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| | | | | The Amazon basin in transition | The ecology of vast forest–river system of the Amazon basin is changing more rapidly than ever as a result of human activity. The indications are that the Amazon may even be transitioning from a net carbon sink to a net carbon source. | | | | | | | | | | | | Kimberlite ascent by assimilation-fuelled buoyancy | Diamond-bearing kimberlites, volcanic rocks beneath the oldest portions of the Earth's crust, can rise rapidly to the Earth's surface. A novel explanation for how this might occur is presented here, involving foaming magma produced by carbon dioxide release. | | | | | | | | | | | | | | Nature Reviews Neuroscience FOCUS ON ADDICTION Read for FREE online at: www.nature.com/nrn/focus/addiction Produced with support from National Institute on Drug Abuse (NIDA) and National Institute on Alcohol Abuse and Alcoholism (NIAAA) National Institutes of Health U.S. Department of Health & Human Services | | | | | | | | | | | | | | | In this week's podcast: the changing face of the Amazon, the genetics of staying sharp as you age and crowd-sourced funding. Plus, the best of the rest from this week's Nature. | | | | | | | Specials - Insight: Frontiers in biology | | | | Five reviews in this issue discuss the role of innate immune signalling in tissue homeostasis and the response to infection, how understanding the DNA damage response has guided the development of inhibitors and helped to establish new principles for treating cancer, the therapeutic potential of patient-derived pluripotent stem cells, the forces that govern tumour evolution and the impact of mouse genetics on the study of bone physiology. ▼ more | | | | | | |
| | | | | | | | | | | | | | | | | Antarctic Treaty is cold comfort ▶ | | | Researchers need to cement the bond between science and the South Pole if the region is to remain one of peace and collaboration. | | | | | | | | Face up to fraud ▶ | | | The UK government and funding agencies must address research misconduct. | | | | | | | | Cap in hand ▶ | | | A word to the wise on getting that much-needed research funding. | | | | | | | | | | | | | | | | | Seven days: 13–19 January 2012 ▶ | | | The week in science: US authorities crack down on plagiarism; failed Mars probe splashes down in the Pacific; and chemical firm BASF shifts its transgenic plant operations out of Europe. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Preventing pandemics: The fight over flu ▶ | | | A proposal to restrict the planned publication of research on a potentially deadly avian influenza virus is causing a furore. Ten experts suggest ways to proceed. | | | | | | | | | | | | | | | | | Fiction: Cosmic creation ▶ | | | Pedro Ferreira explores Alan Lightman's latest novel — a magical-reality take on the origins of the Universe. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Frontiers in biology ▶ | | | Alex Eccleston, Angela Eggleston, Marie-Thérèse Heemels, Barbara Marte & Ursula Weiss | | | | | | | | | | | | | | | | | | | | | | | | |
| | | | | | | Don't miss out on $3 million in research funding seeking immediate proposals for projects focused on modulation of: •B cells •Glial cells, including microglia, macrophages, astrocytes •CNS ion channels, exchangers, transporters Apply TODAY at www.FastForward.org Deadline 05/01/12 | | | | | | | | |
| | | | | | | | | | | | | | | | | | | DNA breaks and chromosome pulverization from errors in mitosis ▶ | | | Karen Crasta, Neil J. Ganem, Regina Dagher, Alexandra B. Lantermann, Elena V. Ivanova et al. | | | Chromosomes within micronuclei are shown to be damaged during S phase and become highly fragmented, and the damaged pieces can be reincorporated into the genome. