.2011.349 Abstract | Full Text Anti-TNF Monoclonal Antibodies in Inflammatory Bowel Disease: Pharmacokinetics-Based Dosing Paradigms Ingrid Ordás, Diane R. Mould, Brian G. Feagan and William J. Sandborn Clin Pharmacol Ther 2012 91: 635-646; advance online publication, February 22, 2012; 10.1038/clpt.2011.328 Abstract | Full Text Research Top REPORTS Lapatinib-Induced Liver Injury Characterized by Class II HLA and Gilbert's Syndrome Genotypes C F Spraggs, L R Parham, C M Hunt and C T Dollery Clin Pharmacol Ther 2012 91: 647-652; advance online publication, February 22, 2012; 10.1038/clpt.2011.277 Abstract | Full Text ARTICLES Imaging of Gastrointestinal Absorption and Biodistribution of an Orally Administered Probe Using Positron Emission Tomography in Humans T Shingaki, T Takashima, Y Wada, M Tanaka, M Kataoka, A Ishii, Y Shigihara, Y Sugiyama, S Yamashita and Y Watanabe Clin Pharmacol Ther 2012 91: 653-659; advance online publication, February 29, 2012; 10.1038/clpt.2011.267 Abstract | Full Text Decreased Warfarin Clearance Associated With the CYP2C9 R150H (*8) Polymorphism Y Liu, H Jeong, H Takahashi, K Drozda, S R Patel, N L Shapiro, E A Nutescu and L H Cavallari Clin Pharmacol Ther 2012 91: 660-665; advance online publication, February 29, 2012; 10.1038/clpt.2011.269 Abstract | Full Text A Modeling and Simulation Approach to Characterize Methadone QT Prolongation Using Pooled Data From Five Clinical Trials in MMT Patients J Florian, C E Garnett, S C Nallani, B A Rappaport and D C Throckmorton Clin Pharmacol Ther 2012 91: 666-672; advance online publication, February 29, 2012; 10.1038/clpt.2011.273 Abstract | Full Text Mechanism of Efavirenz Influence on Methadone Pharmacokinetics and Pharmacodynamics E D Kharasch, D Whittington, D Ensign, C Hoffer, P S Bedynek, S Campbell, K Stubbert, A Crafford, A London and T Kim Clin Pharmacol Ther 2012 91: 673-684; advance online publication, March 7, 2012; 10.1038/clpt.2011.276 Abstract | Full Text The Role and Impact of Research Agendas on the Comparative-Effectiveness Research Among Antihyperlipidemics A G Dunn, F T Bourgeois, S Murthy, K D Mandl, R O Day and E Coiera Clin Pharmacol Ther 2012 91: 685-691; advance online publication, February 29, 2012; 10.1038/clpt.2011.279 Abstract | Full Text Prediction of Codeine Toxicity in Infants and Their Mothers Using a Novel Combination of Maternal Genetic Markers J Sistonen, P Madadi, C J Ross, M Yazdanpanah, J W Lee, M L A Landsmeer, M Nauta, B C Carleton, G Koren and M R Hayden Clin Pharmacol Ther 2012 91: 692-699; advance online publication, March 7, 2012; 10.1038/clpt.2011.280 Abstract | Full Text Predicting Drug Interaction Potential With a Physiologically Based Pharmacokinetic Model: A Case Study of Telithromycin, a Time-Dependent CYP3A Inhibitor MdLT Vieira, P Zhao, E G Berglund, K S Reynolds, L Zhang, L J Lesko and S-M Huang Clin Pharmacol Ther 2012 91: 700-708; advance online publication, March 7, 2012; 10.1038/clpt.2011.305 Abstract | Full Text Warfarin–Amiodarone Drug–Drug Interactions: Determination of [I]u/KI,u for Amiodarone and Its Plasma Metabolites M G McDonald, N T Au, A K Wittkowsky and A E Rettie Clin Pharmacol Ther 2012 91: 709-717; advance online publication, March 7, 2012; 10.1038/clpt.2011.283 Abstract | Full Text Dosing Rationale for Fixed-Dose Combinations in Children: Shooting From the Hip? M Cella, F Kloprogge, M Danhof and O Della Pasqua Clin Pharmacol Ther 2012 91: 718-725; advance online publication, March 7, 2012; 10.1038/clpt.2011.297 Abstract | Full Text Bridging Strategies for Drug Combinations in Pediatric Indications M Cella, M Danhof and O Della Pasqua Clin Pharmacol Ther 2012 91: 726-733; advance online publication, March 7, 2012; 10.1038/clpt.2011.298 Abstract | Full Text Discovery & Development Top TRANSLATION Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Abacavir Dosing M A Martin, T E Klein, B J Dong, M Pirmohamed, D W Haas and D L Kroetz Clin Pharmacol Ther 2012 91: 734-738; advance online publication, February 29, 2012; 10.1038/clpt.2011.355 Full Text DEVELOPMENT Regulatory Aspects of New Medicines Targeted at Treatment of Autoimmune Diseases K M Hull and S Yim Clin Pharmacol Ther 2012 91: 739-742; advance online publication, March 7, 2012; 10.1038/clpt.2012.5 Abstract | Full Text APEC Harmonization Center: Challenges and Issues Relating to Multiregional Clinical Trials in the APEC Region K L Park, T G Kim, S K Seong, S Y Lee and S H Kim Clin Pharmacol Ther 2012 91: 743-746; advance online publication, February 8, 2012; 10.1038/clpt.2011.344 Abstract | Full Text Regulation & Use Top PRACTICE Drug-Induced PML: A Global Agenda for a Global Challenge M Vinhas de Souza, B Keller-Stanislawski, K Blake, A Hidalgo-Simon, P Arlett and G Dal Pan Clin Pharmacol Ther 2012 91: 747-750; advance online publication, February 29, 2012; 10.1038/clpt.2012.4 Abstract | Full Text Corrigendum Top CORRIGENDUM: Paraoxonase 1 (PON1) Gene Variants Are Not Associated With Clopidogrel Response Clin Pharmacol Ther 2012 91: 751; 10.1038/clpt.2012.17 Full Text Advertisement Ensure your access If you are unable to access the articles in thisalert, your library may not subscribe to this journal. 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