Nature Immunology Contents: March 2012 Volume 13 pp 197 - 307

Advertisement Enhanced biological safety for flow cytometry Biosafety cabinets developed for BD flow cytometry instruments provide a high standard of safety, protecting people, products, and the environment. Learn more about the innovations from BD that can improve your workflow, results, and provide the highest level of safety in your lab. bdbiosciences.com/go/biosafety TABLE OF CONTENTS March 2012 Volume 13, Issue 3 Correspondence Commentary News and Views Research Highlights Review Articles Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Resolving Inflammation: Mechanisms and Drug Discovery April 1-3, 2012 - Oxford, UK This conference will bring together scientists and clinicians from academia and industry to provide, through presentations and discussion sessions, a comprehensive overview of the crucial endogenous checkpoints necessary for mounting a limited, yet effective, inflammatory response. Registration deadline is March 12, 2012. For more information and to register visit: www.nature.com/natureconferences/rimdd12         Correspondence Top Oral ivermectin as an unexpected initiator of CreT2-mediated deletion in T cells pp197 - 198 Evann Corbo-Rodgers, Elizabeth S Staub, Tao Zou, Abigail Smith, Taku Kambayashi and Jonathan S Maltzman doi:10.1038/ni.2232 Full Text | PDF Commentary Top Gene-expression measurement: variance-modeling considerations for robust data analysis pp199 - 203 Shankar Subramaniam and Gene Hsiao doi:10.1038/ni.2244 Abstract | Full Text | PDF News and Views Top Motifs for a deadly encounter pp205 - 206 Ken T Coppieters and Matthias G von Herrath doi:10.1038/ni.2226 It is unknown how T cell antigen receptors from autoreactive CD8+ T cells recognize self. A new paper shows that an unorthodox, low-affinity way of interacting with targets may be at the basis of autoimmunity. Full Text | PDF See also: Article by Bulek et al. An invariant road to cross-presentation pp207 - 208 Fei Duan and Pramod K Srivastava doi:10.1038/ni.2235 The invariant chain CD74 prevents the loading of peptides derived from endogenously synthesized proteins onto major histocompatibility complex (MHC) class II molecules in the endoplasmic reticulum. CD74 is now shown to serve a similar function for some MHC class I molecules. Full Text | PDF See also: Article by Basha et al. Casting new light on the TCR pp209 - 211 Adrian Hayday and Robert Tigelaar doi:10.1038/ni.2243 Dynamic imaging portrays intraepidermal T cells as truly autoreactive, constitutively transmitting signals from a putative ligand expressed by normal epithelial cells. Full Text | PDF See also: Article by Chodaczek et al. A new path to IL-1β production controlled by caspase-8 pp211 - 212 Jeremy Dupaul-Chicoine and Maya Saleh doi:10.1038/ni.2241 Maturation of the proinflammatory cytokine IL-1b is achieved mainly by the canonical caspase-1 inflammasome. An alternative caspase-8-dependent inflammasome that is engaged after stimulation with dectin-1 during fungal and mycobacterial infection has now been described. Full Text | PDF See also: Article by Gringhuis et al. Immunology JOBS of the week Post-Doc Fellow, Mir Lab The University of Kansas Medical Center Postdoctoral Position in Immunology New York University Medical Center Postdoctoral Fellow in AIDS Research Beth Israel Deaconess Medical Center (BIDMC) / Harvard Medical School Assistant Professor Massachusetts General Hospital & Harvard Medical School 11 postdoctoral fellowships in microbiology, structural and molecular biology and immunology Institute of Microbiology AS CR More Science jobs from Immunology EVENT Gene Expression and Signaling in the Immune System 24th April - 28th April 2012 US More science events from Research Highlights Top Delineating interferon population genetics | Regulating neutrophil homeostasis | A tale of two bugs | Innate immunity activators | Linking p65 to RPS3 | Memory metabolism Review Top Intrinsic antiviral immunity pp214 - 222 Nan Yan and Zhijian J Chen doi:10.1038/ni.2229 Abstract | Full Text | PDF Articles Top SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates pp223 - 228 Hichem Lahouassa, Waaqo Daddacha, Henning Hofmann, Diana Ayinde, Eric C Logue, Loïc Dragin, Nicolin Bloch, Claire Maudet, Matthieu Bertrand, Thomas Gramberg, Gianfranco Pancino, Stéphane Priet, Bruno Canard, Nadine Laguette, Monsef Benkirane, Catherine Transy, Nathaniel R Landau, Baek Kim and Florence Margottin-Goguet doi:10.1038/ni.2236 SAMHD1 restricts the infection of dendritic cells by human immunodeficiency virus type 1. Margottin-Goguet and colleagues show that SAMHD1 limits viral DNA synthesis by hydrolyzing intracellular dNTPs. Abstract | Full Text | PDF Transcription factor RORα is critical for nuocyte development pp229 - 236 See Heng Wong, Jennifer A Walker, Helen E Jolin, Lesley F Drynan, Emily Hams, Ana Camelo, Jillian L Barlow, Daniel R Neill, Veera Panova, Ute Koch, Freddy Radtke, Clare S Hardman, You Yi Hwang, Padraic G Fallon and Andrew N J McKenzie doi:10.1038/ni.2208 Nuocytes are innate cells with critical roles during infection with parasitic