Nature Reviews Genetics Contents March 2012 Volume 13 Number 3 pp 147-220

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TABLE OF CONTENTS
March 2012 Volume 13 Number 3
Impact Factor 32.745 *	In this issue Research Highlights Reviews Perspectives Also this month Article series: Genome-wide association studies Modelling  Featured article: Understanding transgenerational epigenetic inheritance via the gametes in mammals Lucia Daxinger & Emma Whitelaw
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RESEARCH HIGHLIGHTS Top Development: Parental influences on plant development p147 | doi:10.1038/nrg3175 PDF Gene expression: Looping together the functions of SNPs p148 | doi:10.1038/nrg3180 PDF Cancer genomics: Histone modification at the gene level p148 | doi:10.1038/nrg3181 PDF Disease genetics: Sequencing for diagnosis p150 | doi:10.1038/nrg3176 PDF Genomic instability: Shattered details p150 | doi:10.1038/nrg3177 PDF Gene regulation: Inner control p151 | doi:10.1038/nrg3178 PDF Differentiation: Nuclear pores at the core p151 | doi:10.1038/nrg3179 PDF IN BRIEF Gene expression: Protein-mediated mRNA interference | Genomic instability: Transgenerational effects of anticancer drugs | Cancer: Genomic and epigenomic analyses of cancer | Genome evolution: Unexpected relationship between mutation rate and genome complexity | Population genetics: A population genomic resource for Drosophila melanogaster | Technology: Environmental genomes assembled | Gene regulation: Chromosome dynamics in Polycomb regulation | Behavioural genetics: Separate genetic programmes for sex-specific behaviour PDF Genetics JOBS of the week Postdoc in Bioinformatics Institute of Human Genetics - Dept. of Genomics - University of Bonn Postdoc positions in transgenic research Institute of Molecular Genetics of the ASCR, v.v.i. Postdoctoral Fellow in Computational Biology University of Washington Team Leader Variation EMBL-EBI Postdoctoral Associate - Computational and Systems Biology Center for Genome Dynamics, The Jackson Laboratory More Science jobs from Genetics EVENT Genomic Epidemiology of Malaria 10.-13.06.12 Cambridge, UK More science events from
REVIEWS		Top
Understanding transgenerational epigenetic inheritance via the gametes in mammals Lucia Daxinger & Emma Whitelaw p153 | doi:10.1038/nrg3188 Some epigenetic information can be passed from parents to offspring, but it is difficult to identify the molecular basis of information transferred through the gametes. This Review evaluates the extent of our understanding in mammals. Abstract | Full Text | PDF
Sex and the singular DM domain: insights into sexual regulation, evolution and plasticity Clinton K. Matson & David Zarkower p163 | doi:10.1038/nrg3161 This article reviews our growing understanding of the varied roles of DM domain genes in metazoan sexual development: in the evolution of sexually dimorphic traits and new sex-determining mechanisms and, more recently, in maintaining cell fate in the gonad. Abstract | Full Text | PDF
Article series: Genome-wide association studies Human genetic susceptibility to infectious disease Stephen J. Chapman & Adrian V. S. Hill p175 | doi:10.1038/nrg3114 The discovery of common and rare genetic variants underlying infectious disease susceptibility in humans highlights the involvement of shared host signalling pathways in diverse infectious diseases, and provides insights into the genetic control of immune signalling. Abstract | Full Text | PDF
Causes and consequences of aneuploidy in cancer David J. Gordon, Benjamin Resio & David Pellman p189 | doi:10.1038/nrg3123 Aneuploidy — an abnormal number of chromosomes — typically has a detrimental effect on viability. Somewhat paradoxically, it is a remarkably common feature of cancer. This Review discusses how aneuploidy occurs, the cellular responses to aneuploidy and how aneuploidy can provide particular selective advantages during tumorigenesis. Abstract | Full Text | PDF
Transcription as a source of genome instability Nayun Kim & Sue Jinks-Robertson p204 | doi:10.1038/nrg3152 Transcription poses a risk to the genome through transcription-associated mutagenesis and recombination. This Review discusses recent findings about influences on this genomic instability, such as the rate and direction of transcription or nucleic acid structures, and how these phenomena may be considered across species. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Article series: Modelling Cellular genomics for complex traits Emmanouil T. Dermitzakis p215 | doi:10.1038/nrg3115 The author discusses the advantages and challenges of 'cellular phenotyping' and the way in which this integrated analysis of cellular phenotypes is likely to advance our understanding of the genetic and long-term environmental influences on complex traits. Abstract | Full Text | PDF
Erratum: Protein–RNA interactions: new genomic technologies and perspectives Julian König, Kathi Zarnack, Nicholas M. Luscombe & Jernej Ule p220 | doi:10.1038/nrg3183 Full Text | PDF
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*2010 Journal Citation Report (Thomson Reuters, 2011)

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