Nature Immunology Contents: January 2012 Volume 13 pp 1 - 102

TABLE OF CONTENTS January 2012 Volume 13, Issue 1 Correspondence Meeting Reports News and Views Research Highlights Perspective Articles Resource Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Nature Outlook: Influenza Our centuries-old battle against influenza occasionally erupts into mass death - the 1918 pandemic alone killed at least 50 million people. Can new research offer hope for defeating this pathogen for good? Access the Outlook free online for six months. Produced with support from: Sanofi Pasteur, Crucell, Baxter   Correspondence Top Induction of BALT in the absence of IL-17 p1 Henrike Fleige, Jan D Haas, Felix R Stahl, Stefanie Willenzon, Immo Prinz and Reinhold Förster doi:10.1038/ni.2167 Full Text | PDF Induction of BALT in the absence of IL-17 p2 Javier Rangel-Moreno, Damian M Carragher, Maria de la Luz Garcia-Hernandez, Ji Young Hwang, Kim Kusser, Louise Hartson, Jay K Kolls, Shabaana A Khader and Troy D Randall doi:10.1038/ni.2168 Full Text | PDF Meeting Reports Top Lymphocyte signaling: a Tuscan affair pp3 - 6 Cosima T Baldari, Oreste Acuto, Facundo Batista, Gary Koretzky and Arthur Weiss doi:10.1038/ni.2185 At the third of the three-part EMBO Conference series “Signaling in the immune system,” immunologists presented their most recent findings in this rapidly moving field and discussed new questions and emerging trends. Full Text | PDF 4th Aegean Conference on The Crossroads between Innate and Adaptive Immunity pp7 - 10 Stephen P Schoenberger, Bali Pulendran and Peter D Katsikis doi:10.1038/ni.2192 The worlds of innate and adaptive immunity collided pleasantly and productively as investigators from each field met in Mykonos for the 4th Aegean Conference on the Crossroads Between Innate and Adaptive Immunity. Full Text | PDF News and Views Top Innate iNKT cell help to B cells: fast but does not last pp11 - 13 Agnès Lehuen and Nicolas Fazilleau doi:10.1038/ni.2186 Harnessing invariant natural killer T cells can boost various immune responses. Two studies now shed light on the direct interaction between those cells and B cells that induce strong primary B cell responses. Full Text | PDF See also: Article by Chang et al. | Article by King et al. CD169+ macrophages take the bullet pp13 - 14 Burkhard Ludewig and Luisa Cervantes-Barragan doi:10.1038/ni.2189 Lifting the protective shield provided by the type I interferon system selectively in CD169+ splenic macrophages enforces localized viral replication. Such controlled release of virus amplifies adaptive antiviral immune responses. Full Text | PDF See also: Article by Honke et al. Transmigration of effector T lymphocytes: changing the rules pp15 - 16 Gabriela Constantin and Carlo Laudanna doi:10.1038/ni.2188 The transmigration of effector T lymphocytes is critical to adoptive immune response. The rules for the migration of effector T cells are now reported to be distinct from those that apply to naive and memory T cells. Full Text | PDF See also: Article by Shulman et al. Ikaros changes the face of NuRD remodeling pp16 - 18 Kenneth J Oestreich and Amy S Weinmann doi:10.1038/ni.2191 The inclusion of the transcription factor Ikaros in the NuRD chromatin-remodeling complex regulates both the targeting and activity of the NuRD complex in lymphocytes, thereby influencing developmental gene-expression programs. Full Text | PDF See also: Article by Zhang et al. Immunology JOBS of the week Senior Research Scientist Immunology - Hasselt region (M / F) (BE) biotech company specialized in the research and development of novel therapeutic peptides MRC PhD Studentship in Vaccine Research London School of Hygiene and Tropical Medicine Ph.D. student in biology / biochemistry / immunology Dept of Immunology, Centre de Recherche Public de la Santé, National Public Health Institute Ph.D. student in Chemical Carcinogenesis (pharmacology / biochemistry / biology) Dept of Immunology, Centre de Recherche Public de la Santé, National Public Health Institute Associate Director / Director, Antibody Engineering Genentech More Science jobs from Immunology EVENT Vaccines for Chronic Diseases Symposium 7th Feb - 9th Feb 2012 TX, US More science events from Research Highlights Top Platelets hold the fort | Mining antiviral complexity | Traffic control | Autophagy switch | Regulation by proteoglycans | Gut conversations Perspective Top A new synthesis for antibody-mediated immunity pp21 - 28 Arturo Casadevall and Liise-anne Pirofski doi:10.1038/ni.2184 Abstract | Full Text | PDF Articles Top The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation pp29 - 34 Anke Di, Xiao-Pei Gao, Feng Qian, Takeshi Kawamura, Jin Han, Claudie Hecquet, Richard D Ye, Stephen M Vogel and Asrar B Malik doi:10.1038/ni.2171 The generation of reactive oxygen species needs to be carefully controlled to prevent tissue injury. Malik and colleagues identify a negative feedback mechanism for such production involving the cation channel