Nature Cell Biology contents: January 2012 Volume 14 Number 1, pp 1 - 114

TABLE OF CONTENTS January 2012 Volume 14, Issue 1 Focus Editorials Reviews News and Views Research Highlights Articles Letters Resource Technical Report Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Nature Outlook: Multiple Myeloma Although a cure remains a long way off, study of multiple myeloma is yielding insights into bone biology, the role of the tumour microenvironment and the origins of a whole range of different cancers. Access the Outlook free online for six months and request your free copy. Produced with support from: Onyx Pharmaceuticals, Inc.   Focus on Membrane dynamics January 2012 Volume 14, No 1 Contents NPG Library Cellular membranes in eukaryotes are dynamic structures. The budding and fusion of vesicles, as well as the proper delivery of their contents, requires coordinated interactions between coat complexes, adaptor proteins, cargo molecules and cellular machinery including the cytoskeleton. Membrane dynamics are important for fundamental cell biological processes, and dysfunction in membrane trafficking pathways contributes to myriad diseases and developmental anomalies. The January 2012 issue of Nature Cell Biology presents a series of review articles by leading scientists on recent developments in membrane dynamics — including endocytosis, and vesicle biogenesis and transport — and the importance of these processes in development and disease. An accompanying online library presents selected research papers and reviews from Nature Cell Biology and other Nature journals. Editorials Top Focus on Membrane dynamics p1 doi:10.1038/ncb2415a Cellular membranes in eukaryotes are dynamic structures; this is a key property for their roles in numerous cellular processes. In this issue, we present a series of review articles that highlight recent developments in membrane trafficking, and provide an overview of the importance of trafficking events in development and disease. Full Text | PDF Limited stay for foreign scientists in the UK? p1 doi:10.1038/ncb2415b New immigration proposals restricting the period of stay for highly skilled migrants in the UK could undermine the future of British science. Full Text | PDF Reviews Top Lessons from yeast for clathrin-mediated endocytosis pp2 - 10 Douglas R. Boettner, Richard J. Chi and Sandra K. Lemmon doi:10.1038/ncb2403 Abstract | Full Text | PDF Bridging membrane and cytoskeleton dynamics in the secretory and endocytic pathways pp11 - 19 Mihaela Anitei and Bernard Hoflack doi:10.1038/ncb2409 Abstract | Full Text | PDF COPII and the regulation of protein sorting in mammals pp20 - 28 Giulia Zanetti, Kanika Bajaj Pahuja, Sean Studer, Soomin Shim and Randy Schekman doi:10.1038/ncb2390 Abstract | Full Text | PDF Sorting nexins provide diversity for retromer-dependent trafficking events pp29 - 37 Peter J. Cullen and Hendrik C. Korswagen doi:10.1038/ncb2374 Abstract | Full Text | PDF Shaping development with ESCRTs pp38 - 45 Tor Erik Rusten, Thomas Vaccari and Harald Stenmark doi:10.1038/ncb2381 Abstract | Full Text | PDF News and Views Top Navigating the ERAD interaction network pp46 - 47 Thibault Mayor doi:10.1038/ncb2412 The endoplasmic reticulum (ER)-associated protein degradation (ERAD) pathway, which orchestrates the degradation of ER proteins by the proteasome, involves a plethora of proteins with diverse functions. Using a combination of proteomic and genetic approaches, a recent study provides fresh insights into the organization of the mammalian ERAD interaction network and the functions of its components. Full Text | PDF See also: Resource by Christianson et al. c-Cbl targets active Src for autophagy pp48 - 49 Francesco Cecconi doi:10.1038/ncb2413 Autophagy can promote both cancer cell survival and death, and the mechanisms by which it mediates these disparate processes are under intense investigation. Autophagosomes are now shown to entrap and promote degradation of the active tyrosine kinase Src, enabling tumour cell survival. The E3 ubiquitin ligase c-Cbl acts as an autophagosome cargo receptor for Src. Full Text | PDF See also: Article by Sandilands et al. Research Highlights pH-dependent invadopodia control | A pituitary gland in a dish | Autophagy proteins regulate bone resorption | CRAF breaks up with MEK to regulate mitosis in cancer Cell Biology JOBS of the week Faculty Positions Rutgers, the State University of New Jersey Research Associate in Bioprocess Scale-Down UCL Product Manager Genentech Cell Biology Spanish Department of Science and Innovation Senior Scientist Malaria GSK More Science jobs from Cell Biology EVENT Cellular Oncology Conference � New insights leading to clinical advancement 04.