Scientific Reports Biology Table of Contents e-alert: December 2011

01 December 2011      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports                 Scientific Reports is accepting submissions from all scientific fields. Submit your manuscript now.                 Biological Sciences               Mycobacterium tuberculosis Rv2419c, the missing glucosyl-3-phosphoglycerate phosphatase for the second step in methylglucose lipopolysaccharide biosynthesis ▶     Vítor Mendes, Ana Maranha, Susana Alarico et al.     Mycobacteria synthesize intracellular methylglucose lipopolysaccharides (MGLP) proposed to regulate fatty acid synthesis. Although their structures have been elucidated, the …             SACK-Expanded Hair Follicle Stem Cells Display Asymmetric Nuclear Lgr5 Expression With Non-Random Sister Chromatid Segregation ▶     Yang Hoon Huh, Johnathan King, Justin Cohen et al.     We investigated the properties of clonally-expanded mouse hair follicle stem cells (HF-SCs) in culture. The expansion method, suppression of asymmetric cell kinetics (SACK), is …             Dynein light chain 1 functions in somatic cyst cells regulate spermatogonial divisions in Drosophila ▶     Prakash Joti, Anindya Ghosh-Roy, Krishanu Ray     Stem cell progeny often undergo transit amplifying divisions before differentiation. In Drosophila, a spermatogonial precursor divides four times within an enclosure formed by two …             Cytokine-based high log-scale expansion of functional human dendritic cells from cord-blood CD34-positive cells ▶     Yui Harada, Yae Okada-Nakanishi, Yasuji Ueda et al.     Dendritic cells (DCs) play a crucial role in maintaining the immune system. Though DC-based cancer immunotherapy has been suggested as a potential treatment for various kinds of …             Structure and function analyses of the purified GPCR human vomeronasal type 1 receptor 1 ▶     Karolina Corin, Philipp Baaske, Sandra Geissler et al.     The vomeronasal system is one of several fine-tuned scent-detecting signaling systems in mammals. However, despite significant efforts, how these receptors detect scent remains an …             Non-host resistance to penetration and hyphal growth of Magnaporthe oryzae in Arabidopsis ▶     Misato Nakao, Ryotaro Nakamura, Kaori Kita et al.     Rice blast caused by Magnaporthe oryzae is a devastating disease of rice. Mechanisms of rice resistance to blast have been studied extensively, and the rice–M. oryzae pathosystem …             Bacterial biogeography of the human digestive tract ▶     Jennifer C. Stearns, Michael D. J. Lynch, Dilani B. Senadheera et al.     We present bacterial biogeography as sampled from the human gastrointestinal tract of four healthy subjects. This study generated >32 million paired-end sequences of bacterial 16S …             Genetic variation and linkage disequilibrium in Bacillus anthracis ▶     Michael E. Zwick, Maureen Kiley Thomason, Peter E. Chen et al.     We performed whole-genome amplification followed by hybridization of custom-designed resequencing arrays to resequence 303 kb of genomic sequence from a worldwide panel of 39 …             A Quantitative Analytical Method to Test for Salt Effects on Giant Unilamellar Vesicles ▶     Maik Hadorn, Eva Boenzli, Peter Eggenberger Hotz     Today, free-standing membranes, i.e. liposomes and vesicles, are used in a multitude of applications, e.g. as drug delivery devices and artificial cell models. Because current …             Generation of mouse ES cell lines engineered for the forced induction of transcription factors ▶     Lina S. Correa-Cerro, Yulan Piao, Alexei A. Sharov et al.     Here we report the generation and characterization of 84 mouse ES cell lines with doxycycline-controllable transcription factors (TFs) which, together with the previous 53 lines, …             Differential attraction and repulsion of Staphylococcus aureus and Pseudomonas aeruginosa on molecularly smooth titanium films ▶     Elena P. Ivanova, Vi Khanh Truong, Hayden K. Webb et al.     