Molecular Systems Biology - New articles published 31 January 2012

Latest Articles 31st January 2012   Featured Article Research Article   Web feeds About Open access Advertisement Take a look at this recent article in the EMBO Journal: Cohesin acetyltransferase Esco2 is a cell viability factor and is required for cohesion in pericentric heterochromatin EMBO Open Gabriela Whelan, Emanuel Kreidl, Gordana Wutz, Alexander Egner, Jan-Michael Peters and Gregor Eichele   Featured Article Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress Data-driven modeling was used to analyze the complex signaling dynamics that connect DNA repair with cell survival, cell-cycle arrest, or apoptosis. This analysis revealed an unexpected role for Erk in G1/S arrest and apoptotic cell death following doxorubicin-induced DNA damage. Andrea R Tentner, Michael J Lee, Gerry J Ostheimer, Leona D Samson, Douglas A Lauffenburger & Michael B Yaffe Molecular Systems Biology 8:568; doi:10.1038/msb.2012.1; published 31 January 2012 Synopsis | Full Text | PDF | Supp. Inf. | Review Process Research Article Competing pathways control host resistance to virus via tRNA modification and programmed ribosomal frameshifting Viral infection depends on a complex interplay between host and viral factors. Here, the authors link host susceptibility to viral infection to a network encompassing sulfur metabolism, tRNA modification, competitive binding, and programmed ribosomal frameshifting. Nathaniel D Maynard, Derek N Macklin, Karla Kirkegaard & Markus W Covert Molecular Systems Biology 8:567; doi:10.1038/msb.2011.101; published 31 January 2012 Synopsis | Full Text | PDF | Supp. Inf. | Review Process

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