-08.03.12 Spain More science events from Articles Top Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling pp51 - 60 Emma Sandilands, Bryan Serrels, David G. McEwan, Jennifer P. Morton, Juan Pablo Macagno, Kenneth McLeod, Craig Stevens, Valerie G. Brunton, Wallace Y. Langdon, Marcos Vidal, Owen J. Sansom, Ivan Dikic, Simon Wilkinson and Margaret C. Frame doi:10.1038/ncb2386 Unrestrained Src signalling can be toxic for cancer cells. Wilkinson, Frame and colleagues show that active Src is sequestered in autophagosomes in cancer cells. Inhibition of autophagy induces cancer cell death. Abstract | Full Text | PDF See also: News and Views by Cecconi A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain pp61 - 72 Ben Chih, Peter Liu, Yvonne Chinn, Cecile Chalouni, Laszlo G. Komuves, Philip E. Hass, Wendy Sandoval and Andrew S. Peterson doi:10.1038/ncb2410 Peterson and colleagues find that the B9 complex localizes to the base of the primary cilia, where it functions as a ciliary diffusion barrier. Mutations in some B9 components are linked to human ciliopathies. The authors show that depleting components of the complex impairs primary cilia formation and inhibits the proper localization and function of signalling receptors in the cilia. Abstract | Full Text | PDF Letters Top Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction pp73 - 79 Tobias Sperka, Zhangfa Song, Yohei Morita, Kodandaramireddy Nalapareddy, Luis Miguel Guachalla, André Lechel, Yvonne Begus-Nahrmann, Martin D. Burkhalter, Monika Mach, Falk Schlaudraff, Birgit Liss, Zhenyu Ju, Michael R. Speicher and K. Lenhard Rudolph doi:10.1038/ncb2388 p53 activates Puma-dependent apoptosis and p21-mediated cell-cycle arrest in response to DNA damage. Rudolph and colleagues show that stem-cell functionality in telomerase-deficient mice is improved by the deletion of Puma. Unexpectedly, the accumulation of progenitor cells with damaged short-telomere DNA is not seen in telomerase- and Puma-deficient animals, as p21-mediated cell-cycle arrest is activated to limit the expansion of these cells. First paragraph | Full Text | PDF Polarized cell growth in Arabidopsis requires endosomal recycling mediated by GBF1-related ARF exchange factors pp80 - 86 Sandra Richter, Lena M. Müller, York-Dieter Stierhof, Ulrike Mayer, Nozomi Takada, Benedikt Kost, Anne Vieten, Niko Geldner, Csaba Koncz and Gerd Jürgens doi:10.1038/ncb2389 Jurgens and colleagues show that the ARF GEFs GNOM and GNL2 have essential roles in polarized cell growth of root hairs and pollen, respectively. Their findings support an important function for endosomal recycling, rather than polarized secretion, in the targeted delivery of proteins necessary for polar tip growth. First paragraph | Full Text | PDF The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress pp87 - 92 Kathryn Austgen, Emily T. Johnson, Tae-Ju Park, Tom Curran and Scott A. Oakes doi:10.1038/ncb2395 The signalling pathway by which ER damage triggers apoptosis remains unclear. Oakes and colleagues identify CT10-regulated kinase (CRK) as a pro-apoptotic protein induced by ER stress. Such stress leads to the accumulation of cleaved CRK fragments at mitochondria, sensitizing them to cytochrome c release in a cell-free system. First paragraph | Full Text | PDF Resource Top Defining human ERAD networks through an integrative mapping strategy pp93 - 105 John C. Christianson, James A. Olzmann, Thomas A. Shaler, Mathew E. Sowa, Eric J. Bennett, Caleb M. Richter, Ryan E. Tyler, Ethan J. Greenblatt, J. Wade Harper and Ron R. Kopito doi:10.1038/ncb2383 Improperly folded proteins are targeted for destruction through the endoplasmic-reticulum-associated degradation pathway (ERAD). Kopito and colleagues present a high-resolution interaction analysis of the ERAD system in combination with functional genomics, and identify new ERAD components. Abstract | Full Text | PDF See also: News and Views by Mayor Technical Report Top Single-molecule transcript counting of stem-cell markers in the mouse intestine pp106 - 114 Shalev Itzkovitz, Anna Lyubimova, Irene C. Blat, Mindy Maynard, Johan van Es, Jacqueline Lees, Tyler Jacks, Hans Clevers and Alexander van Oudenaarden doi:10.1038/ncb2384 Three-colour single-molecule fluorescent in situ hybridization is used by van Oudenaarden and colleagues to show overlapping expression of intestinal stem-cell markers during homeostasis, ageing and regeneration. This approach can help identify putative stem cells in tissues and tumours, and can guide functional studies. Abstract | Full Text | PDF Top Advertisement Dermatogenetics February 9-12, 2012 - Miami, FL, USA The conference will cover: genetic variation, gene expression and cellular mechanisms in this shared area of exceptional interest to basic researchers, biopharma and translational medicine. 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