Magnetron sputtering techniques were used to prepare molecularly smooth titanium thin films possessing an average roughness between 0.18 nm and 0.52 nm over 5 μm × 5 μm AFM …             Essential role of microfibrillar-associated protein 4 in human cutaneous homeostasis and in its photoprotection ▶     Shinya Kasamatsu, Akira Hachiya, Tsutomu Fujimura et al.     UVB-induced cutaneous photodamage/photoaging is characterized by qualitative and quantitative deterioration in dermal extracellular matrix (ECM) components such as collagen and …             Conserved repressive function of Krüppel homolog 1 on insect metamorphosis in hemimetabolous and holometabolous species ▶     Jesus Lozano, Xavier Belles     Insect metamorphosis is regulated by ecdysteroids, which induce molts, and juvenile hormone (JH), which inhibits metamorphic changes. The molecular action of ecdysteroids has been …             Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas ▶     Toru Furukawa, Yuko Kuboki, Etsuko Tanji et al.     Intraductal papillary mucinous neoplasm (IPMN) is a common pancreatic cystic neoplasm that is often invasive and metastatic, resulting in a poor prognosis. Few molecular …             Defining the tipping point. A complex cellular life/death balance in corals in response to stress ▶     Ainsworth T. D., Wasmund K., Ukani L. et al.     Apoptotic cell death has been implicated in coral bleaching but the molecules involved and the mechanisms by which apoptosis is regulated are only now being identified. In …             Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells ▶     Hongzhe Li, Peter S. Steyger     Aminoglycoside antibiotics rapidly enter and kill cochlear hair cells via apical mechanoelectrical transduction (MET) channels in vitro. In vivo, it remains unknown whether …             Visualization of plasmid delivery to keratinocytes in mouse and human epidermis ▶     Emilio González-González, Yeu-Chun Kim, Tycho J. Speaker et al.     The accessibility of skin makes it an ideal target organ for nucleic acid-based therapeutics; however, effective patient-friendly delivery remains a major obstacle to clinical …             DNA recognition and transcriptional regulation by the WhiA sporulation factor ▶     Brett K. Kaiser, Barry L. Stoddard     Sporulation in the filamentous bacteria Streptomyces coelicolor is a tightly regulated process involving aerial hyphae growth, chromosome segregation, septation and spore …             The elementary events underlying force generation in neuronal lamellipodia ▶     Ladan Amin, Erika Ercolini, Rajesh Shahapure et al.     We have used optical tweezers to identify the elementary events underlying force generation in neuronal lamellipodia. When an optically trapped bead seals on the lamellipodium …             Intrinsic noise alters the frequency spectrum of mesoscopic oscillatory chemical reaction systems ▶     Rajesh Ramaswamy, Ivo F. Sbalzarini     Mesoscopic oscillatory reaction systems, for example in cell biology, can exhibit stochastic oscillations in the form of cyclic random walks even if the corresponding macroscopic …             Association of Kawasaki disease with tropospheric wind patterns ▶     Xavier Rodó, Joan Ballester, Dan Cayan et al.     The causal agent of Kawasaki disease (KD) remains unknown after more than 40 years of intensive research. The number of cases continues to rise in many parts of the world and KD …             SIRT1 associates with eIF2-alpha and regulates the cellular stress response ▶     Hiyaa Singhee Ghosh, Boris Reizis, Paul D. Robbins     SIRT1 is a NAD dependent protein deacetylase known to increase longevity in model organisms. SIRT1 regulates cellular response to oxidative and/or genotoxic stress by regulating …             Phosphatidylinositol 4,5-bisphosphate (PIP2) controls magnesium gatekeeper TRPM6 activity ▶     Jia Xie, Baonan Sun, Jianyang Du et al.     