Nature Reviews Neuroscience contents February 2012 Volume 13 Number 2 pp 71-145

TABLE OF CONTENTS
February 2012 Volume 13 Number 2
Impact Factor 29.51 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Spectral fingerprints of large-scale neuronal interactions Markus Siegel, Tobias H. Donner & Andreas K. Engel
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RESEARCH HIGHLIGHTS Top Neurodegenerative disease: Preventing 'SIRTain' death by mutant huntingtin p71 | doi:10.1038/nrn3182 Two independent studies link mutant huntingtin to inactivation of the deacetylase enzyme SIRT1 and highlight a neuroprotective role for SIRT1 in mouse models of Huntington's disease. PDF Neuronal circuits: The sound of fear p72 | doi:10.1038/nrn3172 A disinhibitory circuit in the mouse auditory cortex mediates fear conditioning to sounds. PDF Synaptic plasticity: Ubiquitin activates synaptic plasticity p73 | doi:10.1038/nrn3175 NEURL1A-mediated ubiquitylation of CPEB3 alters its activity and regulates hippocampal synaptic plasticity and memory formation. PDF Psychiatric disorders: Why two is better than one p73 | doi:10.1038/nrn3181 The antidepressant fluoxetine increases synaptic plasticity in the amygdala and thereby facilitates fear erasure through extinction. PDF Sensory transduction: How TRPs discriminate between different stimuli p74 | doi:10.1038/nrn3173 Localized expression of different TRP channel isoforms determines behavioural outcomes to different stimuli. PDF Neuroimmunology: Interferon-γ tunes the rhythm p74 | doi:10.1038/nrn3177 Two immune-related molecules regulate network rhythmicity by controlling GABA transmission. PDF Neural development: Clustering connections p74 | doi:10.1038/nrn3187 Repetitive spontaneous activity in developing neural networks causes spatiotemporal clustering of functional synapses on dendrites. PDF IN BRIEF Neural development: Epigenetic regulation of asymmetry | Learning and memory: Becoming a habit: a role for NMDA receptors | Social neuroscience: Oxytocin boosts social awareness | Neural development: Emergence of patterned activity in the motor system | Brain evolution: MicroRNAs: big influence in brain evolution | Ion channels: Optogenetics gets selective! | Neuronal circuits: Mapping the local field potential PDF Neuroscience JOBS of the week Lecturer / Senior Lecturer in Multimodal Communication UCL Psychology & Language Sciences Cognitive, Perceptual and Brain Sciences Research Group Leader in Neuroimmunology / Neurodegeneration University of Freiburg. Dpt. of Neuropathology Principal Scientist, Cellular Neurobiology Biopharmaceutical Company Postdoctoral Fellow (Brain Development & Plasticity) Mount Sinai School of Medicine research associate University of Pennsylvania More Science jobs from Neuroscience EVENT The Traumatic Brain Injury Conference 06.-07.03.12 Washington DC, US More science events from
REVIEWS		Top
Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration Zu-Hang Sheng & Qian Cai p77 | doi:10.1038/nrn3156 The distribution of mitochondria to regions of the neuron that have the greatest requirement for ATP supply maintenance and sequestration of Ca2+ is essential for neuronal function. Sheng and Cai describe the molecular mechanisms regulating mitochondrial transport in neurons and discuss its contribution to aspects of neuronal function. Abstract | Full Text | PDF | Supplementary information
Activity-dependent neurotransmitter respecification Nicholas C. Spitzer p94 | doi:10.1038/nrn3154 The neurotransmitters expressed by neurons were thought to be fixed, but recent evidence suggests that during development, and also in the mature nervous system, neurotransmitter expression can be respecified by activity. This respecification seems to have a homeostatic role at synapses and influences behaviour. Abstract | Full Text | PDF
Interneuron dysfunction in psychiatric disorders Oscar Marín p107 | doi:10.1038/nrn3155 The notion that the disruption of inhibitory circuits might underlie certain clinical features — notably cognitive impairment — in various neuropsychiatric disorders, including schizophrenia and autism, is receiving considerable attention. Focusing heavily on studies in animal models, Oscar Marín reviews the evidence indicating that the basis of such disruption is linked to specific defects in interneuron development and function. Abstract | Full Text | PDF
Spectral fingerprints of large-scale neuronal interactions Markus Siegel, Tobias H. Donner & Andreas K. Engel p121 | doi:10.1038/nrn3137 Cognition results from large-scale interactions among widely distributed brain regions. Siegel and colleagues review studies showing that these interactions are reflected by correlated neuronal oscillations. They propose that correlated oscillations in large-scale cortical networks may be 'fingerprints' of canonical neuronal computations underlying cognitive processes. Abstract | Full Text | PDF
PERSPECTIVES		Top
Computational neuroanatomy of speech production Gregory Hickok p135 | doi:10.1038/nrn3158 The study of speech production has largely been divided into investigations of lower-level articulatory motor control and of higher-level linguistic processing, with these research traditions rarely interacting. In this Opinion article, Hickok argues that these approaches have much to offer each other, and he presents a model of speech production that incorporates ideas from both research traditions and findings from neuroscientific studies of sensorimotor integration. Abstract | Full Text | PDF
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