Molecular Systems Biology - New articles published 17 January 2012

Latest Articles 17 January 2012   Featured Article Research Articles   Web feeds About Open access Advertisement Human quantitative proteomics—take a look at these recent articles published in Molecular Systems Biology: Deep proteome and transcriptome mapping of a human cancer cell line. Nagarjuna Nagaraj, Matthias Mann and colleagues | Mol Sys Biol 7:548 The quantitative proteome of a human cell line Martin Beck, Ruedi Aebersold and colleagues. | Mol Sys Biol 7:549 The quantitative proteomes of human-induced pluripotent stem cells and embryonic stem cells Javier Munoz, Albert J R Heck and colleagues | Mol Sys Biol 7:550   Featured Article Differential network biology Protein and genetic interaction maps have typically been generated under a single condition, providing a static view of the interactome. Recent studies employing differential analysis, however, have revealed that widespread re-wiring of the interactome underlies key biological responses. Trey Ideker & Nevan J Krogan Molecular Systems Biology 8:565; doi:10.1038/msb.2011.99; published 17 January 2012 Full Text | PDF Research Articles Widespread translational control contributes to the regulation of Arabidopsis photomorphogenesis Environmental light regulates and optimizes plant growth and development. Genomic profiling of polysome-associated mRNA reveals that light stimulates dramatic changes in translational regulation, which contribute more to light-induced gene expression changes than transcriptional regulation. Ming-Jung Liu, Szu-Hsien Wu, Ho-Ming Chen & Shu-Hsing Wu Molecular Systems Biology 8:566; doi:10.1038/msb.2011.97; published 17 January 2012 Synopsis | Full Text | PDF | Supp. Inf. | Review Process Bistability in feedback circuits as a byproduct of evolution of evolvability Simulations of the evolution of simple gene regulatory networks reveal that fluctuating environmental selection can lead to the emergence of bistability under certain conditions where fluctuation and mutational rates are in tune. Hiroyuki Kuwahara & Orkun S Soyer Molecular Systems Biology 8:564; doi:10.1038/msb.2011.98; published 17 January 2012 Synopsis | Full Text | PDF | Supp. Inf. | Review Process

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