Nature contents: 05 January 2011

Can't view this email? Click here to view in your browser.     Volume 481 Number 7379      nature •Visit Nature homepage •Subscribe to Nature •View Table of Contents The science that matters. Every week.                       Nature.com presents Antibodypedia Finding the right antibody for the right application just got easier! Visit www.antibodypedia.com to find antibodies that have proved themselves effective for particular applications or to submit antibody validation data from your own experiments.             Jump to the content that matters to you View Table of Contents ▶ ▼ News & Comment   ▼ Biological Sciences   ▼ Chemical Sciences   ▼ Physical Sciences   ▼ Earth & Environmental Sciences   ▼ Careers & Jobs       This week's highlights     Biological Sciences More Biological sciences ▼   A sensing array of radically coupled genetic 'biopixels'   Synchronized populations of Escherichia coli bacteria distributed in quorum-sensing colonies - or biopixels - have been used to build an LCD-like macroscopic clock capable of sensing the presence of arsenic via modulation of the oscillatory period. Biopixel colonies of this type could form the basis of genetic biosensors capable of detecting heavy metals and pathogens.       Physical Sciences More Physical sciences ▼   A gas cloud on its way towards the supermassive black hole at the Galactic Centre   A giant gas cloud has been identified in the constellation of Sagittarius, moving towards the radio source Sgr A*, the site of the supermassive black hole at the centre of the Milky Way. Models predict that as the cloud approaches, X-ray emissions will become much brighter, and a giant radiation flare may be emitted in a few years as the cloud breaks up and feeds gas into the black.       Physical Sciences More Physical sciences ▼   Demonstration of temporal cloaking   The 'time cloak' is a system that, in theory, artificially creates a hole in time by accelerating and slowing down, respectively, the front and rear parts of a probe light beam. Fridman et al. demonstrate such a time cloak in a fibre-based system where an event that causes a clear disturbance to a probe beam appears not to occur at all when the time cloak is switched on.                   Cell Research Editor's Choice 2011 Cell Research is proud to present the Editor's Choice 2011 - a collection of featured articles from 2011 that represent a broad scope in basic molecular and cell biology research. Take advantage of free access to select articles from the Editor's Choice today!                 Podcast & Video     In this week's podcast: the five hardest experiments and a look forward to science in 2012.         News & Comment Read daily news coverage▶ ▲top             THIS WEEK           Editorial                   Reach out about climate ▶     Where political leadership on climate change is lacking, scientists must be prepared to stick their heads above the parapet.             World View                   Blue-sky bias should be brought down to Earth ▶     High-prestige research hogs the money, while the needs — and value — of the US science agencies closest to the public are ignored, says Daniel Sarewitz.             Seven Days                   Seven days: 5 January 2012 ▶     The week in science: researcher arrested for supplying stem-cell clinic; XMRV studies retracted; and a professor faces criminal charges for lab death.           NEWS IN FOCUS           Call to censor flu studies draws fire ▶     Critics say controversy over publication of mutant-H5N1 research highlights biosecurity weaknesses.             Survey tunes in to dark energy ▶     Sonic yardstick offers a measure of Universe's expansion.             New year, new science ▶     Nature looks ahead to the key findings and events that may emerge in 2012.             Q&A: A passion for science without barriers ▶     Nancy Hopkins, renowned champion of gender equality, looks back over her career.             Features                   Frontier experiments: Tough science ▶     Five experiments as hard as finding the Higgs.             Kepler's surprise: The sounds of the stars ▶     Data from NASA's Kepler space telescope have revolutionized the search for planets outside the Solar System — and are now doing the same for asteroseismology.           COMMENT           Science publishing: How to stop plagiarism ▶     Duplication is easily detected by software, yet it remains a problem. Ten experts explain how to stamp it out.             Higgs boson: The need for new physics ▶     Regardless of whether the Higgs detection is confirmed, the standard model is incomplete, says John Ellis.             Sociology of science: Keep standards high ▶     As models of authorship and collaboration change in the digital age, we must rely on trust to filter the products of research, says Jerome Ravetz.             