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | A novel retinoblastoma therapy from genomic and epigenetic analyses ▶ | | | Jinghui Zhang, Claudia A. Benavente, Justina McEvoy, Jacqueline Flores-Otero, Li Ding et al. | | | The retinoblastoma genome is shown to be stable, but multiple cancer pathways are identified that are epigenetically deregulated, providing potential new therapeutic targets. | | | | | | | | Structure of HDAC3 bound to co-repressor and inositol tetraphosphate ▶ | | | Peter J. Watson, Louise Fairall, Guilherme M. Santos & John W. R. Schwabe | | | The crystal structure of histone deacetylase HDAC3 bound to the co-repressor SMRT is reported, and suggests that inositol tetraphosphate could act as a regulator of HDAC3; this has therapeutic implications, because HDACs are emerging targets of anti-cancer drugs. | | | | | | | | Recovery rates reflect distance to a tipping point in a living system ▶ | | | Annelies J. Veraart, Elisabeth J. Faassen, Vasilis Dakos, Egbert H. van Nes, Miquel Lürling et al. | | | Decreased rates of recovery from perturbations, or critical slowing down, are demonstrated in a living system, indicating that recovery rates can be used to probe the resilience of complex systems. | | | | | | | | | | | Global landscape of HIV–human protein complexes ▶ | | | Stefanie Jäger, Peter Cimermancic, Natali Gulbahce, Jeffrey R. Johnson, Kathryn E. McGovern et al. | | | Affinity tagging, mass spectroscopy and a tailor-made scoring system are used to identify 497 high-confidence interactions between human proteins and human immunodeficiency virus proteins. | | | | | | | | Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection ▶ | | | Stefanie Jäger, Dong Young Kim, Judd F. Hultquist, Keisuke Shindo, Rebecca S. LaRue et al. | | | The transcription cofactor CBF-β is shown to regulate the ability of HIV-1 to evade host restriction mediated by the deaminase APOBEC3; it acts by interacting with the HIV protein Vif, so disrupting the Vif–CBF-β interaction could provide a new therapeutic target against HIV-1 infection. | | | | | | | | | | | | | | | | | | | | | | | | | | The Amazon basin in transition ▶ | | | Eric A. Davidson, Alessandro C. de Araújo, Paulo Artaxo, Jennifer K. Balch, I. Foster Brown et al. | | | A synthesis of recent research shows that the effects of human actions have already altered the regional hydrology and energy balance of parts of the Amazon basin, and that interactions between deforestation, fire and climate change are likely to further alter carbon storage, precipitation patterns and river discharge. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
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| | | | | | | | | | | | | | | | | | | Pathway complexity in supramolecular polymerization ▶ | | | Peter A. Korevaar, Subi J. George, Albert J. Markvoort, Maarten M. J. Smulders, Peter A. J. Hilbers et al. | | | Kinetic control of the self-assembly of the π-conjugated oligomer S-chiral oligo(p-phenylenevinylene) (SOPV) reveals two competing pathways, leading to a kinetically favoured metastable product and a thermodynamically favoured stable product with opposite helicity, but the addition of a chiral tartaric acid changes the assembly process to produce only the desired metastable product. | | | | | | | | | | | Structure of HDAC3 bound to co-repressor and inositol tetraphosphate ▶ | | | Peter J. Watson, Louise Fairall, Guilherme M. Santos & John W. R. Schwabe | | | The crystal structure of histone deacetylase HDAC3 bound to the co-repressor SMRT is reported, and suggests that inositol tetraphosphate could act as a regulator of HDAC3; this has therapeutic implications, because HDACs are emerging targets of anti-cancer drugs. | | | | | | | | Global landscape of HIV–human protein complexes ▶ | | | Stefanie Jäger, Peter Cimermancic, Natali Gulbahce, Jeffrey R. Johnson, Kathryn E. McGovern et al. | | | Affinity tagging, mass spectroscopy and a tailor-made scoring system are used to identify 497 high-confidence interactions between human proteins and human immunodeficiency virus proteins. | | | | | | | | Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection ▶ | | | Stefanie Jäger, Dong Young Kim, Judd F. Hultquist, Keisuke Shindo, Rebecca S. LaRue et al. | | | The transcription cofactor CBF-β is shown to regulate the ability of HIV-1 to evade host restriction mediated by the deaminase APOBEC3; it acts by interacting with the HIV protein Vif, so disrupting the Vif–CBF-β interaction could provide a new therapeutic target against HIV-1 infection. