Nature Immunology Contents: February 2012 Volume 13 pp 103 - 196

Advertisement Complimentary PI3 Kinase Pathway Poster Rockland antibodies and assays for Cancer, Cell Biology, Cell Signaling and Neuroscience research are guaranteed to give predictable, repeatable results. Protect your experiments with Rockland antibodies. Compromise elsewhere. Click here to register for a free PI3 Kinase Pathway Poster and visit our redesigned, content-rich website at www.rockland-inc.com TABLE OF CONTENTS February 2012 Volume 13, Issue 2 Obituary Commentary News and Views Research Highlights Review Articles Corrigenda Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement NATURE REVIEWS IMMUNOLOGY CALENDAR 2012 In celebration of our 10th anniversary, Nature Reviews Immunology is delighted to bring you a FREE calendar for 2012. www.nature.com/nri/calendars/2012 Happy New Year to all our readers! See also our 10th anniversary VIEWPOINT and CROSSWORD Sponsored by: eBioscience   Obituary Top Lloyd John Old 1933-2011 p103 Mark J Smyth doi:10.1038/ni.2209 Full Text | PDF Commentary Top Writing a first grant proposal pp105 - 108 Julian G Cambronero, Lee-Ann H Allen, Martha K Cathcart, Louis B Justement, Elizabeth J Kovacs, Kenneth R McLeish and William M Nauseef doi:10.1038/ni.2183 A workshop organized by the Society for Leukocyte Biology offered advice to young scientists on how to decipher the grant-submission process of the US National Institutes of Health and compose a clear, compelling and fundable grant. Full Text | PDF News and Views Top Immuno-waste exposure and further management pp109 - 111 Robbert M Spaapen and Jacques Neefjes doi:10.1038/ni.2204 Since the definition of an immunoselective proteasome, the 'immunoproteasome', its function has been heavily disputed. A mouse with complete deficiency in immunoproteasomes has resolved one issue of the adaptation of the immune system to the proteasome but has raised other questions. Full Text | PDF See also: Article by Kincaid et al. A helping hand from neutrophils in T cell-independent antibody responses? pp111 - 113 Stuart G Tangye and Robert Brink doi:10.1038/ni.2214 Neutrophils and B cells are thought to specialize in driving innate and adaptive immune responses to infection. New data suggest that these cells may also communicate in the splenic marginal zone to drive T cell-independent antibody responses. Full Text | PDF See also: Article by Puga et al. A new therapeutic strategy for malaria: targeting T cell exhaustion pp113 - 115 Gordon J Freeman and Arlene H Sharpe doi:10.1038/ni.2211 Boosting immune responses during malaria remains a challenge. Overcoming T cell exhaustion by blocking coinhibitory receptors offers a promising lead. Full Text | PDF See also: Article by Butler et al. Cellular teamwork in antibacterial innate immunity pp115 - 117 Janelle S Ayres and Russell E Vance doi:10.1038/ni.2212 IFN-γ is a cytokine that is critical for defense against intracellular bacterial pathogens. New work provides evidence that the recognition of bacterial flagellin by the NLRC4 inflammasome in splenic dendritic cells triggers rapid release of IL-18, which leads to IFN-γ production by memory CD8+ T cells. Full Text | PDF See also: Article by Kupz et al. You AhR what you eat? pp117 - 119 B Paige Lawrence and David H Sherr doi:10.1038/ni.2213 AhR is more than just a receptor for pollutants. Studies have now identified crucial roles for this environment-sensing transcription factor in the development and maintenance of gut-associated lymphoid tissues. Full Text | PDF See also: Article by Lee et al. Immunology JOBS of the week Postdoc University of Pittsburgh Postdoctoral Fellow University of Colorado AMC Postdoc position University Hospital Jena, Department of Immunology Sr. Research Associcate - Infectious Disease Genentech Endowed Chair - Immunology of Infectious Diseases Vanderbilt University More Science jobs from Immunology EVENT Gene Expression and Signaling in the Immune System 24th April - 28th April 2012 US More science events from Research Highlights Top Spicing up immunity | T cell timing | Asymmetric division | Erythropoiesis regulator | Inhibiting ubiquitin sensing | Sec22b in cross-presentation Review Top How the TCR balances sensitivity and specificity for the recognition of self and pathogens pp121 - 128 Gerald P Morris and Paul M Allen doi:10.1038/ni.2190 Abstract | Full Text | PDF Articles Top Mice completely lacking immunoproteasomes show major changes in antigen presentation pp129 - 135 Eleanor Z Kincaid, Jenny W Che, Ian York, Hernando Escobar, Eduardo Reyes-Vargas, Julio C Delgado, Raymond M Welsh, Margaret L Karow, Andrew J Murphy, David M Valenzuela, George D Yancopoulos and Kenneth L Rock doi:10.1038/ni.2203 Immunoproteasomes incorporate three alternative β subunits that catalyze peptide cleavage. Rock and colleagues generate mice lacking all three immunoproteasome-specific subunits and reveal marked differences in MHC class I presentation and CD8+ T cell responses. Abstract | Full Text | PDF See also: News and Views by Spaapen & Neefjes The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques pp136 - 143 Janine M van Gils, Merran C Derby, Luciana R Fernandes, Bhama Ramkhelawon, Tathagat D Ray, Katey J Rayner, Sajesh Parathath, Emilie Distel, Jessica L Feig, Jacqueline I