Molecular Therapy - Table of Contents alert Volume 20 Issue 2

TABLE OF CONTENTS Volume 20, Issue 2 (February 2012) In this issue Editorial In This Issue Research Highlights Commentaries Original Articles Corrigendum Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement Molecular Therapy is accepting submissions! Featuring author benefits like ZERO submission fees, Advanced Online Publication (AOP) at http://www.nature.com/mt/journal/vaop/ncurrent/index.html, and inclusion in abstracting and indexing services like ISI, MEDLINE and EMBASE. Molecular Therapy is the only journal ranked within the top 20th percentile in biotechnology, genetics and medicine. To learn more about publishing in Molecular Therapy visit http://www.moleculartherapy.org.   Editorial Top Personalized Medicine: Words That Mean Just What You Choose? Malcolm K Brenner Mol Ther 2012 20: 241-242; 10.1038/mt.2011.311 Full Text In This Issue Top In This Issue Mol Ther 2012 20: 244; 10.1038/mt.2011.296 Full Text Research Highlights Top Research Highlights Mol Ther 2012 20: 245; 10.1038/mt.2011.297 Full Text Commentaries Top Replication-Competent Retroviruses in Gene-Modified T Cells Used in Clinical Trials: Is It Time to Revise the Testing Requirements? Adham S Bear, Richard A Morgan, Kenneth Cornetta, Carl H June, Gwendolyn Binder-Scholl, Mark E Dudley, Steven A Feldman, Steven A Rosenberg, Sheila A Shurtleff, Cliona M Rooney, Helen E Heslop and Gianpietro Dotti Mol Ther 2012 20: 246-249; 10.1038/mt.2011.288 Full Text Signs of Progress in Gene Therapy for Muscular Dystrophy Also Warrant Caution Hansell H Stedman and Barry J Byrne Mol Ther 2012 20: 249-251; 10.1038/mt.2011.307 Full Text Cell-Penetrating RNAs: New Keys to the Castle Donald H Burke Mol Ther 2012 20: 251-253; 10.1038/mt.2011.306 Full Text Original Articles Top Liver Production of Sulfamidase Reverses Peripheral and Ameliorates CNS Pathology in Mucopolysaccharidosis IIIA Mice Albert Ruzo, Miquel Garcia, Albert Ribera, Pilar Villacampa, Virginia Haurigot, Sara Marcó, Eduard Ayuso, Xavier M Anguela, Carles Roca, Judith Agudo, David Ramos, Jesús Ruberte and Fatima Bosch Mol Ther 2012 20: 254-266; advance online publication, October 18, 2011; 10.1038/mt.2011.220 Abstract | Full Text Preclinical Dose-Finding Study With a Liver-Tropic, Recombinant AAV-2/8 Vector in the Mouse Model of Galactosialidosis Huimin Hu, Elida Gomero, Erik Bonten, John T Gray, Jim Allay, Yanan Wu, Jianrong Wu, Christopher Calabrese, Arthur Nienhuis and Alessandra d'Azzo Mol Ther 2012 20: 267-274; advance online publication, October 18, 2011; 10.1038/mt.2011.227 Abstract | Full Text AAV Transduction of Dopamine Neurons With Constitutively Active Rheb Protects From Neurodegeneration and Mediates Axon Regrowth Sang Ryong Kim, Tatyana Kareva, Olga Yarygina, Nikolai Kholodilov and Robert E Burke Mol Ther 2012 20: 275-286; advance online publication, October 18, 2011; 10.1038/mt.2011.213 Abstract | Full Text Antitumor Efficacy of 34.5ENVE: A Transcriptionally Retargeted and “Vstat120”-expressing Oncolytic Virus Ji Young Yoo, Amy Haseley, Anna Bratasz, E Antonio Chiocca, Jianying Zhang, Kimerly Powell and Balveen Kaur Mol Ther 2012 20: 287-297; advance online publication, October 25, 2011; 10.1038/mt.2011.208 Abstract | Full Text Oncolytic Sindbis Virus Targets Tumors Defective in the Interferon Response and Induces Significant Bystander Antitumor Immunity In Vivo Pong-Yu Huang, Jih-Huong Guo and Lih-Hwa Hwang Mol Ther 2012 20: 298-305; advance