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|  | | 28 February 2012 | | | Featured image: | |  | | | Keller et al. report the complete genome sequence of the Tyrolean Iceman and reveal a predisposition to coronary heart disease. |
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| | | | | | Latest Articles | View all Articles | | | | | Ultra-rapid access to words in the brain | | | Lucy J MacGregor, Friedemann Pulvermüller, Maarten van Casteren and Yury Shtyrov | | | The exact speed of spoken word processing by our brain is still unknown. Using MEG to compare brain responses to words and pseudowords, MacGregor et al. show that lexical processing occurs 50 ms after acoustic information is presented, suggesting that our brain's access to word information is near-instantaneous. | | | 28 Feb | Nat Commun 3:711 doi:10.1038/ncomms1715 (2012) | | | Biological sciences Neuroscience | | | | Abstract | Full Text | PDF (710 kB) |
Supplementary Information |
| Precise hierarchical self-assembly of multicompartment micelles OPEN | | | André H. Gröschel, Felix H. Schacher, Holger Schmalz, Oleg V. Borisov, Ekaterina B. Zhulina, Andreas Walther and Axel H.E. Müller | | | Multicompartment micelles can be assembled from block copolymers but it is difficult to manipulate their hierarchical superstructures using straightforward concepts. Here, methods are developed that involve the pre-assembly of subunits for the structurally controlled production of micelles. | | | 28 Feb | Nat Commun 3:710 doi:10.1038/ncomms1707 (2012) | | | Chemical sciences Materials science | | | Nanotechnology | | Abstract | Full Text | PDF (4,474 kB) |
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| Mapping of H3N2 influenza antigenic evolution in China reveals a strategy for vaccine strain recommendation | | | Xiangjun Du, Libo Dong, Yu Lan, Yousong Peng, Aiping Wu, Ye Zhang, Weijuan Huang, Dayan Wang, Min Wang, Yuanji Guo, Yuelong Shu and Taijiao Jiang | | | Influenza vaccines are updated frequently to accommodate changing influenza antigenicity. Here, the authors develop a new computational method for predicting the antigenicity of H3N2 influenza strains based on the HA sequence. | | | 28 Feb | Nat Commun 3:709 doi:10.1038/ncomms1710 (2012) | | | Biological sciences Bioinformatics | | | Evolution Immunology | | | Virology | | Abstract | Full Text | PDF (632 kB) |
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| Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence OPEN | | | Graeme Hewitt, Diana Jurk, Francisco D.M. Marques, Clara Correia-Melo, Timothy Hardy, Agata Gackowska, Rhys Anderson, Morgan Taschuk, Jelena Mann and João F. Passos | | | Irreparable DNA damage leads to apoptosis or senescence. Hewitt et al. show that, in response to genotoxic or oxidative stress, DNA damage occurs predominantly at telomere associated foci, which accumulate with age in vivo, irrespective of telomerase activity. | | | 28 Feb | Nat Commun 3:708 doi:10.1038/ncomms1708 (2012) | | | Biological sciences Cell biology | | | Molecular biology | | Abstract | Full Text | PDF (1,636 kB) |
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| The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation | | | Sarah L. Doyle, Harald Husebye, Dympna J. Connolly, Terje Espevik, Luke A.J. O'Neill and Anne F. McGettrick | | | TLRs have a role in innate immunity and TLR4 recognizes lipopolysaccharide on the cell wall of Gram-negative bacteria. Now, Doyle and colleagues show that a transmembrane protein TMED7, similar to a Drosophila homologue, can negatively control TLR4 signalling, suggesting a conserved role in innate immunity. | | | 28 Feb | Nat Commun 3:707 doi:10.1038/ncomms1706 (2012) | | | Biological sciences Biochemistry Cell biology | | | Immunology | | Abstract | Full Text | PDF (1,769 kB) |
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| Perturbation of sodium channel structure by an inherited Long QT Syndrome mutation | | | Ian W. Glaaser, Jeremiah D. Osteen, Akil Puckerin, Kevin J. Sampson, Xiangshu Jin and Robert S. Kass | | | Perturbation of the cardiac voltage-gated sodium channel, NaV1.5, by drugs or inherited mutation can underlie and trigger cardiac arrhythmias. Here, the role of the NaV1.5 carboxy terminus in channel inactivation is investigated, and structural details of an arrhythmia associated H6 mutant are reported. | | | 28 Feb | Nat Commun 3:706 doi:10.1038/ncomms1717 (2012) | | | Biological sciences Biochemistry | | | Biophysics | | Abstract | Full Text | PDF (821 kB) |
