Nature Reviews Genetics Contents January 2012 Volume 13 Number 1 pp 1-70

TABLE OF CONTENTS
January 2012 Volume 13 Number 1
Impact Factor 32.745 *	In this issue Research Highlights Progress Reviews Also this month FREE Animation: RNA interference Article series: Applications of next-generation sequencing Study designs Regulatory elements  Featured article: Experimental and analytical tools for studying the human microbiome Justin Kuczynski, Christian L. Lauber, William A. Walters, Laura Wegener Parfrey, José C. Clemente, Dirk Gevers & Rob Knight
Subscribe   Facebook   RSS   Recommend to library   Twitter
Advertisement
Nature Outlook: Allergies The increased prevalence of allergies and asthma, especially in the developed world, has raised the stakes in the quest for prevention and cure. Access the Outlook free online for six months. Produced with support from: Nestlé Research Center
RESEARCH HIGHLIGHTS Top Evo–devo: Plastic flies p1 | doi:10.1038/nrg3131 PDF Gene regulation: RNAi gets stuck into transcription p2 | doi:10.1038/nrg3136 PDF Gene expression: Splicing steps aside to consider its options p2 | doi:10.1038/nrg3137 PDF Human evolution: Pathogen influence on human genetic variation p4 | doi:10.1038/nrg3134 PDF Bacterial evolution: Parallel lives p4 | doi:10.1038/nrg3135 PDF Human genetics: Pleiotropic mutations p5 | doi:10.1038/nrg3132 PDF Genomic instability: Close-up on cancer copy number alterations p5 | doi:10.1038/nrg3133 PDF IN BRIEF Human disease: Pathogenic conversions | Functional genomics: Predicting phenotype from genotype in yeast | Transcription: Nucleosome fate influenced by RNA polymerase | Gene regulation: Polycomb and non-coding RNA relocate genes | Gene expression: Secrets of the deep for transcriptomes | RNA interference: Inheritance of an acquired immune response | Development: Histone modification pre-patterning | Disease genomics: Copy number variants and HIV infection control PDF Genetics JOBS of the week Postdoctoral Fellowship Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) macromolecular structural biology and immunology postdoc positions Harbin Institute of Technology Postdoc on Genetic Regulation of Neural Stem Cells UT Southwestern Medical Center at Dallas Postdoctoral Fellow Weill Cornell Medical College, Cornell University Postdoctoral Associate: Genomics of Cancer and Disease Baylor College of Medicine More Science jobs from Genetics EVENT Complex Traits: Genomics and Computational Approaches (B5) 20.-25.02.12 CO, US More science events from
PROGRESS		Top
Uncovering the role of 5-hydroxymethylcytosine in the epigenome Miguel R. Branco, Gabriella Ficz & Wolf Reik p7 | doi:10.1038/nrg3080 The recent discovery of enzymes that convert 5-methylcytosine to 5-hydroxymethylcytosine (5hmC) in mammalian genomes has led to a surge of interesting possible functions for 5hmC, from the regulation of DNA methylation to the biology of pluripotency, differentiation and brain function. Abstract | Full Text | PDF
Genomically humanized mice: technologies and promises Anny Devoy, Rosie K. A. Bunton-Stasyshyn, Victor L. J. Tybulewicz, Andrew J. H. Smith & Elizabeth M. C. Fisher p14 | doi:10.1038/nrg3116 This article describes the promising technologies for generating humanized mouse models — that is, mouse strains containing large sections of human coding and non-coding sequences — for the purposes of improving our understanding of basic genome function and disease and discovering effective therapies. Abstract | Full Text | PDF
REVIEWS		Top
Emerging biomedical applications of synthetic biology Wilfried Weber & Martin Fussenegger p21 | doi:10.1038/nrg3094 Synthetic biological devices can be engineered to achieve high levels of precision and specificity, which makes them ideally suited for use in clinical settings. Devices are being developed to meet a range of biomedical needs, including specific cancer therapies and metabolic control. Abstract | Full Text | PDF
Article series: Applications of next-generation sequencing Repetitive DNA and next-generation sequencing: computational challenges and solutions Todd J. Treangen & Steven L. Salzberg p36 | doi:10.1038/nrg3117 Repeat sequences in DNA remain one of the most challenging aspects of next-generation sequencing data analysis and interpretation. This Review explains the problems and current strategies for handling repeats; ignoring repeats risks missing important biological information. Abstract | Full Text | PDF
Article series: Study designs Experimental and analytical tools for studying the human microbiome Justin Kuczynski, Christian L. Lauber, William A. Walters, Laura Wegener Parfrey, José C. Clemente, Dirk Gevers & Rob Knight p47 | doi:10.1038/nrg3129 Studies of the composition, dynamics and function of the human microbiome have taken off in the past two years thanks to the development of new sequencing technologies and advanced algorithms. This article provides a guide to the experimental and analytical best practices in this flourishing field. Abstract | Full Text | PDF
Article series: Regulatory elements Cis-regulatory elements: molecular mechanisms and evolutionary processes underlying divergence Patricia J. Wittkopp & Gizem Kalay p59 | doi:10.1038/nrg3095 Changes in cis-regulatory sequences, especially enhancers, make a substantial contribution to phenotypic diversity among and within species. Recent studies have begun to uncover the mechanisms underlying cis-regulatory divergence, such as the types of mutations that occur and their influence on transcription factor binding. Abstract | Full Text | PDF | Supplementary information
Corrigendum: Molecular spandrels: tests of adaptation at the genetic level Rowan D. H. Barrett & Hopi E. Hoekstra p70 | doi:10.1038/nrg3138 Full Text | PDF
Corrigendum: Direct-access genetic testing: the view from Europe Larry J. Kricka, Paolo Fortina, Yuan Mai & George P. Patrinos p70 | doi:10.1038/nrg3139 Full Text | PDF
Erratum: Regulatory RNA: Layer by layer Nicola McCarthy p70 | doi:10.1038/nrg3140 Full Text | PDF
Advertisement
Dermatogenetics February 9-12, 2012 - Miami, FL, USA The conference will cover: genetic variation, gene expression and cellular mechanisms in this shared area of exceptional interest to basic researchers, biopharma and translational medicine. For more information and to register visit: www.nature.com/natureconferences/dg2012
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

*2010 Journal Citation Report (Thomson Reuters, 2011)

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our feedback department Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2012 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.