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| | | 14 February 2012 | | | Featured image: | |  | | | Versaevel et al. investigate actomyosin-regulated nuclear remodelling in endothelial cells. |
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Advertisement | | Miami 2012 Winter Symposium: Nanotechnology in Biomedicine
February 26-29, 2012 • Miami, FL, USA
The 45th Miami Winter Symposium will bring together leaders in the field to discuss breakthroughs in new nanomaterials and the challenges in translating these materials into products for the clinic and laboratory.
For more information and to register, visit:
www.nature.com/natureconferences/miami/mws2012
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| | | | | | Latest Articles | View all Articles | | | | | Emergence of non-centrosymmetric topological insulating phase in BiTeI under pressure | | | M.S. Bahramy, B.-J. Yang, R. Arita and N. Nagaosa | | | The spin–orbit interaction affects the electronic structure of many solids to give rise to a host of unusual phenomena. Bahramy et al. theoretically examine its role in the non-centrosymmetric compound BiTeI, and find that under the application of pressure, it leads to topologically insulating behaviour. | | | 14 Feb | Nat Commun 3:679 doi:10.1038/ncomms1679 (2012) | | | Physical sciences Condensed matter | | | Materials science Theoretical physics | | Abstract | Full Text | PDF (1,178 kB) |
Supplementary Information |
| Interferon-γ-producing immature myeloid cells confer protection against severe invasive group A Streptococcus infections OPEN | | | Takayuki Matsumura, Manabu Ato, Tadayoshi Ikebe, Makoto Ohnishi, Haruo Watanabe and Kazuo Kobayashi | | | Myeloid cells are important in the response to severe infection by invasive Streptococcus Group A. In this study, a distinct population of immature myeloid cells with ring shaped nuclei that produce interferon-γ are shown to be important for protection of mice against the early stages of invasive infection. | | | 14 Feb | Nat Commun 3:678 doi:10.1038/ncomms1677 (2012) | | | Biological sciences Immunology Microbiology | | Abstract | Full Text | PDF (1,976 kB) |
Supplementary Information |
| CMOS-based carbon nanotube pass-transistor logic integrated circuits OPEN | | | Li Ding, Zhiyong Zhang, Shibo Liang, Tian Pei, Sheng Wang, Yan Li, Weiwei Zhou, Jie Liu and Lian-Mao Peng | | | Field-effect transistors fabricated from carbon nanotubes have been investigated extensively over the past two decades. This study demonstrates a nanotube-based integrated circuit design that substantially improves the speed and power consumption with respect to silicon-based integrated circuits. | | | 14 Feb | Nat Commun 3:677 doi:10.1038/ncomms1682 (2012) | | | Physical sciences Applied physics | | | Materials science Nanotechnology | | Abstract | Full Text | PDF (1,076 kB) |
Supplementary Information |
| Regulation of histone modification and chromatin structure by the p53–PADI4 pathway | | | Chizu Tanikawa, Martha Espinosa, Akari Suzuki, Ken Masuda, Kazuhiko Yamamoto, Eiju Tsuchiya, Koji Ueda, Yataro Daigo, Yusuke Nakamura and Koichi Matsuda | | | PADI4 is an enzyme that converts arginine residues to citrulline. Here, Tanikawa and colleagues show that, in response to DNA damage, histone H4 and Lamin C are citrullinated in a p53 and PADI4-dependent manner and Padi4-dependent manner and Padi4 null mice are resistant to radiation-induced apoptosis in the thymus. | | | 14 Feb | Nat Commun 3:676 doi:10.1038/ncomms1676 (2012) | | | Biological sciences Cancer | | | Cell biology Medical research | | | Molecular biology | | Abstract | Full Text | PDF (1,337 kB) |
Supplementary Information |
| CPEB-mediated ZO-1 mRNA localization is required for epithelial tight-junction assembly and cell polarity | | | Kentaro Nagaoka, Tsuyoshi Udagawa and Joel D. Richter | | | Zonal occludens and claudin form tight junctions near the apical surface of cells and are important in polarized epithelia. In this study, the translational regulatory sequence-specific RNA binding protein CPEB is shown to be required for the correct localization of zona occluden 1 mRNA in mammary epithelial cells. | | | 14 Feb | Nat Commun 3:675 doi:10.1038/ncomms1678 (2012) | | | Biological sciences Cell biology | | | Developmental biology Molecular biology | | Abstract | Full Text | PDF (1,672 kB) |
Supplementary Information |