Books and Arts                   Robotics: Morals and machines ▶     A view of robotics reveals ethics has not kept up with technology, finds Braden Allenby.             Books in brief ▶             Q&A: The science showman ▶     Chemist and educator Bassam Shakhashiri is known for his dramatic live demonstrations of chemistry in action. As he takes the helm as president of the American Chemical Society (ACS) this week, he talks about the state of science education and how to engage people in chemistry through the wonders of the lab.             Correspondence                   Sustainable development: Call to veto Brazil's forest-code revisions Alison G. Nazareno | National parks: Mauritius is putting conservation at risk F. B. Vincent Florens | Curiosity imaging: Phoenix first to see silt grains on Mars Michael Velbel | Shaping policy: Science and politics need more empathy Len Fisher           Correction                   Corrections ▶                         Royal Society medals and awards 2012 - Call for nominations The Royal Society's medals, awards and prize lectureships provide an opportunity to celebrate excellence in science. We invite you to nominate scientists who have made outstanding achievements. The deadline for nominations is Monday 6 February 2012. For more information please visit royalsociety.org/awards               Biological Sciences ▲top             RESEARCH           Latest Online                   Biomechanics: Leaping lizards and dinosaurs ▶     R. McNeill Alexander             Tail-assisted pitch control in lizards, robots and dinosaurs ▶     Thomas Libby, Talia Y. Moore, Evan Chang-Siu, Deborah Li, Daniel J. Cohen et al.     Comparison of real lizards with a robotic version and a dinosaur model shows that lizards use their tails to control body pitch in aerial motion by means of transfer of angular momentum from the body to the tail.             Differential oestrogen receptor binding is associated with clinical outcome in breast cancer ▶     Caryn S. Ross-Innes, Rory Stark, Andrew E. Teschendorff, Kelly A. Holmes, H. Raza Ali et al.     Genome-wide mapping of oestrogen receptor-α binding sites in primary breast cancer tissues shows that oestrogen receptor binding is dynamically regulated and that the expression of genes near differentially bound regulatory regions is associated with clinical outcome.             Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys ▶     Dan H. Barouch, Jinyan Liu, Hualin Li, Lori F. Maxfield, Peter Abbink et al.     Protective efficacy of novel vaccine candidates in rhesus monkeys opens new paths for the development of an HIV-1 vaccine.             FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas ▶     Shanshan Duan, Lukas Cermak, Julia K. Pagan, Mario Rossi, Cinzia Martinengo et al.     FBXO11 is identified as the F-box protein that normally targets BCL6 for degradation, and FBXO11 deletions or mutations that prevent this function and thus stabilize BCL6 are found in B-cell lymphomas.             Articles and Letters                   A sensing array of radically coupled genetic ‘biopixels’ ▶     Arthur Prindle, Phillip Samayoa, Ivan Razinkov, Tal Danino, Lev S. Tsimring et al.     Thousands of quorum-sensing Escherichia coli colonies are synchronized over centimetres using redox signalling to create ‘biopixels’ that can sense trace amounts of arsenic in water.             Antiparallel EmrE exports drugs by exchanging between asymmetric structures ▶     Emma A. Morrison, Gregory T. DeKoster, Supratik Dutta, Reza Vafabakhsh, Michael W. Clarkson et al.     NMR and single molecule FRET experiments show that antiparallel EmrE dimers interconvert between two identical but oppositely oriented conformations that are each open only to one side of the membrane.             Reversal of cocaine-evoked synaptic potentiation resets drug-induced adaptive behaviour ▶     Vincent Pascoli, Marc Turiault & Christian Lüscher     In mice, cocaine is found to potentiate excitatory transmission in medium-sized spiny neurons expressing the type-1 dopamine receptor; depotentiation reversed cocaine-induced locomotor sensitization, raising the possibility of novel treatments for addiction.             Modulation of TRPA1 thermal sensitivity enables sensory discrimination in Drosophila ▶     Kyeongjin Kang, Vincent C. Panzano, Elaine C. Chang, Lina Ni, Alexandra M. Dainis et al.     Many TRP ion channels respond to more than one category of cue, and how they discriminate between them is largely unknown; the mechanism by which TRPA1 discriminates between sensory stimuli in Drosophila is now determined.             Antibody-based protection against HIV infection by vectored immunoprophylaxis ▶     Alejandro B. Balazs, Joyce Chen, Christin M. Hong, Dinesh S. Rao, Lili Yang et al.     