Nature Reviews Molecular Cell Biology contents February 2012 Volume 13 Number 2 pp61-133

TABLE OF CONTENTS
February 2012 Volume 13 Number 2
Impact Factor 38.65 *	In this issue Research Highlights Progress Reviews Perspectives Also this month Article series: Post-translational modifications  Featured article: Dynamin, a membrane-remodelling GTPase Shawn M. Ferguson & Pietro De Camilli
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RESEARCH HIGHLIGHTS Top Stem cells: Self-help in the niche p61 | doi:10.1038/nrm3279 Cues from differentiating blood progenitors and the niche can collaborate. PDF Post-translational modification: Inactivating PTP1B upon ER stress p62 | doi:10.1038/nrm3269 Sulphydration inhibits the phosphatase activity of PTP1B in response to ER stress. PDF Stem cells: Making fat p62 | doi:10.1038/nrm3273 Human pluripotent stem cells are efficiently reprogrammed to white and brown adipocytes. PDF IN THE NEWS Monkeys show the way p62 | doi:10.1038/nrm3278 PDF Ubiquitylation: DUBs' key to selectivity p64 | doi:10.1038/nrm3268 A UBD containing ankyrin repeats determines the linkage specificity of TRABID. PDF Cell cycle: AMPK moonlights in mitosis p64 | doi:10.1038/nrm3275 Identifies novel AMPKα2 substrates with roles in mitosis. PDF RNA decay: Remember your driver p65 | doi:10.1038/nrm3271 The stability of mRNA can be regulated by the promoter from which it was transcribed. PDF Post-translational modification: A monoubiquitylation pore anchor p66 | doi:10.1038/nrm3276 Monoubiquitylation of Nup159 recruits dynein and regulates cell division. PDF JOURNAL CLUB How a paper on RAC set the standard p66 | doi:10.1038/nrm3277 An exemplary paper changed the actin field for better and for worse. PDF IN BRIEF Cytoskeleton: Making multiple cilia | Cell signalling: A Hippo signal for anoikis | Membrane trafficking: From mitochondria to lysosomes PDF Molecular Cell Biology JOBS of the week PhD Students in Molecular Medicine Laboratory for Molecular Infection Medicine Sweden (MIMS) / Nordic EMBL Partnership PhD Students in Molecular Medicine Institute for Molecular Medicine Finland (FIMM) / Nordic EMBL Partnership Post Doctor Fellow Ming Zhan Associate Microbiologist Kelly Scientific Resources Postdoctoral Research Fellow University of Utah More Science jobs from Molecular Cell Biology EVENT Protein-RNA Interactions in Biology and Disease (C1) 04.-09.03.12 US More science events from
PROGRESS		Top
Illuminating the functional and structural repertoire of human TBC/RABGAPs Marieke A. M. Frasa, Katja T. Koessmeier, M. Reza Ahmadian & Vania M. M. Braga p67 | doi:10.1038/nrm3267 TBC/RABGAPs are negative regulators of RABs that carry a conserved TBC domain. In addition to their roles in intracellular trafficking, they have recently emerged as integrators of signalling between RABs and other small GTPases, and they are frequently dysregulated in disease. Abstract | Full Text | PDF | Supplementary information
REVIEWS		Top
Dynamin, a membrane-remodelling GTPase Shawn M. Ferguson & Pietro De Camilli p75 | doi:10.1038/nrm3266 The dynamin GTPase mediates membrane remodelling during endocytosis. Through complementary approaches, including structural and genetic studies, the mechanisms by which dynamin regulates membrane fission events, and the unique physiological roles of its three isoforms, are becoming clear. Abstract | Full Text | PDF | Supplementary information
The unfolded protein response: controlling cell fate decisions under ER stress and beyond Claudio Hetz p89 | doi:10.1038/nrm3270 The unfolded protein response (UPR) buffers protein-folding stress at the endoplasmic reticulum (ER). Research has provided insight into the regulatory mechanisms of UPR branches initiated by the stress sensors protein kinase RNA-like ER kinase (PERK), inositol-requiring protein 1α (IRE1α) and activating transcription factor 6 (ATF6), and into outcomes of the UPR that are not directly related to protein misfolding. Abstract | Full Text | PDF
A family business: stem cell progeny join the niche to regulate homeostasis Ya-Chieh Hsu & Elaine Fuchs p103 | doi:10.1038/nrm3272 Stem cells reside in discrete microenvironments called niches, which regulate stem cell activity. The stem cell progeny appear to constitute an indispensable component of the niche in a wide range of stem cell systems. These unexpected niche inhabitants provide versatile feedback signals to their parent stem cells. Abstract | Full Text | PDF
Article series: Post-translational modifications Understanding the language of Lys36 methylation at histone H3 Eric J. Wagner & Phillip B. Carpenter p115 | doi:10.1038/nrm3274 Methylation of Lys36 at histone H3 is important for transcription and has also been implicated in diverse processes, including splicing and DNA replication and repair. Understanding the dynamic control of this modification is crucial for understanding the numerous diseases that its dysfunction are linked with. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Satellite cells, the engines of muscle repair Yu Xin Wang & Michael A. Rudnicki p127 | doi:10.1038/nrm3265 Satellite cells are a heterogeneous population of stem and progenitor cells with crucial roles in muscle repair and regeneration. Although paired-box 7 (PAX7) is necessary to maintain the undifferentiated stem cell state, a requirement for PAX7 in adult satellite cells was recently challenged and remains controversial. Abstract | Full Text | PDF
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