| Wind direction and proximity to larval sites determines malaria risk in Kilifi District in Kenya OPEN | | | Janet T. Midega, Dave L. Smith, Ally Olotu, Joseph M. Mwangangi, Joseph G. Nzovu, Juliana Wambua, George Nyangweso, Charles M. Mbogo, George K. Christophides, Kevin Marsh and Philip Bejon | | | Spatial epidemiology studies identify malaria hotspots, which sustain transmission and so could be targeted by control programmes. This study uses spatial data on larval sites and malaria episodes to show that transmission can be disrupted by targeting vector breeding sites close to and downwind of malaria hotspots. | | | 14 Feb | Nat Commun 3:674 doi:10.1038/ncomms1672 (2012) | | | Biological sciences Ecology | | | Medical research | | | Abstract | Full Text | PDF (607 kB) |
| Dynamics of anterior–posterior axis formation in the developing mouse embryo OPEN | | | Samantha A. Morris, Seema Grewal, Florencia Barrios, Sameer N. Patankar, Bernhard Strauss, Lee Buttery, Morgan Alexander, Kevin M. Shakesheff and Magdalena Zernicka-Goetz | | | Detailed analysis of axis development in mouse embryo has been limited. Morris et al. developed an in vitro culture technique that enables the real-time observation of an anterior visceral endoderm formation and show that cell marker asymmetry within the AVE subdomain dictates the direction of the AVE migration. | | | 14 Feb | Nat Commun 3:673 doi:10.1038/ncomms1671 (2012) | | | Biological sciences Cell biology | | | Developmental biology | | Abstract | Full Text | PDF (2,082 kB) |
Supplementary Information |
| PPARγ contributes to PKM2 and HK2 expression in fatty liver OPEN | | | Ganna Panasyuk, Catherine Espeillac, Céline Chauvin, Ludivine A. Pradelli, Yasuo Horie, Akira Suzuki, Jean-Sebastien Annicotte, Lluis Fajas, Marc Foretz, Francisco Verdeguer, Marco Pontoglio, Pascal Ferré, Jean-Yves Scoazec, Morris J. Birnbaum, Jean-Ehrland Ricci and Mario Pende | | | Molecular factors, regulating the expression of specific glycolytic enzymes that favour biosynthetic processes, have remained unknown. Panasyuk et al. identify PPARγ as a novel transcription factor turning on pyruvate kinase M2 and hexokinase 2, which are frequently upregulated in pathophysiological growth. | | | 14 Feb | Nat Commun 3:672 doi:10.1038/ncomms1667 (2012) | | | Biological sciences Biochemistry | | | Cancer Molecular biology | | Abstract | Full Text | PDF (824 kB) |
Supplementary Information |
| Spatial coordination between cell and nuclear shape within micropatterned endothelial cells | | | Marie Versaevel, Thomas Grevesse and Sylvain Gabriele | | | Actin filaments are involved in the modulation of nuclear shape and function, but mechanistic understanding of these processes is lacking. Versaevel et al. show that orientation and deformation of the nucleus are regulated by lateral compressive forces driven by tension in central actomyosin fibres. | | | 14 Feb | Nat Commun 3:671 doi:10.1038/ncomms1668 (2012) | | | Biological sciences Bioengineering | | | Biophysics Cell biology | | Abstract | Full Text | PDF (1,298 kB) |
Supplementary Information |
| Homeostatic neurogenesis in the adult hippocampus does not involve amplification of Ascl1high intermediate progenitors | | | Sebastian Lugert, Miriam Vogt, Jan S. Tchorz, Matthias Müller, Claudio Giachino and Verdon Taylor | | | Neural stem cells generate neurons in the adult hippocampus, but the dynamics of neuron production remain unclear. This study shows that stem cells produce type-2a progenitors, which do not expand as previously thought, but rather generate amplifying immature neuroblasts. | | | 14 Feb | Nat Commun 3:670 doi:10.1038/ncomms1670 (2012) | | | Biological sciences Developmental biology Genetics | | | Neuroscience | | Abstract | Full Text | PDF (2,157 kB) |
Supplementary Information |
| The dynamic relationships between the three events that release individual Na+ ions from the Na+/K+-ATPase OPEN | | | David C. Gadsby, Francisco Bezanilla, Robert F. Rakowski, Paul De Weer and Miguel Holmgren | | | The Na+/K+-ATPase pump exports three Na+ ions for the exchange of two K+ ions, and three transient current components have been associated with Na+ binding and release. Now, these three components are found to be tightly correlated confirming that the binding and release of Na+ ions is sequential. | | | 14 Feb | Nat Commun 3:669 doi:10.1038/ncomms1673 (2012) | | | Biological sciences Biochemistry | | | Biophysics | | Abstract | Full Text | PDF (964 kB) |
Supplementary Information |
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