Alvarez-Leite, Alistair J Rayner, Thomas O McDonald, Kevin D O'Brien, Lynda M Stuart, Edward A Fisher, Adam Lacy-Hulbert and Kathryn J Moore doi:10.1038/ni.2205 Lipid-engorged macrophages accumulate in atherosclerotic plaques where chronic inflammation ensues. Moore and colleagues show that macrophage migration to chemokines and egress is arrested by netrin-1, which is secreted in the plaque lesions. Abstract | Full Text | PDF AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch pp144 - 151 Jacob S Lee, Marina Cella, Keely G McDonald, Cecilia Garlanda, Gregory D Kennedy, Manabu Nukaya, Alberto Mantovani, Raphael Kopan, Christopher A Bradfield, Rodney D Newberry and Marco Colonna doi:10.1038/ni.2187 The generation of certain gut innate lymphoid cell (ILC) populations requires the aryl hydrocarbon receptor (AHR). Colonna and colleagues show that the induction of Notch expression by AHR is required for the development of interleukin 22-producing NKp46+ ILCs. Abstract | Full Text | PDF See also: News and Views by Lawrence & Sherr Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation pp152 - 161 Gonghua Huang, Yanyan Wang, Peter Vogel, Thirumala-Devi Kanneganti, Kinya Otsu and Hongbo Chi doi:10.1038/ni.2207 How signals derived from dendritic cells regulate T cell lineage fate remains unclear. Chi and colleagues identify p38α in dendritic cells as a central integrator of instructive signals for TH17 differentiation. Abstract | Full Text | PDF NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8+ T cells pp162 - 169 Andreas Kupz, Greta Guarda, Thomas Gebhardt, Leif E Sander, Kirsty R Short, Dimitri A Diavatopoulos, Odilia L C Wijburg, Hanwei Cao, Jason C Waithman, Weisan Chen, Daniel Fernandez-Ruiz, Paul G Whitney, William R Heath, Roy Curtiss III, Jürg Tschopp, Richard A Strugnell and Sammy Bedoui doi:10.1038/ni.2195 Noncognate CD8+ memory T cells can be rapidly activated by bacteria. Bedoui and colleagues show that this process is specifically dependent on recognition by and activation of the NLRC4 inflammasome. Abstract | Full Text | PDF See also: News and Views by Ayres & Vance B cell-helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen pp170 - 180 Irene Puga, Montserrat Cols, Carolina M Barra, Bing He, Linda Cassis, Maurizio Gentile, Laura Comerma, Alejo Chorny, Meimei Shan, Weifeng Xu, Giuliana Magri, Daniel M Knowles, Wayne Tam, April Chiu, James B Bussel, Sergi Serrano, José Antonio Lorente, Beatriz Bellosillo, Josep Lloreta, Nuria Juanpere, Francesc Alameda, Teresa Baró, Cristina Diaz de Heredia, Núria Torán, Albert Català, Montserrat Torrebadell, Claudia Fortuny, Victoria Cusí, Carmen Carreras, George A Diaz, J Magarian Blander, Claire-Michele Farber, Guido Silvestri, Charlotte Cunningham-Rundles, Michaela Calvillo, Carlo Dufour, Lucia Dora Notarangelo, Vassilios Lougaris, Alessandro Plebani, Jean-Laurent Casanova, Stephanie C Ganal, Andreas Diefenbach, Juan Ignacio Aróstegui, Manel Juan, Jordi Yagüe, Nizar Mahlaoui, Jean Donadieu, Kang Chen and Andrea Cerutti doi:10.1038/ni.2194 Follicular T cells provide help to B cells to elicit antibody responses. Cerutti and colleagues show that neutrophils provide help to marginal-zone B cells that produce T cell-independent antibodies. Abstract | Full Text | PDF See also: News and Views by Tangye & Brink The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor pp181 - 187 Aikaterini S Papadopoulou, James Dooley, Michelle A Linterman, Wim Pierson, Olga Ucar, Bruno Kyewski, Saulius Zuklys, Georg A Hollander, Patrick Matthys, Daniel H D Gray, Bart De Strooper and Adrian Liston doi:10.1038/ni.2193 Interferon-α is a critical mediator of pathogen-induced thymic involution. Liston and colleagues show that the microRNA miR-29a reduces sensitivity of thymic epithelium to infection signals and protects against thymus involution. Abstract | Full Text | PDF Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection pp188 - 195 Noah S Butler, Jacqueline Moebius, Lecia L Pewe, Boubacar Traore, Ogobara K Doumbo, Lorraine T Tygrett, Thomas J Waldschmidt, Peter D Crompton and John T Harty doi:10.1038/ni.2180 Chronically infected mice upregulate expression of inhibitory molecules on exhausted T cells. Harty and colleagues report similar findings in human patients with malaria and show that blockade of the inhibitory receptors PD-L1 and LAG-3 restores antimalaria responses in mice. Abstract | Full Text | PDF See also: News and Views by Freeman & Sharpe Corrigenda Top Corrigendum: Endocytosed BCRs sequentially regulate MAPK and Akt signaling pathways from intracellular compartments p196 Akanksha Chaturvedi, Rebecca Martz, David Dorward, Michael Waisberg and Susan K Pierce doi:10.1038/ni0212-196a Full Text | PDF Corrigendum: The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells p196 Zhiqiang Zhang, Bin Yuan, Musheng Bao, Ning Lu, Taeil Kim and Yong-Jun Liu doi:10.1038/ni0212-196b Full Text | PDF Corrigendum: STING-dependent signaling p196 Glen N Barber doi:10.1038/ni0212-196c Full Text | PDF Top Advertisement Dermatogenetics February 9-12, 2012 - Miami, FL, USA The conference will cover: genetic variation, gene expression and cellular mechanisms in this shared area of exceptional interest to basic researchers, biopharma and translational medicine. 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