A single injection of a viral vector that encodes antibodies able to neutralize most HIV strains protects humanized mice from HIV infection.             Interactions between cancer stem cells and their niche govern metastatic colonization ▶     Ilaria Malanchi, Albert Santamaria-Martínez, Evelyn Susanto, Hong Peng, Hans-Anton Lehr et al.     For the initiation of metastasis, there must be a small population of cancer stem cells at the secondary site and, to maintain this population and allow proliferation, infiltrating cancer cells must induce the expression of stromal periostin.             Open structure of the Ca2+ gating ring in the high-conductance Ca2+-activated K+ channel ▶     Peng Yuan, Manuel D. Leonetti, Yichun Hsiung & Roderick MacKinnon     The crystal structure of the calcium-bound gating ring of a calcium- and voltage-activated potassium channel shows in detail how the effect of calcium binding on the gating ring produces the conformational change from closed to open.             Structure of a methyl-coenzyme M reductase from Black Sea mats that oxidize methane anaerobically ▶     Seigo Shima, Martin Krueger, Tobias Weinert, Ulrike Demmer, Jörg Kahnt et al.     The crystal structure of the enzyme MCR from methanogenic archaea shows that it is very similar to that of methanotrophic archaea; the differences observed may tune the enzymes for their respective biological context within the sea mats.             News & Views                   Synthetic biology: Bacteria collaborate to sense arsenic ▶     Christopher A. Voigt             Neuroscience: Behavioural effects of cocaine reversed ▶     Marina E. Wolf             Biomechanics: Leaping lizards and dinosaurs ▶     R. McNeill Alexander           NEWS & COMMENT           Call to censor flu studies draws fire | New year, new science | Books in brief           CAREERS           Turning point: Tiago Branco             More Biological Sciences ▶                         Enhance your reading experience High quality content like this deserves the best reading experience. You can now view, highlight and annotate Nature articles through the ReadCube web reader. Link directly to in-line citations, and view supplementary information. By downloading the full ReadCube desktop app you can sync your edits straight from the web reader. Download today.               Chemical Sciences ▲top             RESEARCH           Articles and Letters                   Antiparallel EmrE exports drugs by exchanging between asymmetric structures ▶     Emma A. Morrison, Gregory T. DeKoster, Supratik Dutta, Reza Vafabakhsh, Michael W. Clarkson et al.     NMR and single molecule FRET experiments show that antiparallel EmrE dimers interconvert between two identical but oppositely oriented conformations that are each open only to one side of the membrane.             Open structure of the Ca2+ gating ring in the high-conductance Ca2+-activated K+ channel ▶     Peng Yuan, Manuel D. Leonetti, Yichun Hsiung & Roderick MacKinnon     The crystal structure of the calcium-bound gating ring of a calcium- and voltage-activated potassium channel shows in detail how the effect of calcium binding on the gating ring produces the conformational change from closed to open.           NEWS & COMMENT           Q&A: The science showman             More Chemical Sciences ▶               Physical Sciences ▲top             RESEARCH           Latest Online                   Materials science: A fresh twist for self-assembly ▶     Volker Schaller & Andreas R. Bausch             Biomechanics: Leaping lizards and dinosaurs ▶     R. McNeill Alexander             Tail-assisted pitch control in lizards, robots and dinosaurs ▶     Thomas Libby, Talia Y. Moore, Evan Chang-Siu, Deborah Li, Daniel J. Cohen et al.     Comparison of real lizards with a robotic version and a dinosaur model shows that lizards use their tails to control body pitch in aerial motion by means of transfer of angular momentum from the body to the tail.             Reconfigurable self-assembly through chiral control of interfacial tension ▶     Thomas Gibaud, Edward Barry, Mark J. Zakhary, Mir Henglin, Andrew Ward et al.     Molecular chirality can be used to control interfacial tension in multi-component mixtures of chiral molecules, and tuning the chirality makes it possible to produce and manipulate self-assembling complex chiral structures.             Articles and Letters                   A sensing array of radically coupled genetic ‘biopixels’ ▶     Arthur Prindle, Phillip Samayoa, Ivan Razinkov, Tal Danino, Lev S. Tsimring et al.     Thousands of quorum-sensing Escherichia coli colonies are synchronized over centimetres using redox signalling to create ‘biopixels’ that can sense trace amounts of arsenic in water.             