News: Making visible the invisible By Sarah Kellett | PET scan of the Brain. | Our world is made of atoms, each with a core of protons and neutrons. Change the number of protons and the element changes: hydrogen becomes helium, or uranium becomes lead. Change the number of neutrons in an atom and you get an isotope. For example, fluorine-18 has one less neutron than fluorine found naturally on Earth. Fluorine-18 is radioactive and decays, sending out energy as radiation. Glucose is the sugar used by brains and other organs. By attaching fluorine-18 to glucose the sugar’s movement can be traced by measuring the isotope’s radiation. Tumours eat more sugar than healthy cells and show up bright on medical instruments. This is called a PET scan. But there’s a catch – a bottle of fluorine-18 decays so fast that in two hours only half of it is left. So it has to be made and used quickly. “We have a PET cyclotron (which makes fluorine-18) at TRIUMF, and a chemistry lab where we can add the fluorine to glucose,” says research scientist Tom Ruth from Canada’s National Laboratory for Particle and Nuclear Physics, TRIUMF. Something like a giant pea-shooter moves the fluorine-18 from TRIUMF, where it is made, to the hospital where it is used. “We put it in a small canister the size of a toilet roll, and it’s sent through a tube to the hospital. It takes about two minutes,” says Tom. In Australia we have a research reactor called OPAL that creates technetium-99m, another useful radioactive isotope used to diagnose cancer. Most of the world gets technetium-99 from two other nuclear reactors, which are getting pretty old and often close for repairs. Research is finding new ways to make radioactive isotopes, creating cyclotrons as small as a dining room table. More information Careers link |
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