Nature Reviews Molecular Cell Biology contents March 2012 Volume 13 Number 3 pp135-203

Advertisement
The Future of qPCR is here, and it's digital The QX100™ Droplet Digital™ PCR system from Bio-Rad provides an absolute measure of target DNA molecules, with unmatched precision and sensitivity. This new PCR technology delivers absolute quantitation for applications that include copy number variation, rare event detection and gene expression. Learn more now.
TABLE OF CONTENTS
March 2012 Volume 13 Number 3
Impact Factor 38.65 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Designer proteins: applications of genetic code expansion in cell biology Lloyd Davis & Jason W. Chin
Subscribe   Facebook   RSS   Recommend to library   Twitter
Advertisement
Scientific Reports published the most downloaded paper on nature.com in December. Downloaded over 100,000 times and counting... Make your paper seen. Make your paper open. Submit to Scientific Reports.
RESEARCH HIGHLIGHTS Top Cell death: Programmed necrosis: putting the pieces together p135 | doi:10.1038/nrm3292 Identification of the effectors of programmed necrosis downstream of RIP3 activation. PDF Metabolism: Keeping fit with autophagy p136 | doi:10.1038/nrm3287 Autophagy can be activated by exercise. PDF Small RNAs: Protecting a healthy circulation p136 | doi:10.1038/nrm3296 Protective microRNAs move from endothelial to smooth muscle cells. PDF Telomeres: Damage response cut short p137 | doi:10.1038/nrm3294 Rif1 and Rif2 suppress checkpoint activation at telomeres. PDF Cell polarity: CPEB gets tight with junctions p138 | doi:10.1038/nrm3295 CPEB determines tight junction localization and polarity in mammary epithelial cells. PDF Cell adhesion: FAK or talin: who goes first? p138 | doi:10.1038/nrm3297 FAK promotes early recruitment of talin to nascent adhesions. PDF Development: NUP210 takes cell fate decisions p140 | doi:10.1038/nrm3285 NUP210 regulates gene expression to promote myogenesis and neurogenesis. PDF JOURNAL CLUB Unravelling the lamina network p140 | doi:10.1038/nrm3291 Two studies that elucidated the interacting networks of the nuclear lamina. PDF IN BRIEF Technique: Lysozyme gets wired | Cell signalling: Tuning the Hedgehog pathway | Gene expression: DNMT1 learns to be picky | Transcription: PKM2 as a protein kinase | Membrane trafficking: Adaptor waves at the Golgi PDF Molecular Cell Biology JOBS of the week Research Assistant in Allergy and Immunology University of Southern California (USC) Director - Bioinformatics Core Facility University of Massachusetts Medical School Postdoctoral Fellowship in Skeletal and Stem Cell Biology University of California - San Francisco Postdoctoral fellow Tulane University Tenure-Track or Tenured Professor - Program in Bioinformatics and Integrative Biology University of Massachusetts Medical School More Science jobs from Molecular Cell Biology EVENT Molecular Basis of Vascular Inflammation and Atherosclerosis (C7) 25.-30.03.12 US More science events from
REVIEWS		Top
Y-family DNA polymerases and their role in tolerance of cellular DNA damage Julian E. Sale, Alan R. Lehmann & Roger Woodgate p141 | doi:10.1038/nrm3289 The Y-family DNA polymerases have unique features that enable them to synthesize DNA past damaged bases, a process known as translesion synthesis. As these polymerases copy undamaged DNA with low fidelity, their activity must be tightly regulated. Abstract | Full Text | PDF | Supplementary information
Chromatin replication and epigenome maintenance Constance Alabert & Anja Groth p153 | doi:10.1038/nrm3288 The influence of chromatin structure on the DNA replication programme is reciprocated by replication-coupled mechanisms that re-establish chromatin on newly formed DNA. The tight coupling of these processes is essential for promoting integrity of the genome and epigenome, with possible implications for ageing and cancer. Abstract | Full Text | PDF
Designer proteins: applications of genetic code expansion in cell biology Lloyd Davis & Jason W. Chin p168 | doi:10.1038/nrm3286 The incorporation of unnatural amino acids at defined sites in proteins can now be used to probe protein conformational changes, protein interactions and the role of post-translational modifications in regulating biological function. The use of photocaged amino acids and bio-orthogonal labels for proteins holds great promise for cell biological studies in live cells. Abstract | Full Text | PDF | Supplementary information
Septins: the fourth component of the cytoskeleton Serge Mostowy & Pascale Cossart p183 | doi:10.1038/nrm3284 Septins are highly conserved, GTP-binding proteins that form hetero-oligomeric complexes and higher-order structures, such as filaments and rings. By acting as scaffolds or diffusion barriers, they have roles in numerous biological processes, including cell division and host–pathogen interactions. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
TIMELINE PI3K signalling: the path to discovery and understanding Bart Vanhaesebroeck, Len Stephens & Phillip Hawkins p195 | doi:10.1038/nrm3290 Phosphoinositide 3-kinase (PI3K) signalling is central in the regulation of cellular function. Here, Vanhaesebroeck et al. review the key discoveries that led the identification of the PI3K genes and function to the design of clinical trials with PI3K inhibitors, over a period of less than three decades. Abstract | Full Text | PDF
Advertisement
Nature Insight: Frontiers in Biology This Insight includes reviews on innate immune signalling in tissue homeostasis, the DNA damage response in cancer treatment, therapeutic promise of patient-derived pluripotent stem cells, clonal evolution in cancer and the impact of mouse genetics on the study of bone physiology. Access the Insight online.
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

*Journal Citation Reports, Thomson, 2011

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our feedback department Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2012 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.