A gas cloud on its way towards the supermassive black hole at the Galactic Centre ▶     S. Gillessen, R. Genzel, T. K. Fritz, E. Quataert, C. Alig et al.     A gas cloud three times the mass of Earth is observed falling towards Sagittarius A*, the supermassive black hole at the centre of our Galaxy.             Fast core rotation in red-giant stars as revealed by gravity-dominated mixed modes ▶     Paul G. Beck, Josefina Montalban, Thomas Kallinger, Joris De Ridder, Conny Aerts et al.             Polar methane accumulation and rainstorms on Titan from simulations of the methane cycle ▶     T. Schneider, S. D. B. Graves, E. L. Schaller & M. E. Brown     Simulations reproduce previously unexplained features of Titan’s methane cycle, attributing them to atmospheric instabilities and cold-trapping of methane in the polar regions.             Demonstration of temporal cloaking ▶     Moti Fridman, Alessandro Farsi, Yoshitomo Okawachi & Alexander L. Gaeta     Temporal cloaking hides an event in time from being detected; here this is achieved by speeding up one end of a probe beam and slowing down the other to create a ‘time hole’ and to close it afterwards so that the signal amplitude of an event is much reduced.             Changing Arctic Ocean freshwater pathways ▶     James Morison, Ron Kwok, Cecilia Peralta-Ferriz, Matt Alkire, Ignatius Rigor et al.     The Arctic Oscillation, rather than the Beaufort High, is the main factor affecting the freshening of the Arctic Ocean since the 1990s.             News & Views                   Astrophysics: The final plunge ▶     Mark Morris             Optical physics: How to hide in time ▶     Robert W. Boyd & Zhimin Shi             Materials science: A fresh twist for self-assembly ▶     Volker Schaller & Andreas R. Bausch             Biomechanics: Leaping lizards and dinosaurs ▶     R. McNeill Alexander           NEWS & COMMENT           Reach out about climate | New year, new science | Frontier experiments: Tough science | Kepler's surprise: The sounds of the stars | Higgs boson: The need for new physics | Sociology of science: Keep standards high | Books in brief | Sustainable development: Call to veto Brazil's forest-code revisions Alison G. Nazareno | Curiosity imaging: Phoenix first to see silt grains on Mars Michael Velbel             More Physical Sciences ▶               Earth & Environmental Sciences ▲top             RESEARCH           Articles and Letters                   Polar methane accumulation and rainstorms on Titan from simulations of the methane cycle ▶     T. Schneider, S. D. B. Graves, E. L. Schaller & M. E. Brown     Simulations reproduce previously unexplained features of Titan’s methane cycle, attributing them to atmospheric instabilities and cold-trapping of methane in the polar regions.             Changing Arctic Ocean freshwater pathways ▶     James Morison, Ron Kwok, Cecilia Peralta-Ferriz, Matt Alkire, Ignatius Rigor et al.     The Arctic Oscillation, rather than the Beaufort High, is the main factor affecting the freshening of the Arctic Ocean since the 1990s.             Structure of a methyl-coenzyme M reductase from Black Sea mats that oxidize methane anaerobically ▶     Seigo Shima, Martin Krueger, Tobias Weinert, Ulrike Demmer, Jörg Kahnt et al.     The crystal structure of the enzyme MCR from methanogenic archaea shows that it is very similar to that of methanotrophic archaea; the differences observed may tune the enzymes for their respective biological context within the sea mats.           NEWS & COMMENT           Reach out about climate | New year, new science | Sustainable development: Call to veto Brazil's forest-code revisions Alison G. Nazareno | National parks: Mauritius is putting conservation at risk F. B. Vincent Florens | Curiosity imaging: Phoenix first to see silt grains on Mars Michael Velbel             More Earth & Environmental Sciences ▶                         NATURE REVIEWS IMMUNOLOGY CALENDAR 2012 In celebration of our 10th anniversary, Nature Reviews Immunology is delighted to bring you a FREE calendar for 2012. www.nature.com/nri/calendars/2012 Happy New Year to all our readers! See also our 10th anniversary VIEWPOINT and CROSSWORD: Sponsored by: eBioscience               Careers & Jobs ▲top               Women in business: Finding a way in ▶     Female scientists hoping to become entrepreneurs face obstacles — but there are organizations that can help.                   Turning point: Tiago Branco ▶     UK postdoc hopes his award-winning essay will help open doors.                   Careers related news & comment                   Science publishing: How to stop plagiarism | Q&A: The science showman | National parks: Mauritius is putting conservation at risk F. B. 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