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Pathway complexity in supramolecular polymerization ▶ | | | Peter A. Korevaar, Subi J. George, Albert J. Markvoort, Maarten M. J. Smulders, Peter A. J. Hilbers et al. | | | Kinetic control of the self-assembly of the π-conjugated oligomer S-chiral oligo(p-phenylenevinylene) (SOPV) reveals two competing pathways, leading to a kinetically favoured metastable product and a thermodynamically favoured stable product with opposite helicity, but the addition of a chiral tartaric acid changes the assembly process to produce only the desired metastable product. | | | | | | | | | | | | | | Coherent singlet-triplet oscillations in a silicon-based double quantum dot ▶ | | | B. M. Maune, M. G. Borselli, B. Huang, T. D. Ladd, P. W. Deelman et al. | | | Exploiting the weak interactions between electron spins and nuclear spins in silicon-based quantum dots leads to a dephasing time two orders of magnitude greater than in analogous gallium-arsenide-based devices, demonstrating the potential of silicon as a host material for quantum information processing. | | | | | | | | Reconfigurable self-assembly through chiral control of interfacial tension ▶ | | | Thomas Gibaud, Edward Barry, Mark J. Zakhary, Mir Henglin, Andrew Ward et al. | | | Molecular chirality can be used to control interfacial tension in multi-component mixtures of chiral molecules, and tuning the chirality makes it possible to produce and manipulate self-assembling complex chiral structures. | | | | | | | | | | | Global landscape of HIV–human protein complexes ▶ | | | Stefanie Jäger, Peter Cimermancic, Natali Gulbahce, Jeffrey R. Johnson, Kathryn E. McGovern et al. | | | Affinity tagging, mass spectroscopy and a tailor-made scoring system are used to identify 497 high-confidence interactions between human proteins and human immunodeficiency virus proteins. | | | | | | | | | | | The Amazon basin in transition ▶ | | | Eric A. Davidson, Alessandro C. de Araújo, Paulo Artaxo, Jennifer K. Balch, I. Foster Brown et al. | | | A synthesis of recent research shows that the effects of human actions have already altered the regional hydrology and energy balance of parts of the Amazon basin, and that interactions between deforestation, fire and climate change are likely to further alter carbon storage, precipitation patterns and river discharge. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Kimberlite ascent by assimilation-fuelled buoyancy ▶ | | | James K. Russell, Lucy A. Porritt, Yan Lavallée & Donald B. Dingwell | | | Assimilation of mantle minerals is proposed as a cause of deep-seated exsolution of dissolved volatiles and the driver of kimberlite magma ascent. | | | | | | | | Recovery rates reflect distance to a tipping point in a living system ▶ | | | Annelies J. Veraart, Elisabeth J. Faassen, Vasilis Dakos, Egbert H. van Nes, Miquel Lürling et al. | | | Decreased rates of recovery from perturbations, or critical slowing down, are demonstrated in a living system, indicating that recovery rates can be used to probe the resilience of complex systems. | | | | | | | | | | | The Amazon basin in transition ▶ | | | Eric A. Davidson, Alessandro C. de Araújo, Paulo Artaxo, Jennifer K. Balch, I. Foster Brown et al. | | | A synthesis of recent research shows that the effects of human actions have already altered the regional hydrology and energy balance of parts of the Amazon basin, and that interactions between deforestation, fire and climate change are likely to further alter carbon storage, precipitation patterns and river discharge. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| | | | | | Announcing Principles of Biology, a textbook for the 21st century from Nature Publishing Group Principles of Biology is a peer-reviewed, affordable textbook solution for university-level Introductory Biology courses, featuring 200+ customizable learning modules, 175+ interactive exercises, 3,000+ assessment questions, and access from laptops, smartphones, or tablets. Learn more. | | | | | | | | |
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| | | | | | | | | Outreach: Field hospitality ▶ | | | Hosting guests on research trips can give scientists a chance to showcase their work — but it can also cause distractions. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Careers related news & comment | | | | | | | | | | | | |
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