TRPM6 is crucial for human Mg2 homeostasis as patients carrying TRPM6 mutations develop hypomagnesemia and secondary hypocalcemia (HSH). However, the activation mechanism of TRPM6 …             Simultaneous multilayer scanning and detection for multiphoton fluorescence microscopy ▶     Partha Pratim Mondal, Alberto Diaspro     Fast three-(3D) imaging requires parallel optical slicing of a specimen with an efficient detection scheme. The generation of multiple localized dot-like excitation structures …             Mechanical stretch and shear flow induced reorganization and recruitment of fibronectin in fibroblasts ▶     Robert L. Steward, Chao-Min Cheng, Jonathan D. Ye et al.     It was our objective to study the role of mechanical stimulation on fibronectin (FN) reorganization and recruitment by exposing fibroblasts to shear fluid flow and equibiaxial …             Enhancing apoptosis in TRAIL-resistant cancer cells using fundamental response rules ▶     Vincent Piras, Kentaro Hayashi, Masaru Tomita et al.     The tumor necrosis factor related apoptosis-inducing ligand (TRAIL) induces apoptosis in malignant cells, while leaving other cells mostly unharmed. However, several carcinomas …             A Phospholipidomic Analysis of All Defined Human Plasma Lipoproteins ▶     Monireh Dashti, Willem Kulik, Frans Hoek et al.     Since plasma lipoproteins contain both protein and phospholipid components, either may be involved in processes such as atherosclerosis. In this study the identification of plasma …             One-pot bio-synthesis: N-acetyl-d-neuraminic acid production by a powerful engineered whole-cell catalyst ▶     Fei Tao, Yinan Zhang, Cuiqing Ma et al.     Whole cell biocatalysis is an important tool for pharmaceutical intermediates synthesis, although it is hindered by some shortcomings, such as high cost and toxicity of inducer, …             Dynamic impact of temporal context of Ca2+ signals on inhibitory synaptic plasticity ▶     Shin-ya Kawaguchi, Nobuhiro Nagasaki, Tomoo Hirano     Neuronal activity-dependent synaptic plasticity, a basis for learning and memory, is tightly correlated with the pattern of increase in intracellular Ca2 concentration ([Ca2]i). …             Community-specific evaluation of tool affordances in wild chimpanzees ▶     Thibaud Gruber, Martin N. Muller, Vernon Reynolds et al.     The notion of animal culture, defined as socially transmitted community-specific behaviour patterns, remains controversial, notably because the definition relies on surface …             Tandem assembly of the epothilone biosynthetic gene cluster by in vitro site-specific recombination ▶     Lin Zhang, Guoping Zhao, Xiaoming Ding     We describe a site-specific recombination-based tandem assembly (SSRTA) method for reconstruction of biological parts in synthetic biology. The system was catalyzed by Streptomyces…             Huntingtin mediates dendritic transport of β-actin mRNA in rat neurons ▶     Bin Ma, Jeffrey N. Savas, Man-Shan Yu et al.     Transport of mRNAs to diverse neuronal locations via RNA granules serves an important function in regulating protein synthesis within restricted sub-cellular domains. We recently …             Infantile zinc deficiency: Association with autism spectrum disorders ▶     Hiroshi Yasuda, Kazuya Yoshida, Yuichi Yasuda et al.     Elucidation of the pathogenesis and effective treatment of autism spectrum disorders is one of the challenges today. In this study, we examine hair zinc concentrations for 1,967 …             Galantamine improves olfactory learning in the Ts65Dn mouse model of Down syndrome ▶     Fabio M. Simoes de Souza, Nicolas Busquet, Megan Blatner et al.     Down syndrome (DS) is the most common form of congenital intellectual disability. Although DS involves multiple disturbances in various tissues, there is little doubt that in …             Inactivation of CBF/NF-Y in postnatal liver causes hepatocellular degeneration, lipid deposition, and endoplasmic reticulum stress ▶     Rong Luo, Sherry A. Klumpp, Milton J. Finegold et al.     We previously demonstrated that CBF activity is needed for cell proliferation and early embryonic development. 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