worms. McKenzie and colleagues show that nuocytes differentiate from common lymphoid progenitors and require IL-7, IL-33, Notch and RORα for development. Abstract | Full Text | PDF A CD74-dependent MHC class I endolysosomal cross-presentation pathway pp237 - 245 Genc Basha, Kyla Omilusik, Ana Chavez-Steenbock, Anna T Reinicke, Nathan Lack, Kyung Bok Choi and Wilfred A Jefferies doi:10.1038/ni.2225 The invariant chain CD74 is involved in the formation of major histocompatibility complex class II. Jefferies and colleagues show that it also associates with class I in the endolysomal compartment and is important in cross-presentation. Abstract | Full Text | PDF See also: News and Views by Duan & Srivastava Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome pp246 - 254 Sonja I Gringhuis, Tanja M Kaptein, Brigitte A Wevers, Bart Theelen, Michiel van der Vlist, Teun Boekhout and Teunis B H Geijtenbeek doi:10.1038/ni.2222 Production of the proinflammatory cytokine IL-1β is crucial in host defense. Geijtenbeek and colleagues show that dectin-1 signaling in response to fungi and mycobacteria induces IL-1β maturation via a noncanonical caspase-8-dependent inflammasome. Abstract | Full Text | PDF See also: News and Views by Dupaul-Chicoine & Saleh Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction pp255 - 263 Chong-Shan Shi, Kevin Shenderov, Ning-Na Huang, Juraj Kabat, Mones Abu-Asab, Katherine A Fitzgerald, Alan Sher and John H Kehrl doi:10.1038/ni.2215 Autophagosomes deliver cytoplasmic constituents to lysosomes for degradation. Kehrl and colleagues show that inflammasome activation triggers autophagosome formation, which in turn eliminates active inflammasomes. Abstract | Full Text | PDF Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling pp264 - 271 Michael P Seiler, Rebecca Mathew, Megan K Liszewski, Chauncey Spooner, Kenneth Barr, Fanyong Meng, Harinder Singh and Albert Bendelac doi:10.1038/ni.2230 The mechanisms by which TCR signaling 'instructs' thymic lineages remain unclear. Bendelac and colleagues show that the TCR-induced transcription factor Egr2 specifies the early and late stages of differentiation into the natural killer T cell lineage. Abstract | Full Text | PDF Body-barrier surveillance by epidermal γδ TCRs pp272 - 282 Grzegorz Chodaczek, Veena Papanna, M Anna Zal and Tomasz Zal doi:10.1038/ni.2240 The γδ dendritic epidermal T cells (DETCs) can recognize stress-affected cells. Zal and colleagues show that at steady state, Vγ5 TCRs form immunological synapses that anchor DETC projections to the tight junctions of squamous keratinocytes. Abstract | Full Text | PDF See also: News and Views by Hayday & Tigelaar Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes pp283 - 289 Anna M Bulek, David K Cole, Ania Skowera, Garry Dolton, Stephanie Gras, Florian Madura, Anna Fuller, John J Miles, Emma Gostick, David A Price, Jan W Drijfhout, Robin R Knight, Guo C Huang, Nikolai Lissin, Peter E Molloy, Linda Wooldridge, Bent K Jakobsen, Jamie Rossjohn, Mark Peakman, Pierre J Rizkallah and Andrew K Sewell doi:10.1038/ni.2206 Much is known about crystal structures of MHC class II-autoreactive TCRs. Sewell and colleagues provide the structure of an MHC class I-autoreactive TCR and provide insight into the molecular basis of its diabetogenicity. Abstract | Full Text | PDF See also: News and Views by Coppieters & von Herrath The composition and signaling of the IL-35 receptor are unconventional pp290 - 299 Lauren W Collison, Greg M Delgoffe, Clifford S Guy, Kate M Vignali, Vandana Chaturvedi, DeLisa Fairweather, Abhay R Satoskar, K Christopher Garcia, Christopher A Hunter, Charles G Drake, Peter J Murray and Dario A A Vignali doi:10.1038/ni.2227 IL-35 is an immunomodulatory cytokine, but the molecular details of its effects have remained obscure. Vignali and colleagues determine the IL-35 receptor and how its signaling pathway leads to its suppressive action. Abstract | Full Text | PDF A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation pp300 - 307 Kyoko Ochiai, Mark Maienschein-Cline, Malay Mandal, Joseph R Triggs, Eric Bertolino, Roger Sciammas, Aaron R Dinner, Marcus R Clark and Harinder Singh doi:10.1038/ni.2210 Cycling and cell cycle-arrested pre-B cells both express pre-BCRs, but whether qualitative differences exist in downstream signaling pathways remains controversial. Singh and colleagues show that differences in expression of the adaptor BLNK underlie functional distinctions in pre-BCR signaling. Abstract | Full Text | PDF Top Advertisement Nature Outlook: Traditional Asian Medicine Using scientific techniques to investigate the claims of traditional medicine as practised in countries such as China and Japan can help sort effective treatments from unfounded superstitions.  Access the Outlook free online for six months.  Produced with support from:  Saishunkan Pharmaceutical   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant) For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our customer feedback department Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2012 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.