Nature Reviews Immunology Contents February 2012 Volume 12 Number 2 pp 73-148

TABLE OF CONTENTS
February 2012 Volume 12 Number 2
Impact Factor 35.196 *	In this issue Research Highlights Reviews Also this month  Featured article: How do plants achieve immunity? Defence without specialized immune cells Steven H. Spoel & Xinnian Dong
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RESEARCH HIGHLIGHTS Top Antibody responses: Neutrophils zone in to help B cells p73 | doi:10.1038/nri3159 Marginal zone neutrophils provide help for T cell-independent antibody responses. PDF Trafficking: Effector T cells cross the line p74 | doi:10.1038/nri3153 Intraendothelial chemokine-containing vesicles promote transendothelial T cell migration. PDF T cells: The TFH-like transition of TH1 cells p74 | doi:10.1038/nri3161 Developing TH1 cells pass through a transitional TH1–TFH cell stage. PDF Mucosal immunology: Multifunctional gut IgA+ plasma cells p75 | doi:10.1038/nri3157 IgA+ plasma cells in the gut acquire novel effector mechanisms to maintain homeostasis. PDF Viral immunity: Lose TRAF1, lose control p76 | doi:10.1038/nri3160 Loss of TRAF1 expression associates with T cell dysfunction in chronic infection. PDF Immunometabolism: IL-15 provides breathing space for memory p76 | doi:10.1038/nri3162 IL-15 increases mitochondrial biogenesis and spare respiratory capacity in memory T cells. PDF Autoimmunity: Interfering with brain inflammation p77 | doi:10.1038/nri3154 A potential new strategy to improve the therapeutic efficacy of targeting the type I IFN pathway in multiple sclerosis. PDF IN BRIEF Innate immunity: Phagocytes come back even stronger | B cells: Protective role of innate-like B cells in sepsis | Macrophages: Linking lysosome function to macrophage homeostasis PDF Immunology JOBS of the week Postdoctoral Fellow – Noncoding RNA control of inflammation and cancer City of Hope Beckman Research Institute Postdoctoral Research Fellow Ragon Institute of MGH, MIT and Harvard Associate Director- Internal Medicine (Immunology) Kelly Scientific Resources PhD position in Neuro-immune modulation in humans University of Leuven Macromolecular structural biology and immunology postdoc positions Harbin Institute of Technology More Science jobs from Immunology EVENT Gene Expression and Signaling in the Immune System 24.-28.04.12 US More science events from
REVIEWS		Top
Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways Edward S. Mocarski, Jason W. Upton & William J. Kaiser p79 | doi:10.1038/nri3131 Programmed cell death of infected host cells builds up the first line of defence against viruses. Here, Mocarski and colleagues describe the tight regulation of caspase 8-dependent apoptosis and programmed necrosis and discuss how viral inhibitors of cell death may have contributed to the evolution of programmed necrosis to promote host survival. Abstract | Full Text | PDF
How do plants achieve immunity? Defence without specialized immune cells Steven H. Spoel & Xinnian Dong p89 | doi:10.1038/nri3141 This Review article looks at how the features of vertebrate adaptive immunity — specificity, self-tolerance and memory — can be achieved in plants through different immune strategies. Abstract | Full Text | PDF
Transcriptional programming of the dendritic cell network Gabrielle T. Belz & Stephen L. Nutt p101 | doi:10.1038/nri3149 The dendritic cell (DC) network consists of several DC subsets with distinct functions. Here, Gabrielle Belz and Stephen Nutt focus on transcription factors that regulate DC lineage specification in response to developmental and environmental cues. Abstract | Full Text | PDF
Early immune events in the induction of allergic contact dermatitis Daniel H. Kaplan, Botond Z. Igyártó & Anthony A. Gaspari p114 | doi:10.1038/nri3150 Allergic contact dermatitis is a common skin disease that is driven by an inappropriate immune response to innocuous environmental antigens. This Review focuses on how the early immune mechanisms that are triggered in response to contact allergens promote subsequent disease development. Abstract | Full Text | PDF
Immunomodulatory functions of type I interferons José M. González-Navajas, Jongdae Lee, Michael David & Eyal Raz p125 | doi:10.1038/nri3133 Type I interferons (IFNs) have become synonymous with antiviral immunity. But, as discussed in this Review, type I IFNs also have roles in bacterial infections, in intestinal homeostasis and in inflammatory and autoimmune diseases. Abstract | Full Text | PDF
Expanding roles for CD4+ T cells in immunity to viruses Susan L. Swain, K. Kai McKinstry & Tara M. Strutt p136 | doi:10.1038/nri3152 Immunity to viruses is typically associated with the development of cytotoxic CD8+ T cells. However, CD4+ T cells are also important for protection during viral infection. Here, the authors describe the various ways in which different CD4+ T cell subsets can contribute to the antiviral immune response. Abstract | Full Text | PDF
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