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| Intracellular temperature mapping with a fluorescent polymeric thermometer and fluorescence lifetime imaging microscopy OPEN | | | Kohki Okabe, Noriko Inada, Chie Gota, Yoshie Harada, Takashi Funatsu and Seiichi Uchiyama | | | Intracellular temperature mapping has not previously been achieved. Now, a fluorescent polymeric thermometer has been developed that can be used in combination with fluorescence-lifetime imaging microscopy to allow thermometry with spatial and temperature resolutions of 200 nm and 0.18–0.58 ° C. | | | 28 Feb | Nat Commun 3:705 doi:10.1038/ncomms1714 (2012) | | | Chemical sciences Analytical chemistry | | | Biotechnology | | Abstract | Full Text | PDF (1,531 kB) |
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| Three decades of high-resolution coastal sea surface temperatures reveal more than warming | | | Fernando P. Lima and David S. Wethey | | | A detailed assessment of near-shore temperature changes is needed for improved forecasts of the consequences of coastal warming. Here, changes in coastal sea surface temperature are estimated, showing that although 71% of the world's coastlines are warming, the rates of change have varied spatially. | | | 28 Feb | Nat Commun 3:704 doi:10.1038/ncomms1713 (2012) | | | Earth sciences Climate science | | | | Abstract | Full Text | PDF (10,684 kB) |
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| Rats track odour trails accurately using a multi-layered strategy with near-optimal sampling | | | Adil Ghani Khan, Manaswini Sarangi and Upinder Singh Bhalla | | | Animals track odour trails to find food, a mate or to steer clear of danger. Bhalla and colleagues combine behavioural and physiological measurements to show that rats can track surface-borne odours with near-optimal sampling and are able to predict the path direction on encountering a bifurcation. | | | 28 Feb | Nat Commun 3:703 doi:10.1038/ncomms1712 (2012) | | | Biological sciences Neuroscience | | Abstract | Full Text | PDF (1,313 kB) |
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| Network physiology reveals relations between network topology and physiological function | | | Amir Bashan, Ronny P. Bartsch, Jan. W. Kantelhardt, Shlomo Havlin and Plamen Ch. Ivanov | | | Humans are a network of complex physiological systems, but quantifying these diverse systems is a challenge. This study presents a method to show that each physiological state is characterized by a specific network structure, demonstrating a connection between network topology and function. | | | 28 Feb | Nat Commun 3:702 doi:10.1038/ncomms1705 (2012) | | | Biological sciences Applied physics | | | Biophysics Medical research | | | Abstract | Full Text | PDF (913 kB) |
| Zigzag line defects and manipulation of colloids in a nematic liquid crystal in microwrinkle grooves OPEN | | | Takuya Ohzono and Jun-ichi Fukuda | | | Understanding defects in liquid crystals is important for controlling their structure and self-assembly properties. Here, nematic liquid crystals confined in microwrinkle grooves show new periodic arrangements and zigzag line defects that can trap particles, offering a method for colloid manipulation. | | | 28 Feb | Nat Commun 3:701 doi:10.1038/ncomms1709 (2012) | | | Fluids and plasma physics Plasma physics | | | Materials science Nanotechnology | | Abstract | Full Text | PDF (920 kB) |
Supplementary Information |
| Three-dimensional imaging of single nanotube molecule endocytosis on plasmonic substrates | | | Guosong Hong, Justin Z. Wu, Joshua T. Robinson, Hailiang Wang, Bo Zhang and Hongjie Dai | | | Imaging and tracking the motion of single molecules on cell plasma membranes requires high spatial resolution in three dimensions. Hong et al. develop a plasmonic ruler based on the fluorescence enhancement of carbon nanotubes on a gold plasmonic substrate, allowing the observation of nanotube endocytosis in three dimensions. | | | 28 Feb | Nat Commun 3:700 doi:10.1038/ncomms1698 (2012) | | | Chemical sciences Cell biology | | | Nanotechnology | | Abstract | Full Text | PDF (955 kB) |