online publication, November 8, 2011; 10.1038/mt.2011.245 Abstract | Full Text Modification of the Early Gene Enhancer-promoter Improves the Oncolytic Potency of Adenovirus 11 Han Hsi Wong, Guozhong Jiang, Rathi Gangeswaran, Pengju Wang, Jiwei Wang, Ming Yuan, Hexiao Wang, Vipul Bhakta, Heike Müller, Nicholas R Lemoine and Yaohe Wang Mol Ther 2012 20: 306-316; advance online publication, November 15, 2011; 10.1038/mt.2011.242 Abstract | Full Text Quantitative 3D Tracing of Gene-delivery Viral Vectors in Human Cells and Animal Tissues Ping-Jie Xiao, Chengwen Li, Aaron Neumann and R Jude Samulski Mol Ther 2012 20: 317-328; advance online publication, November 22, 2011; 10.1038/mt.2011.250 Abstract | Full Text Directed Evolution of Adeno-associated Virus for Enhanced Gene Delivery and Gene Targeting in Human Pluripotent Stem Cells Prashanth Asuri, Melissa A Bartel, Tandis Vazin, Jae-Hyung Jang, Tiffany B Wong and David V Schaffer Mol Ther 2012 20: 329-338; advance online publication, November 22, 2011; 10.1038/mt.2011.255 Abstract | Full Text Construction of an Oncolytic Herpes Simplex Virus That Precisely Targets Hepatocellular Carcinoma Cells Xinping Fu, Armando Rivera, Lihua Tao, Bart De Geest and Xiaoliu Zhang Mol Ther 2012 20: 339-346; advance online publication, December 6, 2011; 10.1038/mt.2011.265 Abstract | Full Text Rad51 Promoter-Targeted Gene Therapy Is Effective for In Vivo Visualization and Treatment of Cancer Christopher M Hine, Andrei Seluanov and Vera Gorbunova Mol Ther 2012 20: 347-355; advance online publication, October 18, 2011; 10.1038/mt.2011.215 Abstract | Full Text Atelocollagen-mediated Systemic Delivery Prevents Immunostimulatory Adverse Effects of siRNA in Mammals Shinichiro Inaba, Shunji Nagahara, Naoki Makita, Yuzo Tarumi, Takuji Ishimoto, Seiichi Matsuo, Kenji Kadomatsu and Yoshifumi Takei Mol Ther 2012 20: 356-366; advance online publication, October 25, 2011; 10.1038/mt.2011.221 Abstract | Full Text In Vivo Delivery of Cytoplasmic RNA Virus-derived miRNAs Ryan A Langlois, Jillian S Shapiro, Alissa M Pham and Benjamin R tenOever Mol Ther 2012 20: 367-375; advance online publication, November 15, 2011; 10.1038/mt.2011.244 Abstract | Full Text PCSK9 LNA Antisense Oligonucleotides Induce Sustained Reduction of LDL Cholesterol in Nonhuman Primates Marie W Lindholm, Joacim Elmén, Niels Fisker, Henrik F Hansen, Robert Persson, Marianne R Møller, Christoph Rosenbohm, Henrik Ørum, Ellen M Straarup and Troels Koch Mol Ther 2012 20: 376-381; advance online publication, November 22, 2011; 10.1038/mt.2011.260 Abstract | Full Text Functionally Enhanced siRNA Targeting TNFα Attenuates DSS-induced Colitis and TLR-mediated Immunostimulation in Mice Sandra M Ocampo, Carolina Romero, Anna Aviñó, Joan Burgueño, Miguel A Gassull, Jordi Bermúdez, Ramon Eritja, Ester Fernandez and Jose C Perales Mol Ther 2012 20: 382-390; advance online publication, November 1, 2011; 10.1038/mt.2011.236 Abstract | Full Text Rapidly Regulating Platelet Activity In Vivo With an Antidote Controlled Platelet Inhibitor Shahid M Nimjee, Jens D Lohrmann, Haichen Wang, David J Snyder, Thomas J Cummings, Richard C Becker, Sabah Oney and Bruce A Sullenger Mol Ther 2012 20: 391-397; advance online publication, November 15, 2011; 10.1038/mt.2011.226 Abstract | Full Text RNAi Targeting CXCR4 Inhibits Tumor Growth Through Inducing Cell Cycle Arrest and Apoptosis Tao Yu, Yingying Wu, Yi Huang, Chaoran Yan, Ying Liu, Zongsheng Wang, Xiaoyi Wang, Yuming