Laboratory Investigation - Table of Contents alert Volume 92 Issue 3

TABLE OF CONTENTS Volume 92, Issue 3 (March 2012) In this issue Inside LI Mini Review Research Articles Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement Announcing Open Laboratory Investigation now offers authors the option to publish their articles with immediate open access upon publication. Open access articles will also be deposited on PubMed Central at the time of publication and will be freely available immediately. Find out more from the FAQs page.   Inside LI Top Inside Lab Invest 2012 92: 318-319; 10.1038/labinvest.2012.16 Full Text Mini Review Top Multiple roles of the epithelium-specific ETS transcription factor, ESE-1, in development and disease This review discusses the role of the E26 transformation-specific transcription factor, ESE-1, in regulating pathophysiological processes, such as intestinal development, lung regeneration and allergic airway inflammation, mammary gland development and breast cancer, and synovial joint and vascular inflammation. Understanding the mechanisms by which ESE-1 regulates these processes has implications for treatment of numerous diseases. Jordan R Oliver, Rahul Kushwah and Jim Hu 2012 92: 320-330; advance online publication, December 12, 2011; 10.1038/labinvest.2011.186 Abstract | Full Text Research Articles Top BLOOD, LYMPHATICS, IMMUNE SYSTEM, STEM CELLS Heparin-binding EGF-like growth factor protects intestinal stem cells from injury in a rat model of necrotizing enterocolitis Necrotizing enterocolitis is an often catastrophic disease that typically affects premature newborns. Heparin-binding EGF-like growth factor shows promise as a potential treatment, as it protects intestinal stem cells from injury after hypoxia through the EGFR/MEK1/2 and EGFR/PI3K signaling pathways. Chun-Liang Chen, Xiaoyi Yu, Iyore O-A James, Hong-yi Zhang, Jingyuan Yang, Andrei Radulescu, Yu Zhou and Gail E Besner 2012 92: 331-344; advance online publication, December 12, 2011; 10.1038/labinvest.2011.167 Abstract | Full Text Carboxypeptidase-M is regulated by lipids and CSFs in macrophages and dendritic cells and expressed selectively in tissue granulomas and foam cells Carboxypeptidase-M is expressed selectively in epithelioid and foam macrophages and is upregulated by lipids and colony-stimulating factor. Carboxypeptidase-M has a novel role in lipid uptake and/or metabolism of macrophages by promoting foam cell formation and its detection in tissue sections may be useful for identification of granuloma and foam macrophages. Ioannis Tsakiris, Daniel Torocsik, Adrienn Gyongyosi, Aniko Dozsa, Istvan Szatmari, Attila Szanto, Gyorgyike Soos, Zoltan Nemes, Laszlo Igali, Ildiko Marton, Zoltan Takats, Laszlo Nagy and Balazs Dezso 2012 92: 345-361; advance online publication, December 12, 2011; 10.1038/labinvest.2011.168 Abstract | Full Text BREAST, SKIN, SOFT TISSUE AND BONE SOX2 contributes to melanoma cell invasion The mechanisms of melanoma invasion are poorly understood. The embryonic stem cell transcription factor Sox2 coincides with matrix metalloproteinase-3 expression at the invading interface with dermal stroma. Sox2 is shown to be essential for melanoma invasion and positively correlates with matrix metalloproteinase-3 expression. Sasha D Girouard, Alvaro C Laga, Martin C Mihm, Richard A Scolyer, John F Thompson, Qian Zhan, Hans R Widlund, Chung-Wei Lee and George F Murphy 2012 92: 362-370; advance online publication, December 19, 2011; 10.1038/labinvest.2011.188 Abstract | Full Text ANGIOGENESIS, CARDIOVASCULAR AND PULMONARY SYSTEMS WZ4002, a third-generation EGFR inhibitor, can overcome anoikis resistance in EGFR-mutant lung adenocarcinomas more efficiently than Src inhibitors