Drug Discovery@nature.com 27 January 2012

TABLE OF CONTENTS 27 January 2012 News Analysis Research Highlights Research & Reviews Careers Nature Reviews Drug Discovery is on Twitter Advertisement Nature Reviews Neuroscience FOCUS ON ADDICTION Read for FREE online at: www.nature.com/nrn/focus/addiction Produced with support from National Institute on Drug Abuse (NIDA) and National Institute on Alcohol Abuse and Alcoholism (NIAAA) National Institutes of Health U.S. Department of Health & Human Services   News Top Malaria hopes rise as chemists produce cheap artemisinin doi:10.1038/nature.2012.9895 Alternate chemical process converts waste product into usable drug. Full Text Biotech entrepreneurs swoon over proposed fundraising changes doi:10.1038/nm0112-3 The Small Company Capital Formation Act proposes to allow small, private companies, including biopharmas, to sell up to $50 million in public shares without having to file lengthy, expensive paperwork and divulge financial details to the Securities and Exchange Commission. Full Text Are drugmakers fishing for a market with prescription omega-3s? doi:10.1038/nm0112-6 Drugmakers are offering omega-3 fatty acid pills but, without any head-to-head clinical trials with over-the-counter fish oil, many experts caution that consumers might be getting a raw deal with these prescription medications. Full Text Approval on a knife edge doi:10.1038/nbt.2084 In spite of its modest performance in clinical trials, Benlysta may offer effective relief against lupus. But physicians are still working to identify the right patients. Full Text Analysis Top Heat shock and awe doi:10.1038/scibx.2012.62 Several small molecules identified to decrease toxic protein aggregation in vitro provide proof of concept for Proteostasis Therapeutics Inc.’s approach to treating protein misfolding diseases like Huntington's and cystic fibrosis. Full Text Fresh from the Pipeline: Brentuximab vedotin doi:10.1038/nrd3629 In August 2011, brentuximab vedotin (Adcetris; Seattle Genetics), a CD30-specific antibody-drug conjugate, was approved by the US Food and Drug Administration for the treatment of patients with Hodgkin's lymphoma and patients with systemic anaplastic large cell lymphoma. Full Text From the analyst's couch: A decade of change doi:10.1038/nrd3630 Data on indicators such as the number and success rate of research and development projects illustrate trends in the pharmaceutical industry over the past decade. Full Text Research Highlights Top Vaccines: Enhancing glycan presentation increases vaccine efficacy doi:10.1038/nrd3637 By maximizing the presentation of carbohydrate epitopes to T cells, scientists have constructed a vaccine against group B streptococcus that is significantly more potent than currently available vaccines. Full Text Antiparasitic drugs: Two-pronged tactics for malaria control doi:10.1038/nrd3635 An academia–industry consortium has identified a new class of compounds that confer complete protection against parasite challenge in rodent models of malaria, as well as showing potent in vivo activity against blood-stage parasites. Full Text Epigenetics: Worth another look? doi:10.1038/nrc3187 Patients with non-small-cell lung cancer with tumours that have a specific subset of methylated genes might benefit from combined treatment with a low-dose DNA methyltransferase inhibitor and a histone deacetylase inhibitor. Full Text Research & Reviews Top The pharmacological landscape and therapeutic potential of serine hydrolases doi:10.1038/nrd3620 This article outlines the current state of pharmacology for mammalian serine hydrolases, including marketed drugs, compounds that are under clinical investigation and selective inhibitors emerging from academic probe development efforts. Full Text Cancer immunotherapy comes of age doi:10.1038/nature10673 Advances in the understanding of how tolerance, immunity and immunosuppression regulate antitumour immune responses, together with the advent of targeted therapies, suggest that active immunotherapy represents a path to obtain a durable and long-lasting response in cancer patients. Full Text Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons doi:10.1038/nature10726 Findings from a recent Nature study suggest a therapeutic strategy for reactivating the functional but dormant allele of Ube3a in patients with Angelman syndrome using topoisomerase inhibitors. Full Text Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential doi:10.1038/nm.2582 Antibodies that bind and inhibit activated matrix metalloproteinases 2 and 9 in a manner analogous to the mechanism of action of tissue inhibitors of metalloproteinases are therapeutically effective in mouse models of inflammatory bowel disease. Full Text Drug Discovery JOBS of the week Oncology Group Leader / Project Leader Contract Drug Discovery Organisation Scientist, Biopharmacology Eisai Europe Ltd Stem Cells for Drug Discovery and Neural Repair UC Davis Associate Scientist, Toxicology Genentech Associate or Full Professor UIC College of Pharmacy More Science jobs from Drug Discovery EVENT Resolving Inflammation: Mechanisms and Drug Discovery 01.-03.04.12 Oxford, UK More science events from Careers Top Career snapshots archive Career snapshots feature people associated with drug discovery and drug development, with the aim of providing expert insights and advice on a wide range of positions and career paths in this field. Full Text Top Advertisement SciBX: Science-Business eXchange is a weekly publication that identifies and analyzes the most important translational research articles from over 40 journals. Find out which papers have real scientific and commercial potential, and why. 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