Wen, Changmei Wang and Longjiang Li Mol Ther 2012 20: 398-407; advance online publication, November 22, 2011; 10.1038/mt.2011.257 Abstract | Full Text Efficient Reprogramming of Human Cord Blood CD34+ Cells Into Induced Pluripotent Stem Cells With OCT4 and SOX2 Alone Xianmei Meng, Amanda Neises, Rui-Jun Su, Kimberly J Payne, Linda Ritter, Daila S Gridley, Jun Wang, Matilda Sheng, K-H William Lau, David J Baylink and Xiao-Bing Zhang Mol Ther 2012 20: 408-416; advance online publication, November 22, 2011; 10.1038/mt.2011.258 Abstract | Full Text Mesenchymal Stromal Cells Protect Cancer Cells From ROS-induced Apoptosis and Enhance the Warburg Effect by Secreting STC1 Shinya Ohkouchi, Gregory J Block, Ahmed M Katsha, Masahiko Kanehira, Masahito Ebina, Toshiaki Kikuchi, Yasuo Saijo, Toshihiro Nukiwa and Darwin J Prockop Mol Ther 2012 20: 417-423; advance online publication, December 6, 2011; 10.1038/mt.2011.259 Abstract | Full Text Efficient and Accurate Homologous Recombination in hESCs and hiPSCs Using Helper-dependent Adenoviral Vectors Emi Aizawa, Yuka Hirabayashi, Yuzuru Iwanaga, Keiichiro Suzuki, Kenji Sakurai, Miho Shimoji, Kazuhiro Aiba, Tamaki Wada, Norie Tooi, Eihachiro Kawase, Hirofumi Suemori, Norio Nakatsuji and Kohnosuke Mitani Mol Ther 2012 20: 424-431; advance online publication, December 6, 2011; 10.1038/mt.2011.266 Abstract | Full Text Genetic Targeting of the Active Transcription Factor XBP1s to Dendritic Cells Potentiates Vaccine-induced Prophylactic and Therapeutic Antitumor Immunity Shenghe Tian, Zuqiang Liu, Cara Donahue, Louis D Falo, Jr and Zhaoyang You Mol Ther 2012 20: 432-442; advance online publication, September 20, 2011; 10.1038/mt.2011.183 Abstract | Full Text Phase 1 Gene Therapy for Duchenne Muscular Dystrophy Using a Translational Optimized AAV Vector Dawn E Bowles, Scott WJ McPhee, Chengwen Li, Steven J Gray, Jade J Samulski, Angelique S Camp, Juan Li, Bing Wang, Paul E Monahan, Joseph E Rabinowitz, Joshua C Grieger, Lakshmanan Govindasamy, Mavis Agbandje-McKenna, Xiao Xiao and R Jude Samulski Mol Ther 2012 20: 443-455; advance online publication, November 8, 2011; 10.1038/mt.2011.237 Abstract | Full Text Safety and Feasibility of High-pressure Transvenous Limb Perfusion With 0.9% Saline in Human Muscular Dystrophy Zheng Fan, Keith Kocis, Robert Valley, James F Howard, Manisha Chopra, Hongyu An, Weili Lin, Joseph Muenzer and William Powers Mol Ther 2012 20: 456-461; advance online publication, July 19, 2011; 10.1038/mt.2011.137 Abstract | Full Text Restoration of the Dystrophin-associated Glycoprotein Complex After Exon Skipping Therapy in Duchenne Muscular Dystrophy Sebahattin Cirak, Lucy Feng, Karen Anthony, Virginia Arechavala-Gomeza, Silvia Torelli, Caroline Sewry, Jennifer E Morgan and Francesco Muntoni Mol Ther 2012 20: 462-467; advance online publication, November 15, 2011; 10.1038/mt.2011.248 Abstract | Full Text Corrigendum Top Corrigendum to “Real-time MR Imaging With Gadoteridol Predicts Distribution of Transgenes After Convection-enhanced Delivery of AAV2 Vectors” Mol Ther 2012 20: 468; 10.1038/mt.2011.262 Full Text Corrigendum to “Hematopoietic Stem Cell Mobilization for Gene Therapy of Adult Patients With Severe β-Thalassemia: Results of Clinical Trials Using G-CSF or Plerixafor in Splenectomized and Nonsplenectomized Subjects” Mol Ther 2012 20: 469; 10.1038/mt.2011.240 Full Text Dedicated to the treatment of genetic and acquired diseases? 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