Two EGFR-mutant lung adenocarcinoma cell lines, H1975 (Src inhibitor-resistant), and HCC827 (Src inhibitor-sensitive), when cultured in suspension, undergo apoptosis upon combination treatment that includes the EGFR inhibitor WZ4002. These results suggest that EGFR signaling plays a critical role in the anoikis resistance in EGFR-mutant lung adenocarcinomas. Yuji Sakuma, Yukiko Yamazaki, Yoshiyasu Nakamura, Mitsuyo Yoshihara, Shoichi Matsukuma, Haruhiko Nakayama, Tomoyuki Yokose, Yoichi Kameda, Shiro Koizume and Yohei Miyagi 2012 92: 371-383; advance online publication, December 12, 2011; 10.1038/labinvest.2011.187 Abstract | Full Text HEPATIC AND PANCREATIC SYSTEMS Reversal of liver fibrosis by the antagonism of endocannabinoid CB1 receptor in a rat model of CCl4-induced advanced cirrhosis Experimental treatments for liver fibrosis are generally effective only if given as a prophylactic or early treatment. In contrast, pharmacological antagonism of endocannabinoid CB1-receptor reverses rat liver fibrosis and full-blown cirrhosis, due to the suppression of pro-fibrogenic and pro-inflammatory mediators. Ferdinando A Giannone, Maurizio Baldassarre, Marco Domenicali, Giacomo Zaccherini, Franco Trevisani, Mauro Bernardi and Paolo Caraceni 2012 92: 384-395; advance online publication, December 19, 2011; 10.1038/labinvest.2011.191 Abstract | Full Text Carbon tetrachloride-mediated lipid peroxidation induces early mitochondrial alterations in mouse liver Although lipid peroxidation is implicated in early mitochondrial injury associated with liver fibrosis, lipid peroxidation-independent mechanisms are responsible for early hepatocyte swelling and changes in expression of stress/defense related genes. Therefore, antioxidant therapy may not be an efficient strategy to block early liver damage. Laetitia Knockaert, Alain Berson, Catherine Ribault, Pierre-Emmanuel Prost, Alain Fautrel, Julie Pajaud, Sylvie Lepage, Catherine Lucas-Clerc, Jean-Marc Bégué, Bernard Fromenty and Marie-Anne Robin 2012 92: 396-410; advance online publication, December 12, 2011; 10.1038/labinvest.2011.193 Abstract | Full Text ORAL AND GASTROINTESTINAL SYSTEMS Replication of Crohn's disease-associated AIEC within macrophages is dependent on TNF-α secretion The adherent and invasive Escherichia coli (AIEC) associated with Crohn's disease replicate in active phagolysosomes within macrophages. Replication of AIEC induces the release of TNF-α, which in turn increases intramacrophagic replication. Neutralizing the TNF-α secreted by infected macrophages may therefore represent an effective strategy to control Crohn's disease. Marie-Agnès Bringer, Elisabeth Billard, Anne-Lise Glasser, Jean-Frédéric Colombel and Arlette Darfeuille-Michaud 2012 92: 411-419; advance online publication, October 31, 2011; 10.1038/labinvest.2011.156 Abstract | Full Text CD133+ colon cancer cells are more interactive with the tumor microenvironment than CD133− cells Defining signaling axes promoted in the cancer microenvironment is critical for development of effective therapies. CD133+ colorectal cancer cells exhibit enhanced tumorigenicity compared to CD133− cells because they are more interactive with their stromal microenvironment due to expression of cognate receptors for ligands produced by neighboring carcinoma-associated fibroblasts. Celia Chao, J Russ Carmical, Kirk L Ives, Thomas G Wood, Judith F Aronson, Guillermo A Gomez, Clarisse D Djukom and Mark R Hellmich 2012 92: 420-436; advance online publication, December 12, 2011; 10.1038/labinvest.2011.185 Abstract | Full Text ErbB2 and ErbB3 regulate recovery from dextran sulfate sodium-induced colitis by promoting mouse colon epithelial cell survival ErbB2 and ErbB3 promote colon epithelial cell survival