TRPM2. Abstract | Full Text | PDF Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses pp35 - 43 Pheh-Ping Chang, Patricia Barral, Jessica Fitch, Alvin Pratama, Cindy S Ma, Axel Kallies, Jennifer J Hogan, Vincenzo Cerundolo, Stuart G Tangye, Robert Bittman, Stephen L Nutt, Robert Brink, Dale I Godfrey, Facundo D Batista and Carola G Vinuesa doi:10.1038/ni.2166 Invariant NKT cells elicit the rapid release of cytokines. Two papers by Leadbetter and Vinuesa and colleagues show that these cells can also provide direct help to B cells to elicit rapid antibody responses. Abstract | Full Text | PDF See also: News and Views by Lehuen & Fazilleau Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner pp44 - 50 Irah L King, Anne Fortier, Michael Tighe, John Dibble, Gerald F M Watts, Natacha Veerapen, Ann M Haberman, Gurdyal S Besra, Markus Mohrs, Michael B Brenner and Elizabeth A Leadbetter doi:10.1038/ni.2172 Invariant NKT cells elicit the rapid release of cytokines. Two papers by Leadbetter and Vinuesa and colleagues show that these cells can also provide direct help to B cells to elicit rapid antibody responses. Abstract | Full Text | PDF See also: News and Views by Lehuen & Fazilleau Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus pp51 - 57 Nadine Honke, Namir Shaabani, Giuseppe Cadeddu, Ursula R Sorg, Dong-Er Zhang, Mirko Trilling, Karin Klingel, Martina Sauter, Reinhard Kandolf, Nicole Gailus, Nico van Rooijen, Christoph Burkart, Stephan E Baldus, Melanie Grusdat, Max Löhning, Hartmut Hengel, Klaus Pfeffer, Masato Tanaka, Dieter Höussinger, Mike Recher, Philipp A Lang and Karl S Lang doi:10.1038/ni.2169 Type 1 interferon limits virus replication. Lang and colleagues show that expression of Usp18 in metallophilic macrophages results in less interferon responsiveness, which allows locally restricted virus replication and the induction of adaptive immune responses. Abstract | Full Text | PDF See also: News and Views by Ludewig & Cervantes-Barragan Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity pp58 - 66 Hong-Erh Liang, R Lee Reinhardt, Jennifer K Bando, Brandon M Sullivan, I-Cheng Ho and Richard M Locksley doi:10.1038/ni.2182 Interleukins 4 and 13 are critical for responses to helminthes. Locksley and colleagues use genetically engineered reporter mice to assess the temporal and spatial production of these cytokines in vivo. Abstract | Full Text | PDF Transendothelial migration of lymphocytes mediated by intraendothelial vesicle stores rather than by extracellular chemokine depots pp67 - 76 Ziv Shulman, Shmuel J Cohen, Ben Roediger, Vyacheslav Kalchenko, Rohit Jain, Valentin Grabovsky, Eugenia Klein, Vera Shinder, Liat Stoler-Barak, Sara W Feigelson, Tsipi Meshel, Susanna M Nurmi, Itamar Goldstein, Olivier Hartley, Carl G Gahmberg, Amos Etzioni, Wolfgang Weninger, Adit Ben-Baruch and Ronen Alon doi:10.1038/ni.2173 Endothelium-presented chemokines are critical for the entry of lymphocytes into tissues. Alon and colleagues show that transendothelial migration, but not adhesion, of effector lymphocytes on inflamed endothelium is dependent on chemokine signals. Abstract | Full Text | PDF See also: News and Views by Constantin & Laudanna TGF-β induces the expression of the adaptor Ndfip1 to silence IL-4 production during iTreg cell differentiation pp77 - 85 Allison M Beal, Natalia Ramos-Hernández, Chris R Riling, Erin A Nowelsky and Paula M Oliver doi:10.1038/ni.2154 Induced regulatory T cells are important for peripheral tolerance. Oliver and colleagues identify a key function for the adaptor Ndfip1 in stabilizing the identity and function of such cells. Abstract | Full Text | PDF Harnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesis pp86 - 94 Jiangwen Zhang, Audrey F Jackson, Taku Naito, Marei Dose, John Seavitt, Feifei Liu, Elizabeth J Heller, Mariko Kashiwagi, Toshimi Yoshida, Fotini Gounari, Howard T Petrie and Katia Georgopoulos doi:10.1038/ni.2150 Lymphocyte development is regulated by Ikaros transcription factors. Georgopoulos and colleagues show that Ikaros tethers the nucleosome-remodeling factor Mi-2β and restrains its ability to act at nonlymphoid gene sites. Abstract | Full Text | PDF See also: News and Views by Oestreich & Weinmann Resource Top Principles of dimer-specific gene regulation revealed by a comprehensive characterization of NF-κB family DNA binding pp95 - 102 Trevor Siggers, Abraham B Chang, Ana Teixeira, Daniel Wong, Kevin J Williams, Bilal Ahmed, Jiannis Ragoussis, Irina A Udalova, Stephen T Smale and Martha L Bulyk doi:10.1038/ni.2151 The NF-κB transcription factor family comprises five distinct proteins. Bulyk and colleagues show that homo- and heterodimeric forms of NF-κB recognize distinct κB sites; this introduces additional specificity to NF-κB gene regulation. Abstract | Full Text | PDF Top Advertisement Nature.com presents Antibodypedia Finding the right antibody for the right application just got easier! 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