Molecular Systems Biology - New articles published 28 February 2012

Latest Articles 28th February 2012   Featured Article Research Article   Web feeds About Open access Advertisement What is your top 2011 MSB paper? Check out the top 10 most read research articles published in Molecular Systems Biology in 2011, based on combined HTML and PDF access. The work by Saeidi et al, in particular, received widespread media coverage for making a practical first-step toward fighting infections with engineered microbes It is all on our blog, visit The SevenStones Blog and share your own favourite articles from 2011 by submitting a comment with the link at the bottom of the page (you must register before you can post comments).     Featured Article Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium The effect of kinase, phosphatase and N-acetyltransferase deletions on proteome phosphorylation and acetylation was investigated in Mycoplasma pneumoniae. Bi-directional cross-talk between post-transcriptional modifications suggests an underlying regulatory molecular code in prokaryotes. Vera van Noort, Jan Seebacher, Samuel Bader, Shabaz Mohammed, Ivana Vonkova, Matthew J Betts, Sebastian Kühner, Runjun Kumar, Tobias Maier, Martina O'Flaherty, Vladimir Rybin, Arne Schmeisky, Eva Yus, Jörg Stülke, Luis Serrano, Robert B Russell, Albert JR Heck, Peer Bork & Anne-Claude Gavin Molecular Systems Biology 8:571; doi:10.1038/msb.2012.4; published 28 February 2012 Synopsis | Full Text | PDF | Supp. Inf. | Review Process Research Article Genes adopt non-optimal codon usage to generate cell cycle-dependent oscillations in protein levels Most cell cycle-regulated genes adopt non-optimal codon usage, namely, their translation involves wobbly matching codons. Here, the authors show that tRNA expression is cyclic and that codon usage, therefore, can give rise to cell-cycle regulation of proteins. Milana Frenkel-Morgenstern, Tamar Danon, Thomas Christian, Takao Igarashi, Lydia Cohen, Ya-Ming Hou & Lars Juhl Jensen Molecular Systems Biology 8:572; doi:10.1038/msb.2012.3; published 28 February 2012 Synopsis | Full Text | PDF | Supp. Inf. | Review Process

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