in the context of the wound healing response following colitis and promote colon epithelial cell survival by controlling the expression of proinflammatory cytokines. Yongqin Zhang, Philip E Dubé, M Kay Washington, Fang Yan and D Brent Polk 2012 92: 437-450; advance online publication, December 12, 2011; 10.1038/labinvest.2011.192 Abstract | Full Text Characterization of novel germline c-kit gene mutation, KIT-Tyr553Cys, observed in a family with multiple gastrointestinal stromal tumors A novel gain-of-function germline mutation in the c-kit gene, KIT-Tyr553Cys, is described in a patient with gastrointestinal stromal tumors. The KIT inhibitors imatinib and nilotinib effectively inhibit both autophosphorylation of KIT-Tyr552Cys and proliferation of cells expressing KIT-Tyr552Cys, indicating that both drugs could be used in treatment. Mayumi Nakai, Yuka Hashikura, Mizuka Ohkouchi, Masahiro Yamamura, Takashi Akiyama, Kazuhiro Shiba, Noriko Kajimoto, Yoshitane Tsukamoto, Hiroyuki Hao, Koji Isozaki, Toshihiro Hirai and Seiichi Hirota 2012 92: 451-457; advance online publication, November 14, 2011; 10.1038/labinvest.2011.165 Abstract | Full Text PERIPHERAL AND CENTRAL NERVOUS SYSTEM A pyrosequencing assay for the quantitative methylation analysis of the PCDHB gene cluster, the major factor in neuroblastoma methylator phenotype A novel pyrosequencing technique is described for methylation analysis of gene clusters with high internal homologies. The study confirms the predictive power of this technique for determining neuroblastoma methylator phenotype. Barbara Banelli, Claudio Brigati, Angela Di Vinci, Ida Casciano, Alessandra Forlani, Luana Borzì, Giorgio Allemanni and Massimo Romani 2012 92: 458-465; advance online publication, December 12, 2011; 10.1038/labinvest.2011.169 Abstract | Full Text Wnt activation is implicated in glioblastoma radioresistance The Wnt signaling pathway is up-regulated in radiation-enriched glioblas toma stem cell-like cells, which makes them radioresistant; inhibition of Wnt signaling sensitizes the cells to radiation. Thus, targeting Wnt may assist radiation therapy in glioblastoma patients. Yonghyun Kim, Kang Ho Kim, Jeena Lee, Young-Ae Lee, Misuk Kim, Se Jeong Lee, Kernyu Park, Heekyoung Yang, Juyoun Jin, Kyeung Min Joo, Jeongwu Lee and Do-Hyun Nam 2012 92: 466-473; advance online publication, November 14, 2011; 10.1038/labinvest.2011.161 Abstract | Full Text Aged vervet monkeys developing transthyretin amyloidosis with the human disease-causing Ile122 allele: a valid pathological model of the human disease The first animal model for senile systemic transthyretin (TTR) amyloidosis, a sporadic disease of the elderly, is described. Aged vervet monkeys can spontaneously develop systemic TTR amyloidosis and show cardiac dysfunction. Vervet monkeys have the TTR Ile122 allele, which is a frequent mutation causing human hereditary systemic TTR amyloidosis. Mitsuharu Ueda, Naohide Ageyama, Shinichiro Nakamura, Minami Nakamura, James Kenn Chambers, Yohei Misumi, Mineyuki Mizuguchi, Satoru Shinriki, Satomi Kawahara, Masayoshi Tasaki, Hirofumi Jono, Konen Obayashi, Erika Sasaki, Yumi Une and Yukio Ando 2012 92: 474-484; advance online publication, December 19, 2011; 10.1038/labinvest.2011.195 Abstract | Full Text Advertisement Ensure your access If you are unable to access the articles in this alert, your library may not subscribe to this journal. Our online recommendation form is a simple way to make your librarian aware that this journal is valuable to your research. Recommend now!   Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to Laboratory Investigation. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. 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