EMBO Reports - Table of Contents alert Volume 13 Issue 2, pp 91 - 169

TABLE OF CONTENTS February 2012 | Volume 13, Issue 2 Upfront Science & Society Reviews Scientific Reports Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Upfront Top Editorial All Chinese to me English is nowadays the universal language of science. Howy argues that, to maximize their career prospects, prospective science students worldwide could benefit from English-language immersion schooling from a young age. Howy Jacobs EMBO reports (2012), 13, 91; 10.1038/embor.2011.250 Abstract | Full text | PDF Published online: 01 February 2012 Subject Categories: Scientific Training & Careers Opinion Synthetic biology's flywheel Producing drugs and chemicals efficiently from cells remains a major challenge. Synthetic biologists need to invent the equivalents of the crank and flywheel to improve productivity. Antoine Danchin EMBO reports (2012), 13, 92; 10.1038/embor.2011.253 Abstract | Full text | PDF Published online: 06 January 2012 Subject Categories: Genetically Modified Organisms | Technology, Development & Applications Hot off the Press Neutrophils—the unexpected helpers of B-cell activation A specific subpopulation of neutrophils, termed NBH, has been shown recently to provide help for the differentiation and function of B cells and plasma cells. These novel findings are put in the context of our current understanding of B-cell help. Naomi E Harwood, Patricia Barral and Facundo D Batista EMBO reports (2012), 13, 93 - 94; 10.1038/embor.2011.259 Abstract | Full text | PDF Published online: 13 January 2012 Subject Categories: Immunology Science & Society Top Inside an unquiet mind Both art and science have the power to challenge preconceptions. Neuroscientists, healthcare professionals and service users came together in 2011 to dramatize the scientific and societal issues surrounding mental ill health. Hanna M Critchlow, Paul Herrington and Simon Gunton EMBO reports (2012), 13, 95 - 99; 10.1038/embor.2011.255 Abstract | Full text | PDF Published online: 13 January 2012 Subject Categories: Health & Disease | Societal Issues & Politics The anglerfish deception A recent proposal to reform the EU's policy on the use of genetically modified crops looks good at first sight, but there are dangers for science lurking in the background. Fern Wickson and Brian Wynne EMBO reports (2012), 13, 100 - 105; 10.1038/embor.2011.254 Abstract | Full text | PDF Published online: 13 January 2012 Subject Categories: Genetically Modified Organisms | Societal Issues & Politics Emerging journals Emerging countries have established national scientific journals as an alternative publication route for their researchers. However, these journals eventually need to catch up to international standards. Rogerio Meneghini EMBO reports (2012), 13, 106 - 108; 10.1038/embor.2011.252 Abstract | Full text | PDF Published online: 13 January 2012 Subject Categories: Science Infrastructures & Publishing Research and practice coming together Clinical research and clinical practice have been separated for too long. They need to be brought together again to improve health care and better benefit patients. Philip Hunter EMBO reports (2012), 13, 109 - 112; 10.1038/embor.2011.258 Abstract | Full text | PDF Published online: 13 January 2012 Subject Categories: Health & Disease | Technology, Development & Applications Reviews Top Regulation and function of innate and adaptive interleukin-17-producing cells IL-17-mediated immunity is key for mucosal host defence against a range of pathogens, but can also elicit or aggravate autoimmune and cardiovascular disease, as well as affect tumour formation. The regulation and function of such versatile cells is discussed here. Keiji Hirota, Helena Ahlfors, João H Duarte and Brigitta Stockinger EMBO reports (2012), 13, 113 - 120; 10.1038/embor.2011.248 Abstract | Full text | PDF Published online: 23 December 2011 Subject Categories: Immunology Regulation of TOR by small GTPases Duran and Hall discuss here recent findings on the regulation of mTOR. They specifically focus on the role of small GTPases in this process and how their activity is modulated by a variety of upstream signals that are integrated into a single pathway through mTOR regulation. Raúl V Durán and Michael N Hall EMBO reports (2012), 13, 121 - 128; 10.1038/embor.2011.257 Abstract | Full text | PDF Published online: 13 January 2012 Subject Categories: Cellular Metabolism | Signal Transduction Scientific Reports Top Xenopus paraxial protocadherin inhibits Wnt/β-catenin signalling via casein kinase 2β Paraxial protocadherin (PAPC) is a known cell adhesion molecule that also activates the Wnt/PCP pathway. Steinbeisser and colleagues show here that PAPC not only activates the non-canonical Wnt/PCP pathway but, at the same time, also inhibits the canonical Wnt/beta-catenin pathway through interaction with casein kinase 2. Anja Kietzmann, Yingqun Wang, Dominik Weber and Herbert Steinbeisser EMBO reports (2012), 13, 129 - 134; 10.1038/embor.2011.240 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 23 December 2011 Subject Categories: Signal Transduction | Development ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair PALB2 recruitment to DNA lesions is crucial for BRCA-complex-mediated DNA repair. In this report, Esashi and collaborators show that, in addition to its DNA-binding motifs, PALB2 requires a nucleosome-binding domain called ChAM for proper localization at DNA damage foci and promotion of DNA repair. Jean-Yves Bleuyard, Rémi Buisson, Jean-Yves Masson and Fumiko Esashi EMBO reports (2012), 13, 135 - 141; 10.1038/embor.2011.243 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 23 December 2011 Subject Categories: Genome Stability & Dynamics Histone deacetylase 1 enhances microRNA processing via deacetylation of DGCR8 HDACs are known to control gene expression via promoter histone deacetylation. Furukawa and colleagues now show that, in addition to this role, HDAC1 enhances microRNA production by acetylation of DGCR8, one of the components of the Microprocessor complex that is involved in the early steps of microRNA biogenesis. Taeko Wada, Jiro Kikuchi and Yusuke Furukawa EMBO reports (2012), 13, 142 - 149; 10.1038/embor.2011.247 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 06 January 2012 Subject Categories: RNA Assurance of mitochondrial integrity and mammalian longevity by the p62–Keap1–Nrf2–Nqo1 cascade p62 is a known component of the autophagy machinery in vertebrates. This Scientific Report shows how p62 is also involved in maintaining mitochondrial integrity and, as a consequence, prevents ageing through reduction of excess reactive oxygen species. Jeongho Kwon, Eunhye Han, Chi-Bao Bui, Woochul Shin, Junho Lee, Sejeong Lee, Young-Bong Choi, Ann-Hwee Lee, Kyong-Hoon Lee, Chankyu Park, Martin S Obin, Sung Kyu Park, Yun Jeong Seo, Goo Taeg Oh, Han-Woong Lee and Jaekyoon Shin EMBO reports (2012), 13, 150 - 156; 10.1038/embor.2011.246 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 06 January 2012 Subject Categories: Cellular Metabolism Synergism between altered cortical polarity and the PI3K/TOR pathway in the suppression of tumour growth An unexpected crosstalk is revealed between the growth-promoting PI3K/TOR pathway and cell polarity in the suppression of tumour formation in neural stem cells. The combination of pins loss-of-function and dietary restriction, PI3K mutation or TOR inhibition induces tumorigenesis in Drosophila larval brains. Fabrizio Rossi and Cayetano Gonzalez EMBO reports (2012), 13, 157 - 162; 10.1038/embor.2011.230 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 16 December 2011 Subject Categories: Cell Cycle | Development | Molecular Biology of Disease Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1 NORE1 induces ubiquitin-mediated degradation of oncoprotein HIPK1 by facilitating its interaction with Mdm2. Depletion of HIPK1 in NORE1-silenced lung adenocarcinoma cells inhibits tumour formation in vivo, suggesting this pathway has a major impact in tumorigenesis. Deresa Lee, Sang-Joon Park, Ki Sa Sung, Jikyoung Park, Sean Bong Lee, Sang-Yoon Park, Hyo Jeong Lee, Jang-Won Ahn, So Jung Choi, Seok-Geun Lee, Sung-Hoon Kim, Duk-Hwan Kim, Jhingook Kim, Yongsok Kim and Cheol Yong Choi EMBO reports (2012), 13, 163 - 169; 10.1038/embor.2011.235 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 16 December 2011 Subject Categories: Proteins | Molecular Biology of Disease Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to EMBO reports. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. 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