SciBx is a weekly publication that identifies and analyzes the most important translational research articles from over 40 journals. Find out which papers have real scientific and commercial potential, and why. Subscribe to SciBX and you won't miss the next big thing.
Splicing out BRAF's resistance Kai-Jye Lou doi:10.1038/scibx.2011.1340 U.S. researchers have uncovered a mechanism by which melanomas expressing mutant BRAF acquire resistance to targeted drugs. The findings mark the first time a splice variant has been implicated in cancer drug resistance. Full Text | PDF
TRND take two Chris Cain doi:10.1038/scibx.2011.1341 With 14 projects in place, the NIH's Therapeutics for Rare and Neglected Diseases program will shift its focus from finding projects to building infrastructure and advancing programs into the clinic. Full Text | PDF
Picturing pathology Tracey Baas doi:10.1038/scibx.2011.1342 A Stanford team has developed a computational pathology system called C-Path that provides more accurate prognostic scores of breast cancer tissue than classical pathology. The next steps will be modifying the method to handle whole-tissue slide samples and seeing how it performs in a prospective, multicenter trial. Full Text | PDF
Priming chemo prediction Chris Cain doi:10.1038/scibx.2011.1343 Dana-Farber researchers have developed an in vitro assay that predicts patient response to chemotherapy by directly measuring whether a cell is prone to apoptosis. Eutropics has exclusively licensed the assay and is developing it to predict chemotherapy effectiveness in multiple cancers. Full Text | PDF
NF-κB doi:10.1038/scibx.2011.1345 Mouse and cell culture studies suggest pyrithione zinc and ouabain could be useful for treating AML. Full Text | PDF
F-box protein 11 (FBXO11); B cell CLL lymphoma 6 (BCL6) doi:10.1038/scibx.2011.1346 In vitro and mouse studies suggest increasing FBXO11 levels could help treat BCL6-overexpressing diffuse large B cell lymphoma (DLBCL). Full Text | PDF
Dopamine D2 receptor doi:10.1038/scibx.2011.1347 In vitro and mouse studies suggest dopamine or dopamine D2 receptor agonists could help treat cancer. Full Text | PDF
Epidermal growth factor receptor 1 (EGFR1; HER1; ERBB1); EGFR4 (HER4; ERBB4) doi:10.1038/scibx.2011.1348 Mouse studies suggest an EGF decoy receptor could help treat cancer. Full Text | PDF
StAR-related lipid transfer domain containing 9 (STARD9) doi:10.1038/scibx.2011.1349 In vitro studies suggest inhibiting STARD9 could help treat cancer. Full Text | PDF
Checkpoint kinase 1 (Chk1) doi:10.1038/scibx.2011.1350 Mouse studies identified an isoquinoline-based Chk1 inhibitor called SAR-020106 that could help treat colorectal cancer. Full Text | PDF
c-Myc (MYC) doi:10.1038/scibx.2011.1351 In vitro studies suggest genomic c-Myc quadruplex DNA could be used to treat leukemia. Full Text | PDF
Hepatocyte nuclear factor 4α (HNF4A; TCF); microRNA-124 (miR-124) doi:10.1038/scibx.2011.1352 Mouse and patient sample studies suggest increasing signaling in the HNF4A-miR-124 pathway could help treat hepatocellular carcinoma (HCC). Full Text | PDF
BRAF; Ras doi:10.1038/scibx.2011.1353 Patient and cell culture studies suggest targeting truncated BRAF variants could help treat BRAF V600E mutant melanomas that have acquired resistance to BRAF kinase inhibitors. Full Text | PDF
Bacterial cystathionine β-synthase; bacterial cystathionine γ-lyase doi:10.1038/scibx.2011.1354 In vitro studies suggest inhibiting hydrogen sulfide (H2S) production could help treat bacterial infections. Full Text | PDF
Prostaglandin D2 (PGD2); PGD2 receptor subtype DP1 doi:10.1038/scibx.2011.1355 Mouse studies suggest inhibiting PGD2 could help treat viral infections in aged populations. Full Text | PDF
Translationally controlled tumor protein (TCTP; HRF) doi:10.1038/scibx.2011.1356 Mouse studies suggest inhibiting HRF could help treat allergy and asthma. Full Text | PDF
Bone morphogenetic protein 2 (BMP2); BMP7 (OP-1); CREB binding protein (CREBBP; CBP) doi:10.1038/scibx.2011.1357 Mouse studies suggest BMP2 and BMP7 could help prevent skeletal dysplasias caused by CBP mutations. Full Text | PDF
4-Aminobutyrate aminotransferase (ABAT; GABA-AT) doi:10.1038/scibx.2011.1358 Rat studies identified a GABA-AT inactivator that could help treat cocaine addiction. Full Text | PDF
Mitogen-activated protein kinase kinase 4 (MAP2K4; MKK4); MAP2K7 (MKK7) doi:10.1038/scibx.2011.1359 Cell culture and mouse studies suggest antagonizing MKK4 and MKK7 could help treat AD. Full Text | PDF
Not applicable doi:10.1038/scibx.2011.1360 Rat studies suggest dental-derived stem cells could help treat SCI. Full Text | PDF
Bactericidal/permeability-increasing protein (BPI) doi:10.1038/scibx.2011.1361 Mouse and human studies suggest a recombinant BPI fragment could help decrease radiation toxicity. Full Text | PDF
High throughput identification of chiral oligomers of pentenoic amides (COPAs) as protein ligands doi:10.1038/scibx.2011.1362 Screening libraries of COPAs could help identify new lead compounds. Full Text | PDF
Photocatalytic redox method for incorporating trifluoromethyl (CF3) groups into drug compounds doi:10.1038/scibx.2011.1363 A method of chemical synthesis could incorporate CF3 groups into drug compounds to help improve their in vivo stability. Full Text | PDF
Chemical-genetic interaction networks for target discovery against methicillin-resistant Staphylococcus aureus (MRSA) doi:10.1038/scibx.2011.1364 Chemical-genetic interaction networks could help identify therapeutic targets that sensitize MRSA to antibiotics. Full Text | PDF
Mammalian cell–based discovery of high-affinity human antibodies from IgG libraries doi:10.1038/scibx.2011.1365 A human cell line–based platform could be used to generate high-affinity human antibodies from immunologically diverse IgG libraries. Full Text | PDF
Rational design of glycoconjugate vaccines doi:10.1038/scibx.2011.1366 Glycoconjugate vaccines that maximize the presentation of carbohydrate-specific T cell epitopes to the immune system could lead to the development of more effective vaccines. Full Text | PDF
Topically applied, tumor-activated fluorescence probe for ovarian cancer biopsy and resection doi:10.1038/scibx.2011.1367 A topically applied, tumor-activated fluorescence probe may help improve biopsy and resection of ovarian tumors. Full Text | PDF
Metabolomic signature for metastatic colon cancer prognosis doi:10.1038/scibx.2011.1368 A patient study identified an NMR signature that could help determine metastatic colon cancer prognosis. Full Text | PDF
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