Nature Reviews Microbiology contents March 2012 Volume 10 Number 2 pp 157-234

TABLE OF CONTENTS
March 2012 Volume 10 Number 3
Impact Factor 20.686 *	In this issue Editorial Research Highlights News and Analysis Reviews Analysis Correspondence Also this month  Featured article: Structural insights into the coupling of virion assembly and rotavirus replication Shane D. Trask, Sarah M. McDonald & John T. Patton
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EDITORIAL		Top
The next generation p157 | doi:10.1038/nrmicro2759 A better understanding of the factors that affect children's desire to follow a career in science is vital if we are to inspire the next generation of scientists. Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS Top Bacterial pathogenesis: UPEC helps host to exfoliate p159 | doi:10.1038/nrmicro2758 UPEC pore-forming toxin α-haemolysin (HlyA) stimulates the proteolysis of host proteins involved in cell adhesion, resulting in uroepithelial cell exfoliation. PDF Phage biology: T4 to TA, checkmate p160 | doi:10.1038/nrmicro2748 Phage T4 encodes an antitoxin that is active against multiple Escherichia coli toxins. PDF Cellular microbiology: An unconventional exit for Brucella p160 | doi:10.1038/nrmicro2749 Brucella abortus hijacks autophagy components to complete its life cycle. PDF Bacterial pathogenesis: Controlling Fic proteins p160 | doi:10.1038/nrmicro2757 A general mechanism for controlling the adenylylation activity of Fic proteins has been identified. PDF Host response: Phagocytosis runs like clockwork p162 | doi:10.1038/nrmicro2751 In Drosophila melanogaster, phagocytosis of specific bacteria is regulated by a circadian protein. PDF Biofilms: Biofilms take shape p162 | doi:10.1038/nrmicro2756 Phenol-soluble modulins have a key role in the structuring and detachment of Staphylococcus aureus biofilms. PDF IN BRIEF Evolution: Co-evolution promotes innovation | Bacterial genomics: Universal bacterial barcode | Viral infection: Promiscuous packaging PDF Microbiology JOBS of the week Microbiology Team Leader (Pharmaceuticals) PULSE Scientific 11 postdoctoral fellowships in microbiology, structural and molecular biology and immunology Institute of Microbiology AS CR Lab Scientist Kelly Scientific Resources Quality Technician II - Microbiology Lab 1st Shift 1975 EMD Millipore US More Science jobs from Microbiology EVENT International Human Microbiome Congress 2012 19.-21.03.12 Paris, France More science events from
NEWS AND ANALYSIS		Top
GENOME WATCH Adapting to domesticity Adam J. Reid p163 | doi:10.1038/nrmicro2752 This month's Genome Watch highlights new insights into the impact of food production on the evolution of microorganisms. PDF
DISEASE WATCH In the news p164 | doi:10.1038/nrmicro2760 Our monthly round up of infectious diseases news, which this month includes the spread of a new virus affecting livestock in Europe, the H5N1 controversy and a report that mortality from malaria may be much higher than was previously suspected. PDF
REVIEWS		Top
Structural insights into the coupling of virion assembly and rotavirus replication Shane D. Trask, Sarah M. McDonald & John T. Patton p165 | doi:10.1038/nrmicro2673 Production of viral progeny requires the coordination of a series of events. In this Review, Patton and colleagues examine structural insights into how regulation of the life cycle of rotaviruses and other Reoviridae family members is coupled with the assembly and disassembly of the viral particle. Abstract | Full Text | PDF
A bacterial siren song: intimate interactions between Neisseria and neutrophils Alison K. Criss & H. Steven Seifert p178 | doi:10.1038/nrmicro2713 Interactions between the pathogenic neisseriae (Neisseria gonorrhoeae and Neisseria meningitidis) and neutrophils are central to the progression of both gonorrhoea and meningococcal meningitis. Here, Criss and Seifert review these interactions and propose a model in which this relationship promotes, rather than blocks, the infection cycle. Abstract | Full Text | PDF
Computational tools for the synthetic design of biochemical pathways Marnix H. Medema, Renske van Raaphorst, Eriko Takano & Rainer Breitling p191 | doi:10.1038/nrmicro2717 Synthetic biology approaches for the de novo design of biosynthetic pathways have developed rapidly in recent years. Takano and colleagues describe the latest computational tools available and discuss how they can be applied now and further developed for future synthetic biology efforts. Abstract | Full Text | PDF
ppGpp: magic beyond RNA polymerase Zachary D. Dalebroux & Michele S. Swanson p203 | doi:10.1038/nrmicro2720 The bacterial signalling nucleotide ppGpp is known to regulate promoter selection by RNA polymerase to direct the response to stress. Here, Dalebroux and Swanson look at other ways in which ppGpp helps bacteria to alter their physiology in order to accommodate fluctuating nutrient supplies and environmental stresses. Abstract | Full Text | PDF
From self sufficiency to dependence: mechanisms and factors important for autotransporter biogenesis Denisse L. Leyton, Amanda E. Rossiter & Ian R. Henderson p213 | doi:10.1038/nrmicro2733 Autotransporters are a superfamily of proteins that were thought to contain all of the functional elements required for their delivery, via the type V secretion pathway, to the outer membrane of Gram-negative bacteria. In this Review, Leyton, Rossiter and Henderson describe how recent studies have challenged the perceived simplicity of this secretion pathway. Abstract | Full Text | PDF
ANALYSIS		Top
Genome analyses highlight the different biological roles of cellulases Felix Mba Medie, Gideon J. Davies, Michel Drancourt & Bernard Henrissat p227 | doi:10.1038/nrmicro2729 Many bacteria in a variety of niches contain cellulases. Such microorganisms are primarily considered to be saprophytic, but recent evidence suggests that cellulases are also present in non-saprophytes. By examining the genomes of ∼1,500 bacteria, Henrissat and colleagues confirm this observation and reveal unusual roles for some cellulases. Abstract | Full Text | PDF | Supplementary information
CORRESPONDENCE		Top
Virophages question the existence of satellites Christelle Desnues & Didier Raoult p234 | doi:10.1038/nrmicro2676-c3 Full Text | PDF
Towards a more comprehensive classification of satellite viruses Mart Krupovic & Virginija Cvirkaite-Krupovic p234 | doi:10.1038/nrmicro2676-c4 Full Text | PDF
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