Supplementary Information |
| Repeated growth and bubbling transfer of graphene with millimetre-size single-crystal grains using platinum OPEN | | | Libo Gao, Wencai Ren, Huilong Xu, Li Jin, Zhenxing Wang, Teng Ma, Lai-Peng Ma, Zhiyong Zhang, Qiang Fu, Lian-Mao Peng, Xinhe Bao and Hui-Ming Cheng | | | Grain boundaries in graphene degrade its properties, and large single-crystal graphene is desirable for electronic applications of graphene. Gao et al. develop a method to produce millimetre-sized hexagonal single-crystal graphene grains, and films composed of the grains, on platinum by chemical vapour deposition. | | | 28 Feb | Nat Commun 3:699 doi:10.1038/ncomms1702 (2012) | | | Physical sciences Applied physics | | | Materials science Nanotechnology | | Abstract | Full Text | PDF (1,125 kB) |
Supplementary Information |
| New insights into the Tyrolean Iceman's origin and phenotype as inferred by whole-genome sequencing | | | Andreas Keller, Angela Graefen, Markus Ball, Mark Matzas, Valesca Boisguerin, Frank Maixner, Petra Leidinger, Christina Backes, Rabab Khairat, Michael Forster, Björn Stade, Andre Franke, Jens Mayer, Jessica Spangler, Stephen McLaughlin, Minita Shah, Clarence Lee, Timothy T. Harkins, Alexander Sartori, Andres Moreno-Estrada, Brenna Henn, Martin Sikora, Ornella Semino, Jacques Chiaroni, Siiri Rootsi, Natalie M. Myres, Vicente M. Cabrera, Peter A. Underhill, Carlos D. Bustamante, Eduard Egarter Vigl, Marco Samadelli, Giovanna Cipollini, Jan Haas, Hugo Katus, Brian D. O'Connor, Marc R.J. Carlson, Benjamin Meder, Nikolaus Blin, Eckart Meese, Carsten M. Pusch and Albert Zink | | | The Tyrolean Iceman is 5,300 years old and his mitochondrial genome has been previously sequenced. This study reports the full genome sequence of the Iceman and reveals that he probably had brown eyes, was at risk for coronary disease and may have been infected with the pathogen Lyme borreliosis. | | | 28 Feb | Nat Commun 3:698 doi:10.1038/ncomms1701 (2012) | | | Biological sciences Genetics Molecular biology | | Abstract | Full Text | PDF (830 kB) |
Supplementary Information |
| Male pygmy hippopotamus influence offspring sex ratio OPEN | | | Joseph Saragusty, Robert Hermes, Heribert Hofer, Tim Bouts, Frank Göritz and Thomas B. Hildebrandt | | | Some animal populations are able to shift their birth sex ratio from the expected unity. This study shows, using fluorescence in situ hybridization, that in a captive population of pygmy hippopotamus the males appear to be able to adjust the ratio of X- and Y-chromosome-bearing spermatozoa in their ejaculates. | | | 28 Feb | Nat Commun 3:697 doi:10.1038/ncomms1700 (2012) | | | Biological sciences Zoology | | | Abstract | Full Text | PDF (232 kB) |
| The impact of asymmetrical light input on cerebral hemispheric specialization and interhemispheric cooperation | | | Martina Manns and Juliane Römling | | | Lateralization of the brain can provide evolutionary advantages by enhancing behavioural and cognitive capacities. Manns and Römling confirm that lateralized environmental experience in pigeons induces hemispheric specialization and show that this affects the efficiency of interhemispheric crosstalk. | | | 28 Feb | Nat Commun 3:696 doi:10.1038/ncomms1699 (2012) | | | Biological sciences Neuroscience | | | Abstract | Full Text | PDF (272 kB) |
| Interpolar microtubules are dispensable in fission yeast meiosis II | | | Takashi Akera, Masamitsu Sato and Masayuki Yamamoto | | | Interpolar microtubules were thought to be indispensable for eukaryotic cell division. Here, Akera and colleagues demonstrate that the second division of meiosis in yeast can occur in the absence of interpolar microtubules, and identify the forespore membrane as a force producing structure in cell division. | | | 28 Feb | Nat Commun 3:695 doi:10.1038/ncomms1725 (2012) | | | Biological sciences Cell biology | | | | Abstract | Full Text | PDF (1,343 kB) |
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